Article
Clinical Neurology
David Leppert, Harald Kropshofer, Dieter A. Haring, Frank Dahlke, Ashwini Patil, Rolf Meinert, Davorka Tomic, Ludwig Kappos, Jens Kuhle
Summary: Elevated baseline plasma neurofilament light (pNfL) levels were associated with higher risks of future disability progression and brain atrophy, regardless of acute disease activity in patients with progressive multiple sclerosis. Treatment with siponimod or fingolimod reduced pNfL levels and may serve as a meaningful outcome measure in studies of progressive multiple sclerosis.
Article
Immunology
Alex Allard-Gray, Isaac Boakye, Alioune Camara, Lisa Eisenbeis, Eleny Guimaraes-Teixeira, Oumou Sow, David Zielinski, Jonathon R. Campbell, Dick Menzies
Summary: This study assessed the association between participant behaviors early in tuberculosis preventive treatment (TPT) and subsequent discontinuation. The researchers found that four behavioral predictors recorded early in therapy were more strongly associated with discontinuation than participant characteristics, particularly when multiple predictors were recorded.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Anesthesiology
Eva Rivas, Barak Cohen, Xuan Pu, Li Xiang, Wael Saasouh, Guangmei Mao, Paul Minko, Lauretta Mosteller, Andrew Volio, Kamal Maheshwari, Daniel Sessler, Alparslan Turan
Summary: Postoperative pain and opioid consumption have an impact on the postoperative mobilization of patients recovering from abdominal surgery, while lower pain scores are associated with increased mobility and fewer complications.
Article
Endocrinology & Metabolism
Harpreet S. Bajaj, Melonie Burrows, Jessica Blavignac, Emilia Paron, Fernando Camacho, Errol Gould, Maxime Barakat
Summary: Sustained weight loss improves liver histology in non-alcoholic fatty liver disease. The study found that weight loss, especially in combination with medication treatment, can lead to improved liver health indicators such as ALT and FIB-4 levels.
DIABETES OBESITY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Sergio Davinelli, Sawan Ali, Vincenzo Solfrizzi, Giovanni Scapagnini, Graziamaria Corbi
Summary: Recent evidence suggests that diet can modify the risk of future cognitive impairment and dementia. Carotenoid interventions have shown significant effects on cognitive outcomes and may help reduce the risk of cognitive impairment and dementia.
Article
Biochemistry & Molecular Biology
Asger Wretlind, Viktor Rotbain Curovic, Andressa de Zawadzki, Tommi Suvitaival, Jin Xu, Emilie Hein Zobel, Bernt Johan von Scholten, Rasmus Sejersten Ripa, Andreas Kjaer, Tine Willum Hansen, Tina Vilsboll, Henrik Vestergaard, Peter Rossing, Cristina Legido-Quigley
Summary: Treatment with liraglutide can reduce the levels of C16 ceramide and C24:1 ceramide, which are associated with cardiovascular disease (CVD) risk.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Food Science & Technology
Dandara Baia Bonifacio, Leonara Martins Viana, Alessandra da Silva, Danubia Joanes Rosa Guerra, Caroline Woelffel Silva, Frederico Augusto Ribeiro de Barros, Josefina Bressan
Summary: This review assessed the effects of grape juice consumption on oxidative stress, inflammation, physical performance, muscle damage, and recovery in physical activity practitioners. The meta-analysis showed that acute or chronic consumption of 10/ml/kg/day or 400 ml of grape juice improved antioxidant status but had no effects on markers of oxidative stress, inflammation, physical performance, muscle damage, and recovery in physical activity practitioners.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Dermatology
Jonathan Silverberg, Eric L. Simpson, Emma Guttman-Yassky, Michael J. Cork, Marjolein de Bruin-Weller, Gil Yosipovitch, Laurent Eckert, Zhen Chen, Marius Ardeleanu, Brad Shumel, Thomas Hultsch, Ana B. Rossi, Jennifer D. Hamilton, Jamie M. Orengo, Marcella Ruddy, Neil M. H. Graham, Gianluca Pirozzi, Abhijit Gadkari
Summary: This study analyzed the effects of dupilumab on pain/discomfort in atopic dermatitis (AD) patients and found that dupilumab treatment significantly reduced pain/discomfort compared to placebo. Correlations between pain/discomfort and other symptoms of AD were low to moderate.
