Article
Dentistry, Oral Surgery & Medicine
Merve Seyhan, Emre Serdar Atalay
Summary: This study investigated the effect of core stability training on individuals with temporomandibular disorder. The results showed that both core stability training and Rocabado exercise significantly improved pain and quality of life, but there was no significant difference in function.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Medicine, General & Internal
Malin Ernberg, Hajer Jasim, Karin Wahlen, Bijar Ghafouri
Summary: This study aimed to compare plasma protein levels and interactions in patients with myogenous temporomandibular disorders (TMDM) compared to healthy controls, as well as between two TMDM subgroups (myalgia and myofascial pain), and to explore associations with clinical data.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hye-Kyoung Kim, Mee-Eun Kim
Summary: The objective of this study was to explore the dimensions of three biopsychosocial constructs and identify the latent dimensions of five constructs in patients with TMD. The findings revealed that the constructs can be primarily categorized into two dimensions: psychological (affective) and pain-related (sensory-cognitive).
Article
Clinical Neurology
Martin Domin, Nikolai K. Grimm, Kai Klepzig, Carsten O. Schmidt, Bernd Kordass, Martin Lotze
Summary: The study found that patients with temporomandibular pain showed decreased grey matter volume in the anterior cingulate cortex, while the population-based sample did not show relevant GMV differences. Contradictory results in GMV loss in temporomandibular pain may be based on small sample sizes and selection of patient samples in previous studies.
Article
Clinical Neurology
Matthew J. Reid, Abhishek Dave, Darlynn M. Rojo-Wissar, Chung Jung Mun, Sheera F. Lerman, Luis Buenaver, Howard Tennen, Jennifer Haythornthwaite, Claudia M. Campbell, Patrick Finan, Michael T. Smith
Summary: Existing data demonstrate reduced delta power during sleep in patients with depression and chronic pain. Greater relative delta power during sleep is associated with lower nocturnal and next-day pain in patients with temporomandibular disorder. These findings may help promote interventions which aim to increase nocturnal delta power in clinical pain populations, with the goal of improving pain outcomes.
Article
Dentistry, Oral Surgery & Medicine
Shruti Handa, Jeffry R. Shaefer, David A. Keith
Summary: This study aimed to characterize the clinical features of patients with oro-mandibular dystonia (OMD) who presented with temporomandibular disorder (TMD) symptoms. The results showed that focal dystonia and jaw deviation were the most frequent diagnoses among OMD patients. Dental procedures were found to trigger or worsen symptoms in approximately 36.4% of patients. Nearly all patients had a sensory trick, with approximately half of them using an oral appliance as a sensory trick device. The majority of patients had received a diagnosis of TMD, with myofascial pain of the masticatory muscles being the most prevalent diagnosis. Anxiety was the most common psychological comorbidity.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Article
Anesthesiology
Jarno Knuutila, Juhani Kivipuro, Ritva Napankangas, Juha Auvinen, Paula Pesonen, Jaro Karppinen, Markus Paananen, Pertti Pirttiniemi, Aune Raustia, Kirsi Sipila
Summary: The study found that lower pressure pain threshold and tolerance were associated with myalgia and arthralgia in females, while lower pressure pain threshold and tolerance were associated with multiple site pain-linked TMD in males.
