Review
Psychology, Multidisciplinary
Yan Wang, Liangmei Guo, Xinjuan Xiong
Summary: This meta-analysis found that virtual reality technology can alleviate pain, fear, and anxiety in children and adolescents undergoing needle procedures.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Medicine, General & Internal
Oliver Czech, Adam Wrzeciono, Anna Rutkowska, Agnieszka Guzik, Pawel Kiper, Sebastian Rutkowski
Summary: This systematic review found that virtual reality technology has a significant effect on reducing pain for pediatric patients undergoing needle-related procedures, but its effect on reducing fear and anxiety is not significant. Further research is needed on the implementation of virtual reality technology as a distraction intervention to reduce pain in children and adolescents undergoing needle-related medical procedures.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Chia-Shu Lin, Chen-Yi Lee, Li-Ling Chen, Long-Ting Wu, Shue-Fen Yang, Tze-Fang Wang
Summary: The study found that individuals exhibit higher levels of fear and avoidance intentions towards dental treatments they have not experienced, and this fear and avoidance is associated with dental anxiety. Trait dental anxiety plays a significant role in the fear of non-experienced treatments.
Article
Dentistry, Oral Surgery & Medicine
Chia-Shu Lin, Chen-Yi Lee, Shih-Yun Wu, Li-Ling Chen, Kun-Tsung Lee, Min-Ching Wang, Tze-Fang Wang
Summary: The study validated a Chinese version of the Modified Dental Anxiety Scale (T-MDAS), showing good internal consistency, temporal stability, and validity. Higher dental anxiety was associated with lack of regular dental visits, feeling pain during treatment, and perceived lack of skills and empathy from dentists.
Review
Public, Environmental & Occupational Health
Oliver Czech, Sebastian Rutkowski, Aleksandra Kowaluk, Pawel Kiper, Iwona Malicka
Summary: This systematic review and meta-analysis aimed to analyze the effects of virtual reality (VR) and active video games (AVG) on fear, physical functions, and quality of life in young cancer patients. The results showed that VR has the potential to become an accessory tool in rehabilitation and oncologic treatment, effectively reducing pain associated with standard oncologic care procedures in children.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Orthopedics
Katherine K. Rethman, Cody J. Mansfield, Josh Moeller, Danilo De Oliveira Silva, Julie A. Stephens, Stephanie Di Stasi, Matthew S. Briggs
Summary: The objective of this study was to identify factors associated with kinesiophobia in individuals with patellofemoral pain (PFP) and interventions that may reduce kinesiophobia in individuals with PFP. The findings showed a moderate association between kinesiophobia and poorer function, as well as a weak association between kinesiophobia and higher pain in individuals with PFP. Taping and bracing immediately reduced kinesiophobia, while kinesiophobia-targeted interventions showed promise in reducing kinesiophobia following the full intervention.
Review
Anesthesiology
Guillaume Christe, Geert Crombez, Shannon Edd, Emmanuelle Opsommer, Brigitte M. Jolles, Julien Favre
Summary: Higher levels of pain-related fear, catastrophizing, and depression are significantly associated with reduced spinal movement amplitudes and increased muscle activity in low back pain patients. Pain intensity has a minimal independent association with spinal motor behavior, and the small effect sizes found in the meta-analyses question the role of psychological factors as major causes of spinal movement avoidance.
Review
Nursing
Yan Gao, Yiwei Xu, Naiquan Liu, Ling Fan
Summary: This study systematically reviewed and meta-analyzed the effectiveness of virtual reality (VR) intervention in managing pain, anxiety, and fear in pediatric patients undergoing needle-related procedures. The results showed that compared to the non-VR group, the VR intervention group significantly reduced pain, anxiety, and fear. Subgroup analysis revealed that VR had advantages over conventional and other distraction methods. In conclusion, VR interventions can benefit pediatric patients undergoing needle-related procedures by reducing pain, anxiety, and fear.
JOURNAL OF ADVANCED NURSING
(2023)
Article
Multidisciplinary Sciences
U. Held, J. M. Burgstaller, M. Deforth, J. Steurer, G. Pichierri, M. M. Wertli
Summary: The study investigates the impact of depression and anxiety on the symptoms and function of patients undergoing surgical treatment for DLSS. The results show that depression is associated with more symptoms and worse function, while anxiety does not show a significant association with these measures.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Karolina Andraka, Kacper Kondrakiewicz, Karolina Rojek-Sito, Karolina Ziegart-Sadowska, Ksenia Meyza, Tomasz Nikolaev, Adam Hamed, Miron Kursa, Maja Wojcik, Konrad Danielewski, Marta Wiatrowska, Ewa Kublik, Marek Bekisz, Tomasz Lebitko, Daniel Duque, Tomasz Jaworski, Hubert Madej, Witold Konopka, Pawel M. Boguszewski, Ewelina Knapska
Summary: Animals exhibit various defensive responses to threats, which can also be influenced by the behavior of fearful conspecifics. Research shows that observing a partner undergoing aversive stimulation triggers passive defensive responses, while interacting with a partner that has just undergone aversive stimulation prompts active exploration in animals. The study suggests that the responses of observer animals to social triggers are caused by changes in their affective state rather than mimicry, and that different populations of neurons in the central amygdala are involved in promoting passive or active defensive responses.
