Article
Multidisciplinary Sciences
Chao Liu, Min Zhang, Xinlong Yan, Yanli Ni, Yandong Gong, Cong Wang, Xiaoling Zhang, Lingfei Wan, Hui Yang, Chen Ge, Yunqiao Li, Wenxue Zou, Rui Huang, Xiaohui Li, Bing Sun, Bing Liu, Jinbo Yue, Jinming Yu
Summary: By performing single-cell RNA sequencing on human cervical tissues at different stages of malignancy, this study reveals the transcriptional tumorigenic trajectory of cervical epithelial cells in cervical squamous cell carcinoma (CESC) and identifies key factors involved in CESC initiation and progression. It also shows significant correlations between specific myeloid, lymphoid, and endothelial cell populations and CESC progression, as well as their association with patients' prognosis. Furthermore, the study demonstrates the tumor-promoting function of matrix cancer-associated fibroblasts via the NRG1-ERBB3 pathway in CESC. This research provides valuable insights for refining CESC diagnosis and designing optimal treatment strategies.
Editorial Material
Oncology
James R. Goldenring
Summary: Intestinal-type gastric cancer can arise from precancerous metaplastic lineages, specifically from spasmolytic polypeptide-expressing metaplasia (SPEM) cells. A recent study identified an activating Kras(G12D) mutation in SPEM cells, which propagated into adenomatous and cancerous lesions, suggesting that SPEM lineages can serve as a direct precursor for dysplasia and intestinal-type gastric cancer.
JOURNAL OF PATHOLOGY
(2023)
Review
Gastroenterology & Hepatology
Elyne Backx, Katarina Coolens, Jan-Lars van den Bossche, Isabelle Houbracken, Elisa Espinet, Ilse Rooman
Summary: This review focuses on the pathobiology of pancreatic ductal adenocarcinoma (PDAC) and highlights studies using human cells. The review reveals the remarkable exocrine cell plasticity in adult pancreatic tissue and explores the relationships between these cell states and PDAC molecular subtypes. These findings provide valuable insights into the origins and biology of PDAC.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cell Biology
Angelica Linden Hirschberg, Ivika Jakson, Carlota Graells Brugalla, Daniel Salamon, Dorina Ujvari
Summary: The interaction between insulin and androgens enhances the upregulation of decidualization markers and increases cell size during decidualization, but also restricts cell migration and trophoblast invasion.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Cell Biology
Thomas Dittmar, Ralf Hass
Summary: Cellular fusion is tightly regulated and requires significant changes in cells as well as the expression of specific fusogenic factors and receptors. Fusion can lead to altered cell behaviors and functions, impacting tumor development and treatment.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Priyanka Shivnani, Saroj Shekhawat, Akhilesh Prajapati
Summary: Cancer cachexia is a syndrome characterized by lean body mass loss, negative protein and energy balance, and systemic inflammation, which significantly impacts the quality of life and treatment outcomes of cancer patients. The molecular mechanisms and clinical endpoints of cachexia are not yet well-defined, and there is a need for further research, especially in breast cancer-induced cachexia. Breast cancer stem cells (BCSCs) play a crucial role in breast cancer progression and resistance to chemotherapy, and cytokines in the tumor microenvironment affect their development and self-renewal. The common pathways between cachexia and BCSC signaling could be potential therapeutic targets for both conditions.
CELLULAR SIGNALLING
(2023)
Article
Nanoscience & Nanotechnology
Akhil Jain, Jonathan Gosling, Shaochuang Liu, Haowei Wang, Eloise M. Stone, Sajib Chakraborty, Padma-Sheela Jayaraman, Stuart Smith, David B. Amabilino, Mark Fromhold, Yi-Tao Long, Lluisa Perez-Garcia, Lyudmila Turyanska, Ruman Rahman, Frankie J. Rawson
Summary: This study applies quantum biological tunnelling for electron transfer to control and treat cancer cells by triggering apoptosis through wireless nano-electrochemical tools. The experimental results show that electrical input can selectively trigger electron transport between redox molecules, leading to the elimination of cancer cells. This work demonstrates the potential of quantum-based medical diagnostics and treatments.
NATURE NANOTECHNOLOGY
(2023)
Review
Oncology
Junwei Wang, Cunming Zhang, Baijun Chen, Qingqing Wu
Summary: This paper reports the first case of basal cell carcinoma of the prostate (BCCP) with squamous metaplasia. The patient presented with progressive dyspareunia and had a history of recurrent urinary retention. Imaging studies showed the size of the prostate gland and subsequent surgical procedures confirmed the diagnosis. The patient had a favorable prognosis after treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Li Feng, Zhicong Wang, Li Jing, Zhiguo Zhou, Shuai Shi, Ruoying Deng, Yibing Liu, Qingju Meng
Summary: This study aimed to compare the efficacy and safety of recombinant human endostatin combined with chemotherapy in patients with squamous cell lung cancer. The results showed that the combination treatment had a better therapeutic effect than chemotherapy alone and did not increase the incidence of adverse reactions during treatment.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ran Ke, Samson Ian Sam Lok, Kailash Singh, Billy Kwok Chong Chow, Harald Janovjak, Leo Tsz On Lee
Summary: The study reveals that the formation of heterocomplexes between Kiss1R and GPER significantly reduces Kiss1R-mediated signaling, showcasing a regulatory mechanism of hypothalamic hormone receptors through receptor cooperation and modulation of receptor sensitivity in the reproductive system.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Virology
Sigrid Regauer, Olaf Reich
Summary: Most research on HPV-related squamous cervical carcinogenesis focuses on glycogenated squamous epithelium, while the role of immature squamous metaplastic epithelium and reserve cells as targets of HPV infection has been less explored. Future research should shift focus to reserve cells as target cells and reservoirs of HPV.
