Review
Endocrinology & Metabolism
Xuechun Bai, Lianwen Zheng, Dandan Li, Ying Xu
Summary: Endometrial receptivity in PCOS patients is influenced by various factors such as hormone level changes, imbalance in cytokine proportions, insulin resistance, chronic inflammation, and endometrial morphological changes, which can damage endometrial receptivity, affecting embryo implantation and development.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Maria Candida P. Baracat, Edmund C. Baracat, Ricardo S. Simoes, Manuel J. Simoes, Gustavo A. R. Maciel, Ricardo Azziz, Jose Maria Soares Jr
Summary: Our study aimed to investigate the effects of hormonal and metabolic factors on endometrial quality and progesterone action. Subjects were recruited from an outpatient reproductive endocrinology clinic. Endometrial biopsies were performed before and after progesterone treatment, and metabolic and hormonal serum levels were evaluated. The endometrium of women with PCOS in the second phase showed histomorphometric abnormalities, which were associated with androgen and insulin levels despite progesterone supplementation.
Review
Obstetrics & Gynecology
Jeffrey Pea, Jahnay Bryan, Cynthia Wan, Alexis L. Oldfield, Kiran Ganga, Faith E. Carter, Lynn M. Johnson, Marla E. Lujan
Summary: This systematic review and diagnostic meta-analysis examined the diagnostic accuracy of ultrasonographic features of ovarian morphology in the diagnosis of PCOS. The results showed that follicle number per ovary (FNPO) was the most accurate diagnostic marker in adult women. Ovarian volume (OV) and follicle number per single cross-section (FNPS) had similar sensitivities to FNPO but lower specificities and accuracies. In adolescents, ovarian volume may be a reliable ultrasonographic marker for PCOS diagnosis, although current evidence is limited.
HUMAN REPRODUCTION UPDATE
(2023)
Review
Nutrition & Dietetics
Valeria Calcaterra, Virginia Rossi, Giulia Massini, Francesca Casini, Gianvincenzo Zuccotti, Valentina Fabiano
Summary: Polycystic ovary syndrome (PCOS) affects a significant proportion of reproductive-age females, especially those with obesity. The complex pathogenesis of PCOS has been linked to obesity and dysbiosis. This review analyzes the available literature on the use of probiotics in adolescents with obesity and PCOS, highlighting the potential beneficial effects on hormonal, metabolic, and inflammatory profiles. Studies suggest that probiotic supplementation may improve hormonal profiles, reduce inflammation, and ameliorate lipid metabolism disturbances caused by PCOS. Further research is needed, particularly in adolescent patients, to confirm these findings and evaluate the role of probiotics in managing PCOS.
Article
Genetics & Heredity
Su Liu, Ling Hong, Ruochun Lian, Shan Xiao, Yuye Li, Lianghui Diao, Yong Zeng
Summary: The aim of this study was to identify the transcriptomic characteristics of the endometrium in normoweight and overweight/obese polycystic ovary syndrome (PCOS), and it was found that there are different gene expression patterns between these two subtypes of PCOS, which may affect endometrial functions in PCOS patients.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
D. Abdulkhalikova, A. Sustarsic, E. Vrtacnik Bokal, N. Jancar, M. Jensterle, T. Burnik Papler
Summary: This study aimed to investigate the effects of weight loss on the endometrium specific proteome, endocrine-metabolic characteristics, and motor capabilities of obese women with PCOS and infertility. The results showed increased protein abundance in certain proteins and decreased abundance in others in the endometrium after weight loss, as well as significant reductions in fasting blood glucose and free testosterone levels, and improvements in body composition and physical capacity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jaime M. Moore, Stephanie W. Waldrop, Melanie Cree-Green
Summary: Recent studies have evaluated the effects of different weight loss strategies on hormonal, metabolic, and weight outcomes in individuals with polycystic ovary syndrome (PCOS). Calorie restriction remains a primary nutrition intervention for weight loss in PCOS patients, and a dietary macronutrient composition with lower glycemic carbohydrates may be more effective. Various types of physical activity have been shown to be effective in improving outcomes in PCOS patients and reducing weight.
CURRENT OBESITY REPORTS
(2021)
Article
Obstetrics & Gynecology
Stefano Palomba
Summary: Regardless of ovulatory status, women with PCOS may have reduced reproductive potential due to altered oocytes, embryo and endometrial competence, infertility-related co-morbidities, and an increased risk of pregnancy complications.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Miki Ohara, Hiromi Yoshida-Komiya, Miho Ono-Okutsu, Akiko Yamaguchi-Ito, Toshifumi Takahashi, Keiya Fujimori
Summary: Metformin affects the expression of androgen receptor (AR) and HOXA10 in the endometrium of women with PCOS, potentially improving the abnormal endometrial environment associated with excess androgen levels.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Physiology
Zhu Xue, Juanli Li, Jiaxing Feng, Han Han, Jing Zhao, Jiao Zhang, Yanhua Han, Xiaoke Wu, Yuehui Zhang
Summary: The endometrium is shed periodically in response to hormone secretion, with PCOS patients at risk for disrupted endometrial function due to endocrine and metabolic abnormalities. This can lead to various complications associated with PCOS.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pediatrics
Styliani Geronikolou, Flora Bacopoulou, Stavros Chryssanthopoulos, Dennis Cokkinos, George P. Chrousos
Summary: This study investigated the differences in multiple physiological functions between Greek adolescent/young adult females with PCOS and healthy controls. The results showed early onset of vascular dysfunction, predisposition to hypertension, thermoregulation delays, and metabolic syndrome changes in PCOS patients.
