Article
Anesthesiology
Emanuel Loeza-Alcocer, Michael S. Gold
Summary: Pain in inflammatory bowel disease (IBD) is believed to be caused, in part, by a decrease in peripheral GABAA receptor (GAR)-mediated inhibition. Activating low-affinity GAR or blocking high-affinity GAR may be effective therapeutic strategies for managing IBD pain.
Review
Gastroenterology & Hepatology
Brennan Spiegel
Summary: This article proposes a hypothesis, known as the gravity hypothesis, that seeks to explain the pathogenesis of irritable bowel syndrome (IBS) by relating it to the influence of gravity on human evolution. It suggests that ineffective gravity management systems may lead to the development of IBS. The article reviews the impact of gravity on human evolution, discusses the imperfect adaptation of Homo sapiens to gravity, and explores the consequences of gravity intolerance in relation to IBS. It also considers the diagnostic and therapeutic implications of this hypothesis and suggests further experiments to support or reject it.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Obstetrics & Gynecology
Claire Cardaillac, Amelie Levesque, Thibault Riant, Anais Mortier, Michel Neunlist, Marie-Aimee Perrouin-Verbe, Christelle Volteau, Thibault Thubert, Charlene Brochard, Stephane Ploteau
Summary: This study found through neurophysiological tests that the presence of central sensitization can be objectively assessed in women with chronic pelvic pain, independent of psychological factors.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, Research & Experimental
Marcos Lisboa Neves, Jhenifer Karvat, Roli Rodrigues Simoes, Guilherme Fleury Fina Speretta, Renata Maria Lataro, Morgana Duarte da Silva, Adair Roberto Soares Santos
Summary: The study investigated the effects of ABVN stimulation on pain models in rats and found that stimulation on the left side could inhibit pain signaling, dependent on the activation of the vagus nerve and cholinergic receptors.
Article
Neurosciences
Katharina Schmidt, Julian Kleine-Borgmann, Katrin Scharmach, Diana Muessgens, Sigrid Elsenbruch, Ulrike Bingel, Katarina Forkmann
Summary: Visceral pain is more salient and emotionally intense than somatic pain, leading to higher levels of fear. This fMRI study found that visceral pain reduces neural activity in areas involved in visual processing and memory encoding, affecting cognitive functions.
Article
Neurosciences
Qi-Ya Xu, Hai -Long Zhang, Han Du, Yong -Chang Li, Fu-Hai Ji, Rui Li, Guang-Yin Xu
Summary: Chronic visceral pain is a major challenge for both patients and health providers. Research has found that inhibiting or activating CL glutamatergic neurons has no effect on CFA-induced inflammatory pain, but is critical for visceral pain. Further studies have demonstrated a causal link between such neuronal activity and visceral pain behaviors.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Clinical Neurology
Qianjun Jin, Yuxin Chang, Chenmiao Lu, Lunhao Chen, Yue Wang
Summary: The purpose of this study is to summarize the current understanding of referred pain, including its pathogenesis, characteristics, diagnosis, and treatment. Referred pain can arise not only from local tissue pathology but also from lesions in distant structures. Despite various approaches in the diagnosis and treatment of referred pain, management remains a clinical challenge.
FRONTIERS IN NEUROLOGY
(2023)
Article
Anesthesiology
Julian Kleine-Borgmann, Katharina Schmidt, Katrin Scharmach, Matthias Zunhammer, Sigrid Elsenbruch, Ulrike Bingel, Katarina Forkmann
Summary: This study found that acute visceral pain has a greater impact on visual processing and memory performance compared to somatic pain, and this impact appears to be independent of pain-related cognitions or emotions.
Article
Nutrition & Dietetics
Kordula Lang-Illievich, Christoph Klivinyi, Gudrun Rumpold-Seitlinger, Christian Dorn, Helmar Bornemann-Cimenti
Summary: This study aimed to investigate the analgesic mechanisms of Palmitoylethanolamide (PEA) and found that PEA significantly reduced heat pain, prolonged cold pain tolerance, increased pressure pain tolerance and conditioned pain modulation, decreased wind-up ratio and average distance of allodynia, and improved heat pain tolerance.
Article
Medicine, General & Internal
Luis Matesanz-Garcia, Ferran Cuenca-Martinez, Ana Isabel Simon, David Cecilia, Carlos Goicoechea-Garcia, Josue Fernandez-Carnero, Annina B. Schmid
Summary: This study investigated alterations in central pain processing in patients with carpal tunnel syndrome (CTS) and their association with the central sensitization inventory (CSI). The results showed differences in pain thresholds, conditioned pain modulation, and pain distribution in patients with CTS compared to healthy volunteers. However, the CSI was not associated with changes in central pain processing but with psychological factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ryosuke Iio, Tomoya Manaka, Katsumasa Nakazawa, Yoshihiro Hirakawa, Yoichi Ito, Ayako Ogura, Hiroaki Nakamura
Summary: This study aimed to determine the effects of shoulder osteoarthritis and rotator cuff tears (RCT) on central sensitization (CS) and associated factors. The study found that patients with glenohumeral osteoarthritis (GHOA) had significantly higher CS scores and prevalence than patients with RCT without GHOA. Female sex, severe pain, and long pain duration were associated with higher CS scores.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Kevin Retailleau, Vincent Martin, Stephane Lezmi, Camille Nicoleau, Jacquie Maignel
Summary: This study investigated the effects of botulinum neurotoxin A (BoNT/A) on visceral nociception using an ex vivo model. The results showed that BoNT/A had an inhibitory effect on afferent nerve activity in response to distension and capsaicin, suggesting that it could alleviate visceral pain.