CURRENT OPINION IN VIROLOGY
(2021)
Article
Veterinary Sciences
Gennaro Altamura, Giuseppe Borzacchiello
Summary: The study aims to assess the efficacy of Cetuximab in FOSCC and found that Cetuximab can inhibit the activation of EGFR, reduce cell proliferation and cell viability, and induce cell apoptosis. These results suggest potential anti-cancer activities of Cetuximab in the therapy of FOSCC.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Respiratory System
Sam Strickson, Kirsty F. Houslay, Victor A. Negri, Yoichiro Ohne, Tomas Ottosson, Roger B. Dodd, Catherine Chaillan Huntington, Tina Baker, Jingjing Li, Katherine E. Stephenson, Andy J. O'Connor, J. Sophie Sagawe, Helen Killick, Tom Moore, D. Gareth Rees, Sofia Koch, Caroline Sanden, Yixin Wang, Elise Gubbins, Mahboobe Ghaedi, Roland Kolbeck, Saumyaa Saumyaa, Jonas S. Erjefalt, Gary P. Sims, Alison A. Humbles, Ian C. Scott, Xavier Romero Ros, E. Suzanne Cohen
Summary: This study reveals that IL-33, RAGE, and EGFR act together in an ST2-independent pathway in the airway epithelium, governing abnormal epithelial remodeling and mucus-obstructive features in COPD.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Medicine, General & Internal
Sayantanee Chaudhury, Swagatika Panda, Neeta Mohanty, Saurav Panda, Diksha Mohapatra, Ravishankar Nagaraja, Alkananda Sahoo, Divya Gopinath, Natalia Lewkowicz, Barbara Lapinska
Summary: The association of immunexpression of cancer stem cell markers with clinicopathological and survival outcomes in tongue squamous cell carcinoma (TSCC) patients was evaluated. Observational studies comparing the association of clinicopathological and survival outcomes with cancer stem cell immunexpression in TSCC patients were included in a systematic review and meta-analysis. The findings showed that positive immunexpression was significantly associated with advanced tumor staging and grading, lymph node metastasis, and increased mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Xiao Teng, Zhen Chen, Lichen Zhang, Xiaodong Teng
Summary: This study aims to describe a distinct and rare histological subtype of pulmonary bronchiolar adenoma: bronchiolar adenoma with squamous metaplasia. Clinicopathological, immunohistochemical, and molecular characteristics of five cases were examined. The samples showed bilayered bronchiolar-type cells, sheet-like spindle-oval cells with squamous metaplasia in the stroma. Immunohistochemistry analysis revealed positive staining for TTF-1, Napsin A, P40, P63, and BRAF V600E. It is important to differentiate this subtype from pulmonary sclerosing pneumocytoma.
Article
Endocrinology & Metabolism
Ru-pin Alicia Chi, Tianyuan Wang, Nyssa Adams, San-pin Wu, Steven L. Young, Thomas E. Spencer, Francesco DeMayo
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Gerardo G. B. Herrera, Sydney L. Lierz, Emily A. Harris, Lauren J. Donoghue, Sylvia C. Hewitt, Karina F. Rodriguez, Wendy N. Jefferson, John P. Lydon, Francesco J. DeMayo, Carmen J. Williams, Kenneth S. Korach, Wipawee Winuthayanon
Correction
Oncology
Miriam Teeuwssen, Riccardo Fodde
Article
Medicine, Research & Experimental
Ru-pin Alicia Chi, Tianyuan Wang, Chou-Long Huang, San-pin Wu, Steven L. Young, John P. Lydon, Francesco J. DeMayo
Article
Multidisciplinary Sciences
Olga Kim, Eun Young Park, Sun Young Kwon, Sojin Shin, Robert E. Emerson, Yong-Hyun Shin, Francesco J. DeMayo, John P. Lydon, Donna M. Coffey, Shannon M. Hawkins, Lawrence A. Quilliam, Dong-Joo Cheon, Facundo M. Fernandez, Kenneth P. Nephew, Adam R. Karpf, Martin Widschwendter, Anil K. Sood, Robert C. Bast, Andrew K. Godwin, Kathy D. Miller, Chi-Heum Cho, Jaeyeon Kim
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Endocrinology & Metabolism
Leah Hawkins Bressler, Marc A. Fritz, San-Pin Wu, Lingwen Yuan, Suzanna Kafer, Tianyuan Wang, Francesco J. DeMayo, Steven L. Young
Summary: The study found reduced proliferation and angiogenesis markers, increased inflammation, and altered ER expression patterns in women with suboptimal endometrial thickening after clomiphene treatment. The results suggest potential mechanisms underlying the lower pregnancy rates associated with suboptimal endometrial thickening in these women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biology
Andrea Sacchetti, Miriam Teeuwssen, Mathijs Verhagen, Rosalie Joosten, Tong Xu, Roberto Stabile, Berdine van der Steen, Martin M. Watson, Alem Gusinac, Won Kyu Kim, Inge Ubink, Harmen Jg Van de Werken, Arianna Fumagalli, Madelon Paauwe, Jacco Van Rheenen, Owen J. Sansom, Onno Kranenburg, Riccardo Fodde
Summary: EpCAM(lo) cells are a subpopulation of colon cancer cells with phenotypic plasticity, exhibiting motility, invasiveness, chemoresistance, and high metastatic potential. These cells show enhanced Wnt/beta-catenin signaling, a spectrum of EMT activation states, and a high correlation with the poor-prognosis CMS4 subtype.
