Article
Biochemistry & Molecular Biology
Richard Y. Wu, Karren Xiao, Naomi Hotte, Parul Tandon, Yesmine Elloumi, Lindsy Ambrosio, Garett Dunsmore, Shokrollah Elahi, Karen Kroeker, Levinus A. Dieleman, Karen L. Madsen, Vivian Huang
Summary: This study conducted a longitudinal analysis of cytokines in healthy pregnant women and pregnant women with IBD, and found that maternal serum cytokines during pregnancy are influenced by IBD, disease activity, and medications. Active UC was associated with an elevation in IL-21, while active CD was associated with elevated IFN-gamma, IL-6, and IL-21. Additionally, T1 serum cytokine levels of IL-22 and IL-6 were correlated with worse IBD disease activity throughout pregnancy in women with UC and CD, respectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jieying Chen, Jing Huang, Jiahao Shi, Minrong Li, Erming Zhao, Gang Li, Xiaoyong Chen, Tao Wang, Qiaojia Li, Weiqiang Li, Jianping Ma, Wenzhe Mao, Rui Fang, Jiang Hao, Weijun Huang, Andy Peng Xiang, Xiaoran Zhang
Summary: This study demonstrated that MSCs derived from murine Peyer's patches possess enhanced immunoregulatory ability compared to bone marrow-derived MSCs. They were able to suppress T cell proliferation and inflammatory cytokine production. Furthermore, these Peyer's patch-derived MSCs exhibited greater therapeutic efficacy in murine IBD models. IL-22, which was highly expressed in these MSCs, played a significant role in alleviating the severity of intestinal inflammation.
CELL PROLIFERATION
(2023)
Review
Biochemistry & Molecular Biology
Ioanna Aggeletopoulou, Efthymios P. P. Tsounis, Christos Triantos
Summary: Interleukin-33 (IL-33) is a pleiotropic cytokine with both extracellular and nuclear functions, and its receptor ST2 plays a critical role in regulating inflammatory disorders. The IL-33/ST2 axis is involved in maintaining intestinal homeostasis and mucosal defenses. This review focuses on the pro- and anti-inflammatory effects of the IL-33/ST2 axis in ulcerative colitis and Crohn's disease, as well as the molecular mechanisms underlying its association with IBD pathogenesis. Understanding the IL-33/ST2-mediated mechanisms in IBD has potential for clinical applications as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Bram Verstockt, Azucena Salas, Bruce E. Sands, Clara Abraham, Haim Leibovitzh, Markus Neurath, Niels Vande Casteele
Summary: IL-12 and IL-23 play a crucial role in intestinal homeostasis and inflammation, and are implicated in the pathogenesis of inflammatory bowel disease. Monoclonal antibodies targeting IL-12 and/or IL-23 have been developed for the treatment of Crohn's disease and ulcerative colitis. This Review summarizes the biological characteristics of IL-12 and IL-23, discusses their role in intestinal homeostasis and inflammation, and highlights the development of drugs targeting IL-12 and/or IL-23.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Pediatrics
Asha Jois, George Alex
Summary: Inflammatory bowel disease is a common cause of chronic diarrhea in children and has been increasing worldwide. It includes different subtypes, such as Crohn's disease and ulcerative colitis. Diagnosis requires various investigations including imaging and endoscopy. Treatment depends on the severity and subtype, involving immunosuppressive therapies. Poorly controlled disease can lead to psychosocial impacts, growth impairment, and long-term risks. A multidisciplinary team is recommended for managing the disease. This review focuses on the latest clinical practices for diagnosis and management of inflammatory bowel disease in children.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Malgorzata Galecka, Katarzyna Blizniewska-Kowalska, Agata Orzechowska, Janusz Szemraj, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki
Summary: This research study found that in depressed patients without coexisting inflammatory diseases, the gene expression levels of specific immune-inflammatory factors such as IL-17, IL-21, IL-23, and IL-35 were higher, while Foxp3 expression was lower. The duration of the disease appears to be more important than the severity of depression in relation to the expression of these genes. These findings suggest that specific inflammatory genes may play a role in the etiopathogenesis of depressive disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Immunology
Susanna Esposito, Giulia Antoniol, Marialuisa Labate, Lucrezia Passadore, Patrizia Alvisi, Valeria Dacco, Chiara Ghizzi, Carla Colombo, Nicola Principi
Summary: The incidence of inflammatory bowel diseases (IBDs) is rising globally, leading to a higher risk of infections in children with dysfunctional immune systems. Vaccines are essential for preventing these infections, and should be administered according to specific immunization guidelines for IBD patients. Compliance with vaccination recommendations is generally low, highlighting the need for multidisciplinary educational programs to improve vaccination coverage and protect children with IBD from vaccine-preventable diseases.
