Article
Immunology
Tobias Frauenlob, Theresa Neuper, Christof Regl, Veronika Schaepertoens, Michael S. Unger, Anna-Lena Oswald, Hieu-Hoa Dang, Christian G. Huber, Fritz Aberger, Silja Wessler, Jutta Horejs-Hoeck
Summary: Helicobacter pylori infection increases the responsiveness of monocytes to subsequent bacterial stimulation and induces a unique proteomic signature compared to other inflammation-inducing stimuli. This effect is specific to H. pylori and independent of its virulence factors. The increased reactivity of infected monocytes may contribute to ineffective immune responses and disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Samuel D. R. Dooyema, Jennifer M. Noto, Lydia E. Wroblewski, M. Blanca Piazuelo, Uma Krishna, Giovanni Suarez, Judith Romero-Gallo, Alberto G. Delgado, Richard M. Peek
Summary: In this study, a novel mechanism was identified through which H. pylori actively suppresses STING and RIG-I signaling via downregulation of IRF3 activation, which not only regulates the initial innate immune response, but also drives chronic gastric inflammation and injury.
Article
Dentistry, Oral Surgery & Medicine
Cheng-En Sung, Fu-Gong Lin, Ren-Yeong Huang, Wen-Hui Fang, Wan-Chien Cheng, Yi-Wen Cathy Tsai, Wei-Liang Chen
Summary: Periodontitis is significantly associated with increased odds of H. pylori infection and higher mortality risk of gastrointestinal tract, gastric, and colorectal cancer in individuals with H. pylori infection. The interactive effect between periodontitis and H. pylori infection plays a significant role in regulating the association between periodontitis and mortality due to all cancers.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Immunology
Tobias Frauenlob, Theresa Neuper, Muamera Mehinagic, Hieu-Hoa Dang, Diana Boraschi, Jutta Horejs-Hoeck
Summary: Infection with H. pylori increases the sensitivity of human monocytes to bacterial stimuli, but this effect is only observed with viable H. pylori. This finding provides important insights into how H. pylori can induce chronic inflammation and contribute to the progression of gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Cristina Oana Marginean, Lorena Elena Melit, Maria Oana Sasaran
Summary: The carcinogenicity of H. pylori depends on bacterial virulence factors, environmental factors, and host genetic susceptibility. Microenvironmental factors play a key role in the relationship between H. pylori and microbiota, impacting the immune response and potential inflammation. Further research is needed to understand the precise role of bacterial community features and immune system components in the context of H. pylori infection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Yang-Che Kuo, Lo-Yip Yu, Horng-Yuan Wang, Ming-Jen Chen, Ming-Shiang Wu, Chun-Jen Liu, Ying-Chun Lin, Shou-Chuan Shih, Kuang-Chun Hu
Summary: Infection of Helicobacter pylori is associated with gastric cancer, and populations with a high infection rate have a higher incidence of gastric cancer. Eliminating H. pylori infection can prevent the majority of gastric cancer cases. This review article provides an overview of H. pylori and the gastrointestinal tract environment, contributing to better understanding the correlation between the pathogen and the host.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Review
Immunology
Daniel Sijmons, Andrew J. Guy, Anna K. Walduck, Paul A. Ramsland
Summary: This review discusses the importance of Helicobacter pylori infection and its impact on the host immune system, including mechanisms such as modulation of cell function, secretion of immune signaling molecules, and interference with immune cell differentiation. H. pylori also utilizes its unique lipopolysaccharide structure to mimic the host and interacts with the host through outer membrane proteins.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lianjun Ma, Yang Liu, Yizhao Wang, Jiaxing Yang, Jordan Lu, Shujun Ye, Huijin Feng, Yanqing Liu
Summary: This study aimed to identify innate immunity-related genes in gastric cancer (GC) and investigate their potentials as prognostic markers and therapeutic targets for Helicobacter pylori (Hp)-related GC. The results revealed that protein tyrosine phosphatase non-receptor type 20 (PTPN20) is a significant prognostic marker in Hp-related GC, and it is associated with immune cell infiltration and tumor mutation burden. Furthermore, PTPN20-related genes, PTPN20 protein-protein interactions, and the PTPN20 ceRNA network were also identified.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yeda Wu, Graham K. Murray, Enda M. Byrne, Julia Sidorenko, Peter M. Visscher, Naomi R. Wray
Summary: Genetic factors play a role in peptic ulcer disease, with identified loci near certain genes. Genome-wide association analyses on PUD in the UK Biobank reveal shared architecture with other gastrointestinal disorders and potential links with depression.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Yonatan Shneor Patt, Adi Lahat, Paula David, Chen Patt, Rowand Eyade, Kassem Sharif
Summary: Celiac disease is a complex immune-mediated disease with various pathological manifestations that extend beyond gastrointestinal symptoms. The existing main treatment, a gluten-free diet, presents challenges and alternative therapies are being developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Peter Malfertheiner, M. Constanza Camargo, Emad El-Omar, Jyh-Ming Liou, Richard Peek, Christian Schulz, Stella I. Smith, Sebastian Suerbaum
Summary: Helicobacter pylori infection causes chronic gastritis and can lead to severe gastroduodenal pathologies, including peptic ulcer and gastric cancer. This Primer summarizes the epidemiology, pathophysiology, diagnosis and management of this infection, and discusses patient quality of life and open research questions.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Review
Gastroenterology & Hepatology
Chieh-Chang Chen, Jyh-Ming Liou, Yi-Chia Lee, Tzu-Chan Hong, Emad M. El-Omar, Ming-Shiang Wu
Summary: The complex population of microbes in the human gastrointestinal tract interacts with the host and itself, influencing health and disease development. Helicobacter pylori colonization affects the gastric microenvironment, thus impacting gastric and potentially colonic microbiota. Understanding how H. pylori shapes GI microbiota and the effects of eradication therapy on colonic microbiota are important areas of research.
Article
Biotechnology & Applied Microbiology
Elsayed S. I. Mohammed, Rasha Radey
Summary: The study aimed to investigate the effects of probiotics-feeding on the expression and localization of avian beta defensins and proinflammatory cytokines in the gastrointestinal tract. The results suggest that probiotics-feeding may enhance the immune defense system mediated by AvBDs against infection by Gram-negative bacteria.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Immunology
Dilraj Kaur, Sumeet Patiyal, Chakit Arora, Ritesh Singh, Gaurav Lodhi, Gajendra P. S. Raghava
Summary: Defensins, host defense peptides present in almost all living species, play a crucial role in innate immunity. By analyzing the differences between defensins and AMPs, certain residues were found to be more abundant in defensins. Machine learning models were successfully developed to predict defensins with high accuracy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Wenting Xu, Liming Xu, Chengfu Xu
Summary: The prevalence of H. pylori infection is high worldwide and is associated with various digestive system diseases. H. pylori infection alters the gastrointestinal microflora and contributes to the development of tumors and extragastrointestinal diseases. Probiotics can improve the efficacy of H. pylori eradication therapy by reducing intestinal flora imbalances.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)