EUROPEAN JOURNAL OF PAIN
(2022)
Review
Pharmacology & Pharmacy
Mengjie Wu, Jingyi Cai, Yeke Yu, Sihui Hu, Yingnan Wang, Mengrui Wu
Summary: This study summarized commonly used therapeutic agents and novel bioactive molecules in the management of TMD, as well as discussed emerging therapy strategies, strengthening our understanding of pharmacological approaches for TMD therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Shuang Ba, Pin Zhou, Ming Yu
Summary: The study demonstrates that US therapy can significantly reduce pain and improve function for TMD patients. However, there is a 2.63% recurrence rate in the US group at 6 months post-therapy.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Maria Lavinia Bartolucci, Serena Incerti Parenti, Fabio Pizza, Alessandro Maglioni, Stefano Vandi, Francesco Bortolotti, Giuseppe Plazzi, Giulio Alessandri-Bonetti
Summary: Disturbed nocturnal sleep contributes to orofacial pain through central sensitization. This study evaluated pain sensitivity and the prevalence of temporomandibular disorders (TMDs) in patients with narcolepsy type 1 (NT1). No significant differences were found in pain perception or TMD diagnosis between NT1 patients and controls, but NT1 patients reported higher levels of depressive symptoms.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Hedwig A. van der Meer, Leticia B. Calixtre, Caroline M. Speksnijder, Raoul H. H. Engelbert, Maria W. G. Nijhuis-van der Sanden, Corine M. Visscher
Summary: The study found that for patients with TMD and migraine, improvement in TMD-related disability was comparable to headache-related disability, while no improvements in disability were found for TMD-pain patients with TTH or headaches attributed to TMD.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ji-Hoi Kim, Jung-Hyun Park, Jin-Woo Kim, Sun-Jong Kim
Summary: Ultrasonography can be used to assess the capsular width in painful TMJs, which were found to be wider compared to painless TMJs. Capsular width is a risk factor for TMJ pain and is significantly correlated with pain scores, suggesting a potential link between pain intensity and widened capsular width.
Review
Dentistry, Oral Surgery & Medicine
Timothee Cayrol, Mira Meeus, Vladimir Aron, Claire Gatto, Andre Mouraux, Nathalie A. Roussel, Leo Sallaz, Emanuel N. van den Broeke, Laurent Pitance
Summary: Conflicting results exist regarding the somatosensory profiles of patients with temporomandibular myalgia (TMDm). This review found that mechanical temporal summation is increased in the upper limb of TMDm patients, but not in the jaw area or cervical area. Limited evidence was found for altered thermal temporal summation, conditioned pain modulation, exercise-induced hypoalgesia, placebo analgesia, stress-induced hypoalgesia, and offset analgesia.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yi-Fang Huang, Chung-Ta Chang, Chih-Hsin Muo, Kuan-Ming Chiu, Chun-Hao Tsai, Shih-Ping Liu
Summary: AS significantly impacts the occurrence of TMD, while TMD may play a synergic role in the development of AS.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Aileen Qiu Jin Toh, Joshua Lue Hang Chan, Yiu Yan Leung
Summary: The study found a significantly higher prevalence of TMD in patients with mandibular asymmetry compared to those without, suggesting that mandibular asymmetry could be a possible etiopathologic factor in TMD. Pain disorder and TMJ disorder accounted for 9.7% and 29.9% respectively, with both occurring in 17.2% of cases.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Neuroimaging
Shana A. B. Burrowes, Chandler Sours Rhodes, Timothy J. Meeker, Joel D. Greenspan, Rao P. Gullapalli, David A. Seminowicz
BRAIN IMAGING AND BEHAVIOR
(2020)
Article
Geriatrics & Gerontology
Yu-Jung Jenny Wei, Laurence Solberg, Cheng Chen, Roger B. Fillingim, Marco Pahor, Steven DeKosky, Almut G. Winterstein
Summary: The study found high percentage agreement for depression and behavioral symptoms between MDS 3.0 assessments and medical records, with higher negative agreement than positive agreement. The data from MDS 3.0 may be useful in ruling out depression and behavioral symptoms, but further confirmation in a representative sample of nursing homes is needed.
