Article
Clinical Neurology
C. Leone, A. Di Lionardo, G. Di Pietro, G. Di Stefano, P. Falco, A. J. Blockeel, O. Caspani, L. Garcia-Larrea, A. Mouraux, K. G. Phillips, R. D. Treede, A. Truini
Summary: This neurophysiological study investigated the effects of high-frequency stimulation (HFS) and capsaicin on pain threshold and RIII reflex threshold in healthy humans. Both HFS and capsaicin were found to similarly modulate these thresholds without a concomitant inhibitory effect on the endogenous pain modulatory system.
CLINICAL NEUROPHYSIOLOGY
(2021)
Review
Anesthesiology
Evy Dhondt, Sophie Van Oosterwijck, Thomas Van Branteghem, Jamie L. Rhudy, Lieven Danneels, Jessica Van Oosterwijck
Summary: This study systematically reviewed and meta-analyzed the effects of conservative therapy on spinal nociception measured through the assessment of the nociceptive flexion reflex (NFR). The findings suggest that conservative interventions can decrease NFR area and NFR magnitude, and increase NFR latency by activating descending inhibitory pathways. This is important for preventing and treating chronic pain characterized by enhanced spinal nociception.
Article
Clinical Neurology
A. Guekos, A. C. Grata, M. Hubli, M. Schubert, P. Schweinhardt
Summary: This study aimed to replicate a published study and assess the nociceptive withdrawal reflex (NWR) response to painful heat. The results showed that tonic heat did not influence NWR magnitude, but different stimulation methods affected NWR response rates.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Psychology, Biological
Amber English, Peter D. Drummond
Summary: The study found that acoustic startle stimuli temporarily inhibit nociceptive processing, while electrical stimuli inhibit subsequent auditory processing. However, acoustic startle stimuli did not affect electrically evoked pain, and vice versa. The order of stimuli did not seem to have any impact on pupillary responses or nociceptive flexion reflexes.
Article
Neurosciences
Nobuhiro Takiguchi, Mitsunori Tokuda, Koji Shomoto
Summary: High-intensity transcutaneous electrical nerve stimulation (HI-TENS) does not inhibit pain facilitation.
NEUROSCIENCE LETTERS
(2023)
Article
Biology
Irene de la Rosa-Diaz, Laura Barrero-Santiago, Paz Acosta-Ramirez, Marina Martin-Peces-Barba, Esther Iglesias-Hernandez, Bastien Plisset, Nicolas Lutinier, Margot Belzanne, Roy La Touche, Monica Grande-Alonso
Summary: Persistent pain after breast cancer treatment is still a topic of research. This study aimed to evaluate the influence of psychosocial and psychological factors on pain in breast cancer survivors. The study found that breast cancer survivors with pain had higher scores in central sensitization inventory and pain catastrophizing. The group with neuropathic pain features showed higher levels of fear of movement, anxiety, and depression.
Article
Pediatrics
Maximilian David Mauritz, Felix Uhlenberg, Eik Vettorazzi, Chinedu Ulrich Ebenebe, Dominique Singer, Philipp Deindl
Summary: The study found that administration of propofol increases the nociceptive flexion reflex threshold and Bispectral Index, while decreasing electromyogram and burst-suppression ratio values. Further research is needed to determine if sedated children can benefit from objective pain and sedation monitoring using BIS and NFRT.
Review
Biochemistry & Molecular Biology
Cesar Fernandez-de-las-Penas, Jo Nijs, Randy Neblett, Andrea Polli, Maarten Moens, Lisa Goudman, Madhura Shekhar Patil, Roger D. Knaggs, Gisele Pickering, Lars Arendt-Nielsen
Summary: Pain after COVID-19 infection has become a healthcare emergency. Precision medicine can group patients based on their symptoms and diagnosis for tailored treatments. There are different types of pain after COVID-19, each requiring different treatment approaches. Classifying patients into different pain types is crucial for successful treatment outcomes.
