Functional characterization of EMSY gene amplification in human cancers

Therapeutic Exploitation of Tumor Cell Defects in Homologous Recombination

(2012) Simon Powell et al.   Anti-Cancer Agents in Medicinal Chemistry

Parallel High-Throughput RNA Interference Screens Identify PINK1 as a Potential Therapeutic Target for the Treatment of DNA Mismatch Repair-Deficient Cancers

(2011) S. A. Martin et al.   CANCER RESEARCH

EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases

(2011) Isabelle Cousineau et al.   MOLECULAR GENETICS AND GENOMICS

Indicators of homologous recombination deficiency in breast cancer and association with response to neoadjuvant chemotherapy

(2010) E. H. Lips et al.   ANNALS OF ONCOLOGY

Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study

(2010) Konstantin J. Dedes et al.   BREAST CANCER RESEARCH AND TREATMENT

Synergistic Chemosensitivity of Triple-Negative Breast Cancer Cell Lines to Poly(ADP-Ribose) Polymerase Inhibition, Gemcitabine, and Cisplatin

(2010) K. Hastak et al.   CANCER RESEARCH

Tumor Growth Inhibition by Olaparib in BRCA2 Germline-Mutated Patient-Derived Ovarian Cancer Tissue Xenografts

(2010) U. Kortmann et al.   CLINICAL CANCER RESEARCH

DNA amplifications in breast cancer: genotypic–phenotypic correlations

(2010) Kai-Keen Shiu et al.   Future Oncology

Recommendation of short tandem repeat profiling for authenticating human cell lines, stem cells, and tissues

(2010) Rita Barallon et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Short tandem repeat profiling: part of an overall strategy for reducing the frequency of cell misidentification

(2010) Raymond W. Nims et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Neuroprotection by Minocycline Caused by Direct and Specific Scavenging of Peroxynitrite

(2010) Stefan Schildknecht et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Expression Profile ofBRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer

(2010) Panagiotis A. Konstantinopoulos et al.   JOURNAL OF CLINICAL ONCOLOGY

Personalizing Therapy for Ovarian Cancer:BRCAness and Beyond

(2010) Robert C. Bast et al.   JOURNAL OF CLINICAL ONCOLOGY

Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type

(2010) Magali Lacroix-Triki et al.   JOURNAL OF PATHOLOGY

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

(2010) M William Audeh et al.   LANCET

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study

(2010) Maryou B Lambros et al.   MODERN PATHOLOGY

Expression of EMSY gene in sporadic ovarian cancer

(2010) Julide Altinisik et al.   MOLECULAR BIOLOGY REPORTS

Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging Agents in Pancreatic Cancer

(2010) M. C. Villarroel et al.   MOLECULAR CANCER THERAPEUTICS

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

(2010) Rémi Buisson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors

(2010) K. J. Dedes et al.   Science Translational Medicine

Co-amplification of CCND1 and EMSY is associated with an adverse outcome in ER-positive tamoxifen-treated breast cancers

(2009) Lindsay A. Brown et al.   BREAST CANCER RESEARCH AND TREATMENT

A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines

(2009) Alan Mackay et al.   BREAST CANCER RESEARCH AND TREATMENT

An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

(2009) Rachael Natrajan et al.   BREAST CANCER RESEARCH AND TREATMENT

Tiling Path Genomic Profiling of Grade 3 Invasive Ductal Breast Cancers

(2009) R. Natrajan et al.   CLINICAL CANCER RESEARCH

PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas

(2009) D. S.P. Tan et al.   CLINICAL CANCER RESEARCH

Synthetic lethal targeting ofPTENmutant cells with PARP inhibitors

(2009) Ana M. Mendes-Pereira et al.   EMBO Molecular Medicine

Identification and Characterization of a Novel Nuclear Protein Complex Involved in Nuclear Hormone Receptor-mediated Gene Regulation

(2009) Shivani Garapaty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescencein situhybridization and microarray-based CGH analysis

(2009) Caterina Marchiò et al.   JOURNAL OF PATHOLOGY

Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas

(2009) Felipe C Geyer et al.   JOURNAL OF PATHOLOGY

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis

(2009) S S Kwek et al.   ONCOGENE

Focal amplification and oncogene dependency of GAB2 in breast cancer

(2009) M Bocanegra et al.   ONCOGENE

Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer Targets

(2009) Elizabeth Iorns et al.   PLoS One

Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

(2008) Elizabeth Iorns et al.   BIOCHEMICAL JOURNAL

Characterization of the Recurrent 8p11-12 Amplicon Identifies PPAPDC1B, a Phosphatase Protein, as a New Therapeutic Target in Breast Cancer

(2008) I. Bernard-Pierrot et al.   CANCER RESEARCH

Selective Inhibition of BRCA2-Deficient Mammary Tumor Cell Growth by AZD2281 and Cisplatin

(2008) B. Evers et al.   CLINICAL CANCER RESEARCH

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

(2008) Nicholas C Turner et al.   EMBO JOURNAL

Screening for copy-number alterations and loss of heterozygosity in chronic lymphocytic leukemia—A comparative study of four differently designed, high resolution microarray platforms

(2008) Rebeqa Gunnarsson et al.   GENES CHROMOSOMES & CANCER

Genetic alterations of CCND1 and EMSY in breast cancers

(2008) T Kirkegaard et al.   HISTOPATHOLOGY

The genomic profile ofHER2-amplified breast cancers: the influence of ER status

(2008) C Marchiò et al.   JOURNAL OF PATHOLOGY

Resistance to therapy caused by intragenic deletion in BRCA2

(2008) Stacey L. Edwards et al.   NATURE

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

(2008) S. Rottenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA