Review
Biochemistry & Molecular Biology
Lamberta Ghaly, Vincent Bargnes, Sadiq Rahman, George-Abraam Tawfik, Sergio Bergese, William Caldwell
Summary: Complex regional pain syndrome (CRPS) is a rare and debilitating chronic pain disorder characterized by persistent pain that is disproportionate to any preceding injury. It can significantly impact a person's quality of life, resulting in disability and psychological distress. Despite being recognized for over a century, finding effective treatment for CRPS remains challenging.
Article
Biochemistry & Molecular Biology
Myeounghoon Cha, Kyung Hee Lee, Minjee Kwon, Bae Hwan Lee
Summary: The study compared the pain relief effects of different drugs in a rat model of chronic post-ischemic pain-induced CRPS, finding that these drugs effectively alleviated CRPS-induced mechanical allodynia, improved mechanical sensitivity, and reduced the expression of inflammatory factors.
Article
Clinical Neurology
Corinne van den Berg, Maaike Dirckx, Frank J. P. M. Huygen, Jitske Tiemensma
Summary: The purpose of this study was to evaluate the effectiveness of the anti-inflammatory drug infliximab, a TNF-α inhibitor, in treating patients with complex regional pain syndrome (CRPS). The retrospective study found that out of the 15 patients treated with infliximab, 11 had a positive treatment effect, and 7 patients are still undergoing treatment.
JOURNAL OF PAIN RESEARCH
(2023)
Review
Medicine, General & Internal
Umberto Aldo Arcidiacono, Daniele Armocida, Alessandro Pesce, Marco Maiotti, Luca Proietti, Giancarlo D'Andrea, Antonio Santoro, Alessandro Frati
Summary: CRPS is a rare postoperative condition, often misdiagnosed before pain therapists' intervention. It occurs rarely after spine surgery, with limited literature on reported cases. Most cases are seen following uncomplicated lumbar spine surgery, and the proposed therapies include chemical sympathectomy and spinal cord stimulation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Behavioral Sciences
Axel D. Vitterso, Gavin Buckingham, Antonia F. Ten Brink, Monika Halicka, Michael J. Proulx, Janet H. Bultitude
Summary: This study found no evidence of impaired strategic control or sensorimotor realignment in individuals with Complex Regional Pain Syndrome (CRPS). However, there was some indication that there could be a greater propensity for sensorimotor realignment in the CRPS-affected arm when using the affected hand.
Article
Anesthesiology
Krista Baerg, Susan M. Tupper, Luan Manh Chu, Nicole Cooke, Bruce D. Dick, Marie-Joelle Dore-Bergeron, Sheri Findlay, Pablo M. Ingelmo, Christine Lamontagne, Giulia Mesaroli, Tim F. Oberlander, Raju Poolacherla, Adam Oscar Spencer, Jennifer Stinson, G. Allen Finley
Summary: This study describes the minimum incidence, clinical features, and recommended treatments of pediatric complex regional pain syndrome (CRPS) in Canada. The study found that CRPS has a higher incidence in girls aged 12 and older, with most cases involving the lower limbs. Nonsteroidal anti-inflammatory drugs and acetaminophen were the most commonly prescribed treatments, and there is a need for increased promotion of pain education.
Article
Clinical Neurology
Mohamed A. R. Soliman, Asham Khan, Alexander O. Aguirre, Nicco Ruggiero, Bennett R. Levy, Brandon L. Mariotti, Patrick K. Jowdy, Kenan R. Rajjoub, Ryan M. Hess, Qazi Zeeshan, Robert Starling, John Pollina, Jeffrey P. Mullin
Summary: The study evaluated the effectiveness and safety of a continuous infusion regional anesthesia pump placed after thoracopelvic fusion surgery for treating PSPS. While the pump group showed trends of using fewer opioids in the first 2 days post-surgery and had a shorter hospital stay, no statistically significant difference was found between the pump group and the control group in terms of opioid usage, hospital stay, and 90-day readmission rates.
