Review
Clinical Neurology
Amirhossein Azari Jafari, Muffaqam Shah, Seyyedmohammadsadeq Mirmoeeni, Maryam Sadat Hassani, Shahrzad Nazari, Tristan Fielder, Daniel Agustin Godoy, Ali Seifi
Summary: Traumatic brain injury (TBI) is a leading cause of disability, morbidity, and mortality worldwide. Paroxysmal Sympathetic Hyperactivity (PSH) has been identified as one of the main causes of secondary neuronal injury in TBI patients, with diverse clinical manifestations and significant impact on patient outcomes.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Medicine, General & Internal
Sung Ho Jang, Kyu Hwan Choi
Summary: This study reports a case of stroke patient with concurrent PSH and hypothalamic injury, as demonstrated by DTI imaging. The results indicate that DTI can be a useful imaging method for evaluating the hypothalamic state of patients with PSH after brain injury.
Review
Critical Care Medicine
Justin Siew Yoong Tu, Jake Reeve, Adam M. Deane, Mark P. Plummer
Summary: PSH, occurring in around 10% of patients following acute severe brain injury, is associated with worse outcomes, but there are currently no clinical practice guidelines for treatment. While a variety of drugs have been used to manage PSH according to the literature, there is a lack of moderate-quality evidence to support clinical decision-making.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Medicine, General & Internal
Sidi Mamoun Louraoui, Fadwa Fliyou, Jehanne Aasfara, Abdessamad El Azhari
Summary: Traumatic brain injury (TBI) is a common and serious condition that can lead to paroxysmal sympathetic hyperactivity. The pathophysiology of TBI is still controversial, and there are limited treatment options available.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Samantha M. Bouchal, Ryan M. Naylor, David J. Daniels
Summary: Paroxysmal sympathetic hyperactivity (PSH) is a rare complication following traumatic or hypoxic brain injury, characterized by transient episodes of autonomic hyperactivity. This study focuses on postcraniotomy PSH in pediatric brain tumor patients. The results show that PSH is associated with poorer clinical outcomes, including longer hospital admissions, shorter interval between surgery and cancer therapy initiation, and increased need for long-term cerebrospinal fluid diversion.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2023)
Review
Clinical Neurology
Jiawei Qian, Xiaoqiang Min, Feng Wang, Yuanhua Xu, Wenchao Fang
Summary: This systematic review and meta-analysis examined the incidence of paroxysmal sympathetic hyperactivity (PSH) and its risk factors in adult patients with brain injury. The study found that PSH occurs in nearly a quarter of adult patients with brain injury, and the risk factors include age, traffic accidents, Glasgow Coma Scale score at admission, hydrocephalus, and diffuse axonal injury.
WORLD NEUROSURGERY
(2022)
Article
Immunology
Dongmei Wang, Shuang Su, Miaoqin Tan, Yongming Wu, Shengnan Wang
Summary: This study retrospectively reviewed 24 patients diagnosed with severe anti-NMDARE in the neuro-intensive care unit between 2014 and 2019, finding that 50% of patients had PSH, which was associated with prolonged ICU stay and duration of mechanical ventilation. PSH did not affect hospital mortality and functional outcome at 6 months after discharge.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Shinsuke Muraoka, Yuki Kumagai, Naoki Koketsu, Yoshio Araki, Ryuta Saito
Summary: This study aims to clarify the features of stroke-related paroxysmal sympathetic hyperactivity (PSH). The clinical features and treatment of post-aneurysmal subarachnoid hemorrhage (aSAH) PSH differ from those of aSAH-related hyperadrenergic crises. Early diagnosis and treatment can prevent severe complications, and PSH should be acknowledged as a potential complication of aSAH. Differential diagnosis can aid in developing individualized treatment plans and improving patient prognosis.
