Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kouji Matsushima, De Yang, Joost J. Oppenheim
Summary: This article introduces the research history and related findings of interleukin-8 (IL-8), including the role of IL-8 in inflammation and cancer, as well as its potential as a therapeutic target.
Article
Immunology
Nina L. Cluny, Kewir D. Nyuyki, Wagdi Almishri, Lateece Griffin, Benjamin H. Lee, Simon A. Hirota, Quentin J. Pittman, Mark G. Swain, Keith A. Sharkey
Summary: In experimental colitis, monocytes expressing α4β7 integrin direct the recruitment of neutrophils to cerebral vasculature, leading to elevated cytokine levels and subsequently anxiety-like behavior.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Aiping Ma, Liang Zhang, Xiaokai Ye, Jing Chen, Jie Yu, Liangjin Zhuang, Chaohang Weng, Frank Petersen, Zhanxiang Wang, Xinhua Yu
Summary: The study found a positive association between the duration of illness in patients with severe COVID-19 and serum levels of IL-8 and soluble IL-2R alpha, indicating the involvement of neutrophils and T cells in the evolution of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Estelle Carminita, Lydie Crescence, Nicolas Brouilly, Alexandre Altie, Laurence Panicot-Dubois, Christophe Dubois
Summary: The research indicates that neutrophils rather than NETs are involved in thrombus formation after laser-induced injury. Treatment with DNase-I leads to hydrolysis of ATP and ADP, generating adenosine and inhibiting thrombus formation in vivo.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Mara Zippoli, Anna Ruocco, Rubina Novelli, Francesca Rocchio, Martina Sara Miscione, Marcello Allegretti, Maria Candida Cesta, Pier Giorgio Amendola
Summary: Tumor drug resistance is a significant challenge in clinical oncology, and tumor-associated neutrophils play a crucial role in this process. Understanding how neutrophils regulate tumor progression and resistance is essential for developing new therapeutic approaches.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Alvaro Teijeira, Saray Garasa, Maria del Carmen Ochoa, Assunta Cirella, Irene Olivera, Javier Glez-Vaz, Maria Pilar Andueza, Itziar Migueliz, Maite Alvarez, Maria Esperanza Rodriguez-Ruiz, Ana Rouzaut, Pedro Berraondo, Miguel F. Sanmamed, Jose L. Perez Gracia, Ignacio Melero
Summary: IL-8 plays a key role in guiding neutrophils and monocytes/macrophages through chemotaxis; IL-8-induced NETosis is less dependent on G-proteins and can be inhibited by extracellular Ca+2 chelation; NETosis can be more readily inhibited with anti-CXCR1 antibody than chemotaxis.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Dongxing Cao, Keyu Qian, Nailin Yang, Gang Xu, Xiaohui Wang, Mingming Zhu, Yangyang Wang, Han Li, Jun Shen, Ye Zhang, Zhe Cui
Summary: This study found that thymopentin (TP5) has therapeutic effects in a mouse model of colitis that mimics Crohn's disease (CD), improving colitis by suppressing neutrophil extracellular traps (NETs).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Chen Zhang, Jiantao Zhang, Yanli Zhang, Zian Song, Jing Bian, Huanfa Yi, Zhanchuan Ma
Summary: This study investigated the pathogenesis of ulcerative colitis (UC) and found that neutrophils may promote the conversion of UC into colitis-associated colorectal cancer (CAC). By analyzing transcriptome data, 65 differentially expressed genes related to UC were identified, as well as immune-related biological pathways. The association between neutrophils and UC was confirmed using CIBERSORT and WGCNA analysis. These findings were validated in a mouse model, and 5 genes were identified as potential biomarkers. The results contribute to a better understanding of the pathogenesis of CAC and provide new insights for its prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Marta Emilie Yde Aagaard, Karina Frahm Kirk, Hans Linde Nielsen, Rudi Steffensen, Henrik Nielsen
Summary: This study aimed to compare the production of IL-8 in HT-29 cells infected with C. concisus strains from different gastrointestinal disease phenotypes. The researchers also investigated whether the differentiation of isolates in genomospecies or the presence of the zot gene affected IL-8 production. The results showed that all isolates were able to stimulate IL-8 production, with higher levels compared to non-infected cells. There was no significant difference between disease phenotypes, but the presence of the zot gene showed a tendency towards higher IL-8 production. Further research is needed to determine the role of C. concisus strains in gastrointestinal disease.
Article
Agriculture, Dairy & Animal Science
Mohsen Nikkhah, Mohammad Chamani, Ali Asghar Sadeghi, Reza Hasan-Sajedi
Summary: This study investigated the effects of hydrolyzed yeast on blood cell counts, antioxidant status, and gene expression of cytokines in vaccinated dairy cows. The results showed that cows receiving 20 g/d/head of hydrolyzed yeast had lower malondialdehyde concentrations, higher lymphocyte counts, and regulated expression of cytokines. Supplementation of 20 g/d/head of hydrolyzed yeast is recommended for vaccinated cows.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Rheumatology
Jennifer Amsler, Judith Everts-Graber, Katherine R. Martin, Arnaud Roccabianca, Chloe Lopes, Lea Tourneur, Julie Mocek, Alexandre Karras, Jean-Marc Naccache, Bernard Bonnotte, Maxime Samson, Thomas Hanslik, Xavier Puechal, Benjamin Terrier, Loic Guillevin, Antoine Neel, Luc Mouthon, Veronique Witko-Sarsat
Summary: Our study found that there is a defect in reactive oxygen species (ROS) production by neutrophils from patients with granulomatosis with polyangiitis (GPA) compared with healthy controls, which is not improved by glucocorticoid treatment. In addition, levels of IL-1-related cytokines are significantly increased in GPA patients, especially those with kidney involvement, and return to normal after achieving remission. Moreover, inflammasome-related proteins are dysregulated in neutrophils and serum from GPA patients.
Article
Medicine, General & Internal
Masumi Nakahama-Matsushima, Yoshi-ichiro Kamijyo, Yasunori Umemoto, Takamasa Hashizaki, Yukihide Nishimura, Kazunari Furusawa, Yohei Furotani, Fumihiro Tajima, Ken Kouda
Summary: Exercise increases the IL-6 level, which stimulates the production of inflammatory cytokine antagonists. This study compared the effects of wheelchair half marathon on the immune system of male athletes with CSCI and SCI, and found that the race increases IL-1ra level, possibly mediated through circulatory neutrophils.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Caterina Strisciuglio, Mara Creoli, Chiara Tortora, Massimo Martinelli, Erasmo Miele, Salvatore Paino, Livio Luongo, Francesca Rossi
Summary: This study analyzed the expression of CB2 and factors associated with IBD inflammatory pathways in intestinal biopsies of pediatric CD and UC patients. The results showed an upregulation of CB2 in pediatric IBD, which could have implications for drug discovery.
PEDIATRIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Nicholas H. Adamstein, Jan Hein Cornel, Michael Davidson, Peter Libby, Alessandra de Remigis, Camilla Jensen, Kathrine Ekstroem, Paul M. Ridker
Summary: This post hoc analysis found that ziltivekimab can reduce the neutrophil-lymphocyte ratio (NLR), suggesting its potential in disrupting multiple atherogenic inflammatory pathways. Monitoring the NLR may be helpful in assessing the efficacy of ziltivekimab if it is introduced into clinical practice.
