Article
Medicine, General & Internal
Reagan M. Mogire, Alireza Morovat, John Muthii Muriuki, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Manjinder S. Sandhu, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: The study found that vitamin D deficiency rates among young African children were 0.6% and 7.8%, with factors such as country, age, season, inflammation, and malaria influencing the levels. In addition, variations in the GC gene were associated with vitamin D levels.
Article
Nutrition & Dietetics
Buthaina Yusuf Al-Ajlan, Afnan Freije, Sabika Allehdan, Simone Perna
Summary: This study investigated the prevalence of vitamin D deficiency and its risk factors in children and adolescents aged 10 to 19. The results showed a high prevalence of vitamin D deficiency, especially among boys and overweight/obese individuals. Additionally, there was a significant association between vitamin D deficiency and low serum levels of magnesium and phosphate.
Article
Medicine, General & Internal
Adeel Ahmed Siddiqui, Jagdesh Kumar, Mariyam Adeel, Uzair Yaqoob, Mohammad Irfan Rajput
Summary: This study aims to evaluate the prevalence of vitamin D inadequacy in children with supracondylar fractures. The research found that 35% of children with supracondylar fractures had vitamin D deficiency, with the lowest average levels in the preschool age group. It is suggested that vitamin D supplementation globally could help prevent fractures.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Oncology
Gerrit S. Maier, Manuel Weissenberger, Maximilian Rudert, Klaus E. Roth, Konstantin Horas
Summary: Vitamin D is considered crucial for musculoskeletal health, with a significant number of studies focusing on its potential health benefits and the prevalence of deficiency. Over one billion people worldwide are affected by insufficient levels of vitamin D, sparking debates on its relative importance and prompting further research into its future perspectives.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Tattari Shalini, Raghu Pullakhandam, Santu Ghosh, Bharati Kulkarni, Hemalatha Rajkumar, Harshpal S. Sachdev, Anura V. Kurpad, Geereddy Bhanuprakash Reddy
Summary: There is a high prevalence of vitamin B-12 and folate deficiency among Indian children and adolescents, especially in adolescents. Although there are regional variations, there are no rural-urban differences. These findings suggest the need for further investigation.
Article
Nutrition & Dietetics
Faruk Ahmed, Hossein Khosravi-Boroujeni, Moududur Rahman Khan, Anjan Kumar Roy, Rubhana Raqib
Summary: This study found that hypovitaminosis D is highly prevalent among pregnant rural Bangladeshi women. Parity and gestational age are common risk factors for vitamin D deficiency and insufficiency, while a husband's occupation and anaemia status may predict vitamin D insufficiency. Younger age and sub-optimal vitamin A status are risk factors for vitamin D deficiency in this population.
Article
Nutrition & Dietetics
Reagan M. Mogire, John Muthii Muriuki, Alireza Morovat, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: There is a significant association between vitamin D and iron deficiency in African children. The risk of iron deficiency is increased in children with vitamin D deficiency, and vitamin D concentration variably influences iron status. Therefore, the link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies.
Article
Nutrition & Dietetics
Monia Kittana, Asma Ahmadani, Lily Stojanovska, Amita Attlee
Summary: Children with autism spectrum disorder (ASD) have lower vitamin D levels and the deficiency is strongly correlated with ASD severity. Vitamin D supplementation can significantly reduce ASD severity, but the effect may vary between treatment and control groups. Variations in vitamin D dose protocols and concurrent interventions may contribute to the variability of results. The age of introducing vitamin D intervention may also affect the effectiveness of treatment. Further long-term, well-designed randomized controlled trials are needed to confirm the impact of vitamin D on severity in children with ASD.
Review
Nutrition & Dietetics
Marcela M. Mendes, Anna P. O. Gomes, Maisa M. Araujo, Alexandre S. G. Coelho, Kenia M. B. Carvalho, Patricia B. Botelho
Summary: This review aimed to estimate the prevalence of vitamin D deficiency in South American populations. A total of 96 studies involving 227,758 participants were included. The overall prevalence of vitamin D deficiency was found to be 34.76%. Age, sex, country, latitude, season, and year of publication were factors associated with the prevalence rates. Therefore, public health strategies should address the prevention, detection, and treatment of vitamin D deficiency.
Article
Health Care Sciences & Services
Saleh M. Al-Qahtani, Ayed A. Shati, Youssef A. Alqahtani, Samy A. Dawood, Aesha F. Siddiqui, Mohamed Samir A. Zaki, Shamsun N. Khalil
Summary: The study reveals a high prevalence of vitamin D deficiency among children aged up to two years, with infants, urban dwellers, those who are exclusively breastfed, and those who have limited sun exposure identified as independent risk factors for vitamin D deficiency.
