Article
Oncology
Nicolas Leupin, Pier Luigi Zinzani, Franck Morschhauser, Stephane Dalle, Marie Maerevoet, Jean-Marie Michot, Vincent Ribrag, Fritz Offner, Marie Beylot-Barry, Helene Moins-Teisserenc, Karen Zwaenepoel, Koen de Winne, Maxime Battistella, Anna Hultberg, Domenica Gandini, Mahan Moshir, Julie Jacobs, Tim Delahaye, Aitzaz Khan, Piotr Zabrocki, Karen Silence, Luc van Rompaey, Christophe Borg, Giovanna Motta, Federica Melle, Angelica Calleri, Patrick Pauwels, Hans de Haard, Stefano Pileri, Martine Bagot
Summary: The study investigated the clinical benefit of cusatuzumab in patients with relapsed/refractory cutaneous T-cell lymphoma. Results showed an overall response rate of 23%, with a better response in patients with Sezary syndrome at a dosage of 5mg/kg.
Article
Oncology
Chella Krishna Vadivel, Maria Gluud, Sara Torres-Rusillo, Lasse Boding, Andreas Willerslev-Olsen, Terkild B. Buus, Tea Kirkegaard Nielsen, Jenny L. Persson, Charlotte M. Bonefeld, Carsten Geisler, Thorbjorn Krejsgaard, Anja T. Fuglsang, Niels Odum, Anders Woetmann
Summary: This study demonstrates the nuclear localization of JAK3 in malignant T cells and its interactions with key nuclear proteins, suggesting a novel non-canonical role in cutaneous T cell lymphoma.
Article
Dermatology
D. M. Weiner, Joseph S. Durgin, Maria Wysocka, Alain H. Rook
Summary: In recent decades, immunotherapy has emerged as an effective treatment option for patients with CTCL by stimulating the immune system to clear malignant T cells and repair immune dysfunction. Understanding the interactions with the immune system and treatment outcomes are crucial in utilizing established and emerging immunotherapeutic options for CTCL treatment.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Attila Gabor Szollosi, Attila Olah, Erika Lisztes, Zoltan Griger, Balazs Istvan Toth
Summary: Pruritus, or itch, is a common symptom associated with various skin and immune disorders. Despite significant progress in understanding the molecular mechanisms behind acute and chronic itch, there are still gaps in our knowledge, making the clinical management of pruritic conditions challenging. Recent research has highlighted the interactions between pruriceptive sensory neurons and different cutaneous cell types, particularly in inflammatory conditions, where these cells release mediators that excite the itch-sensing fibers. There is also bidirectional communication, with sensory neurons releasing mediators that maintain an inflamed and itchy tissue environment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
Amrita Goyal, Daniel O'Leary, Kavita Goyal, Krishnan Patel, David Pearson, Murali Janakiram
Summary: Patients with cutaneous T-cell lymphoma (CTCL) have an increased risk of developing second malignancies, especially Hodgkin and non-Hodgkin lymphoma, lung cancer, bladder cancer, and melanoma. These findings provide evidence of a population at increased risk of malignancy, emphasizing the importance of early detection for decreasing the morbidity burden of second malignancies.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Medicine, Research & Experimental
Man Hu, Joerg Scheffel, Daniel Elieh-Ali-Komi, Marcus Maurer, Tomasz Hawro, Martin Metz
Summary: Primary cutaneous T-cell lymphomas (CTCL) are characterized by the accumulation of malignant T-lymphocytes in the skin, leading to severe pruritus that significantly impacts patients' quality of life. Understanding the underlying mechanisms of CTCL pruritus is challenging, but studies suggest that proteases (such as tryptase) and neuropeptides (particularly Substance P) may play a significant role, alongside cytokine receptors, MRGPRs, and TRP channels. Targeting these mediators and receptors could lead to effective treatment options for CTCL pruritus.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Dermatology
Grigorios Theodosiou, Theresa Nissen, Elke Weisshaar, Sandra Plachta-Danielzik, Matthias Augustin, Sonja Stander, Laura B. Von Kobyletzki, Regina Folster-Holst
Summary: This study investigated the prevalence of itch in German schoolchildren and found that 26.2% of the students reported experiencing itch. Chronic itch was found to have a negative impact on sleep and mood.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Dermatology
Joseph S. Durgin, David M. Weiner, Maria Wysocka, Alain H. Rook
