Article
Medicine, General & Internal
Jerome Rambaud, Masoumeh Sajedi, Sally Al Omar, Maryline Chomtom, Michael Sauthier, Simon De Montigny, Philippe Jouvet
Summary: The objective of this study was to develop a predictive model for early diagnosis of ventilator-associated pneumonia (VAP) in a pediatric intensive care unit. Using machine learning and clinical data, a clinical decision support algorithm was developed and showed good accuracy in predicting VAP.
Article
Critical Care Medicine
Qiao He, Wen Wang, Shichao Zhu, Mingqi Wang, Yan Kang, Rui Zhang, Kang Zou, Zhiyong Zong, Xin Sun
Summary: Ventilator-associated pneumonia (VAP) is the most common hospital-acquired infection in intensive care units (ICUs), but the adoption of ventilator-associated event (VAE) surveillance outside the USA is limited. A study in China found that VAE was common in ICU patients with >= 4 ventilator days, and all tiers of VAEs were associated with poor clinical outcomes, including longer hospital stays and increased risk of mortality. These findings emphasize the importance of VAE surveillance and the development of new strategies to prevent VAEs.
Article
Dentistry, Oral Surgery & Medicine
F. S. Ludovichetti, A. Zuccon, P. Positello, N. Zerman, A. Gracco, E. Stellini, S. Mazzoleni
Summary: This literature review investigates the potential correlation between ventilator-associated pneumonia and poor oral hygiene in children, and suggests that improving oral hygiene may affect the onset of nosocomial pneumonia in children.
EUROPEAN JOURNAL OF PAEDIATRIC DENTISTRY
(2022)
Article
Pharmacology & Pharmacy
Luming Zhang, Shaojin Li, Xuehao Lu, Yu Liu, Yinlong Ren, Tao Huang, Jun Lyu, Haiyan Yin
Summary: The study demonstrated that thiamine supplementation may reduce ICU and in-hospital mortality in patients with VAP, suggesting that further clinical trials should be conducted to provide more-solid evidence on its efficacy in improving patient outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Alex R. Schuurman, Robert F. J. Kullberg, Willem Joost Wiersinga
Summary: There has been significant progress in understanding the gut microbiome in health and disease over the past decade. The gut microbiome interacts with the immune system and plays a crucial role in defending the host against pathogens. However, disturbances in the gut microbiome due to disease or interventions like antibiotic treatment can have negative consequences. This review focuses on the potential role of probiotics in the ICU, summarizes evidence from randomized clinical trials, and discusses challenges and future prospects.
Review
Respiratory System
Basem Al-Omari, Peter McMeekin, A. Joy Allen, Ahsan R. Akram, Sara Graziadio, Jana Suklan, William S. Jones, B. Clare Lendrem, Amanda Winter, Milo Cullinan, Joanne Gray, Kevin Dhaliwal, Timothy S. Walsh, Thomas H. Craven
Summary: In VAP research, reference standards typically require microbiological confirmation, with BAL culture being the most commonly used reference standard.
BMC PULMONARY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sheng-Huei Wang, Kuang-Yao Yang, Chau-Chyun Sheu, Yu-Chao Lin, Ming-Cheng Chan, Jia-Yih Feng, Chia-Min Chen, Chih-Yu Chen, Zhe-Rong Zheng, Yu-Ching Chou, Chung-Kan Peng
Summary: This study investigated the prevalence of CSO AB pneumonia and compared the presentation and outcome with CRAB-associated pneumonia. The prevalence of CSO AB among CRAB pneumonia cases was 13.74%. CSO AB and CRAB groups had similar demographic characteristics and disease severities at initial presentation, but CSO AB group had better clinical outcomes at day 7 with longer ICU stay.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Anne-Sophie Valentin, Sandra Dos Santos, Florent Goube, Remi Gimenes, Marie Decalonne, Laurent Mereghetti, Come Daniau, Nathalie van der Mee-Marquet
Summary: The study evaluated the incidence of sink contamination by MDR bacteria and its association with clinical infections in intensive care units. It found that sink contamination and splashing are common and multifactorial infectious risks.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Pharmacology & Pharmacy
Luming Zhang, Shaojin Li, Shiqi Yuan, Xuehao Lu, Jieyao Li, Yu Liu, Tao Huang, Jun Lyu, Haiyan Yin
Summary: Bronchoscopy during invasive mechanical ventilation (IMV) was found to reduce the risk of ICU and in-hospital mortality in patients with ventilator-associated pneumonia (VAP), and this beneficial effect was partially mediated by changes in red blood cell distribution width (RDW) levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Piyali Bhattacharya, Arvind Kumar, Sanat Kumar Ghosh, Sudesh Kumar
Summary: This study aimed to determine the microbiological profile, associated risk factors, and outcome of ventilator-associated pneumonia (VAP) in children. The study found that VAP was associated with prolonged duration of mechanical ventilation, PICU stay, and hospital stay, but not significantly associated with mortality. Gram-negative bacteria were found to be the most common causative organisms in this cohort.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Health Care Sciences & Services
Ralitsa Raycheva, Vanya Rangelova, Ani Kevorkyan
Summary: This study aims to assess the direct costs of ventilator-associated pneumonia (VAP) in the neonatal intensive care unit (NICU). The findings confirm that prolonged hospital stays due to VAP result in increased hospital costs.
Article
Infectious Diseases
Alain Lepape, Anais Machut, Cedric Bretonniere, Arnaud Friggeri, Charles-Herve Vacheron, Anne Savey
Summary: This study compared healthcare-associated infections acquired in intensive care units (HAI-ICUs) among patients with and without COVID-19 in France in 2020, and compared them with patients before the COVID-19 pandemic. The results showed that the occurrence of ventilator-associated pneumonia (VAP) was significantly higher in the COVID-19 group, and VAP and blood-stream infections (BSIs) were also higher in the non-COVID-19 group compared to the pre-pandemic group. This suggests that managing patients with severe disease during a pandemic carries risks for all patients.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Anesthesiology
Michael Mazzeffi, Samuel Galvagno, Clare Rock
Summary: Healthcare-associated infections are a major concern for intensive care unit patients, and understanding evidence-based prevention strategies is crucial for optimizing patient outcomes.
Article
Medicine, General & Internal
Sahbanathul Missiriya Jalal, Ahmed Mansour Alrajeh, Jumanah Abdullah Ali Al-Abdulwahed
Summary: This study assessed the performance of medical professionals in preventing ventilator-associated pneumonia (VAP) and found that some of them had inadequate knowledge. While some medical professionals showed satisfactory performance in preventive measures, there is still room for improvement in healthcare quality and reducing the incidence rate.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Infectious Diseases
Wenjuan Luo, Rui Xing, Canmin Wang
Summary: This study found that ICU patients with VAP had a higher 90-day mortality rate of 33.33% and a 180-day mortality rate of 37.62%, compared to non-VAP patients. After adjusting for confounders, the risk of 90-day and 180-day mortalities in VAP patients were 1.465 times and 1.635 times higher than those in non-VAP patients, respectively. These results suggest that VAP negatively impacts the prognosis of ICU patients.
BMC INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Marco Zampoli, Janine Verstraete, Thao Nguyen-Khoa, Isabelle Sermet-Gaudelus, Heather J. Zar, Tanja Gonska, Brenda M. Morrow
Summary: This study investigated the utility of beta-adrenergic sweat test to exclude cystic fibrosis (CF) in children with inconclusive diagnosis. The results showed that beta-adrenergic sweat test is more accurate than sweat chloride tests (SCT) for excluding CF in children. The study also highlighted the need for age-specific reference ranges for beta-adrenergic sweat test due to differences in sweat secretion between children and adults.
