Review
Nutrition & Dietetics
Maria Giovanna Puoti, Jutta Koglmeier
Summary: This paper discusses the nutritional strategies available for clinicians caring for pediatric patients with short bowel syndrome. The research found that there is currently no consensus on the best way to feed these patients, and there are significant variations in practice between different centers. Therefore, more research is needed to establish common treatment protocols.
Article
Nutrition & Dietetics
Francesco Proli, Andrea Faragalli, Cecile Talbotec, Andrea Bucci, Boutaina Zemrani, Christophe Chardot, Elie Abi Nader, Olivier Goulet, Cecile Lambe
Summary: Plasma citrulline levels can serve as a reliable marker for predicting the probability of weaning off parenteral nutrition in neonatal short bowel syndrome patients. The increase in citrulline levels over time is associated with a higher likelihood of weaning off parenteral nutrition.
CLINICAL NUTRITION
(2021)
Article
Surgery
Savas T. Tsikis, Scott C. Fligor, Thomas I. Hirsch, Paul D. Mitchell, Amy Pan, Kamila Moskowitzova, Ashlyn E. Whitlock, Greta Loring, Eric First, Arthur Nedder, Kathleen M. Gura, Mark Puder
Summary: In a porcine model of short bowel syndrome with intestinal failure, the use of an immobilized lipase cartridge (ILC) in conjunction with enteral feeding reduced parenteral nutrition (PN) dependence, improved nutrient absorption, and increased bowel growth.
Article
Nutrition & Dietetics
Igor Sukhotnik, Reut Levi, Hadar Moran-Lev
Summary: Essential amino acids are crucial in promoting intestinal adaptation after significant small gut resection. The role of dietary amino acids in the nutritional management of infants and children with intestinal failure and short bowel syndrome (SBS) has been extensively studied over the past three decades. Breast milk is recommended as the first-line enteral regimen for infants with SBS, and hydrolyzed formulas or amino acid formulas are recommended when breast milk is not available or tolerated. The superiority of amino acid formulas over hydrolyzed formulas has not been proven. Glutamine supplementation in SBS infants does not affect their dependence on parenteral nutrition. Circulating citrulline is considered an important indicator of survival and nutritional prognosis in SBS patients. Early enteral nutrition and dietary amino acid supplementation are essential for intestinal adaptation and reducing the reliance on parenteral nutrition after bowel resection in children.
Article
Engineering, Biomedical
Zhengming Zhou, Ke Li, Lei Shi, Yunfeng Wang, Yunxiang He, Wen Hu, Junling Guo
Summary: A nutrient carrier platform constructed with green tea catechin and ferrous ions effectively prolongs the residence and absorption time of nutrients in the intestine, improving the nutritional status, anemia, immune function, intestinal tissue growth, and integrity of the intestinal barrier in a rat model of short bowel syndrome. The platform also modulates gut microbial dysbiosis and increases the abundance of beneficial bacteria. This study provides evidence for the use of polyphenol-based nanocomplexes as enteral nutrition preparation for SBS treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yuling Zhao, Haixia Feng, Ying Wang, Lu Jiang, Junkai Yan, Wei Cai
Summary: This study discovered that villus atrophy is a major cause of intestinal failure in children with short bowel syndrome (SBS) who receive parenteral nutrition (PN), but the mechanism is unclear. The study demonstrated the crucial role of farnesoid X receptor (FXR) signaling and fatty acid oxidation (FAO) in PN-induced villus atrophy. Impaired FXR/CPT1a axis and disturbed FAO may play a pivotal role in PN-induced villus atrophy, contributing to intestinal failure in SBS patients.
Article
Nutrition & Dietetics
Zuzanna Zaczek, Paulina Jurczak-Kobus, Mariusz Panczyk, Joanna Braszczynska-Sochacka, Krystyna Majewska, Marek Kunecki, Karolina Dabrowska, Jacek Sobocki
Summary: In this study, patients receiving home parenteral nutrition after discontinuation of TED treatment were followed up for 9 years, showing that the PN volume requirements increased within 4-5 years after treatment cessation and in some cases even exceeded pretreatment values.
