Article
Clinical Neurology
Eleonora Vecchio, Silvia Giovanna Quitadamo, Katia Ricci, Giuseppe Libro, Marianna Delussi, Raffaella Lombardi, Giuseppe Lauria, Marina de Tommaso
Summary: This study evaluated multichannel laser evoked potentials (LEPs) in patients with fibromyalgia (FM) and small fiber impairment. The results showed that the amplitude and topography of LEPs were not coherent with epidermal nerve fiber density loss, but rather reflected the clinical expression of pain and psychopathological factors.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Jessica Archibald, Oscar Ortiz, Alinda Enzler, Jan Rosner, John L. K. Kramer
Summary: We provide evidence for increased activation of the anterior cingulate cortex during prolonged pain processing using laser-evoked potentials in response to a shortened and methodologically improved repetitive painful stimulation paradigm. This provides new evidence for the scientific community and the paradigm can be feasibly completed in a calendar week.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Gabriele Sebastianelli, Chiara Abagnale, Francesco Casillo, Ettore Cioffi, Vincenzo Parisi, Cherubino Di Lorenzo, Mariano Serrao, Camillo Porcaro, Jean Schoenen, Gianluca Coppola
Summary: This study compared the effects of visual stimulation on somatosensory processing in healthy volunteers and migraine patients. The results suggest a malfunctioning multisensory integration process in migraine patients, potentially caused by abnormal excitability of thalamo-cortical loops.
Article
Audiology & Speech-Language Pathology
Timm Rosburg, Ralph Mager
Summary: The amplitude of the auditory evoked N1 component depends on the interstimulus interval, increasing with longer intervals until saturating around 10 seconds. The conflicting accounts of N1 recovery and habituation predict different outcomes for passive oddball experiments, with evidence suggesting that N1 refractoriness may play a more significant role in explaining stimulus repetition effects.
Article
Medicine, General & Internal
Antonio Curra, Lucio Marinelli, Filippo Cotellessa, Laura Mori, Chiara Avanti, Daniela Greco, Manuela Gorini, Paolo Missori, Francesco Fattapposta, Carlo Trompetto
Summary: The study evaluated the habituation of somatosensory evoked potentials (SEPs) in patients with mild-to-moderate Alzheimer's disease or vascular dementia, finding differences in N20 amplitudes between AD-type and VD-type patients. Lack of habituation was more prominent in AD-type patients, suggesting impaired synaptic efficacy mechanisms in Alzheimer's disease compared to vascular dementia.
MEDICINA-LITHUANIA
(2021)
Article
Biology
Haleh Fotowat, Florian Engert
Summary: Larval zebrafish exposed repeatedly to dark looming stimuli habituate to these signals and stop responding with escape swims. These stimuli can be separated into spatial expansion and overall dimming, each with their own behavioral algorithms. Brain imaging experiments suggest the existence of two separate neural pathways, one for expansion detection and escape, and another for dimming inhibition of escape response. The second pathway is contextually modulated and responsible for the silencing of successive escape responses.
Article
Clinical Neurology
Nicolas Lejeune, Eva Petrossova, Ken Steffen Frahm, Andre Mouraux
Summary: This study aimed to compare the nociceptive event-related brain potentials elicited by a high-speed contact-thermode and an infrared CO2 laser stimulator. The results showed that CHEPs were reduced in amplitude and delayed in latency compared to LEPs for 55 degrees C stimuli. When stimuli were perceptually matched, the amplitudes were similar, but CHEPs still had delayed latencies. These differences can be explained by skin thermal inertia and heating profiles at the dermo-epidermal junction. In conclusion, CHEPs could be used as an alternative to LEPs for diagnosing neuropathic pain.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Mustafa Ahmed Mahmutoglu, Ulf Baumgaertner, Andre Rupp
Summary: This study aimed to model posterior insular activity in EEG recordings, showing that the activity in this region contributes significantly to the late part of the LEP. Modeling the late LEP activity may help differentiate posterior insular activity from other ongoing cortical activity.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Anesthesiology
Caroline Perchet, Koichi Hagiwara, Charbel Salameh, Luis Garcia-Larrea
Summary: Recording cold-evoked potentials (CEPs) can improve the objective assessment of human thermo-nociceptive function. The reliability and diagnostic use of CEP recordings in clinical conditions have not been documented. Joint recording of CEPs and laser-evoked potentials (LEPs) can increase the sensitivity of neurophysiological techniques to thin fiber-spinothalamic lesions, especially when abnormalities of cold perception predominate.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Clinical Neurology
Elena Antelmi, Giovanna Maddalena Squintani, Angela Sandri, Marianna Lippolis, Alessia Segatti, Michele Tinazzi
Summary: This study aimed to assess the descending diffuse noxious inhibitory control in patients with restless legs syndrome (RLS). The study found that compared to healthy controls, RLS patients had a poorer inhibitory effect on the pain perception system when exposed to noxious condition stimulation.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Edyta Dziadkowiak, Marta Waliszewska-Prosol, Malgorzata Wieczorek, Joanna Bladowska, Slawomir Budrewicz, Maria Ejma
Summary: The study identified significant changes in multiple parameters of visually evoked potentials, brainstem auditory evoked potentials, and somatosensory evoked potentials in patients with myasthenia gravis, suggesting disturbances in the bioelectric activities of the central and peripheral nervous system.