AGING & MENTAL HEALTH
(2021)
Article
Clinical Neurology
Samar Khoury, Qiao-Ping Wang, Marc Parisien, Pavel Gris, Andrey Bortsov, Sarah D. Linnstaedt, Samuel A. McLean, Andrew S. Tungate, Tamar Sofer, Jiwon Lee, Tin Louie, Susan Redline, Mari Anneli Kaunisto, Eija A. Kalso, Hans Markus Munter, Andrea G. Nackley, Gary D. Slade, Shad B. Smith, Dmitri Zaykin, Roger B. Fillingim, Richard Ohrbach, Joel D. Greenspan, William Maixner, G. Gregory Neely, Luda Diatchenko
Summary: This study identified two new genetic loci associated with sleep quality, with NPY as an important sleep gene and MPP6 potentially impacting sleep quality as well. Further research may help elucidate the mechanisms through which these genes influence sleep variability in humans.
Article
Neurosciences
Timothy J. Meeker, Nichole M. Emerson, Jui-Hong Chien, Mark Saffer, Oscar Joseph Bienvenu, Anna Korzeniewska, Joel D. Greenspan, Frederick Arthur Lenz
Summary: The study suggests that sustained attention to painful stimuli leads to a decrease in response willingness over time on task, while the ability to discriminate between target and nontarget remains unchanged. High trait anxiety is associated with slower reaction times and decreased willingness to respond during the task, highlighting the important role of trait anxiety in pain vigilance.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Anesthesiology
Sheila M. Gaynor, Andrey Bortsov, Eric Bair, Roger B. Fillingim, Joel D. Greenspan, Richard Ohrbach, Luda Diatchenko, Andrea Nackley, Inna E. Tchivileva, William Whitehead, Aurelio A. Alonso, Thomas E. Buchheit, Richard L. Boortz-Marx, Wolfgang Liedtke, Jongbae J. Park, William Maixner, Shad B. Smith
Summary: The ROPA method effectively classifies chronic pain patients into subgroups based on biopsychosocial profiles, allowing for personalized pain medicine and reducing patient burden. This clustering algorithm shows promise in classifying patients based on pathophysiological mechanisms rather than structural or anatomical diagnoses.
Article
Health Care Sciences & Services
Mamoun T. Mardini, Subhash Nerella, Matin Kheirkhahan, Sanjay Ranka, Roger B. Fillingim, Yujie Hu, Duane B. Corbett, Erta Cenko, Eric Weber, Parisa Rashidi, Todd M. Manini
Summary: This study examines the temporal association between ecological momentary assessments of pain and GPS metrics in older adults with symptomatic knee osteoarthritis. The findings show that higher intensity knee pain is associated with lower life-space mobility, and the associations between pain intensity and GPS features are more likely to be statistically significant within individuals.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Genetics & Heredity
Mariaelisa Graff, Anne E. Justice, Kristin L. Young, Eirini Marouli, Xinruo Zhang, Rebecca S. Fine, Elise Lim, Victoria Buchanan, Kristin Rand, Mary F. Feitosa, Mary K. Wojczynski, Lisa R. Yanek, Yaming Shao, Rebecca Rohde, Adebowale A. Adeyemo, Melinda C. Aldrich, Matthew A. Allison, Christine B. Ambrosone, Stefan Ambs, Christopher Amos, Donna K. Arnett, Larry Atwood, Elisa Bandera, Traci Bartz, Diane M. Becker, Sonja Berndt, Leslie Bernstein, Lawrence F. Bielak, William J. Blot, Erwin P. Bottinger, Donald W. Bowden, Jonathan P. Bradfield, Jennifer A. Brody, Ulrich Broeckel, Gregory Burke, Brian E. Cade, Qiuyin Cai, Neil Caporaso, Chris Carlson, John Carpten, Graham Casey, Stephen J. Chanock, Guanjie Chen, Minhui Chen, Yii-Der Chen, Wei-Min Chen, Alessandra Chesi, Charleston W. K. Chiang, Lisa Chu, Gerry A. Coetzee, David Conti, Richard S. Cooper, Mary Cushman, Ellen Demerath, Sandra L. Deming, Latchezar Dimitrov, Jingzhong Ding, W. Ryan Diver, Qing Duan, Michele