Article
Behavioral Sciences
David Watson, Lee Anna Clark, Leonard J. Simms, Roman Kotov
Summary: In this study, fear and anxiety are examined in the context of personality and psychopathology models, along with their assessment. Anxiety is a sustained, future-oriented response to potential threat, while fear is a brief, present-focused response to acute threat. Assessing individual differences in fear can be done through phobic responses to specific stimuli or through differentiating between harm avoidance and risk taking. These measures are correlated with various personality traits and factors within psychopathology models.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Behavioral Sciences
David Watson, Lee Anna Clark, Leonard J. Simms, Roman Kotov
Summary: This article explores the relationships between fear and anxiety within structural models of personality and psychopathology, as well as important issues related to their assessment. Anxiety represents a core facet within the domain of neuroticism, while fear is a response to acute threat. Different assessment methods reflect individual differences in fear and anxiety.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Behavioral Sciences
L. Fraunfelter, G. W. Alpers, A. B. M. Gerdes
Summary: Fear generalization, which is the extension of fear from one conditioned stimulus to similar cues, is a defining feature of anxiety disorders. However, the link between generalization and pathological anxiety, as well as its moderators, has not been formally integrated. This systematic review and meta-analysis clarifies the relationship and provides recommendations for further research.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Anesthesiology
Maria Monika Wertli, Barbara Aegler, Candida S. McCabe, Sharon Grieve, Alison Llewellyn, Stephanie Schneider, Lucas M. Bachmann, Florian Brunner
Summary: The study aimed to assess resilience in patients with CRPS 1 and explore its relationship with patient outcomes. Results showed that resilience was positively correlated with quality of life and pain self-efficacy, while pain catastrophizing was negatively correlated. Anxiety, depression, and fatigue were also inversely associated with resilience. The findings suggest that resilience is an independent factor in CRPS 1 and is associated with relevant parameters of the condition.
Article
Chemistry, Multidisciplinary
Victor Riquelme-Aguado, Antonio Gil-Crujera, Josue Fernandez-Carnero, Ferran Cuenca-Martinez, Guillermo Baviano Klett, Francisco Gomez Esquer
Summary: The aim of this study was to evaluate whether emotional and cognitive factors influence the limb laterality discrimination task in women with fibromyalgia syndrome (FMS). The results showed that FMS patients had longer reaction times for laterality discrimination in hands and exhibited emotional and cognitive disorders compared with healthy subjects. However, there was no correlation between limb laterality discrimination and psychological variables.
APPLIED SCIENCES-BASEL
(2023)
Article
Rheumatology
Andrew Moore, Christopher Eccleston, Rachael Gooberman-Hill
Summary: This study investigated the role of embodiment and incorporation in understanding experiences of pain and discomfort after total knee replacement surgery. The findings showed that some patients did not fully accept the prosthetic joint and felt a lack of connection and control over it. The study highlights the importance of treating patients as whole individuals and focusing on modifying their relationship with the new joint to achieve optimal postoperative outcomes.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Vikki Wylde, Emily Sanderson, Tim J. Peters, Wendy Bertram, Nicholas Howells, Julie Bruce, Christopher Eccleston, Rachael Gooberman-Hill
Summary: This study described the screening and recruitment process of a randomized trial and evaluated the associations between knee pain and function 3 months after total knee replacement (TKR). The results showed that the severity of pain after TKR was associated with overall health, physical health, pain worry, and satisfaction with surgery outcomes. Functional limitation was associated with depression, pain worry, satisfaction with surgery outcomes, and pain acceptance.
ARTHRITIS CARE & RESEARCH
(2022)
Review
Anesthesiology
Emma Fisher, Gemma Villanueva, Nicholas Henschke, Sarah J. Nevitt, William Zempsky, Katrin Probyn, Brian Buckley, Tess E. Cooper, Navil Sethna, Christopher Eccleston
Summary: Chronic pain in childhood is a global public health issue. A systematic review and meta-analysis were conducted to summarize the evidence of pharmacological, physical, and psychological therapies for children with chronic pain. Psychological therapy was found to be the most effective method in managing pain.