Article
Nutrition & Dietetics
Valentina De Cosmi, Alessandra Mazzocchi, Veronica D'Oria, Alessandro Re, Giulia Carla Immacolata Spolidoro, Gregorio P. Milani, Cristiana Berti, Silvia Scaglioni, Claudia Giavoli, Silvia Bergamaschi, Giulia Rodari, Eriselda Profka, Roberto Colombo, Carlo Agostoni
Summary: This study investigated the effect of vitamin D and DHA co-supplementation on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. The study found that more than 50% of the children improved their vitamin D status at the end of the study, but co-supplementation was not more effective than vitamin D plus wheat germ oil.
Review
Nutrition & Dietetics
Maria Oana Sasaran, Cristina Oana Marginean, Ancuta Lupu, Ana Maria Koller
Summary: This review assesses the relationship between vitamin D deficiency and H. pylori infection, finding that vitamin D deficiency may be a potential risk factor for H. pylori infection and is directly linked to eradication failure. An inverse linear relationship exists between vitamin D status and gastric cancer risk, but the involvement of H. pylori in this correlation is still uncertain. Further population-based studies are needed to explore this subject in more depth.
Article
Pediatrics
Cuneyt Karagol, Aysu Duyan Camurdan
Summary: This study aims to determine the frequency of vitamin D deficiency and its influencing factors in healthy children. The results showed that 18-24.9% of healthy children have vitamin D deficiency or insufficiency. The frequency of vitamin D deficiency increases with age, and the most severe cases are found in adolescent girls. Other risk factors include winter or spring season and living in regions north of the 40th parallel.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Fanny Loddo, Steve Nauleau, David Lapalus, Sophie Tardieu, Olivier Bernard, Farid Boubred
Summary: This population-based record-linkage study examined the association between maternal gestational Vitamin D3 supplementation and early respiratory health in offspring. The study found that infants prenatally exposed to maternal Vitamin D3 supplementation had a longer gestational age at birth and a lower risk of respiratory illness. This study provides evidence for the positive impact of maternal gestational Vitamin D3 supplementation on early respiratory outcomes in young children.
Article
Nutrition & Dietetics
Jabulani R. Ncayiyana, Leonardo Martinez, Elizabeth Goddard, Landon Myer, Heather J. Zar
Summary: The study found a high prevalence of vitamin D deficiency in South African infants, with factors such as study site, socioeconomic status, and gender being associated with serum 25(OH)D-3 levels. Birth in winter and breastfeeding were identified as the strongest predictors of lower vitamin D concentrations.
Article
Genetics & Heredity
Ahmed S. N. Alhendi, Derek Lim, Shane McKee, Meriel McEntagart, Katriona Tatton-Brown, I. Karen Temple, Justin H. Davies, Deborah J. G. Mackay
Summary: Whole-genome sequencing (WGS) analysis revealed genetic variants in 27% of participants with Silver-Russell syndrome (SRS), including coding SNVs in genes such as CDKN1C, IGF2, IGF1R and ORC1, as well as maternal-effect variants and UPD regions. WGS is a valuable tool for diagnosing SRS and related disorders in cases where traditional molecular testing is inconclusive.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Endocrinology & Metabolism
Tim D. Cheetham, Michael Cole, Mario Abinun, Amit Allahabadia, Tim Barratt, Justin H. Davies, Paul Dimitri, Amanda Drake, Zainaba Mohamed, Robert D. Murray, Caroline A. Steele, Nicola Zammitt, Sonya Carnell, Jonathan Prichard, Gillian Watson, Sophie Hambleton, John N. S. Matthews, Simon H. S. Pearce
Summary: In this study, young patients with Graves hyperthyroidism were treated with a combination of RTX and short-term ATD, resulting in a remission rate of 48% at 24 months, indicating the potential of RTX in improving remission rates in young patients with Graves hyperthyroidism. A randomized trial of adjuvant RTX in this patient population is warranted.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Meera Shaunak, Lucy Side, Nadeem Afzal, Justin Huw Davies
Summary: An atypical presentation of a pathogenic STK11 gene variant was reported in siblings without meeting the clinical diagnostic criteria for Peutz-Jeghers Syndrome (PJS). Endocrinological investigation is necessary for prepubertal gynaecomastia and prepubertal macro-orchidism, with PJS being an important differential diagnosis. Genetic testing and gastroenterological investigation of parents may aid in diagnosis.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2022)
Article
Genetics & Heredity
Sarah E. Grosvenor, Justin H. Davies, Margaret Lever, Julie Sillibourne, Deborah J. G. Mackay, I. Karen Temple
Summary: This report presents a patient with clinical features of both Beckwith-Wiedemann syndrome and Temple syndrome, in whom epimutations were found at the imprinted regions associated with both syndromes, indicating the presence of multilocus imprinting disturbance. The study emphasizes the importance of testing for multilocus imprinting disturbance in diagnosing patients with atypical clinical presentations of imprinting disorders.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2022)
Article
Endocrinology & Metabolism
Rebecca J. Moon, Laura D. F. Cooke, Stefania D'Angelo, Elizabeth M. Curtis, Philip Titcombe, Justin H. Davies, Keith M. Godfrey, Jane K. Cleal, Rohan M. Lewis, Cyrus Cooper, Nicholas C. Harvey
Summary: There is an association between specific single nucleotide polymorphisms (SNPs) in genes related to vitamin D metabolism pathway and cord blood 25(OH)D in both mothers and offspring, indicating a potential role of genetic factors in this relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Rebecca J. Moon, Stefania D'Angelo, Sarah R. Crozier, Keith M. Godfrey, Justin H. Davies, Cyrus Cooper, Nicholas C. Harvey
Summary: This study found that the association between skull bone mineral density (BMD) and anthropometric, body composition, and dietary variables is weaker compared to other skeletal regions of interest (ROI) assessed by dual-energy X-ray absorptiometry (DXA). These findings provide a quantitative basis for the recommendation to exclude the skull from whole-body DXA analyses in children.