Summary: CTCLs are malignancies of skin-trafficking T cells, with patients experiencing immune dysfunction and susceptibility to infections. Therapies stimulating immunity show superior outcomes compared to conventional chemotherapy. Recent research has identified potential therapeutic targets by better understanding the pathogenesis of immune deficits in CTCL patients.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Morgan Nguyen, Tessa LeWitt, Yanzhen Pang, Katherine Bagnowski, Maria L. Espinosa, Jaehyuk Choi, Joan Guitart, Walter Liszewski, Xiaolong Alan Zhou
Summary: This study investigated the relationship between lifestyle and demographic factors and disease severity, stage, and health-related quality of life (HRQoL) in patients with cutaneous T-cell lymphoma (CTCL). The findings suggest that a history of chemical exposure and race may be risk factors for advanced-stage CTCL and poorer HRQoL outcomes. Other factors such as obesity, smoking, education level, etc. were not significantly associated with disease severity or stage.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Heather M. Mahurin, Erica Tarabadkar, Daniel S. Hippe, Kristina Lachance, Ellen J. Kim, Elizabeth T. Loggers, Michi M. Shinohara
Summary: The study characterized the patterns of integrative medicine (IM) use and health-related quality of life (HRQoL) in patients with cutaneous T-cell lymphoma (CTCL). It found that most patients used IM to treat their disease and manage symptoms, but those using IM reported more severe itching and worse HRQoL. Further studies on IM interventions in CTCL patients are needed.
COMPLEMENTARY THERAPIES IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Shuichi Nakai, Eiji Kiyohara, Rei Watanabe
Summary: CTCL is a heterogeneous group of non-Hodgkin lymphoma, mainly including MF and SS, with malignant cells possibly originating from different T cell phenotypes. The pathogenesis and therapeutic strategies for CTCL remain unclear due to the similar characteristics between malignant cells and anti-tumor T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Johannes Wohlrab, Tim Mentel, Adina Eichner
Summary: This study demonstrates that the investigated medical device can safely and effectively activate heat-sensitive receptors in the skin to alleviate itch sensation. Clinical studies are needed to confirm its therapeutic efficacy in treating pruritus.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Review
Microbiology
Magdalena Lyko, Alina Jankowska-Konsur
Summary: This translated article discusses the role of the skin microbiome in the development of CTCL. By analyzing the composition and diversity of the skin microbiome, the influence of microorganisms on CTCL is revealed. Additionally, the involvement of Staphylococcus aureus in CTCL pathogenesis is explored, and the influence of therapeutic options on the microbiome is discussed.
Article
Biochemistry & Molecular Biology
S. van Santen, J. J. Out, W. H. Zoutman, K. D. Quint, R. Willemze, M. H. Vermeer, C. P. Tensen
Summary: Recent studies have shown low translational and transcriptional expression levels of IL31 in CTCL patients. Detectable low IL31 serum levels were only observed in SS and FMF patients, not in patients with classic MF. These findings suggest a limited role for IL31 in CTCL pathogenesis.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Oncology
Chalid Assaf, Nathalie Waser, Martine Bagot, Mary He, Tina Li, Mehul Dalal, Francois Gavini, Fabrizio Trinchese, Athanasios Zomas, Meredith Little, Nicola Pimpinelli, Pablo L. Ortiz-Romero, Timothy M. Illidge
Summary: This study provides real-world data on the treatment patterns and outcomes of relapsed or refractory CTCL, highlighting the diverse treatment approaches and the lack of consensus in managing this condition.
Article
Medicine, General & Internal
Catherine J. Evans, Laura Potts, Ursula Dalrymple, Andrew Pring, Julia Verne, Irene J. Higginson, Wei Gao
Summary: This study examined patient characteristics and factors associated with mortality in adults admitted to intermediate care units in England. One in four patients died within 1 year, with respiratory conditions, dementia, liver disease, cancer, and increasing multimorbidity being indicators for palliative care assessment. The need for greater integration of palliative care in intermediate care units has been highlighted due to an aging population.
Review
Nursing
Fei Fei, Jonathan Koffman, Xiaohan Zhang, Wei Gao
Summary: This systematic review explores symptom clusters in COPD patients, identifying four common clusters but also noting inconsistencies in composition across studies. Future research should focus on establishing a common definition, standardizing criteria for symptom inclusion, and considering patients' subjective experiences.
WESTERN JOURNAL OF NURSING RESEARCH
(2022)
Article
Clinical Neurology
K. Ray Chaudhuri, Katarina Rukavina, Victor McConvey, Angelo Antonini, Stefan Lorenzl, Roongroj Bhidayasiri, Maria Elisa Pimentel Piemonte, Shen-Yang Lim, Edward Richfield, Richard Walker, Raquel Bouca-Machado, Sabrina Bajwah, Wei Gao, Dhaval Trivedi, Janis Miyasaki
Summary: The ongoing COVID-19 pandemic has a significant impact on patients with Parkinson's disease and their caregivers, affecting their mental health and worsening physical symptoms both in the short and long term. Personalized palliative care strategies are needed globally in a lockdown setting, with validated assessment tools applied remotely to address specific motor or non-motor symptoms.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2021)
Article
Public, Environmental & Occupational Health
R. Wilson, F. Gaughran, T. Whitburn, I. J. Higginson, W. Gao
Summary: The study revealed that patients with serious mental disorders are more likely to utilize acute care services and die in the hospital at the end of life. Patients with more comorbidities tend to receive more end-of-life care and have a higher rate of hospital deaths.
Article
Medicine, General & Internal
James M. Beattie, Irene J. Higginson, Theresa A. McDonagh, Wei Gao
Summary: The study compared trends in place of death for heart failure patients with and without comorbid dementia before and after the implementation of the Mental Capacity Act. The results showed a shift in place of death from hospital to home for patients without dementia following the enforcement of the MCA. The prevalence of death in care homes was higher for patients with dementia.
Article
Public, Environmental & Occupational Health
Nadine Seward, Charlotte Hanlon, Ahmed Abdella, Zulfa Abrahams, Atalay Alem, Ricardo Araya, Max Bachmann, Alemayehu Bekele, Birke Bogale, Nataliya Brima, Dixon Chibanda, Robyn Curran, Justine Davies, Andualem Beyene, Lara Fairall, Lindsay Farrant, Souci Frissa, Jennifer Gallagher, Wei Gao, Liz Gwyther, Richard Harding, Muralikrishnan R. Kartha, Andrew Leather, Crick Lund, Maggie Marx, Kennedy Nkhoma, Jamie Murdoch, Inge Petersen, Ruwayda Petrus, Andre van Rensburg, Jane Sandall, Nick Sevdalis, Andrew Sheenan, Amezene Tadesse, Graham Thornicroft, Ruth Verhey, Chris Willott, Martin Prince
Summary: To achieve universal health coverage, it is important to strengthen health systems and provide high-quality care. The National Institute for Health Research Global Research Unit on Health System Strengthening in Sub-Saharan Africa (ASSET) aims to address this need through a four-year program, focusing on research methods and stakeholder engagement to improve the effectiveness of health system strengthening interventions.
GLOBAL HEALTH ACTION
(2022)
Article
Primary Health Care
Javiera Leniz, Martin Gulliford, Irene J. Higginson, Sabrina Bajwah, Deokhee Yi, Wei Gao, Katherine E. Sleeman
Summary: This study aimed to explore factors associated with hospital admissions among people dying with dementia. The study found that patients with more GP contacts had a higher risk of multiple hospital admissions, while higher continuity of care and identification of palliative care needs were associated with a lower frequency of these admissions.