PEDIATRIC PULMONOLOGY
(2023)
Article
Critical Care Medicine
Stacey L. Valentine, Sapna R. Kudchadkar, Shan Ward, Brenda M. Morrow, Vinay M. Nadkarni, Martha A. Q. Curley
Summary: This article provides an updated review of nonpulmonary treatments for pediatric acute respiratory distress syndrome (PARDS) and generates clinical practice recommendations, good practice statements, and research statements to optimize and standardize care for PARDS patients and identify areas for further investigation.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Courtney M. Rowan, Adrienne G. Randolph, Narayan Prabhu Iyer, Steven Kwasi Korang, Martin C. J. Kneyber
Summary: This article provides an updated review of pulmonary-specific ancillary therapies for pediatric acute respiratory distress syndrome (PARDS) to update the recommendations and statements on clinical practice and research. The evidence for these specific therapies remains low, and further investigation is needed to understand their role in PARDS.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Analia Fernandez, Vicent Modesto, Peter C. Rimensberger, Steven K. Korang, Narayan P. Iyer, Ira M. Cheifetz
Summary: This study aims to provide evidence and recommendations for invasive mechanical ventilation support of patients with pediatric acute respiratory distress syndrome (PARDS). Through the analysis of pediatric and adult acute respiratory distress syndrome literature, recommendations and guidelines for mechanical ventilation in pediatric patients were developed. However, further research is needed due to the limited pediatric data available for the management of PARDS patients requiring invasive mechanical ventilation.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Jocelyn K. Grunwell, Mary Dahmer, Anil W. Sapru, Michael Quasney, Heidi Flori
Summary: This article reviews studies on the pathobiology, severity, and risk stratification of pediatric acute respiratory distress syndrome (PARDS) in children, aiming to guide current medical practice and identify important areas for future research. A comprehensive literature search was conducted, and relevant evidence was summarized and used to develop clinical recommendations. The findings include one clinical recommendation and six research statements related to risk stratification and characterization of PARDS severity.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Narayan Iyer, Robinder Khemani, Guillaume Emeriaud, Yolanda. M. Lopez-Fernandez, Steven Kwasi Korang, Katherine M. Steffen, Ryan. P. Barbaro, Melania. M. Bembea
Summary: This article presents the methodology used for The Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) which aimed to develop evidence-based clinical recommendations and expert-based consensus statements for pediatric acute respiratory distress syndrome (PARDS). Electronic searches were conducted and data extraction was done using a standardized form. The conference involved a multidisciplinary group of international experts and utilized the GRADE system and appropriateness method. The findings were disseminated through primary and supplemental publications.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Guillaume Emeriaud, Yolanda Lopez-Fernandez, Narayan Prabhu Iyer, Melania M. Bembea, Asya Agulnik, Ryan P. Barbaro, Florent Baudin, Anoopindar Bhalla, Werther Brunow de Carvalho, Christopher L. Carroll, Ira M. Cheifetz, Mohammod J. Chisti, Pablo Cruces, Martha A. Q. Curley, Mary K. Dahmer, Heidi J. Dalton, Simon J. Erickson, Sandrine Essouri, Analia Fernandez, Heidi R. Flori, Jocelyn R. Grunwell, Philippe Jouvet, Elizabeth Y. Killien, Martin C. J. Kneyber, Sapna R. Kudchadkar, Steven Kwasi Korang, Jan Hau Lee, Duncan J. Macrae, Aline Maddux, Vicent M. Alapont, Brenda M. Morrow, Vinay M. Nadkarni, Natalie Napolitano, Christopher J. L. Newth, Marti Pons-Odena, Michael W. Quasney, Prakadeshwari Rajapreyar, Jerome Rambaud, Adrienne G. Randolph, Peter Rimensberger, Courtney M. Rowan, L. Nelson Sanchez-Pinto, Anil Sapru, Michael Sauthier, Steve L. Shein, Lincoln S. Smith, Katerine Steffen, Muneyuki Takeuchi, Neal J. Thomas, Sze Man Tse, Stacey Valentine, Shan Ward, R. Scott Watson, Nadir Yehya, Jerry J. Zimmerman, Robinder G. Khemani
Summary: This study is an international consensus conference aiming to update the guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and previously unaddressed topics. The study involved 11 subgroups addressing 11 topic areas, resulting in 146 recommendations and statements that will facilitate the implementation and adherence to the best clinical practice.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Brenda Morrow, Asya Agulnik, Werther Brunow de Carvalho, Mohammod Jobayer Chisti, Jan Hau Lee