Article
Multidisciplinary Sciences
Andrew M. Kelleher, Rohit Setlem, Francoise Dantzer, Francesco J. DeMayo, John P. Lydon, W. Lee Kraus
Summary: This study found that catalytic inhibition or genetic ablation of PARP-1 and PARP-2 in the uterus led to pregnancy loss in mice, associated with increased p53 signaling and an increased population of senescent decidual cells, with decidualization failure being the cause of pregnancy loss.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Developmental Biology
Manoj K. Madhavan, Francesco J. DeMayo, John P. Lydon, Niraj R. Joshi, Asgerally T. Fazleabas, Ripla Arora
Summary: The uterine luminal epithelium folds characteristically in mammals, including humans, horses and rodents. However, the precise function of these folds remains unknown. This study reveals dynamic changes in the 3D uterine folding pattern during early pregnancy and suggests that the folds and chambers are two distinct structures with specific roles in implantation and post-implantation morphogenesis.
Article
Developmental Biology
Mackenzie J. Dickson, Yeong Seok Oh, Artiom Gruzdev, Rong Li, Nuria Balaguer, Andrew M. Kelleher, Thomas E. Spencer, San-Pin Wu, Francesco J. DeMayo
Summary: Approximately 75% of unsuccessful pregnancies are caused by implantation failure. This study developed a mouse strain with a decidual-specific iCre recombinase and confirmed its activity and tissue specificity during pregnancy. This research provides a valuable tool for investigating genetic networks and cellular dynamics associated with decidualization and infertility.
Article
Endocrinology & Metabolism
Sylvia C. Hewitt, San-pin Wu, Tianyuan Wang, Madhumita Ray, Marja Brolinson, Steven L. Young, Thomas E. Spencer, Alan DeCherney, Francesco J. DeMayo
Summary: This study investigates the molecular processes underlying estrogen responses and their effects on endometrial health. By analyzing the ESR1 cistromes and transcriptomes of endometrial biopsies and organoids, the study identifies candidate ESR1 target genes and reveals differences in the distribution and regulation of ESR1 binding sites between different stages of the menstrual cycle. The findings provide valuable resources for understanding how estrogen affects endometrial function and health.
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact via Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of- function CTCF mutation indicates its importance in uterine homeostasis. Deleting Ctcf gene in female reproductive tissues of mice resulted in reduced uterine glands and hypoplastic uteri with decreased endometrial stroma. Ctcf deletion also altered the expression of progesterone-responsive genes, including Ihh, Fst, and Errfi1. Our findings highlight the key role of uterine Ctcf in progesterone-dependent expression and optimal post-pubertal uterine development.
Article
Multidisciplinary Sciences
Rong Li, Tianyuan Wang, Ryan M. Marquardt, John P. Lydon, San-Pin Wu, Francesco J. DeMayo
Summary: Estrogen and progesterone regulate uterine biology through their receptors ERα and PR, respectively. This study identifies TRIM28 as a protein that interacts with ERα and PR to regulate uterine function. TRIM28 deficiency disrupts PR and ERα chromatin binding, resulting in the inability of the uterus to support early pregnancy.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Sylvia C. Hewitt, Artiom Gruzdev, Cynthia J. Willson, San-Pin Wu, John P. Lydon, Niels Galjart, Francesco J. DeMayo
Summary: Receptors for estrogen and progesterone interact through Cohesin/CTCF loop extrusion at enhancers distal from regulated genes. Loss-of-function CTCF mutation in endometrial tumors indicates its importance in uterine homeostasis. Our study reveals that uterine Ctcf plays a key role in progesterone-dependent expression of uterine genes underlying optimal post-pubertal uterine development.
Article
Multidisciplinary Sciences
San-Pin Wu, Tianyuan Wang, Zheng-Chen Yao, Mary C. Peavey, Xilong Li, Lecong Zhou, Irina V. Larina, Francesco J. DeMayo
Summary: PGR plays a pivotal role in directing the molecular program for uterine remodeling and pregnancy support. Mutant PGR can lead to dysfunction of the myometrium, affecting fertility and pregnancy adaptation.