Article
Gastroenterology & Hepatology
David Burnett, Mary Margaret Brown, Anthony Otley, Stefan Kuhle
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2020)
Article
Gastroenterology & Hepatology
Williams Turpin, Sun-Ho Lee, Juan Antonio Raygoza Garay, Karen L. Madsen, Jonathan B. Meddings, Larbi Bedrani, Namita Power, Osvaldo Espin-Garcia, Wei Xu, Michelle Smith, Anne M. Griffiths, Paul Moayyedi, Dan Turner, Ernest G. Seidman, A. Hillary Steinhart, John K. Marshall, Kevan Jacobson, David Mack, Hien Huynh, Charles N. Bernstein, Andrew D. Paterson, Kenneth Croitoru
Article
Gastroenterology & Hepatology
Yael Haberman, Phillip Minar, Rebekah Karns, Phillip J. Dexheimer, Sudhir Ghandikota, Samuel Tegge, Daniel Shapiro, Brianne Shuler, Suresh Venkateswaran, Tzipi Braun, Allison Ta, Thomas D. Walters, Robert N. Baldassano, Joshua D. Noe, Joel Rosh, James Markowitz, Jennifer L. Dotson, David R. Mack, Richard Kellermayer, Anne M. Griffiths, Melvin B. Heyman, Susan S. Baker, Dedrick Moulton, Ashish S. Patel, Ajay S. Gulati, Steven J. Steiner, Neal LeLeiko, Anthony Otley, Maria Oliva-Hemker, David Ziring, Ranjana Gokhale, Sandra Kim, Stephen L. Guthery, Stanley A. Cohen, Scott Snapper, Bruce J. Aronow, Michael Stephens, Greg Gibson, Jonathan R. Dillman, Marla Dubinsky, Jeffrey S. Hyams, Subra Kugathasan, Anil G. Jegga, Lee A. Denson
Summary: This study identified an ileal gene program for macrophage and fibroblast activation linked to stricturing complications in treatment of naïve pediatric CD. The research may inform novel small molecule therapeutic approaches targeting macrophage and fibroblast activation and angiogenesis to reverse the stricturing gene signature.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Amy Grant, Bradley MacIntyre, Michael D. Kappelman, Anthony R. Otley
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2020)
Article
Genetics & Heredity
Williams Turpin, Larbi Bedrani, Osvaldo Espin-Garcia, Wei Xu, Mark S. Silverberg, Michelle I. Smith, Juan Antonio Raygoza Garay, Sun-Ho Lee, David S. Guttman, Anne Griffiths, Paul Moayyedi, Remo Panaccione, Hien Huynh, Hillary A. Steinhart, Guy Aumais, Levinus A. Dieleman, Dan Turner, Andrew D. Paterson, Kenneth Croitoru
BMC MEDICAL GENETICS
(2020)
Article
Nutrition & Dietetics
Mohsin Rashid, Jennifer Haskett, Lisa Parkinson McGraw, Angela Noble, Johan van Limbergen, Anthony Otley
Summary: Educating patients on a gluten-free diet for celiac disease through distributed education is as effective as in-person education, offering convenience and cost savings for families. The study showed that families in remote areas can benefit from virtual education sessions provided by experienced dietitians.
CANADIAN JOURNAL OF DIETETIC PRACTICE AND RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Amanda Ricciuto, David R. Mack, Hien Q. Huynh, Kevan Jacobson, Anthony R. Otley, Jennifer deBruyn, Wael El-Matary, Colette Deslandres, Mary E. Sherlock, Jeffrey N. Critch, Kevin Bax, Prevost Jantchou, Ernest G. Seidman, Nicholas Carman, Mohsin Rashid, Aleixo Muise, Eytan Wine, Matthew W. Carroll, Sally Lawrence, Johan Van Limbergen, Eric Benchimol, Thomas D. Walters, Anne M. Griffiths, Peter C. Church
Summary: This study found that diagnostic delay in pediatric inflammatory bowel disease may lead to stricturing/internal fistulising complications and growth impairment in children with Crohn's disease. The delay has negative impacts on CD, while no significant association was observed in UC/IBD-U.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Medicine, General & Internal
Paul Moayyedi, Glenda MacQueen, Charles N. Bernstein, Stephen Vanner, Premysl Bercik, Karen L. Madsen, Michael Surette, John D. Rioux, Levinus A. Dieleman, Elena Verdu, Russell J. de Souza, Anthony Otley, Laura Targownik, John Lavis, Jennifer Cunningham, Deborah A. Marshall, Sandra Zelinsky, Aida Fernandes
Article
Gastroenterology & Hepatology
Heather J. Galipeau, Alberto Caminero, Williams Turpin, Miriam Bermudez-Brito, Alba Santiago, Josie Libertucci, Marco Constante, Juan Antonio Raygoza Garay, Gaston Rueda, Sarah Armstrong, Alex Clarizio, Michelle Smith, Michael G. Surette, Premysl Bercik, Kenneth Croitoru, Elena F. Verdu
Summary: Increased fecal proteolytic activity was found before the clinical diagnosis of UC, which may serve as a noninvasive biomarker of inflammation associated with changes in gut microbiota. The study suggests potential therapeutic targets for at-risk populations based on antiprotease treatments.
