Article
Orthopedics
T. Blikman, W. Rienstra, T. M. van Raaij, A. J. Ten Hagen, B. Dijkstra, W. P. Zijlstra, S. K. Bulstra, M. Stevens, I van den Akker-Scheek
Summary: Adding duloxetine treatment appears to be beneficial for end-stage knee OA patients with neuropathic-like symptoms (at risk of CS), but seems to be nonresponsive in end-stage Hip OA patients.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Anesthesiology
Bo Chen, Jingrui Duan, Shengyue Wen, Jian Pang, Min Zhang, Hongsheng Zhan, Yuxin Zheng
Summary: Duloxetine showed significant reductions in pain intensity and improvement in general activity, physical function, global impression of improvement, and clinical global impression of severity for knee osteoarthritis patients, but did not demonstrate superiority in pain subscale and serious adverse events compared to placebo. Further rigorous randomized controlled trials are needed to confirm its effectiveness.
CLINICAL JOURNAL OF PAIN
(2021)
Article
Multidisciplinary Sciences
Man Soo Kim, In Jun Koh, Keun Young Choi, Sung Cheol Yang, Yong In
Summary: The study found that duloxetine and opioids showed no significant difference in pain control, function, and side effects for up to one year after total knee arthroplasty. Despite the need for further randomized controlled trials to confirm the side effects of duloxetine, it can be considered as an alternative to opioids for postoperative pain control following TKA.
Article
Medicine, Research & Experimental
Nadia Ammitzboll, Lars Arendt-Nielsen, Davide Bertoli, Christina Brock, Anne Estrup Olesen, Andreas Kappel, Asbjorn Mohr Drewes, Kristian Kjaer Petersen
Summary: The global burden of osteoarthritis is on the rise, leading to an increased need for alternative pain management strategies. This study aims to investigate how duloxetine may modulate central pain mechanisms in OA patients, potentially providing insights into its analgesic effects.
Article
Orthopedics
J. K. Sullivan, J. Huizinga, R. R. Edwards, D. J. Hunter, T. Neogi, E. Yelin, J. N. Katz, E. Losina
Summary: In the United States, duloxetine is a cost-effective treatment for knee osteoarthritis patients, especially for those with moderate pain or who are unable to undergo total knee replacement surgery. Among younger subjects with severe pain, duloxetine is cost-effective at certain willingness-to-pay thresholds.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Orthopedics
Shuhei Otsuki, Yoshinori Okamoto, Kuniaki Ikeda, Hitoshi Wakama, Tomohiro Okayoshi, Masashi Neo
Summary: This study found that perioperative use of duloxetine from 2 weeks before surgery to 2 weeks after surgery is beneficial for perioperative pain management and improvement of the Knee Injury and Osteoarthritis Outcome Score (KOOS) following high tibial osteotomy.
Review
Physiology
Qinxin Zhou, Jixin Chen, Weijie Yu, Kun Yang, Tianci Guo, Puyu Niu, Yuntian Ye, Aifeng Liu
Summary: This study evaluated the efficacy and safety of duloxetine for knee osteoarthritis. It found that duloxetine may be effective in improving pain and depressive symptoms, but the available evidence quality is low and further improvement in study design and evidence quality is needed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Nico Magni, Jill Collier, Peter McNair, David A. Rice
Summary: The study found that 42% of patients with symptomatic hand OA experienced neuropathic pain, which was associated with higher pain intensity. Pain intensity was correlated with the number of pain medications and body schema alterations, but not with psychological factors, hand function, and sleep.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Junad Khan, Qian Wang, Olga A. Korczeniewska, Rotem McNeil, Yanfang Ren, Rafael Benoliel, Eli Eliav
Summary: This study found that exercise-induced hypoalgesia (EIH) profiles in rats can predict the development of hypersensitivity following injury and support targeted pharmacological treatment. Rats with deficient analgesic response following exercise benefit more from treatment with duloxetine and gabapentin.
EUROPEAN JOURNAL OF PAIN
(2023)
Review
Orthopedics
Xuezhi Ma, Shijie Zhou, Wenyuan Sun, Jie Sun, Guangguang Li, Lining Wang, Yang Guo
Summary: This article evaluates the efficacy and safety of duloxetine in treating chronic musculoskeletal pain (CMP). The study found that duloxetine can significantly improve patients' pain levels and depressive symptoms, without any significant serious adverse reactions.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Noha O. Mansour, Sherif Boraii, Mohamed Hassan Elnaem, Mahmoud E. Elrggal, Tamer Omar, Amr Abdelraouf, Doaa H. Abdelaziz
Summary: This study evaluated the effect of preoperative oral duloxetine on postoperative pain control in patients undergoing laparoscopic cholecystectomy. The results showed that preoperative use of duloxetine significantly reduced postoperative pain and decreased the occurrence of postoperative nausea and vomiting.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Larissa Staurengo-Ferrari, Ivan J. M. Bonet, Dioneia Araldi, Paul G. Green, Jon D. Levine
Summary: Duloxetine is an effective treatment for chemotherapy-induced peripheral neuropathy (CIPN), but our ability to predict patient response is still limited. A study found that neuroendocrine stress axes play a role in the analgesic effect of duloxetine in CIPN. Duloxetine can prevent and reverse mechanical hyperalgesia associated with CIPN, and its effectiveness differs between genders and in response to stress.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Orthopedics
J. J. Heerey, R. Srinivasan, R. Agricola, A. Smith, J. L. Kemp, T. Pizzari, M. G. King, P. R. Lawrenson, M. J. Scholes, R. B. Souza, T. Link, S. Majumdar, K. M. Crossley
Summary: This study compared early hip osteoarthritis features on MRI in high-impact athletes with and without hip and/or groin pain. The findings suggest that hip and/or groin pain was associated with higher SHOMRI and labral scores, but early hip OA features were not associated with iHOT33 or HAGOS.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Anesthesiology
Francesca L. Beaudoin, Rachel Gaither, Weston C. DeLomba, Samuel A. McLean
Summary: This study investigated the tolerability and preliminary efficacy of duloxetine as a nonopioid therapeutic option for preventing persistent musculoskeletal pain after trauma or injury. The results showed that duloxetine was well tolerated in both dosage groups and there were no serious adverse events. There was a significant difference in pain over time for the 60 mg group compared to the placebo group, but not for the 30 mg group. The findings suggest that duloxetine may be a treatment option for reducing the transition from acute to persistent pain.
Editorial Material
Orthopedics
Peter E. Mueller, Thomas R. Niethammer
Summary: Bone marrow lesions (BML) are often caused by stress-related bone marrow edema, associated with cartilage loss. Treatment of cartilage damage requires addressing the underlying bone marrow edema, and the critical point for successful treatment of larger defects is treating the cartilage defect effectively.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)