Article
Oncology
Salome Adam, Melissa S. Y. Thong, Eva Martin-Diener, Bertrand Camey, Celine Egger Hayoz, Isabelle Konzelmann, Seyed Mohsen Mousavi, Christian Herrmann, Sabine Rohrmann, Miriam Wanner, Katharina Staehelin, Rato T. Strebel, Marco Randazzo, Hubert John, Hans-Peter Schmid, Anita Feller, Volker Arndt
Summary: Three distinct classes of the pain, fatigue, and depression cluster were identified among long-term prostate cancer survivors, with class 1 having low pain, low physical and emotional fatigue, and moderate depressive symptoms; class 2 having low physical fatigue and pain, moderate emotional fatigue, and high depressive symptoms; and class 3 having high scores for all symptoms. Survivors in class 2 and 3 were more likely to have physical inactivity, history of depression or specific comorbidities, receive radiation therapy, and have worse health-related quality of life outcomes.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Marilyn J. Hammer, Bruce A. Cooper, Lee-May Chen, Alexi A. Wright, Rachel Pozzar, Stephanie V. Blank, Bevin Cohen, Laura Dunn, Steven Paul, Yvette P. Conley, Jon D. Levine, Christine Miaskowski
Summary: The purpose of this study was to identify distinct subgroups of gynecologic cancer patients receiving chemotherapy who experience different combinations of pain, fatigue, sleep disturbance, and depression. The study found that there were two distinct classes of patients, with the high class showing higher levels of symptom burden and poorer quality of life outcomes.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Clinical Neurology
Denise Shuk Ting Cheung, Naomi Takemura, Robert Smith, Wing Fai Yeung, Xinyi Xu, Alina Yee Man Ng, Shing Fung Lee, Chia-Chin Lin
Summary: Qigong interventions have significant benefits in improving sleep and fatigue symptoms in cancer patients, with Taichi being the most commonly studied form. However, the effect on depressive symptoms is not significant. The improvement in sleep through qigong is largely mediated by its impact on reducing fatigue, while these benefits may diminish after 3 months.
Article
Health Care Sciences & Services
Marilyn J. Hammer, Bruce Cooper, Steven M. Paul, Kord M. Kober, Frances Cartwright, Yvette P. Conley, Fay Wright, Jon D. Levine, Christine Miaskowski
Summary: Pain, fatigue, sleep disturbance, and depression often co-occur in oncology patients and negatively impact quality of life. This study identified three distinct patient subgroups based on their experiences with a pre-specified symptom cluster and found differences in demographic, clinical, and symptom characteristics as well as quality of life outcomes among these subgroups.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Oncology
Joanna E. Fardell, Sim Yee (Cindy) Tan, Kim Kerin-Ayres, Haryana M. Dhillon, Janette L. Vardy
Summary: A significant number of cancer survivors struggle to work due to symptoms after treatment. Symptom clusters, including pain, emotional, and cognitive symptoms, have a significant impact on work ability. Older survivors and those with more advanced cancer stages are more likely to experience limitations in their work ability.
