Article
Biochemistry & Molecular Biology
Ozlem Ozen Karakus, Kavitha Godugu, Shaker A. Mousa
Summary: Polymer-drug conjugates are gaining interest as novel anticancer agents for targeted therapy. The synthesized BG-PEG(1600)-TAT showed improved solubility, binding affinity to integrin alpha v beta 3, and greater anticancer and anti-angiogenesis activities compared to existing treatments, making it a potential clinical candidate for neuroblastoma management.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Qinqin Peng, Ke Sha, Yingzi Liu, Mengting Chen, San Xu, Hongfu Xie, Zhili Deng, Ji Li
Summary: The study found that angiogenesis was enhanced in both rosacea patients and LL37-induced rosacea-like mice, with inhibition of angiogenesis alleviating rosacea-like features. Activation of mTORC1 in endothelial cells was observed in the lesional skin, and inhibiting mTORC1 decreased angiogenesis and blocked rosacea development. In vitro results showed that inhibiting mTORC1 signaling significantly decreased LL37-induced tube formation of human endothelial cells, suggesting that targeting angiogenesis may be a potential therapy for rosacea.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Shahram Seyfi, Kayvan Latifi, Parviz Amri Male, Mahmoud Sadeghi Haddad Zavareh, Khadijeh Ezoji, Mousa Mohammadnia-Afrozi
Summary: This study retrospectively evaluated the clinical treatment outcomes of COVID-19 inpatients who received IFN-beta 1-a and IFN-beta 1-b. The results showed no significant difference between the two groups in terms of shortening disease time, clinical improvements, and other outcomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Jenny Shim, Kelly C. Goldsmith
Summary: Neuroblastoma is a common pediatric solid tumor with a high risk of recurrence, where targeting YAP may hold therapeutic potential. This review highlights the role of YAP in neuroblastoma and the tumor microenvironment, emphasizing its significance in potential therapeutic strategies.
Review
Immunology
Megen C. Wittling, Shannon R. Cahalan, Eric A. Levenson, Ronald L. Rabin
Summary: Type I interferons (IFN-I) were first discovered as antiviral factors, but they also modulate immunity and suppress cancer cell proliferation. There are 16 different IFN-I gene products, and investigating their shared and unique aspects is important for understanding their roles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Mohamed El-Tanani, Hamdi Nsairat, Alaa A. Aljabali, Angel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Gowhar A. Naikoo, Walhan Alshaer, Murtaza M. Tambuwala
Summary: The mammalian target of rapamycin (mTOR), a signalling system, is necessary for various cell proliferation activities. It recognizes PI3KAKT stress signals as a serine-threonine kinase. The abnormal regulation of mTOR pathway has been proven to be crucial in cancer growth and advancement. This review primarily discusses the normal functions of mTOR as well as its abnormal roles in cancer development.
Article
Cell Biology
Luca Occhigrossi, Manuela D'Eletto, Alessio Vecchio, Mauro Piacentini, Federica Rossin
Summary: cGAS/STING pathway is involved in the production of interferon upon bacterial infection, cancer cells, and DNA damage. TG2 plays a role in limiting IFNI production by forming covalent cross-linked IRF3 dimers. This study reveals a novel TG2-dependent mechanism by which cancer cells reduce IFNI production after DNA damage.
CELL DEATH DISCOVERY
(2022)
Article
Infectious Diseases
Sema Serter Kocoglu, Muecahit Secme, Ceren Oy, Gozde Korkusuz, Levent Elmas
Summary: This study aimed to investigate the antiproliferative effects of monensin alone and in combination with rapamycin on neuroblastoma cells mediated by the PI3K/AKT signaling pathway. The results showed that monensin exerts an antiproliferative effect by targeting the PI3K/AKT signaling pathway in neuroblastoma cells. It is suggested that monensin and its combination with rapamycin may be an effective therapeutic candidate for treating neuroblastoma.
Article
Oncology
Diala F. Hamade, Michael W. Epperly, Renee Fisher, Wen Hou, Donna Shields, Jan-Peter van Pijkeren, Amitava Mukherjee, Jian Yu, Brian J. Leibowitz, Anda M. Vlad, Lan Coffman, Hong Wang, M. Saiful Huq, Ziyu Huang, Claude J. Rogers, Joel S. Greenberger
Summary: Irradiation can be an effective treatment for ovarian cancer, but its use is limited by intestinal toxicity. Strategies to mitigate toxicity are important and LR-IFN-beta, a genetically engineered probiotic, shows potential as a safe and feasible radiation mitigator. LR-IFN-beta protects the intestine, improves survival, and can potentially revolutionize OC patient management when combined with platinum/taxane-based chemotherapy.
Editorial Material
Endocrinology & Metabolism
Jin Young Huh, Jae Bum Kim
Summary: A new study highlights the role of TIM4(+) resident ATMs in modulating adipocyte size through platelet-derived growth factor-CC production, thus influencing adipose tissue expansion during development and diet-induced obesity.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Mackenzie Henderson, Daniel B. Horton, Vikram Bhise, Gian Pal, Greta Bushnell, Chintan V. Dave
Summary: This study evaluated patterns of disease-modifying therapy (DMT) initiations in multiple sclerosis (MS) patients in the US from 2001 to 2020. The results showed that oral DMTs were the most commonly initiated treatment by 2020. However, the reasons for this shift are still unclear.
Article
Biochemistry & Molecular Biology
Jiahui Ding, Paulomi Aldo, Cai M. Roberts, Paul Stabach, Hong Liu, Yuan You, Xuemin Qiu, Jiwon Jeong, Anthony Maxwell, Brett Lindenbach, Demetrios Braddock, Aihua Liao, Gil Mor
Summary: The study identified ISG20 as a key component in controlling Zika virus infection and successfully developed a recombinant ISG20-Fc protein that could potentially serve as an antiviral treatment option for high-risk populations, especially pregnant women.
Article
Infectious Diseases
Sema Serter Kocoglu, Fatma Bahar Sunay, Pakize Nur Akkaya
Summary: This study investigated the therapeutic effects of single and combined monensin and rapamycin treatments on mTOR signaling pathway-mediated apoptosis and tumor growth in a neuroblastoma cell xenograft model. The combination of monensin and rapamycin reduced tumor growth, triggered apoptosis, and suppressed the expression of PI3K/AKT/mTOR. These preclinical results may pave the way for developing new therapeutic approaches to treat neuroblastoma.
Review
Oncology
Fiona M. Healy, Lekh N. Dahal, Jack R. E. Jones, Yngvar Floisand, John F. Woolley
Summary: Myeloid malignancies encompass a diverse group of disorders, each presenting unique challenges and treatments, from aggressive acute myeloid leukaemia to chronic myeloid leukaemia with drug resistance and relapse. Interferon therapy shows promise in treating drug-resistant cases and may have a role beyond front-line therapies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Mir Hilal Ahmad, Balaram Ghosh, Moshahid Alam Rizvi, Mansoor Ali, Loveleena Kaur, Amal Chandra Mondal
Summary: Neuroblastoma is a common heterogeneous extracranial cancer in infancy that is associated with aberrant activation of the Wnt signaling pathway. The Wnt signaling pathway regulates the development and differentiation of neural crest cells and affects the proliferation and metastasis of neuroblastoma. Inhibiting the Wnt signaling pathway can induce apoptosis and prevent the occurrence of neuroblastoma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)