Article
Dermatology
Amy S. Paller, Jonathan I. Silverberg, Michael J. Cork, Emma Guttman-Yassky, Benjamin Lockshin, Alan D. Irvine, Moon Bum Kim, Kenji Kabashima, Zhen Chen, Yufang Lu, Ashish Bansal, Ana B. Rossi, Arsalan Shabbir
Summary: This study assessed the efficacy and safety of dupilumab in patients with severe erythrodermic atopic dermatitis (AD). The results showed that dupilumab significantly improved AD signs and symptoms, including affected body surface area, Eczema Area and Severity Index (EASI) score, and Pruritus Numerical Rating Scale (PP-NRS) score. The treatment also led to reductions in serum biomarker levels.
Article
Immunology
Niccolo Buetti, Olivier Mimoz, Leonard Mermel, Stephane Ruckly, Nicolas Mongardon, Claire Dupuis, Jean-Paul Mira, Jean-Christophe Lucet, Bruno Megarbane, Sebastien Bailly, Jean-Jacques Parienti, Jean-Francois Timsit
Summary: Analysis of nearly 5000 patients revealed that using ultrasound guidance for catheter insertion is associated with increased risk of infection, especially in jugular and femoral veins.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Guang-Tan Lin, Jun-Yu Chen, Qi-Yue Chen, Qing Zhong, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Chang-Ming Huang
Summary: Intraoperative lymph node dissection and postoperative adjuvant chemotherapy have a significant impact on the overall survival of gastric cancer patients. Major lymph node noncompliance and adjuvant chemotherapy noncompliance lead to poorer prognosis. Adjuvant chemotherapy can improve prognosis in the case of nonmajor lymph node noncompliance during surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Anesthesiology
David Sidebotham, Ivor Popovich, Thomas Lumley
Summary: A small proportion of multicentre critical care trials report statistically significant differences in mortality outcomes, possibly due to lower-than-expected effect sizes and a low proportion of participants who could benefit from the interventions. Bayesian modelling suggests that researchers may overestimate the true population effect sizes for critical care interventions.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Infectious Diseases
Angela Yen Moore, Kara Hurley, Stephen Andrew Moore
Summary: This study aimed to analyze the efficacy of using sarecycline in Hispanics with moderate-to-severe acne. The results showed a significant reduction in facial inflammatory lesion counts in Hispanic patients with acne treated with oral sarecycline for 12 weeks. Therefore, oral sarecycline shows promising results as a safe and effective treatment for acne in Hispanics.
Article
Urology & Nephrology
David A. Bushinsky, Jeffrey J. Budden, Philip A. Kalra, Jinwei Yuan, Carol Moreno Quinn, Murray Epstein
Summary: This study aimed to investigate the efficacy of patiromer on patients with chronic kidney disease (CKD), hyperkalemia and hyperphosphatemia. The results showed that after 2 weeks and 4 weeks of patiromer treatment, both serum phosphorus and potassium levels were reduced to the normal range, and the tolerance was good. Rating: 8/10.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Gastroenterology & Hepatology
Neeraj Narula, Emily C. L. Wong, Parambir S. Dulai, John K. Marshall, Jean-Frederic Colombel, Walter Reinisch
Summary: The study demonstrates that CD patients with non-passable strictures can achieve certain level of clinical and endoscopic remission after treatment, but they are less likely to achieve clinical remission compared to patients with passable or no strictures.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Anesthesiology
Jonathan Hansen, Markus Pohlmann, Jan H. Beckmann, Phil Klose, Matthias Gruenewald, Jochen Renner, Ulf Lorenzen, Gunnar Elke
Summary: This study compared arterial pressure monitoring using NIBP and Nexfin(R) with the gold-standard IAP. The results showed a correlation between NIBP, Nexfin(R), and IAP in absolute arterial pressure values, but the interchangeability was not high. Nexfin(R) showed better trending ability compared to NIBP.
