Article
Biochemistry & Molecular Biology
Fumi Seshima, Takahiro Bizenjima, Hideto Aoki, Kentaro Imamura, Daichi Kita, Daisuke Irokawa, Daisuke Matsugami, Yurie Kitamura, Keiko Yamashita, Hiroki Sugito, Sachiyo Tomita, Atsushi Saito
Summary: This study evaluated the long-term outcomes of using recombinant human fibroblast growth factor (rhFGF)-2 with or without deproteinized bovine bone mineral (DBBM) for treating periodontal intrabony defects. The results showed that the combination therapy significantly enhanced radiographic bone fill (RBF) and both treatments had favorable clinical and patient-reported outcomes.
Article
Chemistry, Multidisciplinary
Bingjin Wang, Gaocai Li, Qianqian Zhu, Weifang Liu, Wencan Ke, Wenbin Hua, Yiming Zhou, Xianlin Zeng, Xuhui Sun, Zhen Wen, Cao Yang, Yue Pan
Summary: In this study, a wearable pulsed triboelectric nanogenerator (WP-TENG) driven by human body movement was used to achieve bone repair. The study demonstrated that the triboelectric stimulation via mechanosensitive ion channel Piezo1 can rejuvenate aged bone marrow mesenchymal stem cells (BMSCs) and enhance their osteogenesis potential. Furthermore, the study showed that the triboelectric stimulation can also promote the angiogenesis of human umbilical vein endothelial cells (HUVECs). This research provides a potential mechanism for rejuvenating aged BMSCs and a theoretical basis for bone regeneration using triboelectric stimulation.
Review
Chemistry, Multidisciplinary
Antonio Mazzotti, Laura Langone, Elena Artioli, Simone Ottavio Zielli, Alberto Arceri, Stefania Setti, Massimiliano Leigheb, Elena Manuela Samaila, Cesare Faldini
Summary: Foot and ankle injuries are common in sports, and one of the main challenges is the time it takes for athletes to resume playing after trauma. Pulsed electromagnetic fields (PEMFs) have been listed as a conservative treatment option to speed up the recovery process and prevent joint degeneration. This review outlines the current applications of PEMFs in foot and ankle sport-related injuries, specifically in treating bone marrow edema, osteochondral defects, fractures, and nonunions. Despite the need for further high-quality studies, PEMFs appear to be a valid aid in promoting bone healing, resolving bone marrow edema, reducing joint inflammation, preserving articular cartilage, and relieving pain.
APPLIED SCIENCES-BASEL
(2023)
Review
Clinical Neurology
Brian Fiani, Athanasios Kondilis, Juliana Runnels, Preston Rippe, Cyrus Davati
Summary: The growth of pulsed electromagnetic field (PEMF) therapy has had a revolutionary effect on bone tissue proliferation and vascular flow in post-operative bone growth. Despite proven effectiveness in stimulating fusion rates in postoperative spinal surgery, patient compliance is challenging due to factors such as extended treatment time and cost. Advancements in PEMF device development are making treatment more affordable and accessible, leading to increased recovery rates and greater treatment options for patients.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2021)
Article
Biotechnology & Applied Microbiology
Jie Zhou, Yanlin Zhu, Dongqing Ai, Mengjiao Zhou, Han Li, Yiru Fu, Jinlin Song
Summary: Low-intensity pulsed ultrasound (LIPUS) can improve orthodontic tooth movement and alveolar bone remodeling by promoting the interaction between osteoblasts and osteoclasts, thus enhancing the effectiveness of orthodontic treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Anatomy & Morphology
Jiao Li, Yang Lv, Haoyu Wang, Yang Liu, Junxu Ren, Haiping Wang
Summary: By using lentivirus-mediated FGF-2 gene transfection, the differentiation of rat BMSCs into cardiomyocyte-like cells was enhanced, with higher expression levels of cardiac differentiation markers, and specific features observed in the nucleus and cytoplasm.
Article
Cell & Tissue Engineering
Luis Fernandez de Castro, Brian J. Sworder, Byron Mui, Kathryn Futrega, Agnes Berendsen, Matthew D. Phillips, Nathan J. Burbach, Natasha Cherman, Sergei Kuznetsov, Yankel Gabet, Kenn Holmbeck, Pamela G. Robey
Summary: The role of SFRP2 in bone marrow stromal cells remains unclear, but deficiency of Sfrp2 may impair skeletal growth and regeneration, affecting the function and self-renewal of bone cells.