WORLD NEUROSURGERY
(2023)
Article
Immunology
Zhongyun Chen, Yan Zhang, Xiaowen Wu, Huijin Huang, Weibi Chen, Yingying Su
Summary: This study aimed to explore the clinical characteristics and prognosis of autonomic dysfunction and PSH in patients with anti-NMDAR encephalitis, and evaluate the efficacy of drugs used to suppress PSH episodes. The study found that PSH is common in patients with anti-NMDAR encephalitis, especially in severe cases, and can be effectively managed by several drug monotherapies. Autonomic dysfunction or PSH do not seem to compromise the neurological recovery of patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
He Miao, Huijin Huang, Weibi Chen, Ying-Ying Su, Yan Zhang
Summary: This prospective study analyzed the clinical characteristics and prognosis of paroxysmal sympathetic hyperactivity (PSH) in patients with severe nontraumatic brain injury. The incidence of PSH was 3.6%, and it was mainly associated with neurological diseases such as acute cerebral infarction, anti-N-methyl-D-aspartate receptor encephalitis, hypoxic encephalopathy, and acute disseminated encephalitis. Patients with PSH had a poorer prognosis, and effective control of PSH was achieved with medications such as diazepam, clonazepam, midazolam, and dexmedetomidine.
Article
Education, Scientific Disciplines
Abdulrahman Alshaya, Mohammed Aldhaeefi, Nada Alodhaiyan, Maha Alqahtani, Sarah Althewaibi, Wala Alshahrani, Khalid Al Sulaiman, Shmeylan A. Al Harbi, Ramesh Vishwakarma, Tariq Aldabbagh
Summary: This study found that patients with TBI who received clonidine had better functional outcomes during their ICU stay than those who did not. However, there were no significant differences in other secondary outcomes.
Article
Neurosciences
Juntao Yin, Wan Wang, Yu Wang, Guofeng Li, Yongmei Kong, Xiaoqiang Li, Yingdong Xu, Yuqing Wei
Summary: This study presents three cases of acute large vessel occlusion (LVO) in the posterior circulation with paroxysmal sympathetic hyperactivity (PSH) as the initial symptom. After endovascular treatment, PSH symptoms disappeared in all patients. These cases suggest that acute posterior circulation-related ischemic stroke with PSH as the first symptom should be considered.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Timothy M. Markman, Naga Venkata K. Pothineni, Tarek Zghaib, Jeffrey Smietana, Daniel McBride, Nigel A. Amankwah, Kristin A. Linn, Ramanan Kumareswaran, Matthew Hyman, Jeffrey Arkles, Pasquale Santangeli, Robert D. Schaller, Gregory E. Supple, David S. Frankel, Rajat Deo, David Lin, Michael P. Riley, Andrew E. Epstein, David J. Callans, Francis E. Marchlinski, Roy Hamilton, Saman Nazarian
Summary: The study demonstrated the potential therapeutic effects of transcutaneous magnetic stimulation in reducing ventricular tachycardia burden safely, especially in patients without cardiac implantable electronic devices.
Article
Clinical Neurology
Yuzo Fujino, Kensuke Shiga, Masatoshi Hori, Aiko Tamura, Takahiro Iizuka
Summary: PERM is an immune-mediated disorder, but dexmedetomidine, a highly selective alpha 2-adrenergic agonist, may alleviate paroxysmal symptoms by decreasing noradrenergic neuronal activity, resulting in attenuation of antibody-mediated disinhibited increased motor and sympathetic activity. Dexmedetomidine may be useful as an adjunctive symptomatic therapy in PERM and related disorders.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
M. Pentony, M. Featherstone, Y. Sheikh, A. Stroiescu, H. Bruell, I. Gill, K. M. Gorman
Summary: This study aimed to investigate the proportion and trajectory of dystonia in children with acquired brain injury (ABI) admitted to a pediatric intensive care unit (PICU). The results showed an incidence of dystonia of 3.2% in the ABI patients, with higher rates in the hypoxia/anoxia and traumatic brain injury (TBI) cohorts. Dystonia emerged early and persisted in the majority of patients at 6 months, requiring ongoing medical therapies.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2022)
Article
Immunology
Emily R. Levy, Lisa Musick, Matthew S. Zinter, Tess Lang, Mort J. Cowan, Peggy S. Weintrub, Christopher C. Dvorak
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2016)
Article
Public, Environmental & Occupational Health