Review
Nutrition & Dietetics
Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
Summary: Musculoskeletal deficits are commonly reported in patients with inflammatory bowel disease (IBD), particularly Crohn's disease. The adverse effects on bone and muscle are multifactorial, including inflammation, nutritional deficits, and therapies, leading to increased risk of osteoporosis and sarcopenia. Ib children with IBD, these factors may impact optimal bone and muscle accrual.
Review
Biochemistry & Molecular Biology
Aleksandra Korta, Julia Kula, Krzysztof Gomulka
Summary: Interleukin-23 (IL-23) is a proinflammatory cytokine that plays a role in tissue damage. It interacts with both the innate and adaptive immune systems, and the IL-23/Th17 axis appears to be involved in the development of chronic intestinal inflammation. Despite the incomplete understanding of the etiology and pathophysiology of inflammatory bowel disease (IBD), research on IL-23 shows potential for clinical applications as therapeutic targets in IBD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Julie Rempel, Kanika Grover, Wael El-Matary
Summary: Children and adolescents with inflammatory bowel disease (IBD) are at risk of developing anemia and various micronutrient deficiencies at diagnosis and one year follow-up. Factors such as age and albumin levels may play a role in predicting anemia in these patients.
Article
Biochemistry & Molecular Biology
Paulina Krawiec, Elzbieta Pac-Kozuchowska
Summary: This study aimed to evaluate the level of serum elafin in children with inflammatory bowel disease (IBD) and its relationship with disease activity. The results showed that serum elafin levels were significantly elevated in children with IBD, especially during active phases. ROC analysis suggested that serum elafin could be a potential biomarker for ulcerative colitis.
Article
Dermatology
Keisuke Kobayashi, Sakiko Chikazawa, Yue Chen, So Suzuki, Nao Ichimasu, Kazumoto Katagiri
Summary: Sex hormones, particularly estrogen, have dual effects on the pathogenesis of psoriasis. Estrogen can suppress inflammation by enhancing IL-10 production, but can also enhance inflammation by inducing IL-22 and IL-23 expression.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Akira Andoh, Atsushi Nishida
Summary: IL-33, IL-36, and IL-38 are members of the IL-1 cytokine family and their expression is increased in the inflamed mucosa of patients with inflammatory bowel disease (IBD). IL-33 and IL-36 have pro- and anti-inflammatory functions, while IL-38 acts as an anti-inflammatory cytokine by antagonizing the IL-36 receptor. IL-33 and IL-36 also play a crucial role in intestinal fibrosis, a characteristic manifestation of IBD.
JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Immunology
Lauren A. Zenewicz
Summary: Cytokines, including IL-22, play crucial roles in inflammation, with their activity regulated by factors like IL-22BP. IL-22BP, a soluble receptor homolog, binds to IL-22 with greater affinity, impacting the biological functions of IL-22, yet further research is needed to fully understand its role and regulation mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhenzhen Deng, Shengfeng Wang, Cuifang Wu, Chunjiang Wang
Summary: This study investigated the association between IL-17 inhibitors and the onset of inflammatory bowel disease (IBD). The results showed that IL-17 inhibitor treatment is associated with exacerbation and new onset of IBD and colitis. Obtaining a detailed patient history before treatment and monitoring gastrointestinal symptoms and intestinal inflammatory biomarkers is important for safe use of these drugs.
FRONTIERS IN PHARMACOLOGY
(2023)