Article
Immunology
Caroline K. Bundi, Angela Nalwoga, Lawrence Lubyayi, John Muthii Muriuki, Reagan M. Mogire, Herbert Opi, Alexander J. Mentzer, Cleopatra K. Mugyenyi, Jedida Mwacharo, Emily L. Webb, Philip Bejon, Thomas N. Williams, Joseph K. Gikunju, James G. Beeson, Alison M. Elliott, Francis M. Ndungu, Sarah H. Atkinson
Summary: Iron deficiency in children is associated with lower levels of specific antibodies to malaria, potentially leading to impaired acquisition of immunity to the disease. These lower antibody levels persist over time in iron-deficient children.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Environmental Sciences
Tahere Farkhondeh, Borhan Mansouri, Lukasz J. Binkowski, Martyna Blaszczyk, Meghdad Pirsaheb, Nammam Ali Azadi, Maciej Sloboda, Alireza Amirabadizadeh, Seyed Yoosef Javadmoosavi
Summary: This study reviewed and meta-analyzed the association between iron deficiency anemia (IDA) and blood lead levels (BLL) among children, finding significantly higher BLL in IDA children and a higher risk of IDA development in children with BLL > 10 mu g/dL. Systematic monitoring of Fe and Pb levels among children, especially in countries with limited sources of nutritious food, is recommended. Further studies are necessary to examine the association between IDA and BLL in detail, as only a few studies were available for this meta-analysis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Yang Liu, Chengdong Xu, Feiyan Liu, Gexin Xiao, Shaoqi Zhou, Liming Huang, Ni Lin, Jianyi Li, Dong Chen, Qi Fu, Huijun Wang, Qingfeng Du
Summary: The study revealed that the development of the lead industry is associated with children's blood lead levels in different regions of China. Economic development in leaded areas was linked to inequity in children's BLLs, while in areas without lead industries, there was little correlation between economic development and children's BLLs.
ENVIRONMENTAL POLLUTION
(2022)
Article
Pediatrics
Joseph M. Braun, Kimberly Yolton, Nicholas Newman, David E. Jacobs, Mark Taylor, Bruce P. Lanphear
Summary: The study found that the EPA's residential dust lead regulations place children at increased risk of lead poisoning, with the 2019 post-abatement lead clearance standards associated with higher risk compared to dust lead hazard standards. Extrapolating the findings to US children, it was estimated that the 2019 EPA standards could put up to 36,700 children at risk of lead poisoning.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Marissa Hauptman, Michelle L. Rogers, Matthew Scarpaci, Barbara Morin, Patrick M. Vivier
Summary: This study examines the persistence of neighborhood-level lead poisoning disparities in Rhode Island from 2006 to 2019. It finds that despite significant progress in reducing lead exposure, disparities in lead poisoning persist at the neighborhood level.
PEDIATRIC RESEARCH
(2023)
Review
Environmental Sciences
Jintao Huang, Zhijun Zeng, Xijin Xu, Qianwen Tian, Keyang Zheng, Xia Huo
Summary: Blood lead levels (BLLs) in e-waste-exposed children have been decreasing over time. A meta-analysis of 51 studies from six countries found that the total geometric mean BLL was 7.54 μg/dL. BLLs displayed a decreasing trend from 11.77 μg/dL in 2004-2006 to 4.63 μg/dL in 2016-2018. Nearly 95% of studies showed that e-waste-exposed children had significantly higher BLLs than the reference groups. The difference in BLLs between the exposure group and reference group decreased from 6.60 μg/dL in 2004 to 1.99 μg/dL in 2018. It was found that children from Guiyu had higher BLLs compared to other regions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Environmental Sciences
Jintao Huang, Zhijun Zeng, Xijin Xu, Qianwen Tian, Keyang Zheng, Xia Huo
Summary: Blood lead levels (BLLs) among children in e-waste recycling areas have been decreasing over time, but are still higher compared to children not exposed to e-waste. The difference in BLLs between exposed and reference groups is gradually decreasing.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Shuo Wang, Yuan Jin, Jing Chen, Lin Lu, Yanan Li, Qianwen Zhao, Shuhua Bu, Xue Geng, Ge Guan, Weidong Qu, Yuxin Zheng, Jinglong Tang
Summary: The study investigated blood lead levels of over a million Chinese children and teenagers over the past 30 years, showing a declining trend with higher levels in boys compared to girls. Regions like Yunnan, Guizhou, and Shanxi had relatively high levels of lead exposure. Despite the decrease, Chinese children's lead levels are still higher than those in developed countries, indicating the need for more efforts in lead control for children.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Carla Moscheo, Maria Licciardello, Piera Samperi, Milena La Spina, Andrea Di Cataldo, Giovanna Russo
Summary: Iron deficiency anemia is a common hematological disorder in children with room for improvement in its management. The introduction of new iron formulations, both oral and parenteral, offers more effective and less toxic treatment options, while parenteral iron may continue to evolve.