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and lower BV/TV. The new BMA parameter Ad.N/BS is correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and with lower BV/TV. A new BMA parameter, Ad.N/BS, is positively correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while that of metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Immunology
Shikha Shrivastava, Joshua M. Carmen, Zhongyan Lu, Shraddha Basu, Rajeshwer S. Sankhala, Wei-Hung Chen, Phuong Nguyen, William C. Chang, Jocelyn King, Courtney Corbitt, Sandra Mayer, Jessica S. Bolton, Alexander Anderson, Isabella Swafford, Guillermo D. Terriquez, Hung V. Trinh, Jiae Kim, Ousman Jobe, Dominic Paquin-Proulx, Gary R. Matyas, Gregory D. Gromowski, Jeffrey R. Currier, Elke Bergmann-Leitner, Kayvon Modjarrad, Nelson L. Michael, M. Gordon Joyce, Allison M. W. Malloy, Mangala Rao
Summary: This study demonstrates the impact of adjuvants on the development of Tfh and B cells, and their influence on antibody responses in mice vaccinated with SpFN adjuvanted with either ALFQ or AH. ALFQ vaccination resulted in increased size and frequency of GC B cells, higher frequency of IL-21-producing Tfh and GC B cells, and elicitation of robust cross-neutralizing antibodies against SARS-CoV-2 variants. No cross-neutralizing antibodies against Omicron were induced with AH. These findings highlight the importance of ALFQ in orchestrating early induction of antigen-specific Tfh and GC B cell responses and long-lived plasma cells in the bone marrow.
Article
Acoustics
Yunji Wang, Jie Li, Jianpin Zhou, Ye Qiu, Jinlin Song
Summary: Through experimental research, it was found that the combination therapy of low-intensity pulsed ultrasound (LIPUS) and bone marrow stromal cells (BMSCs) can enhance alveolar bone regeneration in periodontal diseases, achieving better therapeutic effects.
Article
Biochemistry & Molecular Biology
Dan Ma, Ping Liu, Chujiao Hu, Zhen Zhou, Ping Wang, Yan Wang, Yaming Zhang, Yunsheng Ran, Pinghao Li, Jiangyuan Zhao, Jishi Wang, Chengliang Zhang, Lei Tang
Summary: This study revealed the important role of intracellular angiopoietin-1 (ANG-1) overexpression in drug resistance of chronic myeloid leukemia (CML), which promotes CML cell resistance through activation of the JAK/STAT pathway and enhancement of STAT5a phosphorylation. Therefore, intracellular ANG-1 may serve as a potential strategy for overcoming CML resistance.
Article
Multidisciplinary Sciences
Kang-Moon Song, Woo Jean Kim, Min-Ji Choi, Ki-Dong Kwon, Anita Limanjaya, Kalyan Ghatak, Jiyeon Ock, Guo Nan Yin, Yasufumi Sato, Soon-Sun Hong, Ji-Kan Ryu, Jun-Kyu Suh
Summary: The study demonstrates the important role of VASH1 in diabetic erectile dysfunction, showing that it can restore erectile function by inducing angiogenic factors.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Antigona Ulndreaj, Angela Li, Yonghong Chen, Rickvinder Besla, Shaun Pacheco, Marwan G. Althagafi, Myron I. Cybulsky, Thomas Lindsay, Clinton S. Robbins, John S. Byrne
Summary: The study found that aortic macrophage accumulation in abdominal aortic aneurysm (AAA) is primarily caused by adventitial recruitment of Lyve-1(-) macrophages, with a relative depletion of Lyve-1(+) macrophages. Selective targeting of macrophage subtypes may represent a potential novel therapeutic avenue for the medical treatment of AAA.
Article
Clinical Neurology
Antonio Uccelli, Alice Laroni, Rehiana Ali, Mario Alberto Battaglia, Morten Blinkenberg, Lou Brundin, Michel Clanet, Oscar Fernandez, James Marriot, Paolo Muraro, Seyed Massood Nabavi, Roberto S. Oliveri, Ernst Radue, Cristina Ramo Tello, Irene Schiavetti, Johann Sellner, Per Soelberg Sorensen, Maria Pia Sormani, Jens Thomas Wuerfel, Mark S. Freedman
Summary: The MESEMS study aimed to evaluate the safety and activity of autologous bone marrow-derived MSCs in patients with active multiple sclerosis. The results showed that MSC treatment did not affect GELs and does not support its use in treating multiple sclerosis.