Rachel L. Wattier, Emily R. Levy, Amit J. Sabnis, Christopher C. Dvorak, Andrew D. Auerbach
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2017)
Article
Critical Care Medicine
Erik C. Madsen, Emily R. Levy, Kate Madden, Anna A. Agan, Ryan M. Sullivan, Dionne A. Graham, Adrienne G. Randolph
PEDIATRIC CRITICAL CARE MEDICINE
(2017)
Article
Immunology
Emily R. Levy, James M. McCarty, Andi L. Shane, Peggy S. Weintrub
CLINICAL INFECTIOUS DISEASES
(2013)
Article
Public, Environmental & Occupational Health
E. R. Levy, S. Swami, S. G. Dubois, R. Wendt, R. Banerjee
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2012)
Article
Immunology
Emily R. Levy, Wai-Ki Yip, Michael Super, Jill M. Ferdinands, Anushay J. Mistry, Margaret M. Newhams, Yu Zhang, Helen C. Su, Gwenn E. McLaughlin, Anil Sapru, Laura L. Loftis, Scott L. Weiss, Mark W. Hall, Natalie Cvijanovich, Adam Schwarz, Keiko M. Tarquinio, Peter M. Mourani, Michele Kong, Ronald C. Sanders, Glenda Hefley, David Tellez, Katri Typpo, Barry Markovitz, Ana Lia Graciano, Heidi Flori, Nick Anas, Ofelia Vargas-Shiraishi, Patrick McQuillen, Angela Czaja, Peter Mourani, Christopher Carroll, John S. Giuliano, Joana Tala, Gwenn McLaughlin, Matthew Paden, Keiko Tarquinio, Cheryl L. Stone, Bria M. Coates, Juliane Bubeck Wardenburg, Neethi Pinto, Vicki Montgomery, Janice Sullivan, Anna A. Agan, Stephanie Ash, Anushay Mistry, Margaret Newhams, Melania Bembea, Stephen C. Kurachek, Allan Doctor, Mary Hartman, Edward Truemper, Sidharth Mahapatra, Machelle Dawson, Daniel L. Levin, Sholeen Nett, J. Dean Jarvis, Chhavi Katyal, Kate Ackerman, L. Eugene Daugherty, Ryan Nofziger, Steve Shein, Mark W. Hall, Lisa Steele, Neal J. Thomas, Debra Spear, Julie Fitzgerald, Scott Weiss, Jenny L. Bush, Kathryn Graham, Frederick E. Barr, Renee Higgerson, LeeAnn Christie, Marita Thompson, Cindy Darnell-Bowens, Nancy Jaimon, Douglas F. Willson, Rainer Gedeit, Kathy Murkowski, Philippe A. Jouvet, Marc-Andre Dugas, Adrienne G. Randolph
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Medicine, General & Internal
John Charles O'Horo, James R. Cerhan, Elliot J. Cahn, Philippe R. Bauer, Zelalem Temesgen, Jon Ebbert, Andy Abril, Omar M. Abu Saleh, Mariam Assi, Elie F. Berbari, Dennis M. Bierle, Wendelyn Bosch, Charles D. Burger, Edison J. Cano Cevallos, Casey M. Clements, Eva M. Carmona Porquera, Natalia E. Castillo Almeida, Douglas W. Challener, Supavit Chesdachai, Isin Y. Comba, Cristina G. Corsini Campioli, Sarah J. Crane, Ala S. Dababneh, Mark J. Enzler, Hind J. Fadel, Ravindra Ganesh, Alice Gallo De Moraes, John R. Go, Joel E. Gordon, Pooja R. Gurram, Pramod K. Guru, Erika L. Halverson, Michael F. Harrison, Heather A. Heaton, Ryan Hurt, Mary J. Kasten, Augustine S. Lee, Emily R. Levy, Claudia R. Libertin, Jorge M. Mallea, William F. Marshall, Gautam Matcha, Anne M. Meehan, Pablo Moreno Franco, William G. Morice, Jennifer J. O'Brien, Richard Oeckler, Steve Ommen, Caitlin P. Oravec, Robert Orenstein, Natalie J. Ough, Raj Palraj, Bhavesh M. Patel, Vincent S. Pureza, Brian Pickering, David M. Phelan, Raymund R. Razonable, Stacey Rizza, Priya Sampathkumar, Devang K. Sanghavi, Ayan Sen, Jason L. Siegel, Kai Singbartl, Aditya S. Shah, F. N. U. Shweta, Leigh L. Speicher, Gina Suh, Hussam Tabaja, Aaron Tande, Henry H. Ting, Russell C. Tontz, James J. Vaillant, Paschalis Vergidis, Mohamed Y. Warsame, Zachary A. Yetmar, Catherine (Cate) D. Zomok, Amy W. Williams, Andrew D. Badley
Summary: Mayo Clinic's experience in managing COVID-19 patients shows lower hospitalization and mortality rates, likely due to the use of multidisciplinary team evaluation, clinical trials, remote monitoring, and maintaining adequate operating capacity. These best practices can be a guide for other healthcare systems in responding to the pandemic.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Peripheral Vascular Disease
Mauricio F. Jin, Scott M. Thompson, Ann C. Comstock, Emily R. Levy, Christopher J. Reisenauer, Ian R. McPhail, Edwin A. Takahashi
Summary: A retrospective study on the placement of PICCs in the great saphenous vein (GSV) and anterior accessory great saphenous vein (AAGSV) showed a technical success rate of 100%, with a high complication rate of 37.9%, predominantly line associated infection.
