Article
Anesthesiology
Fabio Carlos Lucas de Oliveira, Camille Cossette, Catherine Mailloux, Timothy H. Wideman, Louis-David Beaulieu, Hugo Masse-Alarie
Summary: The study aimed to assess the reliability of pressure pain threshold (PPT) and temporal summation of pain (TSP) in individuals with chronic low back pain (CLBP), and explore the impact of different measurement sequences on reliability metrics. The results showed excellent relative reliability for PPT and good to excellent reliability for TSP at the low back and hand sites among individuals with CLBP. It is recommended to use 3 measurements for PPT and 2 for TSP to optimize reliability.
CLINICAL JOURNAL OF PAIN
(2023)
Article
Orthopedics
Demario S. Overstreet, Ava N. Michl, Terence M. Penn, Deanna D. Rumble, Edwin N. Aroke, Andrew M. Sims, Annabel L. King, Fariha N. Hasan, Tammie L. Quinn, D. Leann Long, Robert E. Sorge, Burel R. Goodin
Summary: The study found that temporal summation of mechanical pain significantly and prospectively predicted greater movement-evoked pain and poorer physical function in individuals with chronic low back pain. However, neither temporal summation nor conditioned pain modulation were significantly related to self-reported pain severity or pain interference.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Oncology
Burel R. Goodin, Demario S. Overstreet, Terence M. Penn, Rahm Bakshi, Tammie L. Quinn, Andrew Sims, Travis Ptacek, Pamela Jackson, D. Leann Long, Edwin N. Aroke
Summary: This study investigated the relationship between conditioned pain modulation (CPM) and DNA methylation (DNAm) changes in individuals with chronic low back pain (cLBP). The study found differentially methylated CpG sites (DMCs) associated with pain-related genes and pathways. These findings suggest potential therapeutic targets for central sensitization, but further research is needed to confirm the relationship between CPM, central sensitization, and non-specific cLBP.
CLINICAL EPIGENETICS
(2022)
Article
Anesthesiology
Paulo E. P. Teixeira, Kevin Pacheco-Barrios, Elif Uygur-Kucukseymen, Roberto Mathias Machado, Ana Balbuena-Pareja, Stefano Giannoni-Luza, Maria Alejandra Luna-Cuadros, Alejandra Cardenas-Rojas, Paola Gonzalez-Mego, Piero F. Mejia-Pando, Timothy Wagner, Laura Dipietro, Felipe Fregni
Summary: CPM was not significantly correlated with self-reported pain intensity scores. The relative power of EEG in specific brain regions was significantly associated with CPM, while the relative power at certain EEG bands in the central area was significantly correlated with self-reported pain intensity scores.
Article
Anesthesiology
J. B. Larsen, P. Madeleine, L. B. Sorensen, J. Sachau, J. C. Otto, R. Baron, L. Arendt-Nielsen
Summary: This study found that the conditioned pain modulation (CPM) responses in chronic knee pain patients may differ and affect pain outcomes. Subgrouping chronic pain patients based on their CPM responses could be useful for phenotyping and personalizing management regimes.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Orthopedics
Josu Zabala Mata, Ion Lascurain-Aguirrebena, Estibaliz Dominguez Lopez, Jon Jatsu Azkue
Summary: The study found that patients with nonspecific chronic neck pain (NSNP) have increased pronociceptive and impaired antinociceptive mechanisms, contributing to long-lasting pain and treatment failures. However, the observational nature of the study prevents establishing a clear cause-effect relationship. Normal PPT values should not be interpreted as absence of altered nociceptive processing in the clinic environment.