K. Evans, Adeyinka G. Falusi, Jessica D. Faul, Myriam Fornage, Caroline Fox, Barry Freedman, Melissa Garcia, Elizabeth M. Gillanders, Phyllis Goodman, Omri Gottesman, Struan F. A. Grant, Xiuqing Guo, Hakon Hakonarson, Talin Haritunians, Tamara B. Harris, Curtis C. Harris, Brian E. Henderson, Anselm Hennis, Dena G. Hernandez, Joel N. Hirschhorn, Lorna Haughton McNeill, Timothy D. Howard, Barbara Howard, Ann W. Hsing, Yu-Han H. Hsu, Jennifer J. Hu, Chad D. Huff, Dezheng Huo, Sue A. Ingles, Marguerite R. Irvin, Esther M. John, Karen C. Johnson, Joanne M. Jordan, Edmond K. Kabagambe, Sun J. Kang, Sharon L. Kardia, Brendan J. Keating, Rick A. Kittles, Eric A. Klein, Suzanne Kolb, Laurence N. Kolonel, Charles Kooperberg, Lewis Kuller, Abdullah Kutlar, Leslie Lange, Carl D. Langefeld, Loic Le Marchand, Hampton Leonard, Guillaume Lettre, Albert M. Levin, Yun Li, Jin Li, Yongmei Liu, Youfang Liu, Simin Liu, Kurt Lohman, Vaneet Lotay, Yingchang Lu, William Maixner, JoAnn E. Manson, Barbara McKnight, Yan Meng, Keri L. Monda, Kris Monroe, Jason H. Moore, Thomas H. Mosley, Poorva Mudgal, Adam B. Murphy, Rajiv Nadukuru, Mike A. Nalls, Katherine L. Nathanson, Uma Nayak, Amidou N'Diaye, Barbara Nemesure, Christine Neslund-Dudas, Marian L. Neuhouser, Sarah Nyante, Heather Ochs-Balcom, Temidayo O. Ogundiran, Adesola Ogunniyi, Oladosu Ojengbede, Hayrettin Okut, Olufunmilayo Olopade, Andrew Olshan, Badri Padhukasahasram, Julie Palmer, Cameron D. Palmer, Nicholette D. Palmer, George Papanicolaou, Sanjay R. Patel, Curtis A. Pettaway, Patricia A. Peyser, Michael F. Press, D. C. Rao, Laura J. Rasmussen-Torvik, Susan Redline, Alex P. Reiner, Suhn K. Rhie, Jorge L. Rodriguez-Gil, Charles N. Rotimi, Jerome Rotter, Edward A. Ruiz-Narvaez, Benjamin A. Rybicki, Babatunde Salako, Michele M. Sale, Maureen Sanderson, Eric Schadt, Pamela J. Schreiner, Claudia Schurmann, Ann G. Schwartz, Daniel A. Shriner, Lisa B. Signorello, Andrew B. Singleton, David S. Siscovick, Jennifer A. Smith, Shad Smith, Elizabeth Speliotes, Margaret Spitz, Janet L. Stanford, Victoria L. Stevens, Alex Stram, Sara S. Strom, Lara Sucheston, Yan Sun, Salman M. Tajuddin, Herman Taylor, Kira Taylor, Bamidele O. Tayo, Michael J. Thun, Margaret A. Tucker, Dhananjay Vaidya, David J. Van den Berg, Sailaja Vedantam, Mara Vitolins, Zhaoming Wang, Erin B. Ware, Sylvia Wassertheil-Smoller, David R. Weir, John K. Wiencke, Scott M. Williams, L. Keoki Williams, James G. Wilson, John S. Witte, Margaret Wrensch, Xifeng Wu, Jie Yao, Neil Zakai, Krista Zanetti, Babette S. Zemel, Wei Zhao, Jing Hua Zhao, Wei Zheng, Degui Zhi, Jie Zhou, Xiaofeng Zhu, Regina G. Ziegler, Joe Zmuda, Alan B. Zonderman, Bruce M. Psaty, Ingrid B. Borecki, L. Adrienne Cupples, Ching-Ti Liu, Christopher A. Haiman, Ruth Loos, Maggie C. Y. Ng, Kari E. North
Summary: The study identified new height-related loci in African ancestry individuals and revealed additional signals by combining African and European GWAS data, improving the fine-mapping of potential causal variants shared between populations of African and European ancestry.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Mathematics, Interdisciplinary Applications
Charles E. Knott, Stephen Gomori, Mai Ngyuen, Susan Pedrazzani, Sridevi Sattaluri, Frank Mierzwa, Kim Chantala
Summary: Integrating survey data with alternative data sources to paint a complete biobehavioral picture of trauma patients presents complex system challenges, but offers greater scientific understanding of long-term trauma effects. Starting in emergency departments, this approach aims to understand, prevent, and predict adverse posttraumatic neuropsychiatric sequelae impacting over 40 million Americans annually.