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Review
Endocrinology & Metabolism
Zulazmi Sutaji, Marjanu Hikmah Elias, Mohd Faizal Ahmad, Abdul Kadir Abdul Karim, Muhammad Azrai Abu
Summary: This study conducted a comprehensive analysis of the molecular mechanisms in the endometrium of polycystic ovary syndrome (PCOS) patients and identified dysregulation of the cell cycle as a fundamental biological process affecting endometrial decidualization during the implantation window.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Obstetrics & Gynecology
Leyi Fu, Ningning Xie, Fan Qu, Jue Zhou, Fangfang Wang
Summary: This study conducted a systematic review and meta-analysis to investigate the association between polycystic ovary syndrome (PCOS) and metabolic syndrome (MetS) in adolescents. The results showed that adolescents with PCOS were more than three times as likely to have MetS compared to controls. Obese adolescents with PCOS also had a higher risk of MetS compared to those with obesity but without PCOS. Blood pressure and lipid metabolism were found to be affected in adolescents with PCOS, indicating that PCOS could increase the frequency of MetS by influencing these factors independent of obesity.
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jialyu Huang, Jiaying Lin, Leizhen Xia, Lifeng Tian, Dingfei Xu, Peipei Liu, Jing Zhu, Qiongfang Wu
Summary: The study found that decreased endometrial thickness in women with PCOS is independently associated with an increased risk of preterm birth, low birthweight, and small-for-gestational age.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Liana Senaldi, Resmy Palliyil Gopi, Sarah Milla, Bina Shah
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2015)
Article
Endocrinology & Metabolism
Manish Raisingani, Maria F. Contreras, Kris Prasad, John G. Pappas, Michelle L. Kluge, Bina Shah, Raphael David
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2016)
Article
Endocrinology & Metabolism
Maria Contreras, Manish Raisingani, Donald Walt Chandler, William D. Curtin, Julia Barillas, Preneet Cheema Brar, Kris Prasad, Bina Shah, Raphael David
HORMONE RESEARCH IN PAEDIATRICS
(2017)
Article
Endocrinology & Metabolism
Maria F. Contreras, Manish Raisingani, Kris Prasad, Bonita Franklin, Bina Shah
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2017)
Review
Obstetrics & Gynecology
Lisa Kenigsberg, Sadana Balachandar, Kris Prasad, Bina Shah
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2013)
Article
Obstetrics & Gynecology
Melissa Pawelczak, Jamie Rosenthal, Sarah Milla, Ying-Hua Liu, Bina Shah
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2014)
Article
Endocrinology & Metabolism
Matthew Winfeld, Payal Patel, Bina Shah, Ruth Nass, Sarah Milla
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2013)
Article
Endocrinology & Metabolism
Marion Kessler, Aditya Kaul, Claritsa Santos-Malave, William Borkowsky, Jason Kessler, Bina Shah
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2013)
Article
Endocrinology & Metabolism
Vivian L. Chin, Ziyong Cai, Leslie Lam, Bina Shah, Ping Zhou
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2015)
Review
Endocrinology & Metabolism
Shilpa Mehta, Vikash Oza, Renee Potashner, Patricia Zamora, Manish Raisingani, Bina Shah
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2018)
Review
Endocrinology & Metabolism
Stephanie Yeager, Shilpa Mehta, Misha Sodhi, Bina Shah
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
Melissa Kaori S. Litao, Ana Gutierrez Alvarez, Bina Shah
Summary: In pediatric AIH patients, 16% had neutropenia at presentation, but this resolved in the short term and did not worsen with thionamides. Thionamides may be used with caution in these patients with close monitoring of blood counts.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Deepa Badrinath Murthy, Ana Gutierrez Alvarez, Wendy Vargas, Melissa Kaori Silva Litao, Bina Shah
Summary: This case report presents a rare case of a seven-year-old male with Hashimoto's thyroiditis and GAD-65 central nervous system disease. During the course of treatment, thyroid function gradually declined, leading to the development of other neurological symptoms.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pediatrics
Sonia Kaushal, Manish Raisingani, Raphael David, Bina Shah
CASE REPORTS IN PEDIATRICS
(2017)
Article
Pediatrics
Manish Raisingani, Resmy Palliyil Gopi, Bina Shah
CASE REPORTS IN PEDIATRICS
(2017)