Article
Nutrition & Dietetics
Salma Fourati, Annick Hamon, Rita Daclat, Joe-Elie Salem, Katell Peoc'h, Johanne Le Beyec, Francisca Joly, Jean-Marc Lacorte
Summary: This study found that ApoB-48 protein could be used as a marker to assess intestinal function in patients with short bowel syndrome. There was a positive correlation between ApoB-48 and residual small bowel length, and lower levels of ApoB-48 were observed in patients dependent on parenteral nutrition.
Review
Nutrition & Dietetics
Yolanda Ber, Santiago Garcia-Lopez, Carla J. Gargallo-Puyuelo, Fernando Gomollon
Summary: This article discusses the different functions of the small intestine and large intestine in nutrient absorption, as well as the causes, consequences, and management of malnutrition in patients with inflammatory bowel diseases, short bowel syndrome, and malignant and benign digestive tumors.
Article
Nutrition & Dietetics
Jerome Filippi, Amandine Rubio, Virgine Lasserre, Jean Maccario, Stephanie Walrand, Nathalie Neveux, Servane Le Plenier, Xavier Hebuterne, Luc Cynober, Christophe Moinard
Summary: The study found that citrulline supplementation promotes body weight gain, preserves muscle trophicity, and enhances intestinal adaptation in a dose-dependent manner in a model of resected rats.
Review
Nutrition & Dietetics
Fabio Bioletto, Chiara D'Eusebio, Fabio Dario Merlo, Umberto Aimasso, Marta Ossola, Marianna Pellegrini, Valentina Ponzo, Alessia Chiarotto, Antonella De Francesco, Ezio Ghigo, Simona Bo
Summary: Teduglutide is an effective treatment for reducing parenteral support in patients with short bowel syndrome. Our meta-analysis provides pooled estimates of response and weaning rates over time and identifies intestinal anatomy as a significant predictor of these outcomes.
Article
Surgery
Jon S. Thompson, Fedja A. Rochling, Elizabeth Lyden, Shaheed Merani, Luciano M. Vargas, Wendy J. Grant, Alan N. Langnas, David F. Mercer
Summary: Previous cholecystectomy in SBS patients does not affect the nutritional prognosis of SBS, regardless of the intestinal remnant length and anatomy type.
AMERICAN JOURNAL OF SURGERY
(2022)
Review
Nutrition & Dietetics
John K. DiBaise, James S. Scolapio
Summary: This article highlights the importance of home parenteral and enteral nutrition in clinical nutrition and the development of these therapies to support patients. It emphasizes the need for healthcare providers to understand all aspects of HPEN in order to provide safe, effective, and cost-effective support to patients.
Article
Nutrition & Dietetics
Toshiyuki Sato, Motoi Uchino, Jiro Takeuchi, Yutaro Fujihira, Kazuma Shimizu, Keiko Yokoyama, Soichi Yagi, Koji Kaku, Yusuke Takashima, Maiko Ikenouchi, Kentaro Kojima, Mikio Kawai, Kazuko Nagase, Koji Kamikozuru, Yoko Yokoyama, Tetsuya Takagawa, Hiroki Ikeuchi, Kenji Watanabe, Shinichiro Shinzaki
Summary: This study investigated the short-term effects of TED on CD patients with SBS-IF and found that TED significantly reduced the need for parenteral support. Some patients were able to successfully discontinue home parenteral support after using TED.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Daniela Gattini, Christina Belza, Raphael Kraus, Yaron Avitzur, Wendy J. Ungar, Paul W. Wales
Summary: This study compared the cost-effectiveness of teduglutide with standard care in children with short bowel syndrome (SBS). The results showed that although teduglutide was not cost-effective initially, starting the treatment after natural intestinal adaptation and adjusting the cost based on weight dosing made it a cost-effective intervention compared to standard care.
CLINICAL NUTRITION
(2023)