Article
Anesthesiology
Benedikt Schick, Benjamin Mayer, Steffen Walter, Sascha Gruss, Ronald Stitz, Pauline Stitz, Eberhard Barth
Summary: The study showed a negative association between NFRT measurement and BPS in critically ill patients, with NFRT almost twice as high in patients with a RASS score of -5 compared to those with a RASS score >= -4. NFRT measurement provides guidance for evaluating nociceptive processes in patients with RASS scores <= -4.
BMC ANESTHESIOLOGY
(2021)
Review
Anesthesiology
Greig R. R. Adams, Wiebke Gandhi, Richard Harrison, Carien M. M. van Reekum, Desmond Wood-Anderson, Ian Gilron, Tim V. V. Salomons
Summary: Central sensitization (CS) refers to increased pain responsiveness due to sensitization of neurons in the central nervous system. This review aimed to investigate whether self-report questionnaires linked with CS are associated with enhanced nociceptive responses or measure sensitivity in a broader sense (i.e., emotional responses).
Review
Biochemistry & Molecular Biology
Martina Favretti, Cristina Iannuccelli, Manuela Di Franco
Summary: Fibromyalgia is a complex and heterogeneous clinical syndrome characterized by widespread pain and various other symptoms, negatively impacting the lives of patients. The diagnosis of fibromyalgia is still clinical, leading to diagnostic uncertainties and patient dissatisfaction. Research for a specific biomarker for fibromyalgia has been unsuccessful. The discovery of a reliable biomarker would aid in early identification and intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Cesar Fernandez-de-las-Penas, Jo Nijs, Barbara Cagnie, Robert D. Gerwin, Gustavo Plaza-Manzano, Juan A. Valera-Calero, Lars Arendt-Nielsen
Summary: Myofascial pain syndrome involves the presence of myofascial trigger points (TrPs), which can cause referred pain. The classification of TrPs as primary or secondary phenomena and their relationship to central or peripheral nervous system disorders is controversial. The International Association for the Study of Pain (IASP) proposed a clinical criteria and grading system in 2021 to classify patients based on nociceptive, neuropathic, or nociplastic pain phenotypes. While myofascial TrP pain is traditionally categorized as nociceptive, evidence suggests it may also be present in patients with predominantly nociplastic pain. Successful clinical treatment outcomes may be achieved by accurately classifying myofascial TrP pain into these phenotypes.
Article
Biochemistry & Molecular Biology
Edurne Ubeda-D'Ocasar, Juan Antonio Valera-Calero, Gracia Maria Gallego-Sendarrubias, Cesar Fernandez-de-Las-Penas, Jose Luis Arias-Buria, Matilde Morales-Cabezas, Lars Arendt-Nielsen, Margarita Cigaran-Mendez
Summary: This study found a good convergent association between S-LANSS and PainDETECT in women with FMS. Additionally, S-LANSS was associated with PPTs whereas PainDETECT was associated with pain intensity and CSI, suggesting that both questionnaires assess different spectrums of the neuropathic and pain sensitization components of the condition and hence provide synergistic information.
Review
Clinical Neurology
Mohammadreza Amiri, Jamie Rhudy, Kei Masani, Dinesh Kumbhare
Summary: The study found that there may not be a significant difference in the nociceptive flexion reflex threshold between patients with fibromyalgia and healthy controls. The main sources of heterogeneity in the effect sizes were the total and female sample sizes. A unified and rigorous methodology is needed for future assessments of the nociceptive flexion reflex threshold in patients with fibromyalgia.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Anesthesiology
Juan Antonio Valera-Calero, Edurne Ubeda-D'Ocasar, Jose Luis Arias-Buria, Cesar Fernandez-de-las-Penas, Gracia Maria Gallego-Sendarrubias, Margarita Cigaran-Mendez
Summary: This study found that age, pain intensity at rest and pain during daily living activities, anxiety levels and pressure pain sensitivity are associated with the central sensitization inventory (CSI) in women with fibromyalgia (FMS).
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Hematology
Christopher R. France, Janis L. France, Lina K. Himawan, Pete Lux, Jeannine McCullough
Summary: Fear related to blood donation is associated with an increased risk of vasovagal reactions and a decreased likelihood of attempting another donation. Donors who report fear are more likely to experience vasovagal reactions, which in turn reduces the odds of attempting a repeat donation.