Article
Clinical Neurology
Jahrane Dale, Stephen L. Schmidt, Kyle Mitchell, Dennis A. Turner, Warren M. Grill
Summary: This review describes the general features, mechanisms, technical recording factors, and clinical applications of brain evoked potentials (EPs) generated by deep brain stimulation (DBS) for Parkinson's disease (PD). DBS-evoked potentials arise from a complex integration of antidromic and orthodromic conduction pathway responses and provide valuable information for understanding the mechanisms and circuits involved in symptom treatment. These signals may serve as biomarkers for improving DBS outcomes and function. However, there are still critical gaps in our understanding of the mechanisms and clinical application of DBS-induced EPs.
Article
Clinical Neurology
Mayur Sharma, Victoria A. Scott, Tyler Ball, Joshua R. Castle, Joseph Neimat, Brian J. Williams
Summary: This report presents the first application of trans-cranial motor evoked potential (TcMEP) and electromyography (EMG) during MRI-guided laser interstitial thermal therapy (LITT) for a left thalamic glioblastoma. The procedure was successful with no complications encountered. Further investigations are needed to understand the potential utility of this technique for eloquent brain tumors.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Zhenxing Zhang, Yi Wang, Tao Luo, Huaguang Qi, Lin Cai, Yang Yuan, Jingfeng Li
Summary: The aim of this study was to assess the value of dermatomal somatosensory evoked potentials (DSEPs) and cortical somatosensory evoked potentials (SSEPs) in monitoring spinal cord function for patients with congenital scoliosis (CS). The study found that DSEPs are more sensitive to microscopic posterior column dysfunction in CS patients that cannot be detected by either radiology or routine clinical examination. Therefore, preoperative DSEPs assessment is recommended for intraoperative monitoring.
Review
Clinical Neurology
Estelle Nakul, Fabrice Bartolomei, Christophe Lopez
Summary: This article reviews studies on vestibular evoked potentials (EPs) using various methods of vestibular stimulation, revealing the spatiotemporal dynamics of vestibular information processing. Results show short, middle, and late latency EPs, with generator analysis providing new insights into the neuroimaging of the vestibular system.
FRONTIERS IN NEUROLOGY
(2021)
Article
Rheumatology
Sara Nysom Christiansen, Lykke Midtboll Ornbjerg, Simon Horskjaer Rasmussen, Anne Gitte Loft, Johan Askling, Florenzo Iannone, Jakub Zavada, Brigitte Michelsen, Michael Nissen, Fatos Onen, Maria Jose Santos, Manuel Pombo-Suarez, Heikki Relas, Gary J. Macfarlane, Matija Tomsic, Catalin Codreanu, Bjorn Gudbjornsson, Irene Van der Horst-Bruinsma, Daniela Di Giuseppe, Bente Glintborg, Elisa Gremese, Karel Pavelka, Eirik Klami Kristianslund, Adrian Ciurea, Nurullah Akkoc, Anabela Barcelos, Carlos Sanchez-Piedra, Ritva Peltomaa, Gareth T. Jones, Ziga Rotar, Ruxandra Ionescu, Gerdur Grondal, Marleen G. H. Van de Sande, Karin Laas, Mikkel Ostergaard, Merete L. Hetland
Summary: This study investigated the time trends in baseline characteristics and treatment outcomes of TNF inhibitor (TNFi) treatment in bio-naive axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) patients. The results showed that over the past decades, clinicians have implemented more aggressive treatment strategies in spondyloarthritis, leading to shorter disease duration at treatment initiation, decreased retention rates, and higher remission rates.