JOURNAL OF VASCULAR ACCESS
(2022)
Article
Clinical Neurology
Kerri L. LaRovere, Becky J. Riggs, Tina Y. Poussaint, Cameron C. Young, Margaret M. Newhams, Mia Maamari, Tracie C. Walker, Aalok R. Singh, Heda Dapul, Charlotte V. Hobbs, Gwenn E. McLaughlin, Mary Beth F. Son, Aline B. Maddux, Katharine N. Clouser, Courtney M. Rowan, John K. McGuire, Julie C. Fitzgerald, Shira J. Gertz, Steven L. Shein, Alvaro Coronado Munoz, Neal J. Thomas, Katherine Irby, Emily R. Levy, Mary A. Staat, Mark W. Tenforde, Leora R. Feldstein, Natasha B. Halasa, John S. Giuliano, Mark W. Hall, Michele Kong, Christopher L. Carroll, Jennifer E. Schuster, Sule Doymaz, Laura L. Loftis, Keiko M. Tarquinio, Christopher J. Babbitt, Ryan A. Nofziger, Lawrence C. Kleinman, Michael A. Keenaghan, Natalie Z. Cvijanovich, Philip C. Spinella, Janet R. Hume, Kari Wellnitz, Elizabeth H. Mack, Kelly N. Michelson, Heidi R. Flori, Manish M. Patel, Adrienne G. Randolph
Summary: This study investigated the range and severity of neurologic involvement among children and adolescents associated with COVID-19, revealing that many patients showed clinical symptoms, but mainly presented with transient symptoms. A small number of cases developed severe, and even life-threatening, neurologic conditions.
Article
Hematology
Cyril Jacquot, Oren Gordon, Daniel Noland, Jeffrey R. Donowitz, Emily Levy, Sanjay Jain, Zachary Willis, Casey Rimland, Michele Loi, Antonio Arrieta, Kyle Annen, Noelle Drapeau, Stephanie Osborne, Monica I. Ardura, Satyam Arora, Elise Zivick, Meghan Delaney
Summary: A multi-institutional registry was created to study the use of convalescent COVID-19 plasma (CCP) in pediatric patients. The results showed that CCP was safe and well-tolerated in children, with no serious adverse events reported.
Article
Cardiac & Cardiovascular Systems
Emily Levy, Jennifer Blumenthal, Kathleen Chiotos, Elizabeth H. Stephens, Joseph A. Dearani
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2020)
Article
Infectious Diseases
Emily R. Levy, Kathryn A. Hutchins, Gregory J. Schears, Vilmarie Rodriguez, W. Charles Huskins
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2020)
Article
Cardiac & Cardiovascular Systems
Emily Levy, Jennifer Blumenthal, Kathleen Chiotos, Joseph A. Dearani
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2020)
Review
Pediatrics
Matt S. Zinter, Emily R. Levy, Shira J. Gertz
JOURNAL OF PEDIATRIC INTENSIVE CARE
(2014)