Review
Anesthesiology
Bethea A. Kleykamp, Robert H. Dworkin, Dennis C. Turk, Zubin Bhagwagar, Penney Cowan, Christopher Eccleston, Susan S. Ellenberg, Scott R. Evans, John T. Farrar, Roy L. Freeman, Louis P. Garrison, Jennifer S. Gewandter, Veeraindar Goli, Smriti Iyengar, Alejandro R. Jadad, Mark P. Jensen, Roderick Junor, Nathaniel P. Katz, J. Patrick Kesslak, Ernest A. Kopecky, Dmitri Lissin, John D. Markman, Michael P. McDermott, Philip J. Mease, Alec B. O'Connor, Kushang Patel, Srinivasa N. Raja, Michael C. Rowbotham, Cristina Sampaio, Jasvinder A. Singh, Ilona Steigerwald, Vibeke Strand, Leslie A. Tive, Jeffrey Tobias, Ajay D. Wasan, Hilary D. Wilson
Summary: Chronic pain clinical trials have traditionally assessed benefit and risk outcomes separately. However, recent research suggests that a composite metric that considers both benefit and risk together can offer valuable insights into treatment effects. This article, based on expert opinions from a consensus meeting, reviews the use of benefit-risk assessment tools in published chronic pain clinical trials. The review finds that these metrics are underutilized in such trials, and proposes that they should be applied at both individual and group levels of analysis to better understand the relationship between benefits and risks in different patient subpopulations. The systematic assessment of benefit-risk has the potential to enhance the clinical relevance of randomized clinical trial results.
Review
Anesthesiology
Elaine Wainwright, Steven Bevan, Fiona M. Blyth, Saman Khalatbari-Soltani, Michael J. L. Sullivan, Karen Walker-Bone, Christopher Eccleston
Review
Anesthesiology
Robert Andrew Moore, Emma Fisher, Christopher Eccleston
Summary: This article points out the problems that exist in current systematic reviews, including low-quality trials, insufficient rigor in review methodology, ignorance of key pain issues, small sample sizes, and over-optimistic judgments about treatment effects. The authors argue that the majority of systematic reviews have fatal flaws and only a small percentage have adequate methods and clinical usefulness, therefore their results should be dismissed. The authors call for critical systematic reviews to improve trial quality and advocate for their encouragement and protection.
EUROPEAN JOURNAL OF PAIN
(2022)
Article
Anesthesiology
Neil E. O'Connell, R. Andrew Moore, Gavin Stewart, Emma Fisher, Leslie Hearn, Christopher Eccleston, Amanda C. de C. Williams
Summary: This study systematically examined multiple related trials from the same author to investigate the bias risk, governance procedures, and trustworthiness of the research. The results revealed significant differences between some of the trial results and the existing evidence, and the explanations provided by the author were not satisfactory. The study further identified issues related to research governance, data plausibility, results, and data duplication. These findings decrease the trustworthiness of the trials.
Article
Clinical Neurology
Nina Kreddig, Monika Ilona Hasenbring, Edmund Keogh
Summary: Increasing attentional focus away from pain can affect pain experience, and cognitive strategies can help with pain by changing attention allocation. This study examined the effects of two cognitive strategies, thought suppression and focused distraction, on pain-related attention and found that these strategies did not influence pain-related attention, but thought suppression had short-term benefits in terms of pain and perceived threat.
Review
Anesthesiology
Edmund Keogh
Review
Anesthesiology
Andrew Moore, Emma Fisher, Christopher Eccleston
Summary: The randomised controlled trial, the foundation of clinical research, is often flawed in design, conduct, and reporting, leading to concerns about its trustworthiness. Common flaws include bias, small sample sizes, irrelevant outcomes, and inability to detect efficacy. Some trials have been fabricated, with the fields of anaesthesia and pain having a larger number. This review highlights the need for special measures to improve the quality and confidence of clinical evidence.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Letter
Health Care Sciences & Services
Amanda C. de C. Williams, Leslie Hearn, R. Andrew Moore, Gavin Stewart, Emma Fisher, Christopher Eccleston, Neil E. O'Connell
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Letter
Anesthesiology
Neil Edward O'Connell, R. Andrew Moore, Gavin Stewart, Emma Fisher, Leslie Hearn, Christopher Eccleston, Amanda C. de C. Williams
Review
Anesthesiology
Christopher Eccleston, Emma Begley, Hollie Birkinshaw, Ernest Choy, Geert Crombez, Emma Fisher, Anna Gibby, Rachael Gooberman-Hill, Sharon Grieve, Amber Guest, Abbie Jordan, Amanda Lilywhite, Gary J. Macfarlane, Candida McCabe, John McBeth, Anthony E. Pickering, Tamar Pincus, Hannah M. Sallis, Samantha Stone, Danielle Van der Windt, Diego Vitali, Elaine Wainwright, Colin Wilkinson, Amanda C. de C. Williams, Anica Zeyen, Edmund Keogh
Article
Computer Science, Software Engineering
J. Bartlett, E. Fisher, S. Liikkanen, J. Turunen, M. Skog, C. Eccleston
Summary: This study presents a new embodied Semi-Autonomous Mentoring Intelligence (SAMI) avatar used in an immersive virtual reality intervention for chronic pain. The research findings provide insights on methods to establish working alliance with non-human agents, optimal characteristics of non-human agents, and features of effective automation.
FRONTIERS IN VIRTUAL REALITY
(2022)