Article
Orthopedics
Vicente Sanchis-Alfonso, Maria Beser-Robles, Ana Navarro-Calvo, Laura Lopez-Company, Alejandro Rosello-Anon, Julio Domenech-Fernandez
Summary: This study found a higher prevalence of central sensitization in patients with anterior knee pain, and it was associated with greater disability, anxiety, and depression. However, there was no association with pain intensity, catastrophizing, and kinesiophobia. Depression was identified as a significant predictor of central sensitization.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Psychiatry
Jana Luisa Aulenkamp, Adriane Icenhour, Sigrid Elsenbruch
Summary: The role of psychological factors in chronic visceral pain and its treatment is important. Negative expectations have a significant impact on treatment and pain responses, but their effects in the context of visceral pain have been rarely studied. Experimental research can provide insights into the effects of negative expectations in both visceral and somatic pain modalities.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Ning-Ning Ji, Lei Du, Ying Wang, Ke Wu, Zi-Yang Chen, Rong Hua, Yong-Mei Zhang
Summary: Visceral hypersensitivity in irritable bowel syndrome is associated with the downregulation of membrane SK2 in the hypothalamic paraventricular nucleus. Activation of SK2 may alleviate visceral hypersensitivity, suggesting SK2 activators as a potential intervention for visceral pain.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Anesthesiology
Timothy J. Brennan, Richard C. Lennertz, Sinyoung Kang
Review
Clinical Neurology
Debra B. Gordon, Oscar A. de Leon-Casasola, Christopher L. Wu, Kathleen A. Sluka, Timothy J. Brennan, Roger Chou
Article
Clinical Neurology
Roger Chou, Debra B. Gordon, Oscar A. de Leon-Casasola, Jack M. Rosenberg, Stephen Bickler, Tim Brennan, Todd Carter, Carla L. Cassidy, Eva Hall Chittenden, Ernest Degenhardt, Scott Griffith, Renee Manworren, Bill McCarberg, Robert Montgomery, Jamie Murphy, Melissa F. Perkal, Santhanam Suresh, Kathleen Sluka, Scott Strassels, Richard Thirlby, Eugene Viscusi, Gary A. Walco, Lisa Warner, Steven J. Weisman, Christopher L. Wu
Article
Clinical Neurology
Chandan G. Reddy, Brian D. Dalm, Oliver E. Flouty, George T. Gillies, Matthew A. Howard, Timothy J. Brennan
WORLD NEUROSURGERY
(2016)
Article
Clinical Neurology
Michael L. Kent, Patrick J. Tighe, Inna Belfer, Timothy J. Brennan, Stephen Bruehl, Chad M. Brummett, Chester C. Buckenmaier, Asokumar Buvanendran, Robert I. Cohen, Paul Desjardins, David Edwards, Roger Fillingim, Jennifer Gewandter, Debra B. Gordon, Robert W. Hurler, Henrik Kehlet, John D. Loeser, Sean Mackey, Samuel A. McLean, Rosemary Polomano, Siamak Rahman, Srinivasa Raja, Michael Rowbotham, Santhanam Suresh, Bernard Schachte, Kristin Schreiber, Mark Schumacher, Brett Staceyi, Steven Stanos, Knox Todd, Dennis C. Turk, Steven J. Weisman, Christopher Wu, Daniel B. Carr, Robert H. Dworkin, Gregory Terman
Review
Anesthesiology
Michael L. Kent, Patrick J. Tighe, Inna Belfer, Timothy J. Brennan, Stephen Bruehl, Chad M. Brummett, Chester C. Buckenmaier, Asokumar Buvanendran, Robert I. Cohen, Paul Desjardins, David Edwards, Roger Fillingim, Jennifer Gewandter, Debra B. Gordon, Robert W. Hurley, Henrik Kehlet, John D. Loeser, Sean Mackey, Samuel A. McLean, Rosemary Polomano, Siamak Rahman, Srinivasa Raja, Michael Rowbotham, Santhanam Suresh, Bernard Schachtel, Kristin Schreiber, Mark Schumacher, Brett Stacey, Steven Stanos, Knox Todd, Dennis C. Turk, Steven J. Weisman, Christopher Wu, Daniel B. Carr, Robert H. Dworkin, Gregory Terman
Article
Multidisciplinary Sciences
Daisuke Sugiyama, Sinyoung Kang, Timothy J. Brennan
Letter
Respiratory System
Emine Ozgur Bayman, Kalpaj R. Parekh, John Keech, Timothy J. Brennan
JOURNAL OF THORACIC DISEASE
(2017)
Letter
Respiratory System
Emine Ozgur Bayman, Kalpaj R. Parekh, John Keech, Timothy J. Brennan
JOURNAL OF THORACIC DISEASE
(2017)
Letter
Anesthesiology
Emine Ozgur Bayman, Timothy J. Brennan
Article
Clinical Neurology
Chandan G. Reddy, John W. Miller, Kingsley O. Abode-Iyamah, Sina Safayi, Saul Wilson, Brian D. Dalm, Douglas C. Fredericks, George T. Gillies, Matthew A. Howard, Timothy J. Brennan
JOURNAL OF PAIN RESEARCH
(2018)
Review
Health Care Sciences & Services
Daenis Camire, Jason Erb, Henrik Kehlet, Timothy Brennan, Ian Gilron
JMIR RESEARCH PROTOCOLS
(2020)
Article
Anesthesiology
Daisuke Sugiyama, Sinyoung Kang, Nicholas Arpey, Preeyaphan Arunakul, Yuriy M. Usachev, Timothy J. Brennan
Article
Anesthesiology
Emine Ozgur Bayman, Kalpaj R. Parekh, John Keech, Atakan Selte, Timothy J. Brennan
Review
Anesthesiology
Emine O. Bayman, Richard Lennertz, Timothy J. Brennan