Article
Pediatrics
Rebecca Jane Moon, Justin Huw Davies
Summary: This study assessed the actual practice of pubertal staging by paediatricians and paediatric endocrinology nurse specialists in the UK. The study found that most clinicians consider pubertal staging an intimate examination, but documentation of consent and use of formal chaperones is not standard practice. Many respondents use a parent as a chaperone, and patient objections and availability of chaperones were perceived barriers to chaperone use.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Letter
Pediatrics
Justin Huw Davies, Molly Handcock, Paul Cook, Olivia Kaye, Rebecca Jane Moon
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Endocrinology & Metabolism
Samantha J. Case, Rebecca J. Moon, Tara Bharucha, Justin H. Davies
Summary: This case report highlights a previously unreported complication of cardiac thrombosis following zoledronate treatment in a child. Echocardiography should be considered to evaluate the cardiovascular status of children receiving zoledronate.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)
Review
Pediatrics
Talat Mushtaq, Salma R. Ali, Nabil Boulos, Roisin Boyle, Tim Cheetham, Justin Huw Davies, Charlotte Jane Elder, Hoong-Wei Gan, Peter C. Hindmarsh, Harshini Katugampola, Nils Krone, Maria Salomon Estebanez, Savitha Shenoy, Sally Tollerfield, Sze Choong Wong, Fiona Regan
Summary: Adrenal insufficiency (AI) is a condition where the adrenal glands fail to produce enough cortisol. It can be caused by primary adrenal dysfunction or secondary to hormonal deficiency or suppression. Children with AI may present with nonspecific symptoms such as poor growth, lethargy, weight loss, and abdominal pain. Treatment involves replacing cortisol with hydrocortisone, especially during times of stress. However, there are no standardized guidelines for managing AI in children under 18 in the UK, leading to significant variations in care. This paper aims to provide guidance for recognizing and treating AI and adrenal crisis in children and young people during illness, medical, dental, and surgical procedures.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Primary Health Care
H. L. Storr, J. Freer, J. Child, J. H. Davies
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Editorial Material
Primary Health Care
Justin H. Davies, Jenny Child, Joseph Freer, Helen L. Storr
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Martin O. Savage, Malcolm D. C. Donaldson, Justin H. Davies, Helen L. Storr
Summary: Paediatric endocrinology was recognized in Western European countries in the 1960s and 1970s, but its development varies in different countries. This review discusses the key stages in establishing modern centres and emphasizes the importance of determination, vision, and knowledge acquisition through international fellowships. Scientific societies and telemedicine models play important roles in supporting and networking with experienced colleagues.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Rebecca J. Moon, Stefania D'Angelo, Christopher R. Holroyd, Sarah R. Crozier, Keith M. Godfrey, Justin H. Davies, Cyrus Cooper, Nicholas C. Harvey
Summary: This study examines differential mother-offspring and father-offspring associations in body composition in early childhood. The results show a strong association between maternal fat mass and the fat mass of their daughters but not their sons, while there were weaker associations between the body composition of fathers and their children.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Rebecca J. Moon, Harry D. Green, Stefania D'Angelo, Keith M. Godfrey, Justin H. Davies, Elizabeth M. Curtis, Cyrus Cooper, Nicholas C. Harvey
Summary: A systematic review and meta-analysis showed that moderate- to high-dose vitamin D supplementation during pregnancy has a positive effect on offspring bone mineralisation, with increased bone mineral density (BMD) in children aged 4-6 years and a smaller effect on bone mineral content.
OSTEOPOROSIS INTERNATIONAL
(2023)