Article
Rheumatology
C. (L) M. C. van Campen, P. C. Rowe, F. W. A. Verheugt, F. C. Visser
Summary: The study demonstrated that the pressure pain threshold decreased in ME/CFS patients after head-up tilt test, while healthy controls did not show significant changes; The temporal summation in ME/CFS patients compared to healthy controls was higher both pre- and post-HUT, but did not change post-HUT.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Yitian Yuan, Lin Ma, Jingwen Wang, Wei Liu, Wenwu Zhu
Summary: Temporal sentence grounding in videos is improved using a novel semantic conditioned dynamic modulation (SCDM) mechanism, which leverages the sentence semantics to improve the correlation between sentence and video. The proposed model is able to localize video segments of various temporal scales and adjust temporal boundaries for more accurate grounding results.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2022)
Article
Anesthesiology
Stephen Bruehl, Christopher R. France, Amanda L. Stone, Rajnish Gupta, Asokumar Buvanendran, Melissa Chont, John W. Burns
Summary: The study found that the level of conditioned pain modulation (CPM) was associated with the analgesic and subjective responses to morphine, with greater CPM usually resulting in better effects of the drug. There was minimal moderation by sex or chronic pain status, but men may show a stronger positive relationship between CPM and morphine analgesia in certain aspects of evoked pain.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Anesthesiology
Thorvaldur S. Palsson, Steffan W. M. Christensen, Enrico De Martino, Thomas Graven-Nielsen
Summary: The study aimed to investigate whether rehabilitation in chronic low back pain patients would result in changes in pain sensitivity measurement. The results showed significant improvements in pain intensity, functional disability, fear-avoidance beliefs, and pain sensitivity in LBP patients undergoing rehabilitation, but changes in pain sensory profile were not directly correlated with clinical presentation improvements. The value of screening pain sensitivity in LBP patients in primary care settings needs further investigation due to patient heterogeneity and assessment method sensitivity.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Clinical Neurology
Jessica A. Peterson, Michael G. Bemben, Rebecca D. Larson, Hugo Pereira, H. Michael Crowson, Christopher D. Black
Summary: This study reveals that CPM was impaired in individuals who had symptomatic COVID-19, which may have long-term implications on pain modulation.
Article
Clinical Neurology
Soren O'Neill, Liam Holm, Johanne Brinch Filtenborg, Lars Arendt-Nielsen, Casper Glissmann Nim
Summary: The study examined the impact of CPM effect on pain induced by temporal summation and single stimuli in low-back pain patients. The results suggest that repeated pressure pain may be better suited as the CPM test stimuli, and using temporal summation as the test stimulus in a CPM paradigm may be more sensitive.
SCANDINAVIAN JOURNAL OF PAIN
(2021)
Article
Orthopedics
Maria L. E. Andersson, Emelie Thoren, Charlotte Sylwander, Stefan Bergman
Summary: The aim of this study was to examine the associations between chronic widespread pain, widespread pain sensitivity, leptin, and metabolic factors in individuals with knee pain. The study also investigated these associations in a subgroup of individuals with normal BMI. The results showed that participants who fulfilled the criteria for chronic widespread pain were more likely to be women, obese, and had increased leptin levels. The study suggested that leptin is associated with both chronic widespread pain and low pressure pain thresholds.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Biology
Marcel Simis, Kevin Pacheco-Barrios, Karen Vasquez-Avila, Ingrid Rebello-Sanchez, Joao Parente, Luis Castelo-Branco, Anna Marduy, Paulo S. de Melo, Marta Imamura, Linamara Battistella, Felipe Fregni
Summary: This study aimed to assess the factors predicting a dysfunctional conditioned pain modulation (CPM) in chronic knee OA. Linear and logistic multivariate regression models were used to analyze the relationship between demographics, clinical, and neurophysiological factors and CPM. The study found a significant negative association between WOMAC pain scores and CPM, as well as associations with balance and brain frequency changes.
Article
Neurosciences
Jiang-Ti Kong, Dokyong Sophia You, Christine Sze Wan Law, Beth D. Darnall, James J. Gross, Rachel Manber, Sean Mackey
Summary: In chronic low back pain, there is a modest association between temporal summation and conditioned pain modulation, regardless of anatomical testing location, demographics, and negative affect. These findings will contribute to enhancing the methodology and interpretation of TS and CPM measurements in clinical pain populations.
