Article
Pharmacology & Pharmacy
Mohammad-Reza Ghovanloo, Mark Estacion, Grant P. Higerd-Rusli, Peng Zhao, Sulayman Dib-Hajj, Stephen G. Waxman
Summary: CBG selectively inhibits Na(v)1.7 channels in DRG neurons, contributing to its analgesic properties. At lower concentrations, CBG blocks sodium G(max) and slows recovery from inactivation, while higher concentrations also induce a hyperpolarizing shift in the half-voltage of inactivation. Experimental results suggest that CBG attenuates DRG excitability.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Xiaoyu Zhang, Fangxia Xu, Lijuan Wang, Jinbao Li, Jianhai Zhang, Lina Huang
Summary: The study suggests that alpha 7 nAChR could serve as a potential therapeutic target for chronic inflammatory pain, mediating pain sensitivity and neuroinflammatory action through the TRAF6/NF-kappa B signaling pathway.
INFLAMMOPHARMACOLOGY
(2021)
Article
Neurosciences
Donghang Zhang, Wenling Zhao, Jin Liu, Mengchan Ou, Peng Liang, Jia Li, Yali Chen, Daqing Liao, Siqi Bai, Jiefei Shen, Xiangdong Chen, Han Huang, Cheng Zhou
Summary: NALCN plays a significant role in chronic neuropathic pain, and knockdown of NALCN can significantly alleviate pain-related symptoms.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Biology
Yucheng Xiao, Jonathan W. Theile, Agnes Zybura, Yanling Pan, Zhixin Lin, Theodore R. Cummins
Summary: In this study, the authors demonstrate that I-NaR can be reconstituted in a heterologous system by coexpression of sodium channel alpha-subunits and A-type fibroblast growth factor homologous factors (FHFs). They also identify the N-terminus of FHF as the critical molecule responsible for A-type FHFs-mediated I-NaR. Moreover, knockdown of FHF4A significantly reduces I-NaR amplitude and suppresses excitability in nociceptive sensory neurons.
Article
Neurosciences
Nivanthika K. Wimalasena, Daniel G. Taub, Jaehoon Shim, Sara Hakim, Riki Kawaguchi, Lubin Chen, Mahmoud El-Rifai, Daniel H. Geschwind, Sulayman D. Dib-Hajj, Stephen G. Waxman, Clifford J. Woolf
Summary: Mutations in the Scn9a gene can lead to various pain and neuropathy disorders. Previous studies have shown that the Nav1.7 gene mutation affects sodium conductance and neuronal excitability, but does not affect mechanical and thermal sensitivity in young mice. However, this new research demonstrates that as mice with this mutation age, they develop insensitivity to pain and cold, as well as skin lesions. Electrophysiology and RNA sequencing reveal a loss of sodium conductance and decreased expression of cLTMR genes in aged mice with the mutation.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Li-Ping Xia, Hao Luo, Qiang Ma, Ya-Kai Xie, Wei Li, Hailan Hu, Zhen-Zhong Xu
Summary: GPR151 in nociceptive dorsal root ganglion neurons plays a crucial role in the pathogenesis of neuropathic pain by controlling neuronal hyperexcitability and promoting spinal microglial activation, indicating its potential as a therapeutic target for neuropathic pain treatment.
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yiru Wang, Xinyi Wang, Renfei Qi, Ying Lu, Yu Tao, Dongsheng Jiang, Yufang Sun, Xinghong Jiang, Chunfeng Liu, Yuan Zhang, Jin Tao
Summary: The study reveals a novel mechanism by which IL-33/ST2 suppresses A-type K+ currents in sensory neurons, leading to increased neuronal excitability and pain sensitivity. This mechanism involves the suppression of the tumorigenicity 2 (ST2) receptor and the activation of a Syk-dependent p38 beta signaling pathway. Targeting IL-33/ST2-mediated p38 beta signaling may represent a therapeutic approach to ameliorate pain behaviors.
Article
Chemistry, Medicinal
Ziyi Zhai, Xianjing Zhang, Yuchao Ding, Ziming Huang, Qian Li, Mingyue Zheng, Kenka Cho, Zhihui Dong, Weiguo Fu, Zaixing Chen, Baohong Jiang
Summary: Eugenol has potential therapeutic effects against abdominal aortic aneurysm (AAA) by inhibiting disease progression and protecting the integrity of the aortic structure. It exerts its effects by down-regulating the expressions of COX-2 and NF-kappa B.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Lipeng Tang, Tong Li, Bowen Zhang, Zihao Zhang, Xiaoyi Sun, Ying Zhu, Bing Feng, Zuqing Su, Laijun Yang, Hongxia Li, Huazhen Liu, Yuchao Chen, Zhenhua Dai, Xirun Zheng, Mingxian Li, Chutian Li, Jie Zhao, Xinmin Qiu, Shuyan Ye, Han Liu, Guangjuan Zheng, Ben Li, Chuanjian Lu
Summary: Punicalagin (PUN) shows therapeutic potential for psoriasis by inhibiting inflammatory response and cell signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Anesthesiology
Ling -Jun Xu, Jing Wang, Gui-Dan Li, Kai-Feng Shen, Xing-Hui He, Wei Wu, Cui-Cui Liu
Summary: In this study, it was found that the reduction of SIRT1 and the upregulation of Nav1.7 in the dorsal root ganglion contribute to the development of oxaliplatin-induced neuropathic pain in rats. Activating SIRT1 or blocking Nav1.7 can alleviate pain symptoms.
Article
Immunology
Shouye Hu, Yanqi Li, Bo Wang, Kan Peng
Summary: The study showed that TRIM38 can alleviate IL-1 beta-induced apoptosis and degeneration of chondrocytes by suppressing the NF-kappa B signaling pathway. This work suggests a potential role of TRIM38 in osteoarthritis and proposes it as a new therapeutic target for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zengxin Jiang, Guobin Qi, Wei Lu, Hao Wang, Defang Li, Weibin Chen, Lei Ding, Xiuying Yang, Hengfeng Yuan, Qingmin Zeng
Summary: This study found that omaveloxolone exerts antioxidative, anti-inflammatory, antiapoptotic and anti-ECM degradation effects via activation of the Nrf2/ARE signaling pathway and inhibition of the NF-kappa B signaling pathway in chondrocytes in vitro and attenuates osteoarthritis progression in vivo, suggesting its potential as a therapeutic agent for OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
Article
Allergy
SuJin Hwang, Christina Tatsi, Hye Sun Kuehn, Julie E. Niemela, Jennifer Stoddard, Yan Su, Maya Lodish, Gulbu Uzel, Rosanne Spolski, Warren J. Leonard, Steven M. Holland, Thomas A. Fleisher, Constantine A. Stratakis, Sergio D. Rosenzweig
Summary: This study investigated the immunological effects of pediatric endogenous Cushing syndrome (eCs) and its treatment. The results showed that the decrease in thymic output, lymphocyte proliferation, and increase in apoptosis were the underlying causes of T-cell lymphopenia in eCs patients. Additionally, IL-21 levels were decreased in both natural and in vitro glucocorticoid environments, but the addition of IL-21 in vitro counteracted the proapoptotic effects of glucocorticoid therapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)