Article
Public, Environmental & Occupational Health
Marc R. Larochelle, Svetla Slavova, Elisabeth D. Root, Daniel J. Feaster, Patrick J. Ward, Sabrina C. Selk, Charles Knott, Jennifer Villani, Jeffrey H. Samet
Summary: The study found that opioid overdose death rates remained stable from 2018 to 2019 across 67 HEALing Communities Study communities, with a significant increase among non-Hispanic Black individuals. An anti-racist public health approach is needed to address this crisis of opioid-related harms.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Anesthesiology
Anna Zajacova, Hanna Grol-Prokopczyk, Roger Fillingim
Summary: Previous literature on race/ethnicity and pain has often neglected to include all major US racial groups or consider the impact of different pain operationalizations. This study examines the prevalence of chronic pain in various racial groups and finds that Asian Americans have the lowest pain prevalence, while Native American and multiracial adults have the highest pain prevalence. The study also reveals that racial disparities in pain are larger than previously recognized, and these disparities remain consistent across different definitions of pain.
Article
Clinical Neurology
Jenna M. Wilson, Carin A. Colebaugh, K. Mikayla Flowers, Demario Overstreet, Robert R. Edwards, William Maixner, Shad B. Smith, Kristin L. Schreiber
Summary: Persistent postmastectomy pain after breast surgery varies in duration and severity. This study used a clustering algorithm called ROPA to identify three patient groups with different risk levels for chronic pain. The Global Symptoms cluster had the worst pain outcomes. The findings suggest that understanding individual characteristics is important for predicting pain outcomes.
Letter
Anesthesiology
Anna Zajacova, Hanna Grol-Prokopczyk, Roger Fillingim
Article
Mathematics, Interdisciplinary Applications
Naomi C. Brownstein, Jianwen Cai, Shad Smith, Luda Diatchenko, Gary D. Slade, Eric Bair
Summary: This study proposes a general method for analyzing arbitrary phenotypes using inverse probability weighting and bootstrapping for standard error estimation. The method can be applied to study the association between secondary phenotypes and original covariates, especially in complex association tests and analyses of haplotypes with ambiguous phase.
Article
Public, Environmental & Occupational Health
Amy LiKamWa, Josue Cardoso, Jill Sonke, Roger B. Fillingim, Staja Q. Booker
Summary: This study investigated the effects of music on acute pain sensitivity and found that singing can increase pain tolerance compared to simply listening to music. Additionally, singing proficiency and musical factors were found to be associated with pain sensitivity.
Article
Geriatrics & Gerontology
Charlotte Rouzaud Laborde, Erta Cenko, Mamoun T. Mardini, Subhash Nerella, Matin Kheirkhahan, Sanjay Ranka, Roger B. Fillingim, Duane B. Corbett, Eric Weber, Parisa Rashidi, Todd Manini
Summary: This study evaluated satisfaction, usability, and compliance with the ROAMM smartwatch app for individuals with knee osteoarthritis. Most participants rated the app positively and were willing to participate in long-term research, indicating that this is a viable approach for remotely collecting health symptoms and behaviors.