BMC ANESTHESIOLOGY
(2022)
Article
Medicine, General & Internal
Arved Weimann, Wolfgang H. Hartl, Michael Adolph, Matthias Angstwurm, Frank M. Brunkhorst, Andreas Edel, Geraldine de Heer, Thomas W. Felbinger, Christiane Goeters, Aileen Hill, K. Georg Kreymann, Konstantin Mayer, Johann Ockenga, Sirak Petros, Andreas Ruemelin, Stefan J. Schaller, Andrea Schneider, Christian Stoppe, Gunnar Elke
Summary: There is a lack of structured and evidence-based recommendations for assessing and monitoring nutritional status in intensive or intermediate care patients. This position paper provides consensus-based recommendations from the Section Metabolism and Nutrition of the German Interdisciplinary Association for Intensive and Emergency Medicine, supplementing the current guidelines in this field.
MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN
(2022)
Article
Critical Care Medicine
John Muscedere, Sean M. Bagshaw, Gordon Boyd, Stephanie Sibley, Norman Patrick, Andrew Day, Miranda Hunt, Darryl Rolfson
Summary: In this pilot study, we demonstrate the feasibility of measuring frailty in critically ill patients over the course and recovery of their illness, and the readiness with which processes of care and adverse events can be captured.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2022)
Article
Critical Care Medicine
Gennaro De Pascale, Massimo Antonelli, Mieke Deschepper, Kostoula Arvaniti, Koen Blot, Ben Creagh Brown, Dylan de Lange, Jan De Waele, Yalim Dikmen, George Dimopoulos, Christian Eckmann, Guy Francois, Massimo Girardis, Despoina Koulenti, Sonia Labeau, Jeffrey Lipman, Fernando Lipovetsky, Emilio Maseda, Philippe Montravers, Adam Mikstacki, Jose-Artur Paiva, Cecilia Pereyra, Jordi Rello, Jean-Francois Timsit, Dirk Vogelaers, Stijn Blot
Summary: The study found that urgent and successful source control is associated with improved odds of survival in patients with secondary peritonitis. Source control is more determinative for outcome compared to empirical antimicrobial treatment.
INTENSIVE CARE MEDICINE
(2022)
Review
Nutrition & Dietetics
Ellen Dresen, Omy Naidoo, Aileen Hill, Gunnar Elke, Matthias Lindner, Joop Jonckheer, Elisabeth De Waele, Patrick Meybohm, Ranna Modir, Jayshil J. Patel, Kenneth B. Christopher, Christian Stoppe
Summary: Patients receiving ECMO may experience disease-associated metabolic, endocrinologic, and immunologic alterations, which along with the technical components of ECMO, can increase their risk for malnutrition. However, specific recommendations for medical nutrition therapy (MNT) in ECMO patients are limited and lack guidance. This article aims to provide evidence-based guidance for MNT in adult patients receiving ECMO to develop institutional protocols for clinical practice.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Surgery
Christian Stoppe, Bernard McDonald, Patrick Meybohm, Kenneth B. Christopher, Stephen Fremes, Richard Whitlock, Siamak Mohammadi, Dimitri Kalavrouziotis, Gunnar Elke, Rolf Rossaint, Philipp Helmer, Kai Zacharowski, Ulf Guenther, Matteo Parotto, Bernd Niemann, Andreas Boening, C. David Mazer, Philip M. Jones, Marion Ferner, Yoan Lamarche, Francois Lamontagne, Oliver J. Liakopoulos, Matthew Cameron, Matthias Mueller, Alexander Zarbock, Maria Wittmann, Andreas Goetzenich, Erich Kilger, Lutz Schomburg, Andrew G. Day, Daren K. Heyland
Summary: High-dose intravenous sodium selenite treatment did not reduce morbidity or mortality in high-risk cardiac surgery patients.
Article
Critical Care Medicine
Thomas Schmoch, Patrick Moehnle, Markus A. Weigand, Josef Briegel, Michael Bauer, Frank Bloos, Patrick Meybohm, Didier Keh, Markus Loeffler, Gunnar Elke, Thorsten Brenner, Holger Bogatsch
Summary: This study found that sepsis-induced coagulopathy (SIC) occurs in 22.1-24.2% of severe sepsis patients. SIC is associated with higher mortality and morbidity, and may serve as an early warning sign for sepsis.
ANNALS OF INTENSIVE CARE
(2023)
Article
Medicine, General & Internal
Jill Jussli-Melchers, Mohamed Ahmed Salem, Jan Schoettler, Christine Friedrich, Katharina Huenges, Gunnar Elke, Thomas Puehler, Jochen Cremer, Assad Haneya
Summary: Elderly patients undergoing surgery for infective endocarditis have more preoperative risk factors and postoperative complications, with lower survival rates. Surgery is the only concept to increase long-term survival and should be generously offered to all patients who are still able to take care of themselves.