Article
Physiology
Namita Power, Williams Turpin, Osvaldo Espin-Garcia, Michelle I. Smith, Kenneth Croitoru
Summary: In a cohort of 39 healthy relatives of Crohn's disease patients, there was no significant correlation found between serum ZO-1 levels and physiological measures of intestinal permeability such as LMR. This suggests that ZO-1 and I-FABP are not reliable markers of gut permeability as defined by LMR.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Katherine A. Dunn, Zara Forbrigger, Jessica Connors, Mushfiqur Rahman, Alejandro Cohen, Johan Van Limbergen, Morgan G. Langille, Andrew W. Stadnyk, Joseph P. Bielawski, Susanne L. Penny, Tamara MacDonald, Ketan Kulkarni
Summary: Investigating stool samples from pediatric acute lymphoblastic leukemia patients treated with pegaspargase revealed a significant decline in asparagine, accompanied by changes in 31 microbial genes. These changes involve genes related to amino acid metabolism, nutrient sensing, and pathways associated with cancer.
LEUKEMIA & LYMPHOMA
(2021)
Review
Biology
Bashir Bietar, Christian Lehmann, Andrew W. Stadnyk
Summary: Patients with stroke, traumatic brain injury, or other forms of CNS injury are at a higher risk of nosocomial infections due to CNS injury-induced immunosuppression (CIDS). While the initial response in the brain post-injury is pro-inflammatory, subsequent release of immunomodulatory neurotransmitters leads to suppression of local and systemic immunity. Understanding the mechanisms of CIDS, its impact on susceptibility to infections, and potential treatments is crucial for vulnerable patients such as stroke survivors.
Article
Immunology
Edwin Leong, Zheng Pang, Andrew W. Stadnyk, Tong-Jun Lin
Summary: This study demonstrates that deficiency in the calcineurin A alpha isoform results in a decreased allergic immune response by mast cells, characterized by reduced release of preformed and de novo synthesized mediators as well as impaired activation of NF-kB signaling pathway.
JOURNAL OF INNATE IMMUNITY
(2021)
Article
Cell Biology
Lauren P. Westhaver, Sarah Nersesian, Adam Nelson, Leah K. MacLean, Emily B. Carter, Derek Rowter, Jun Wang, Boris L. Gala-Lopez, Andrew W. Stadnyk, Brent Johnston, Jeanette E. Boudreau
Summary: Tissue damage results in the release of damage-associated molecular patterns, including mitoDAMPs, which can regulate inflammation through the lymphocyte response. NK cells and T cells adopt regulatory phenotypes and functions in response to mitoDAMPs, interrupting cytotoxicity, interferon gamma production, T cell proliferation, and anti-viral T cell activation.
Review
Gastroenterology & Hepatology
Huong D. Nguyen, Hanan M. Aljamaei, Andrew W. Stadnyk
Summary: The relationship between intestinal epithelial cells and IL-10 reveals an important aspect of the innate immune function of the gut.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)