WORLD NEUROSURGERY
(2021)
Article
Medicine, Research & Experimental
Richa Pande, Ayush Parikh, Botros Shenoda, Sujay Ramanathan, Guillermo M. Alexander, Robert J. Schwartzman, Seena K. Ajit
Summary: CRPS is a chronic pain condition characterized by inflammation and debilitating pain. Downregulation of miR-605 may exacerbate inflammation and affect the expression of CXCL5. Further studies suggest that miR-605 may regulate inflammation by modulating CXCL5 in patients with poor response to ketamine.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Behavioral Sciences
Janet H. Bultitude, Karin Petrini
Summary: The study found that individuals with CRPS can optimally integrate visual and self-motion cues under some conditions, despite their lower reliability, and use different strategies compared to controls.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ana Vaz, Andreia Costa, Andre Pinto, Ana Isabel Silva, Paulo Figueiredo, Antonio Sarmento, Lurdes Santos
Summary: Neurological complications in ICU patients with COVID-19, such as peripheral nerve lesions, can have various causes and may increase the risk of developing Complex Regional Pain Syndrome. A multidisciplinary approach for early diagnosis and treatment is crucial for intervention and prognosis of nerve injuries.
Article
Health Care Sciences & Services
Soo Jin Kwon, Yoonjung Kim
Summary: This study examined the experiences and challenges of 11 Korean patients diagnosed with complex regional pain syndrome, finding that they experienced unique pain and complex emotions, as well as feelings of loneliness and lack of support.
Article
Medicine, General & Internal
Yu Min Ki, Hue Jung Park, Seung Hyun Yi, Woo Seog Sim, Jin Young Lee
Summary: This article describes a case of latent infection at the implantable generator pocket site 9 years after spinal cord stimulation (SCS) implantation in a patient with complex regional pain syndrome (CRPS). The patient underwent SCS removal surgery and recovered successfully.
Review
Neurosciences
Tian-Shu Li, Rui Wang, Xuan Su, Xue-Qiang Wang
Summary: Complex regional pain syndrome causes severe pain and dysfunction, greatly impacting patients' quality of life. Exercise therapy is gaining attention for its ability to relieve pain and improve physical function. This article summarizes the effectiveness and underlying mechanisms of exercise interventions for complex regional pain syndrome, and outlines a progressive multi-stage exercise program. Exercise options for patients with complex regional pain syndrome include graded motor imagery, mirror therapy, progressive stress loading training, and progressive aerobic training. Overall, exercise training for complex regional pain syndrome not only reduces pain, but also improves physical function and mental well-being. The underlying mechanisms of exercise interventions include remodeling the nervous system, regulating blood flow and stress levels, releasing endogenous opioids, and increasing anti-inflammatory cytokines. This article provides a clear explanation and summary of exercise research for complex regional pain syndrome. In the future, more high-quality studies with larger sample sizes may provide additional exercise regimens and stronger evidence of effectiveness.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Luis Henrique A. Sousa, Caroline de O. Costa, Eduardo M. Novak, Giana S. Giostri
Summary: This study systematically analyzed the evidence of complex regional pain syndrome (CRPS) after carpal tunnel syndrome surgery (CTSS), including its risks, associated factors, and treatments. The incidence of CRPS after CTSS was found to be 2-5%, and its diagnosis remains a challenge with unclear risk factors.
Review
Behavioral Sciences
Juliete Palandi, Josiel Mileno Mack, Isabela Longo de Araujo, Marcelo Farina, Franciane Bobinski
Summary: This study provides a comprehensive framework of animal models used to investigate CRPS by reviewing 93 preclinical studies. The results show that the main objective of the included studies was to understand the CRPS model, with the most common characteristics being rats, males, and adults exposed to ischemia/reperfusion or tibia fracture. The most widely adopted method for nociceptive evaluation was the use of von Frey monofilaments. However, future studies should include more heterogeneous animals, multiple assessment tools, and improve measures to reduce bias for better translational science between animal models and individuals with CRPS.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)