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Article
Psychology, Clinical
Liadh Timmins, Alexandra Pitman, Michael King, Wei Gao, Katherine Johnson, Peihan Yu, Debbie Braybrook, Anna Roach, Steve Marshall, Elizabeth Day, Ruth Rose, Paul Clift, Kathryn Almack, Deok Hee Yi, Katherine Bristowe, Richard Harding
Summary: This study compared bereavement outcomes for partners of same-gender and different-gender decedents and found that same-gender bereaved partners reported significantly more psychological distress, but there were no significant differences in complicated grief outcomes.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Javiera Leniz, Lesley A. Henson, Jean Potter, Wei Gao, Tom Newsom-Davis, Zia Ul-Haq, Amanda Lucas, Irene J. Higginson, Katherine E. Sleeman
Summary: The study found that increased contacts with community nurses were associated with fewer hospital admissions in the last 30 days and fewer emergency department visits in the last 2 weeks for people with end-of-life cancer. However, increased contacts with general practitioners were associated with a higher risk of more hospital admissions in the last 90 days and more emergency department visits in the last 2 weeks. Therefore, expanding community nursing could potentially reduce acute hospital use at the end of life.
Article
Respiratory System
Deokhee Yi, Charles C. Reilly, Gao Wei, Irene J. Higginson
Summary: This study found that breathlessness services were cost-effective compared to usual care, resulting in cost savings and improved quality of life. Additionally, tailoring service attributes to individual preferences increased the uptake of these services.
Article
Health Care Sciences & Services
Katherine Bristowe, Liadh Timmins, Debbie Braybrook, Steve Marshall, Alexandra Pitman, Katherine Johnson, Elizabeth Day, Paul Clift, Ruth Rose, Deokhee Yi, Peihan Yu, Wei Gao, Anna Roach, Kathryn Almack, Michael King, Richard Harding
Summary: This study explored the specific experiences of LGBT+ individuals in partner bereavement and their decision-making processes regarding disclosure of relationships/identities. The findings highlight the additional stressors faced by LGBT+ people in bereavement and the varying levels of disclosure across social networks.
PALLIATIVE MEDICINE
(2023)
Article
Respiratory System
Lisa Jane Brighton, Claire M. Nolan, Ruth E. Barker, Suhani Patel, Jessica A. Walsh, Oliver Polgar, Samantha S. C. Kon, Wei Gao, Catherine J. Evans, Matthew Maddocks, William D. C. Man
Summary: This study compared the characteristics of two commonly used frailty measures, the Fried Frailty Phenotype (FFP) and the Short Physical Performance Battery (SPPB), in people with stable chronic obstructive pulmonary disease (COPD). The study found that both measures identified similar proportions of frail individuals and had predictive value for survival time.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Review
Health Policy & Services
Houshen Li, Ping Guo, Wei Gao, Charles Normand, Richard Harding
Summary: This study reviewed the issues related to advanced cancer patients in China and assessed the suitability and quality of existing outcome measures. The results showed that there are currently no appropriate and valid outcome measures for advanced cancer patients in China. Further research is needed to improve the care and assessment of patients in this population.
JOURNAL OF CANCER POLICY
(2023)
Article
Health Care Sciences & Services
Hannah May Scott, Lucy Coombes, Debbie Braybrook, Anna Roach, Daney Hardardottir, Katherine Bristowe, Clare Ellis-Smith, Irene Higginson, Wei Gao, Myra Bluebond-Langner, Bobbie Farsides, Fliss E. M. Murtagh, Lorna K. Fraser, Richard Harding
Summary: The COVID-19 pandemic and lockdowns have had a negative impact on children and young people with life-limiting or life-threatening conditions and their families, resulting in loss of social support, disruption of vital services, and increased psychological distress.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Health Care Sciences & Services
Ivan Shun Lau, Zeljko Kraljevic, Mohammad Al-Agil, Shelley Charing, Alan Quarterman, Harold Parkes, Victoria Metaxa, Katherine Sleeman, Wei Gao, Richard J. B. Dobson, James T. Teo, Phil Hopkins
Summary: This study aimed to explore linguistic nuances around dying in hospital and the accuracy of prognostication, highlighting the importance of terminology in discussions about limitation of life-sustaining treatment and end-of-life care. The findings showed diverse vocabulary used in these discussions, with varying associations to 7-day mortality, emphasizing the need for correct application of terminology for effective communication.
BMJ HEALTH & CARE INFORMATICS
(2021)