Article
Clinical Neurology
Mark H. Pitcher, Michael Von Korff, M. Catherine Bushnell, Linda Porter
Article
Rheumatology
Minhui Liu, Susan M. McCurry, Basia Belza, Adrian Dobra, Diana T. Buchanan, Michael V. Vitiello, Michael Von Korff
ARTHRITIS CARE & RESEARCH
(2019)
Article
Medicine, General & Internal
Konrad Fr Schmidt, Daniel Schwarzkopf, Laura-Mae Baldwin, Frank M. Brunkhorst, Antje Freytag, Christoph Heintze, Konrad Reinhart, Nico Schneider, Michael von Korff, Susanne Worrack, Michel Wensing, Jochen Gensichen, M. Baenfer, C. Berhold, A. Bindara-Klippel, M. Corea, D. Davydov, L. Eckholdt, F. Eissler, Engel Ch, C. Fleischmann-Struzek, A. Freitag, S. Gehrke-Beck, A. Geist, H. Gerlach, A. Goldmann, J. Graf, F. Hamzei, M. Hartmann, Ch Hartog, Ch Heintze, K. Huelle, U. Jakobi, S. Kerth, D. Keh, F. Klefisch, R. Kuehnemund, H. Kuhnsch, Th Lehmann, J. Lehmke, P. Lehmkuhl, A. Meier-Hellmann, J. Muehlberg, F. Mueller, F. Oehmichen, G. Ollenschlaeger, M. Oppert, M. Pohl, S. Rademacher, L. Reil, A. Sablotzki, M. Schelle, G. Schelling, A. Scherag, T. Schreiber, C. Spies, P. Thiel, G. Tiedemann, L. Toepfer, S. Toussaint
AMERICAN JOURNAL OF MEDICINE
(2020)
Article
Anesthesiology
Michael Von Korff, Lynn L. DeBar, Erin E. Krebs, Robert D. Kerns, Richard A. Deyo, Francis J. Keefe
Article
Health Care Sciences & Services
Mark D. Sullivan, Denise Boudreau, Laura Ichikawa, David Cronkite, Ladia Albertson-Junkans, Gladys Salgado, Michael VonKorff, David S. Carrell
JOURNAL OF GENERAL INTERNAL MEDICINE
(2020)
Review
Chemistry, Analytical
Ariel B. Neikrug, Ivy Y. Chen, Jake R. Palmer, Susan M. McCurry, Michael Von Korff, Michael Perlis, Michael V. Vitiello
Review
Clinical Neurology
Manu Thakral, Michael Von Korff, Susan M. McCurry, Charles M. Morin, Michael V. Vitiello
SLEEP MEDICINE REVIEWS
(2020)
Article
Health Care Sciences & Services
Patricia Robinson, Michael Von Korff, Terry Bush, Elizabeth H. B. Lin, Evette J. Ludman
FAMILIES SYSTEMS & HEALTH
(2020)
Article
Health Care Sciences & Services
Sarah Shoemaker-Hunt, Wesley Sargent, Holly Swan, Christina Mikosz, Kyle Cobb, Douglas McDonald, Nicole Keane, Michael von Korff, Michael Parchman, Jan Losby
AMERICAN JOURNAL OF MEDICAL QUALITY
(2021)
Article
Anesthesiology
Michael Von Korff, Lynn L. DeBar, Richard A. Deyo, Meghan Mayhew, Robert D. Kerns, Joseph L. Goulet, Cynthia Brandt
Article
Clinical Neurology
Manu Thakral, Michael Von Korff, Susan M. McCurry, Charles M. Morin, Michael V. Vitiello
Summary: The study evaluated the performance of ISI-3 as a short screening tool to identify clinically significant insomnia in an older primary care population. The ISI-3 showed high discriminant validity in identifying insomnia and a score of >= 7 had high sensitivity and specificity. Further validation studies are needed in other community and clinical populations.
Editorial Material
Psychiatry
Johan Ormel, Michael VonKorff
Summary: The viewpoint discusses the necessity of a paradigm shift in preventing and evaluating common mental disorders to reduce prevalence on a population level.
Meeting Abstract
Nursing
Manu Thakral, Michael Von Korff, Susan McCurry, Charles Morin, Michael Vitiello
Article
Pharmacology & Pharmacy
David S. Carrell, Ladia Albertson-Junkans, Arvind Ramaprasan, Grant Scull, Matt Mackwood, Eric Johnson, David J. Cronkite, Andrew Baer, Kris Hansen, Carla A. Green, Brian L. Hazlehurst, Shannon L. Janoff, Paul M. Coplan, Angela DeVeaugh-Geiss, Carlos G. Grijalva, Caihua Liang, Cheryl L. Enger, Jane Lange, Susan M. Shortreed, Michael Von Korff
JOURNAL OF DRUG ASSESSMENT
(2020)
Article
Public, Environmental & Occupational Health
Deborah Fulton-Kehoe, Michael Von Korff, Jaymie Mai, Virginia Weir, Kathryn H. Lofy, Jennifer Sabel, David Tauben, Gary Franklin
JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE
(2020)