Article
Environmental Sciences
Cleo Tebby, Julien Caudeville, Yasmil Fernandez, Celine Brochot
Summary: The decrease in lead levels in air and drinking water has resulted in a decrease in blood lead levels in children over the last 40 years, but there is still no known safe level of lead exposure for developmental effects. A study in France mapped predicted blood lead levels in children, finding that drinking water and food were the main sources of lead exposure, with the former being prominent in children over 2 years old. The study also showed discrepancies in predicted blood lead levels for infants and children aged 2 to 6, with the latter being more accurately predicted.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pediatrics
Tharwat El Zahran, Hala Mostafa, Hani Hamade, Moustafa Al Hariri, Aed Saab, Hani Tamim, Rasha Tohme, Dany A. Al Hamod, Durriyah Sinno, Rasha Dorothy Sawaya, Ziad Kazzi
Summary: The study in Lebanese children showed a marked decrease in blood lead levels, likely attributed to factors including the ban of leaded gasoline. Higher education level and income, more rooms at home, and residing close to construction sites were associated with lower BLL, while residing in older houses and using traditional remedies were associated with higher BLL. Conducting a larger nationally representative study may provide more insights into blood lead levels in Lebanon.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Toxicology
Monica Shirley Mani, Venzil Lavie Dsouza, Herman Sunil Dsouza
Summary: This study investigated the influence of DMT1 gene polymorphism on blood lead levels, showing that heterozygous CA carriers had higher Pb-B levels and a negative association with hemoglobin. The C allele may be a risk allele contributing to increased susceptibility to high Pb-B retention in lead exposed individuals.
TOXICOLOGY LETTERS
(2021)
Article
Nutrition & Dietetics
Aida Zeckanovic, Marko Kavcic, Tomaz Prelog, Alenka Smid, Janez Jazbec
Summary: The study concluded that "Your" Iron Syrup is an effective, well-tolerated, and safe option for managing nutritional iron deficiency in children, leading to significant increases in ferritin and hemoglobin levels in comparison to a placebo.
Article
Environmental Sciences
Given Moonga, Moses N. Chisola, Ursula Berger, Dennis Nowak, John Yabe, Hokuto Nakata, Shouta Nakayama, Mayumi Ishizuka, Stephan Bose-O'Reilly
Summary: This study used a geospatial approach to investigate spatial clustering and hotspots of blood lead levels in children in Kabwe, Zambia. The results showed distinct hotspots with high lead levels in communities close to the old lead and zinc mining site, and coldspots with low lead levels in areas distant to the mine.
ENVIRONMENTAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Saeun Park, Ezekiel Mupere, Troy C. Lund, James S. Hodges, Emily C. Moody, Elena Colicino, Michael K. Georgieff, Sarah E. Cusick
Summary: This study found an association between iron deficiency and heavy metal burden, particularly cobalt and manganese, among Ugandan children. Further research is needed to confirm these findings and investigate the combined effects of coexposure to neurotoxicants on the neurodevelopment of young children.
JOURNAL OF NUTRITION
(2023)
Article
Obstetrics & Gynecology
Mona Nabulsi, Rayan Ghanem, Hanan Smaili, Ali Khalil
Summary: The use of the inverted syringe technique did not improve breastfeeding outcomes for women with inverted nipples. Larger clinical trials are needed to confirm these findings.
INTERNATIONAL BREASTFEEDING JOURNAL
(2022)
Article
Clinical Neurology
Piero Perucca, Kate Stanley, Natasha Harris, Anne M. McIntosh, Ali A. Asadi-Pooya, Mohamad A. Mikati, Danielle M. Andrade, Patricia Dugan, Chantal Depondt, Hyunmi Choi, Erin L. Heinzen, Gianpiero L. Cavalleri, Russell J. Buono, Orrin Devinsky, Michael R. Sperling, Samuel F. Berkovic, Norman Delanty, David B. Goldstein, Terence J. O'Brien
Summary: This study investigated whether rare genetic variations influence seizure outcomes of MTLE surgery. The results showed that MTLE cases carried a higher burden of ultrarare missense variants in constrained genes and genes encoding voltage-gated cation channels. However, these genetic variations did not have a major role in the failure of MTLE surgery.