Article
Psychiatry
Hee-Ju Kim, Joon Ho Moon, Su Wol Chung, Ivo Abraham
Summary: This study found that a substantial number of cancer patients experienced a cluster of psycho-neurological symptoms, and that older age and elevated pro-inflammatory cytokines were associated with experiencing the symptom cluster. The activity of indolamine-2.3 dioxygenase (IDO) was associated with pro-inflammatory cytokine activity and the symptom cluster experience. Symptom severity, pro-inflammatory cytokines, and IDO activity were higher in cancer patients compared to healthy controls.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Review
Oncology
Soo Hyun Kim, Ji Hyun Sung, Sung-Hee Yoo, Sanghee Kim, Kyunghwa Lee, Eui Geum Oh, Jiyeon Lee
Summary: This study aimed to evaluate the effectiveness of digital self-management symptom interventions on symptom outcomes in adult cancer patients. The meta-analysis of 32 randomized controlled trials demonstrated that digital self-management interventions had significant effects on reducing symptom burden and relieving pain, fatigue, anxiety, and depression.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Article
Mathematical & Computational Biology
Zixin Shu, Jingjing Wang, Hailong Sun, Ning Xu, Chenxia Lu, Runshun Zhang, Xiaodong Li, Baoyan Liu, Xuezhong Zhou
Summary: Symptom phenotypes have been an important entity in clinical diagnosis and management, with the challenge of non-specificity needing to be addressed for the advancement of symptom science and precision health. Network medicine provides a successful approach for understanding complex disease phenotypes and can be a useful tool for symptom science. By incorporating symptom co-occurrences, high-quality symptom-gene associations, and protein-protein interactions, researchers in this study explored the molecular network patterns of symptom phenotypes and found that the molecular network diversity partially explains the clinical diversity of symptom phenotypes.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2021)
Article
Clinical Neurology
Xiaofang Dong, Sen Yang, Yuanli Guo, Peihua Lv, Yanjin Liu
Summary: This study identified latent classes of acute stroke patients with distinct experiences of symptom clusters. Three classes, including all high symptom, high psychological disorder, and all low symptom, were identified. The results can help identify high-risk patients and create effective targeted interventions for stroke patients with different symptom clusters.
JOURNAL OF PAIN RESEARCH
(2022)
Review
Rehabilitation
Areum Han
Summary: This study examined the effects of mindfulness-and acceptance-based interventions (MABIs) on reducing symptoms in individuals with multiple sclerosis (MS). The results showed significant effects of MABIs in reducing symptoms of depression, anxiety, stress, and pain, but a moderate effect on fatigue symptoms. Future high-quality studies with follow-up evaluations are needed to further support these findings and explore intervention features that enhance and sustain effects.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Health Care Sciences & Services
Michael Nissen, Nuria Barrios Campo, Madeleine Flaucher, Katharina M. Jaeger, Adriana Titzmann, Dominik Blunck, Peter A. Fasching, Victoria Engelhardt, Bjoern M. Eskofier, Heike Leutheuser
Summary: During pregnancy, almost all women experience pregnancy-related symptoms, but the relationship between these symptoms and pregnancy outcomes is not well understood. Many pregnancy apps allow women to track their symptoms, but the resulting data are primarily used for commercial purposes. This study aims to examine the occurrence, course, and correlation of symptoms throughout pregnancy using self-reported app data. The findings reveal previously unknown or disputed symptom trajectories and relationships, emphasizing the potential of using industry data for scientific research.
NPJ DIGITAL MEDICINE
(2023)
Article
Oncology
Ying Sheng, Janet S. Carpenter, Steven M. Paul, Yvette P. Conley, Jon D. Levine, Christine Miaskowski
Summary: Patients with breast cancer commonly report symptoms such as anxiety, depression, sleep disturbance, fatigue, cognitive dysfunction, pain, and palpitations. This study compared the severity and occurrence rates of these symptoms, as well as quality of life outcomes, between patients with and without palpitations. The results showed significant differences and decrements in psychological symptoms and quality of life for patients with palpitations.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Article
Oncology
Meng -Yuan Li, Stephen Wai Hang Kwok, Jing-Yu (Benjamin) Tan, Daniel Bressington, Xian-Liang Liu, Tao Wang, Shun-Li Chen
Summary: This study evaluated the feasibility and preliminary effects of somatic acupressure (SA) for managing the fatigue-sleep disturbance-depression symptom cluster (FSDSC) among breast cancer survivors. The results of a randomized controlled trial showed that both true and sham SA had significant improvements on FSDSC and depression, and participants had positive views towards SA as a beneficial strategy for symptom management. This study demonstrated the potential effectiveness of SA for managing the FSDSC.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Article
Multidisciplinary Sciences
Eun Joo Yang, Keun Seok Lee, Myong Cheol Lim, Ji Yeon Baek, Ji-Youn Han, Eun-Seung Yu, Seung Hyun Chung
Summary: The study found that symptom perception significantly affects functioning, with experienced symptoms indirectly affecting somatic sensations but not directly associated with disability. A complex model with first-order (somatic sensation) and second-order (experienced symptoms) factors provided a good fit, better conceptualizing the structure of symptoms.