Article
Hematology
Kyle S. Jensen, Barbara M. Masser, Tanya E. Davison, Nina Van Dyke, Janis L. France, Christopher R. France
Summary: This study aimed to explore the impact of an automated Web-based motivational interview on the motivation, intention, and behavior of O-negative blood donors. The results showed that donors who completed the motivational interview or active control interview returned to donate more frequently and more quickly compared to those who experienced business-as-usual practices. However, further analysis indicated that this improved return behavior was not likely due to specific properties of the motivational interview or active control interview activities.
Article
Psychology, Clinical
Andrew W. Manigault, Ryan C. Shorey, Gabrielle Decastro, Haley M. Appelmann, Katrina R. Hamilton, Matt C. Scanlin, Christopher R. France, Peggy M. Zoccola
Summary: Meta-analyses have shown a small association between acute stressors and cardiovascular health, but recent research suggests that this effect may be underestimated due to individual differences in habituation to stressors. In a randomized controlled trial comparing MBSR, CBT, and a control condition, both interventions led to increased perceived control over thoughts, which was associated with improved blood pressure habituation. These findings suggest that stress reduction interventions that enhance perceived control over thoughts may have beneficial effects on cardiovascular health.
Article
Public, Environmental & Occupational Health
Bernard Appiah, Lucy Asamoah-Akuoko, Christopher France, Antonio Rene, Nathan Amanquah, Imelda Bates
Summary: As low-and middle-income countries implement COVID-19 vaccination programs, vaccine hesitancy could hinder the success. Pharmacists can address this issue by utilizing caller tune technology to deliver COVID-19 vaccine messages and combat misinformation.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2022)
Article
Hematology
Christopher R. France, Janis L. France, Lina K. Himawan
Summary: This study examined the level of payment needed to motivate individuals to engage in blood, plasma, and platelet donations, and found that many respondents indicated that money can convince them to donate, despite expressing a strong commitment to nonremunerated donation.
Article
Hematology
Christopher R. France, Janis L. France, Dominic W. Ysidron, Benjamin Samstein
Summary: This study investigated the relationships between blood donation history, registration as a non-living and living organ donor, and motivations. The results showed that blood donation history was not significantly related to organ donor registration or interest in being an organ donor. However, registered organ donors reported more positive motivations for organ donation.
TRANSFUSION MEDICINE
(2022)
Article
Health Care Sciences & Services
Alexander T. Peebles, Susanne van der Veen, Alexander Stamenkovic, Christopher R. France, Peter E. Pidcoe, James S. Thomas
Summary: This study compared lumbar flexion excursion and velocity across previous and newly developed virtual reality tools in a healthy control cohort. Results showed that in terms of lumbar motion and target impact location, the new virtual reality game Fishality resembled Reachality more than Dodgeality, suggesting its effectiveness in shaping movement behaviors.