ANNALS OF NEUROLOGY
(2023)
Letter
Behavioral Sciences
Mohamad A. Mikati
EPILEPSY & BEHAVIOR
(2022)
Letter
Behavioral Sciences
Mohamad A. Mikati, Julie Uchitel
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2023)
Letter
Clinical Neurology
Eleni Panagiotakaki, Maria T. Papadopoulou, Gaetan Lesca, Alexis Arzimanoglou, Mohamad A. Mikati
Article
Clinical Neurology
Katrina Peariso, Ravindra S. Arya, Tracy Glauser, Nicholas Abend, Cristina Barcia Aguilar, Marta L. Amengual-Gual, Anne Anderson, Brian Appavu, J. Nicholas E. Brenton, Jessica Carpenter, Kevin D. Chapman, Justice Clark, William Gaillard, Marina Gainza-Lein, Joshua Goldstein, Howard M. Goodkin, Zachary S. Grinspan, Rejean Guerriero, Paul Horn, Linda A. Huh, Robert H. Kahoud, Sarah Kelley, Eric Kossoff, Kush Kapur, Yi-Chen Lai, B. Oyinkan A. Marquis, Tiffani McDonough, Mohamad Mikati, Lindsey P. Morgan, Edward T. Novotny, Adam Ostendorf, Eric Payne, Juan Piantino, James E. Riviello, Tristan C. Sands, Carl Stafstrom, Robert Tasker, Dmitry S. Tchapyjnikov, Alejandra Vasquez, Mark Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper, PSERG
Summary: This study aimed to identify patient-specific factors associated with the development of refractory convulsive status epilepticus (RSE) in children treated in emergency care. The study found that a family history of seizures and the use of rectal diazepam were associated with a decreased likelihood of RSE.
Letter
Clinical Neurology
Mohamad A. Mikati, Ghada El-Hajj Fuleihan
Letter
Clinical Neurology
Mohamad A. Mikati
Article
Clinical Neurology
Maria K. Sentmanat, Maria T. Papadopoulou, Lyndsey Prange, Carmen Fons, Elisa De Grandis, Aikaterini Vezyroglou, April Boggs, Samantha Su, Marion Comajuan, Jeffrey Wuchich, Sigurdur Johannesson, Jennifer Anticona Huaynate, Michela Stagnaro, Andrey Megvinov, Alexis Arzimanoglou, Rosaria Vavassori, Eleni Panagiotakaki, Mohamad A. Mikati
Summary: This study aimed to develop methods for recording Alternating Hemiplegia of Childhood (AHC) spells. The results showed that video-library training, event-calendar with weekly reviews, and e-Diary were effective tools for improving spell identification, ensuring consistent documentation, and encouraging long-term usage.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2023)
Article
Clinical Neurology
Shital H. Patel, Eleni Panagiotakaki, Maria T. Papadopoulou, Carmen Fons, Elisa De Grandis, Aikaterini Vezyroglou, Simona Balestrini, Hwanhee Hong, Beiyu Liu, Lyndsey Prange, Alexis Arzimanoglou, Rosaria Vavassori, Mohamad A. Mikati
Summary: This article describes the development process of a methodology for a multicenter natural history study of alternating hemiplegia of childhood, serving as a prototype disease for rare neurodevelopmental disorders. The authors employed a systematic approach to identify relevant questions, challenges, and appropriate methods to address them. The proposed solutions involve the development and standardization of specific tools, tailored measurement methods, unified data collection protocols, and specialized analysis methods.
JOURNAL OF CHILD NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Mona Nabulsi, Hanan Smaili, Nour Abou Khalil
Summary: This study describes the adaptation and validation of the Arabic version of the Maternal Postpartum Quality of Life (MAPP-QOL) questionnaire. The questionnaire was tested on a sample of Lebanese postpartum women and showed good psychometric properties. The Arabic MAPP-QOL may be a useful tool for measuring maternal postpartum quality of life.