Article
Clinical Neurology
Heather G. Belanger, Christine Lee, Mirene Winsberg
Summary: This study aimed to explore the heterogeneity of symptoms in patients with MDD and identified four different MDD phenotypes. The findings suggest that the heterogeneity in MDD may explain treatment response variations. These results can be used to study recovery rates following treatment and develop clinical decision support tools and artificial intelligence algorithms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Oncology
Burcu Sengez, Brian Carr, Hani Alotaibi
Summary: This article focuses on the association between EMT and inflammation in the context of HCC progression. EMT and inflammation are closely correlated with tumor aggressiveness and poor outcomes, and cellular heterogeneity is a common result. Identifying EMT-related biomarkers and understanding EMT regulatory molecules will contribute to promising developments in clinical practice and can be used for predicting metastasis.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Surgery
Veysel Ersan, Sertac Usta, Cemalettin Aydin, Brian Carr, Sinan Karatoprak, Sezai Yilmaz
Summary: This study retrospectively examined the outcomes of non-transplant surgical approaches in patients with Bismuth-Corlette (BC) type IV perihilar cholangiocarcinoma (pCCA). The results showed that patients who underwent hepatectomy and had negative lymph nodes achieved the best survival rates. However, achieving high survival rates remains challenging in this patient population.
ACTA CHIRURGICA BELGICA
(2023)
Article
Gastroenterology & Hepatology
Mikhail Efanov, Diana Salimgereeva, Ruslan Alikhanov, Andrew G. R. Wu, David Geller, Federica Cipriani, Davit L. Aghayan, Asmund Avdem Fretland, Jasper Sijberden, Andrea Belli, Marco V. Marino, Vincenzo Mazzaferro, Adrian K. H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Prieto, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee-Chien Yong, Constantino Fondevila, Fernando Rotellar, Gi-Hong Choi, Ricardo Robless Campos, Xiaoying Wang, Robert P. Sutcliffe, Johann Pratschke, Eric Lai, Charing C. Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, Paulo Herman, Fabrizio Di Benedetto, T. Peter Kingham, Rong Liu, Tran Cong Duy Long, Alessandro Ferrero, Giovanni Battista Levi Sandri, Daniel Cherqui, Olivier Scatton, Go Wakabayashi, Roberto I. Troisi, Tan-To Cheung, Atsushi Sugioka, Ho-Seong Han, Mohammad Abu Hilal, Olivier Soubrane, David Fuks, Luca Aldrighetti, Bjorn Edwin, Brian K. P. Goh
Summary: This study compares the outcomes of laparoscopic liver resection of segments 7 and 8 and finds that atypical resection of segment 7 is more difficult than segment 8, while segmentectomy 8 is more difficult than segmentectomy 7.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Yun-Le Linn, Andrew G. Wu, Ho-Seong Han, Rong Liu, Kuo-Hsin Chen, David Fuks, Olivier Soubrane, Daniel Cherqui, David Geller, Tan-To Cheung, Bjorn Edwin, Luca Aldrighetti, Mohammad Abu Hilal, Roberto Troisi, Go Wakabayashi, Brian K. P. Goh
Summary: This study reviewed the literature on difficulty scoring systems (DSS) for minimally invasive liver resection (MILR) and found that existing DSS are effective in predicting the difficulty of the surgery.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Epameinondas Dogeas, David A. A. Geller, Samer Tohme, Jennifer Steel, Winifred Lo, Brittany Morocco, Amit Tevar, Michele Molinari, Christopher Hughes, Abhinav Humar
Summary: This study compared textbook outcomes (TO) of open live donor right hepatectomy (RH) versus open right hepatic lobectomy for cancer in a single Western center and identified clinical factors associated with failure to achieve a TO. The results showed that the TO rate after RH for live donor purposes was 92.2% and for RH for cancer cases was 53.7%.
Article
Oncology
Qiang Du, Silvia Liu, Kun Dong, Xiao Cui, Jing Luo, David A. Geller
Summary: Metastasis is the main cause of death in patients with colorectal cancer. The study found that iNOS downregulation induces the EMT program and promotes metastasis in colorectal cancer. The reduced expression of iNOS may serve as a potential therapeutic target for patients with colorectal cancer.