Review
Medicine, General & Internal
Gabriele Mandarelli, Florenzo Iannone, Stefano Ferracuti, Ignazio Grattagliano, Marcello Benevento, Biagio Solarino, Davide Ferorelli, Roberto Catanesi
Summary: The study reviewed the literature on biological agents and found that there were no specific studies addressing the issue of informed consent in patients receiving biological agents. However, the association between biological agents and serious infections or malignancies needs to be disclosed in the informed consent process, and ethical and clinical issues related to experimenting with new agents with potential serious adverse effects deserve attention.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Rheumatology
Michael Nissen, Benedicte Delcoigne, Daniela Di Giuseppe, Lennart Jacobsson, Merete Lund Hetland, Adrian Ciurea, Lucie Nekvindova, Florenzo Iannone, Nurullah Akkoc, Tuulikki Sokka-Isler, Karen Minde Fagerli, Maria Jose Santos, Catalin Codreanu, Manuel Pombo-Suarez, Ziga Rotar, Bjorn Gudbjornsson, Irene Van der Horst-Bruinsma, Anne Gitte Loft, Burkhard Moeller, Herman Mann, Fabrizio Conti, Gozde Yildirim Cetin, Heikki Relas, Brigitte Michelsen, Pedro Avila Ribeiro, Ruxandra Ionescu, Carlos Sanchez-Piedra, Matija Tomsic, Arni Jon Geirsson, Johan Askling, Bente Glintborg, Ulf Lindstroem
Summary: This multicenter study of axSpA patients found similar one-year treatment outcomes between TNFi monotherapy and csDMARD co-therapy. Heterogeneity across countries limited the identification of specific subgroups, such as peripheral arthritis, that may benefit from co-therapy.
Review
Immunology
Florenzo Iannone, Fabrizio Conti, Alberto Cauli, Alberto Farina, Roberto Caporali
Summary: The subcutaneous formulation of infliximab CT-P13 has been authorized for the treatment of multiple diseases and has shown good efficacy in clinical practice. Compared to intravenous injection, subcutaneous administration has optimized clinical characteristics and practical advantages. However, further research is needed to explore its limitations due to limited clinical experience and lack of long-term drug retention data.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Letter
Rheumatology
Alessandra Bettiol, Maria Letizia Urban, Federica Bello, Davide Fiori, Irene Mattioli, Giuseppe Lopalco, Florenzo Iannone, Allyson Egan, Lorenzo Dagna, Marco Caminati, Simone Negrini, Elena Bargagli, Marco Folci, Franco Franceschini, Roberto Padoan, Oliver Flossmann, Roser Solans, Jan Schroeder, Marc Andre, Laura Moi, Paola Parronchi, Dario Roccatello, Savino Sciascia, David Jayne, Domenico Prisco, Augusto Vaglio, Giacomo Emmi
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Manuel Pombo-Suarez, Carlos Sanchez-Piedra, Juan Gomez-Reino, Kim Lauper, Denis Mongin, Florenzo Iannone, Karel Pavelka, Dan C. Nordstrom, Nevsun Inanc, Catalin Codreanu, Kimme L. Hyrich, Denis Choquette, Anja Strangfeld, Burkhard F. Leeb, Ziga Rotar, Ana Rodrigues, Eirik Klami Kristianslund, Tore K. Kvien, Ori Elkayam, Galina Lukina, Sytske Anne Bergstra, Axel Finckh, Delphine Sophie Courvoisier
Summary: The objective of this study was to compare the effectiveness of cycling Janus kinase inhibitors (JAKi) with switching to biologic disease-modifying antirheumatic drug (bDMARD) in patients with rheumatoid arthritis (RA). The results showed that both strategies had similar observed drug retention rates after 2 years, but cycling JAKi was associated with higher retention after adjusting for confounders. It was also found that if the first JAKi was discontinued due to an adverse event (AE), it was more likely that the second JAKi would also be stopped due to an AE. Improvement in Clinical Disease Activity Index (CDAI) over time was similar in both strategies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Fabio Cacciapaglia, Stefano Stano, Marco Fornaro, Florenzo Iannone
Summary: The use of immunoglobulin has shown efficacy in the treatment of different rheumatologic autoimmune systemic diseases. A study on immunoglobulin therapy for systemic sclerosis showed encouraging results in improving skin symptoms. We present a case of a young woman with rapidly progressive diffuse cutaneous systemic sclerosis who had significant skin improvement after one year of subcutaneous immunoglobulin treatment. A narrative literature review on alternative treatments for systemic sclerosis skin involvement, focusing on immunoglobulin use, was also carried out.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Roberta Zerlotin, Marco Fornaro, Mariella Errede, Patrizia Pignataro, Clelia Suriano, Maddalena Ruggieri, Silvia Colucci, Florenzo Iannone, Maria Grano, Graziana Colaianni