Article
Clinical Neurology
Marta Amengual-Gual, Ivan Sanchez Fernandez, Alejandra Vasquez, Nicholas S. Abend, Anne Anderson, Ravindra Arya, Cristina Barcia Aguilar, J. Nicholas Brenton, Jessica L. Carpenter, Kevin E. Chapman, Justice Clark, Raquel Farias-Moeller, William D. Gaillard, Tracy A. Glauser, Joshua L. Goldstein, Howard P. Goodkin, Yi-Chen Lai, Mohamad A. Mikati, Lindsey A. Morgan, Edward J. Novotny, Adam P. Ostendorfr, Eric T. Payne, Katrina Peariso, Juan Piantino, Latania Reece, James J. Riviello, Kumar Sannagowdara, Theodore Sheehan, Robert C. Tasker, Dmitry Tchapyjnikov, Alexis A. Topjianv, Mark S. Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper
Summary: Delayed treatment in status epilepticus is associated with increased resistance, morbidity, and mortality. This study examines the prehospital management pathway and timeliness of Emergency Medical Services in children with refractory convulsive status epilepticus. The results indicate that a substantial number of patients did not receive any anti-seizure medication before arriving at the hospital, and patients with a history of seizures were more likely to receive prehospital treatment.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Article
Clinical Neurology
Ignacio Valencia, Allyson L. Alexander, Danielle M. Andrade, Miguel Arevalo-Astrada, Clio Rubinos, Nancy Auer, Jacquelyn L. Bainbridge, Sallie A. Baxendale, Fabrice Bartolomei, Danielle A. Becker, Anne T. Berg, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Shivani Bhatnagar, Ingmar Bluemcke, Hal Blumenfeld, Gordon F. Buchanan, David E. Burdette, Jorge G. Burneo, Robyn M. Busch, Patrick Chauvel, Jeannie Chin, Lisa Clifford, Kelly R. Conner, Mark J. Cook, Jeannine Conway, Ramon Diaz-Arastia, Cornelia Drees, Jacqueline A. French, Taneeta Mindy Ganguly, Michael A. Gelfand, Tracy A. Glauser, Ezequiel Gleichgerrcht, Alica M. Goldman, Jorge Gonzalez-Martinez, Jean Gotman, Zachary Grinspan, Shanna Guilfoyle, Gita Gupta, Michael Hammer, Adam L. Hartman, Katie Hentges, R. Edward Hogan, Linda Huh, Ann Hyslop, Barbara Jobst, Colin B. Josephson, Sarah A. Kelley, Kelly Knupp, Matthias Koepp, Sanjeev Kothare, Esther Krook-Magnuson, Jasmine Kwasa, Maite La Vega-Talbott, Alice D. Lam, Jong Woo Lee, Daniel H. Lowenstein, Sarita Maturu, Luis Carlos Mayor, Carrie McDonald, Heather R. McKee, Guy M. McKhann, Kimford J. Meador, Heather C. Mefford, Elizabeth H. Michael, Mohamad A. Mikati, John J. Millichap, James W. Mitchell, Leah S. Myers, Dean Naritoku, Kerri L. Neville, Jeffrey Noebels, Terence J. O'Brien, Chima O. Oluigbo, Anup D. Patel, Milena K. Pavlova, Jeanne T. Paz, Page B. Pennell, M. Scott Perry, Piero Perucca, Asla Pitkaenen, Madona Plueger, Mary Jo Pugh, Mark Quigg, Shilpa B. Reddy, Christopher Ryan, Tamara S. Reynolds, Martha Sajatovic, Cesar Santana-Gomez, Linsday Schommer, Stephan Schuele, Renee A. Shellhaas, Daniel W. Shrey, Rani K. Singh, Michael R. Sperling, Saher Suleman, Jessica W. Templer, Maria Thom, Eugen Trinka, Sophia M. Varadkar, Naymee Velez-Ruiz, Jana Veliskova, Yuliya Voskobiynyk, Janelle L. Wagner, Jacy L. Wagnon, Claire Waller, Jill Waller, Zhong Irene Wang, Michelle W. Welborn, Elaine Wirrell, Barbara Jobst
Summary: The American Epilepsy Society Meeting 2022 in Nashville attracted over 6000 attendees and felt as busy as before the pandemic. The meeting provided a variety of symposia covering topics such as seizure generation, epilepsy pathophysiology, anti-seizure medications, and new treatment tools. It also included discussions on epilepsy comorbidities, practical issues in epilepsy care, and personal stories from patient advocates. Special lectures and smaller group sessions focused on specific areas of interest, and satellite symposia showcased the latest advancements in pharmaceutical and engineering fields.
Article
Biochemistry & Molecular Biology
Eleni Panagiotakaki, Francesco D. Tiziano, Mohamad A. Mikati, Lisanne S. Vijfhuizen, Sophie Nicole, Gaetan Lesca, Emanuela Abiusi, Agnese Novelli, Lorena Di Pietro, Aster V. E. Harder, Nicole M. Walley, Elisa De Grandis, Anne-Lise Poulat, Vincent Des Portes, Anne Lepine, Marie-Cecile Nassogne, Alexis Arzimanoglou, Rosaria Vavassori, Jan Koenderink, Christopher H. Thompson, Alfred L. George, Fiorella Gurrieri, Arn M. J. M. van den Maagdenberg, Erin L. Heinzen
Summary: This study identified genetic variants in various neurodevelopmental genes, including SCN2A, that lead to AHC or AHC-like presentation in the majority of ATP1A3-negative patients. However, the genetic cause of some patients remains unknown, suggesting the involvement of other mutational mechanisms or oligo- or polygenic risk factors.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Scott Zheng, Minu-Tshyeto Bidzimou, Leonie Kurzlechner, Zhushan Zhang, Robin M. Perelli, Mary E. Moya-Mendez, Mohamad A. Mikati, Andrew P. Landstrom