MOLECULAR CANCER RESEARCH
(2023)
Review
Oncology
Winifred M. M. Lo, Samer T. T. Tohme, David A. A. Geller
Summary: Minimally invasive surgery, including laparoscopic and robotic approaches, is a safe and effective option for treating liver metastases from colorectal cancer. Laparoscopic liver resection (LLR) is associated with shorter hospital stays and similar post-operative complications compared to open techniques. LLR allows for early initiation of chemotherapy and simultaneous resection of colorectal and liver tumors can be safe in selected patients. Robotic liver resection (RLR) has comparable safety and may improve resection rates. It is important to carefully select patients and ensure surgeon experience when considering minimally invasive liver surgery for colorectal liver metastases.
Editorial Material
Oncology
Luca Giacomelli, Rodolfo Sacco, Simonetta Papa, Brian I. Carr
Article
Health Care Sciences & Services
Kate Loveys, Michael Antoni, Liesje Donkin, Mark Sagar, Elizabeth Broadbent
Summary: This study compared the feasibility and acceptability of virtual humans, teletherapy, and self-guided e-manuals in delivering stress management interventions. Results showed that all three technologies were feasible and acceptable for delivering one module of cognitive behavioral stress management to distressed adult women. The technologies had unique strengths and limitations that may depend on individual characteristics and specific circumstances.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychology, Clinical
Ruth G. St Fleur, Sara M. St George, Daniel J. Feaster, Tae Kyoung Lee, Michael H. Antoni
Summary: The study examined the effects of cognitive behavioral therapy (CBT)-based group interventions on the quality of life (QoL) in breast cancer patients. It found that the intervention improved emotional and functional QoL by increasing benefit finding. This effect was particularly significant among patients with low optimism levels before surgery.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Oncology
Brian I. I. Carr, Vito Guerra
Summary: Multiple serum parameters were evaluated to determine their relationship with survival in patients with hepatocellular carcinoma. The combination of serum albumin plus GGT levels was found to be the most prognostically useful among the inflammation parameters that were tested.
Article
Oncology
Xicai Li, Jingquan Huang, Qiulin Wu, Qiang Du, Yingyu Wang, Yubin Huang, Xiaoyong Cai, David A. Geller, Yihe Yan
Summary: This study reveals the relationship between CHK1 expression and the tumor microenvironment in hepatocellular carcinoma (HCC). High CHK1 expression is associated with advanced tumor stage and poor prognosis. CHK1 inhibition and cisplatin induce DNA damage and apoptosis in HCC cells. CHK1 directly interacts with IRF1 to regulate MICA expression, which is correlated with NK cell and CD8+T cell infiltration in HCC.
Article
Medicine, General & Internal
Fatih Ozdemir, Volkan Ince, Sertac Usta, Brian I. I. Carr, Harika G. G. Bag, Ayse Nur Akatli, Aysegul Sagir Kahraman, Sezai Yilmaz
Summary: This study reviewed and compared the prognostic impact and clinicopathologic features of incidental hepatocellular carcinoma (iHCC) patients and hepatocellular carcinoma diagnosed before liver transplantation (pdHCC) patients. The results showed that iHCC patients had better histopathologic features and survival rates with lower tumor recurrence compared to pdHCC patients.
MEDICINA-LITHUANIA
(2023)
Review
Immunology
Lisa H. Butterfield, Yana G. Najjar
Summary: The approval of immune checkpoint inhibitors has shifted the treatment paradigm for malignancies. Combination therapies and biomarker studies are important for maximizing clinical efficacy.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Juraj Adamik, Paul V. Munson, Deena M. Maurer, Felix J. Hartmann, Sean C. Bendall, Rafael J. Arguello, Lisa H. Butterfield
Summary: This study analyzed the transcriptomic and immune-metabolic profiles of dendritic cells (DCs) from patients with late-stage melanoma. The results suggest that the metabolic profile of DCs is associated with the immunostimulatory potential of cancer vaccines.
NATURE COMMUNICATIONS
(2023)