Summary: In this cohort study, 41 patients with DM and IMNM were examined. The results showed lower expression of FNDC5 in the muscle biopsies of these patients compared to the control group, while serum irisin levels were higher. The authors hypothesize that increased expression of ADAM10 in the skeletal muscle of DM and IMNM patients may be responsible for the discrepancy between irisin levels and FNDC5 expression. Further research is needed to understand the mechanisms underlying exacerbated FNDC5 cleavage and muscle irisin resistance in these inflammatory myopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Fausto Salaffi, Cesare Siragusano, Alessandra Alciati, Giulia Cassone, Salvatore D'Angelo, Serena Guiducci, Ennio Giulio Favalli, Fabrizio Conti, Elisa Gremese, Florenzo Iannone, Roberto Caporali, Marco Sebastiani, Gian Franco Ferraccioli, Giovanni Lapadula, Fabiola Atzeni
Summary: Axial spondyloarthritis (axSpA) is a group of chronic rheumatic diseases primarily affecting the axial skeleton. It includes ankylosing spondylitis, reactive arthritis, arthritis/spondylitis associated with psoriasis (PsA), and arthritis/spondylitis associated with inflammatory bowel diseases (IBD). Pain is a common and important symptom of axSpA, which can progress to chronic pain and significantly impact the quality of life. The development of axSpA inflammation involves complex interactions between genetic, epigenetic, and environmental factors, as well as dysregulated immune responses. Inhibition of IL-23 and IL-17 has been explored as a potential therapeutic strategy for axSpA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Vincenzo Venerito, Andreina Manfredi, Antonio Carletto, Stefano Gentileschi, Fabiola Atzeni, Serena Guiducci, Marlea Lavista, Laura La Corte, Elisa Pedrollo, Arnaldo Scardapane, Caterina Tomassini, Bruno Frediani, Carlo Salvarani, Florenzo Iannone, Marco Sebastiani
Summary: The aim of this multicenter retrospective study was to investigate the effectiveness and safety of JAK-inhibitors (JAKi) in patients with rheumatoid arthritis (RA) and interstitial lung disease (ILD). The study suggests that JAKi therapy might be a safe therapeutic option for patients with RA-ILD in a short-term follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vincenzo Venerito, Pasquale Stefanizzi, Luca Cantarini, Marlea Lavista, Maria Grazia Galeone, Antonio Di Lorenzo, Florenzo Iannone, Silvio Tafuri, Giuseppe Lopalco
Summary: RA patients treated with JAK inhibitors or anti-cellular bDMARDS have an increased risk of herpes zoster (HZ). This prospective study assessed the immunogenicity and safety of the Adjuvanted Recombinant Zoster Vaccine (RZV) in RA patients on JAK inhibitors or anti-cellular bDMARDS. The results showed that RZV vaccination induced a similar immune response in RA patients compared to healthy controls, regardless of the treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rheumatology
Vincenzo Venerito, Emre Bilgin, Florenzo Iannone, Sedat Kiraz
Summary: Natural Language Processing (NLP) and Large Language Models (LLMs) such as GPT, ChatGPT, or LLAMA have gained significant attention recently. They have impacted finance, economics, and healthcare in terms of diagnostic/scoring systems. Additionally, academic life, particularly in the field of rheumatology, is also experiencing the opportunities and challenges brought by NLP and LLMs.
Review
Medicine, General & Internal
Simone Perniola, Maria Sole Chimenti, Francesca Romana Spinelli, Bruno Frediani, Rosario Foti, Sara Ferrigno, Cristina Garufi, Giulia Cassone, Vincenzo Venerito, Fabiola Atzeni, Roberto Caporali, Fabrizio Conti, Ennio Giulio Favalli, Florenzo Iannone, Marco Sebastiani, Gian Franco Ferraccioli, Giovanni Lapadula, Elisa Gremese
Summary: Rheumatoid Arthritis (RA) is a complex disease with various clinical phenotypes, categorized by disease duration, seropositivity for rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA), joint subtype, clinical behavior, and other subgroups. This review provides a summary of the multifaceted aspects of RA, specifically focusing on the association between autoimmune status and clinical outcomes, achievement of remission, and treatment response, as discussed in the 2022 International GISEA/OEG Symposium.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Florenzo Iannone, Giuseppe Lopalco, Fabio Cacciapaglia, Vincenzo Venerito, Simone Perniola, Marco Fornaro
Summary: This study aimed to evaluate the effectiveness of bDMARDs in RA patients negative for RF and ACPA. The results showed that tocilizumab had a higher survival rate compared to abatacept in RF/ACPA negative RA patients.