Summary: This study conducted a review to optimize the recognition of pediatric acute respiratory distress syndrome (PARDS) in resource-limited settings (RLS) and provided recommendations for clinical practice and future research in these settings. The study found that PARDS remains poorly described in RLS and future studies are urgently needed to describe the epidemiology, management, and outcomes of PARDS in RLS.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Christopher L. Carroll, Natalie Napolitano, Marti Pons-Odena, Narayan Prabhu Iyer, Steven Kwasi Korang, Sandrine Essouri
Summary: This study developed evidence-based recommendations for the effectiveness of noninvasive respiratory support for pediatric acute respiratory distress syndrome (PARDS), including considerations of timing, duration, disease severity, and treatment delivery. The study found that noninvasive ventilation (NIV) is widely used for respiratory failure in children and may be beneficial for some patients with PARDS, but close monitoring is required for worsening disease and NIV failure.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Nadir Yehya, Lincoln J. Smith, Neal J. M. Thomas, Katherine M. Steffen, Jerry Zimmerman, Jan Hau J. Lee, Simon J. L. Erickson, Steven L. Shein
Summary: This article presents the revisions of the definitions for Pediatric Acute Respiratory Distress Syndrome (PARDS) made during the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2). Through the assessment of a large number of research data, 17 consensus-based definition statements were generated to update the definitions of PARDS, Possible PARDS, and At-Risk for PARDS.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
L. Nelson Sanchez-Pinto, Michael Sauthier, Prakadeshwari Rajapreyar, Werther Brunow de Carvalho, Philippe Jouvet, Christopher Newth
Summary: This study aims to summarize the relevant evidence on clinical informatics interventions in pediatric and adult respiratory distress syndrome (ARDS) and generate recommendations and statements based on expert consensus. The use of electronic algorithms and clinical informatics tools can significantly improve patient outcomes in PARDS.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Review
Critical Care Medicine
David J. Zorko, James Dayre McNally, Bram Rochwerg, Neethi Pinto, Katie O'Hearn, Mohammed A. Almazyad, Stefanie G. Ames, Peter Brooke, Florence Cayouette, Cristelle Chow, Jose Colleti Junior, Conall Francoeur, Julia A. Heneghan, Yasser M. Kazzaz, Elizabeth Y. Killien, Supun Kotteduwa Jayawarden, Ruben Lasso, Laurie A. Lee, Aoife O'Mahony, Mallory A. Perry, Miguel Rodriguez-Rubio, Ryan Sandarage, Hazel A. Smith, Alexandra Welten, Belinda Yee, Karen Choong
Summary: The study aims to evaluate the existing literature for case definitions of pediatric chronic critical illness (CCI) and prolonged pediatric intensive care unit (PICU) admission, and explore the methodologies used to derive these definitions. It was found that the definitions of CCI often include concepts such as PICU length of stay, medical complexity or chronic conditions, recurrent admissions, technology dependence, and uncertain prognosis. The definitions for prolonged PICU admission are commonly based on investigator opinion or statistical method, with durations of greater than or equal to 14 or 28 days. A consensus definition is needed to advance research in this important area of pediatric critical care.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Peta M. A. Alexander, Rebecca A. Aslakson, Erin F. Barreto, Jan Hau Lee, Heather Meissen, Brenda M. Morrow, Lama Nazer, Richard D. Branson, Kirby P. Mayer, Natalie Napolitano, Meghan B. Lane-Fall, Andrea Sikora, Preeti R. John, R. Phillip Dellinger, Margaret Parker, Andrew Argent, Adjoa Boateng, Thomas P. Green, Sapna R. Kudchadkar, David M. Maslove, Megan A. Rech, Lauren R. Sorce, Robert C. Tasker, Timothy G. Buchman, Paul A. Checchia
Summary: The SCCM Reviewer Academy aims to establish a community of skilled peer reviewers with diverse backgrounds and promote high-quality reviews in SCCM journals. The goals include providing accessible resources, educating and mentoring healthcare professionals, and upholding standards for insightful reviews. This manuscript will summarize the mission of the Academy, discuss the importance of peer review, review process, and ethical standards for reviewers, and inspire readers to integrate medical journalism into their careers.
CRITICAL CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Marco Zampoli, Janine Verstraete, Cathy Baird, Greg Calligaro, Brenda Morrow
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Pediatrics
Adewale Adetunji, Priya Gajjar, Valerie Luyckx, Deveshni Reddy, Peter Nourse, Ashton Coetzee, Nicole Collison, Theresa Abdo, Taryn Pienaar, Christel Du Buisson, Jonathan Buckley, Brenda Morrow, Mignon McCulloch
PEDIATRIC TRANSPLANTATION
(2023)