JMIR SERIOUS GAMES
(2022)
Meeting Abstract
Rheumatology
M. Bredemeier, A. Duarte, M. Pinheiro, B. Stadler, J. C. Macieira, R. Ranza, J. Miranda, V. Valim, G. Castro, M. Bertolo, M. D. F. Sauma, V. Fernandes, A. C. Medeiros-Ribeiro, R. Botelho, C. Brenol, H. M. Da Silveira De Carvalho, S. Studart, G. Da Rocha Castelar Pinheiro, L. Rocha, H. De Leon De Lima, I. Pereira, M. Ohira Gazzeta, A. Kakehasi, P. Louzada, A. L. S. Hayata, F. Pina, M. Alves Ferreira, L. Balarini, I. G. Silveira, S. Kowalski, D. Titton, R. Mendonca Da Silva Chakr, A. Ranzolin, I. Laurindo, R. Xavier
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
R. Chakr, M. Bredemeier, A. Duarte, M. Pinheiro, B. Stadler, J. C. Macieira, R. Ranza, J. Miranda, V. Valim, G. Castro, M. Bertolo, M. D. F. Sauma, V. Fernandes, A. C. Medeiros-Ribeiro, R. Botelho, C. Brenol, H. M. Da Silveira De Carvalho, S. Studart, G. Da Rocha, Castelar Pinheiro, L. Rocha, I. Pereira, H. De Leon De Lima, M. Ohira Gazzeta, A. Kakehasi, P. Louzada, A. L. S. Hayata, F. Pina, C. Lupo, L. Balarini, I. Silveira, S. Schowalski, D. Titton, A. Ranzolin, I. Laurindo, R. Xavieron
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
L. Denardi Doria, R. Cavalheiro Do Espirito Santo, L. Santos, D. Nobrega De Moraes, E. Pena, J. Katarina Schoer Portes, A. A. Gasparin, N. Pamplona Bueno De Andrade, V. Hax, R. Xavier, R. Mendonca Da Silva Chakr
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
L. Santos, R. Cavalheiro Do Espirito Santo, E. Pena, L. Denardi Doria, S. Pilotti, D. Nobrega De Moraes, M. Marchezan Menezes Da Silva, V. Hax, C. Brenol, O. Monticielo, R. Mendonca Da Silva Chakr, R. Xavier
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Psychology, Clinical
Shin Ye Kim, Sung Yong Park, Babetta Mathai, Jacob Daheim, Christopher France, Betsaida Delgado
Summary: This study used structural equation modeling to examine the application of Social Cognitive Theory (SCT) in chronic pain management and the risk of opioid misuse. The results showed that social cognitive factors have a significant impact on pain dysfunction and opioid misuse risk. Individualism was positively associated with satisfaction with pain support, pain self-efficacy, and pain acceptance, but negatively associated with the risk of opioid misuse; collectivism was positively associated with the risk of opioid misuse.
JOURNAL OF CLINICAL PSYCHOLOGY
(2022)
Article
Health Care Sciences & Services
Muge Dereli, Turhan Kahraman, Christopher R. France
Summary: This study translated the Pain Resilience Scale (PRS) into Turkish and examined its psychometric properties for evaluating behavioral engagement and cognitive-emotional regulation in the context of pain. The Turkish version of PRS demonstrated a stable factor structure and strong validity, making it a reliable instrument for assessing pain resilience.
EVALUATION & THE HEALTH PROFESSIONS
(2023)
Article
Rheumatology
Vanessa Hax, Julia Tessari, Emerson Pena, Rafaela Cavalheiro do Espirito Santo, Leonardo Peterson dos Santos, Andrese Aline Gasparin, Markus Bredemeier, Tayane Muniz Fighera, Poli Mara Spritzer, Ricardo Machado Xavier, Rafael Mendonca da Silva Chakr
Summary: This study aimed to determine the prevalence and clinical profile of the physical frailty phenotype (PFP) in patients with systemic sclerosis (SSc) and to evaluate the diagnostic accuracy of the FRAIL scale, Edmonton frailty scale (EFS), and Short Physical Performance Battery (SPPB) using the PFP as a reference standard. The results showed that frailty is common in patients with SSc and is associated with disability, limitations in daily activities, and hospitalizations in the past year. Malnutrition and more severe gastrointestinal symptoms were also more common in frail patients. Both the FRAIL scale and EFS demonstrated excellent diagnostic accuracy against the PFP.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Hematology
Christopher R. France, Janis L. France, Dominic W. Ysidron, Caroline D. Martin, Louisa Duffy, Debra A. Kessler, Mark Rebosa, Shiraz Rehmani, Victoria Frye, Beth H. Shaz
Summary: This study investigated the motivators and barriers of young, first-time blood donors and found that prosocial motivation was the most commonly reported motivator, while fear was the most commonly reported barrier. The reported motivators and barriers were not significantly related to donation behavior, but certain barriers such as fear of fainting/dizziness, fear of needles/pain, personal commitments conflicting with donating, and perceiving oneself as unsuited to donate for health reasons were significantly associated with donation behavior. Differences in motivators and barriers were also observed among different sexes, races, and ethnicities.