JOURNAL OF CLINICAL MEDICINE
(2022)
Correction
Critical Care Medicine
John Muscedere, Sean M. M. Bagshaw, Gordon Boyd, Stephanie Sibley, Patrick Norman, Andrew Day, Miranda Hunt, Darryl Rolfson
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Article
Nutrition & Dietetics
Matthias Lindner, Martin Padar, Merli Mandul, Kenneth B. Christopher, Annika Reintam Blaser, Hans-Christoph Gratz, Gunnar Elke, Kaspar F. Bachmann
Summary: This study analyzed the current practice of gastric residual volume (GRV) measurement in critically ill patients and its association with clinical outcomes. The study found significant variability in GRV measurement techniques but this did not affect the amount of GRV. High GRV may serve as a marker of gastrointestinal dysfunction and disease severity, but it is not associated with mortality or number of ventilator-free days.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Christian Stoppe, Ellen Dresen, Sebastian Wendt, Gunnar Elke, Jayshil J. Patel, Liam McKeever, Michael Chourdakis, Bernard McDonald, Patrick Meybohm, Matthias Lindner, Rakesh C. Arora, Ben O'Brien, Vera von Dossow, Sergey Efremov, Vladimir Lomivorotov, Charlene Compher, Jill Yaung, Taryne Imai, Michael Nurok, Andrea Ho, Christian von Loeffelholz, Foong Pui Hing, Xuran Jiang, Daren K. Heyland
Summary: A study was conducted to describe the current nutrition practices in critically ill cardiac surgery patients worldwide. The study found that patients had significant delays in starting enteral nutrition and received low levels of energy and protein. There was also tremendous variability in site performance. However, achieving optimal nutrition performance is feasible.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Ellen Dresen, Quirin Notz, Johannes Menger, Anna L. Homayr, Matthias Lindner, David I. Radke, Christian Stoppe, Gunnar Elke
Summary: Medical nutrition therapy (MNT) is crucial for critically ill patients in the ICU. The optimal timing, dosing, and composition of energy and nutrient supply, as well as the role of micronutrients, are still debated topics due to heterogeneity in research findings. Implementing personalized MNT strategies in clinical practice poses challenges. This review aims to summarize recent evidence and provide guidance for evidence-based approaches to nutrient supply in the ICU.
NUTRITION IN CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Gunnar Elke, Wolfgang H. Hartl, Michael Adolph, Matthias Angstwurm, Frank M. M. Brunkhorst, Andreas Edel, Geraldine de Heer, Thomas W. Felbinger, Christiane Goeters, Aileen Hill, K. Georg Kreymann, Konstantin Mayer, Johann Ockenga, Sirak Petros, Andreas Ruemelin, Stefan J. Schaller, Andrea Schneider, Christian Stoppe, Arved Weimann
Summary: This paper provides recommendations on laboratory monitoring of macronutrient and micronutrient intake, as well as the use of indirect calorimetry in medical nutrition therapy for critically ill adult patients. Furthermore, recommendations are given for disease-related or individual level determination of substitution and pharmacotherapy for vitamins and trace elements.
MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN
(2023)
Article
Medicine, General & Internal
Matthias Lindner, David I. Radke, Gunnar Elke
Summary: The gut microbiota, consisting of over 1200 different bacteria, forms a symbiotic relationship with the human organism. It plays a crucial role in maintaining homeostasis of the immune system and essential metabolic processes. This article summarizes recent findings on the role of the bacterial gut microbiota in sepsis, which is highly relevant in intensive care medicine.
MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN
(2023)
Review
Critical Care Medicine
Johannes Menger, Zheng-Yii Lee, Quirin Notz, Julia Wallqvist, M. Shahnaz Hasan, Gunnar Elke, Martin Dworschak, Patrick Meybohm, Daren K. Heyland, Christian Stoppe
Summary: Supplementation of vitamin D in critically ill patients may reduce mortality and shorten ICU length of stay and duration of mechanical ventilation. Parenteral administration might have a greater impact on overall mortality. Heterogeneity and assessed certainty among the studies limit the generalizability of the results.