Article
Multidisciplinary Sciences
Youqiang Sun, Mengmeng Liang, Yuemeng Xing, Yinfan Duan, Shuangxiao Zhang, Baogui Deng, Xiaobing Xiang, Bengen Zhou
Summary: Cyasterone alleviates apoptosis of rat BMSCs induced by Dexamethasone through the PI3K/AKT signaling pathway and promotes bone repair in SIONFH rats by reducing the percentage of empty bone lacunae.
Article
Biochemistry & Molecular Biology
Xin Jiang, Wenjing Chen, Hang Su, Fuguo Shen, Wenlong Xiao, Wencai Sun
Summary: The study demonstrates that puerarin promotes osteogenesis in steroid-induced necrosis of the femoral head by upregulating miR-34a, improving osteoblast viability and differentiation. Puerarin attenuates the inhibitory effects of dexamethasone on bone formation, indicating its potential therapeutic value in treating SONFH.
Article
Endocrinology & Metabolism
Wei Zhu, Faxue Zhang, Junjie Lu, Chen Ma, Lin Shen, Desheng Hu, Xiaojuan Xu, Bo Shuai
Summary: This study aimed to investigate the differential expression of exosomal miRNAs in the bone marrow tissue of Modified Qing' E Formula (MQEF) in a steroid-induced ischemic necrosis of the femoral head (INFH) model. The results showed that MQEF can regulate the expression of these exosomal miRNAs, and miR-185-3p and miR-129b-5p/PI3K-Akt signal axis may be part of the mechanism of MQEF against steroid-induced INFH.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Chemistry, Medicinal
Shenqi Zhang, Chengbin Wang, Lei Shi, Qingyun Xue
Summary: The recent global outbreak of COVID-19 has raised important questions regarding the use of corticosteroid therapy, dosage, and duration, as well as prevention, early detection, and timely intervention of SANFH. Due to possible biases in the data selection and lack of large-scale research data support, more studies are needed to establish the gold standard for these issues.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Zhai Sheng, Han Xiaoping, Ding Lu, Wang XiZhe, Zhang Jie, Lv Qing, Cui Yong
Summary: SINFH is a femoral head necrotic disease caused by prolonged use of hormones. Dysfunction modules in the study focused on aspects such as circulation, gland development, bone development and reconstruction, calcium production, and fatty acid metabolism regulation. Zinc and adenosine monophosphate were identified as potential drug targets for SINFH dysfunction, which is closely related to bone development and reconstruction.
Article
Oncology
Ning Yang, Hongzhi Wang, Weicheng Zhang, Houyi Sun, Meng Li, Yaozeng Xu, Lixin Huang, Dechun Geng
Summary: Transcriptome and proteome studies revealed significant differences in DEGs and DEPs between Control and FHN groups. DEGs were mainly involved in the PI3K-Akt pathway, while DEPs were mainly focused on the glycolysis/gluconeogenesis pathway. SERPINE2, STMN1, and other genes/proteins were identified as key players in the pathogenesis of FHN, affecting cell viability and apoptosis.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Orthopedics
Masahiro Maruyama, Tzuhua Lin, Nicolas I. Kaminow, Timothy Thio, Hunter W. Storaci, Chi-Chun Pan, Zhenyu Yao, Michiaki Takagi, Stuart B. Goodman, Yunzhi P. Yang
Summary: This study evaluated the efficacy of core decompression for steroid-associated osteonecrosis of the femoral head in rabbits. The results showed that core decompression improved morphological properties but did not significantly improve mechanical strength in the femoral head at early-stage osteonecrosis. Additional biological and mechanical strategies may be needed to enhance the outcomes of early-stage steroid-associated osteonecrosis.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Cell Biology
Yuhao Liu, Liang Mo, Hongduo Lu, Yangwenxiang Wei, Jiahao Zhang, Samuel Bennett, Jiake Xu, Chi Zhou, Bin Fang, Zhenqiu Chen
Summary: This study demonstrates that Dragon's Blood resin has potent anti-inflammatory, antioxidant, and angiogenic properties, which can effectively alleviate steroid-induced osteonecrosis of the femoral head. The resin inhibits osteoclastogenesis and reduces reactive oxygen species (ROS) generation by modulating specific gene and protein expression. In vivo experiments further confirm its curative impacts on osteoclast and ROS activities in a rat model of SIONFH.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Veterinary Sciences
Kaiyi Pang, Shujie Wang, Meng Li, Zhenlei Zhou
Summary: This study investigated the effects of MP and 3-MA on chondrocyte autophagy and bone quality in broilers, revealing that autophagy may play a role in MP-induced femoral head necrosis in broilers.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Cell Biology
Jiahe Liu, Chenzhi Li, Fan Yang, Minde Li, Baolin Wu, Haojie Chen, Shaopeng Li, Xiuzhi Zhang, Jiahui Yang, Yan Xia, Mingjian Wu, Yancheng Li, Baoyi Liu, Dewei Zhao
Summary: This study aimed to establish a new mouse model of osteonecrosis using angiotensin II combined with asparaginase and dexamethasone, and to study the effects of this drug combination on femoral head osteonecrosis in mice. The results showed that this drug combination can significantly promote necrosis of the femoral head and disrupt the local blood supply.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kai Nan, Jun-peng Pei, Li-hong Fan, Yuan-kai Zhang, Xin Zhang, Kang Liu, Zhi-bin Shi, Xiao-qian Dang, Kun-zheng Wang
Summary: Resveratrol can reverse abnormal osteogenesis/osteoclastogenesis activity by upregulating miR-146a and stabilizing osteogenesis/osteoclastogenesis homeostasis through Wnt/FOXO and Sirt1/NF-κB pathways.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Immunology
Hongduo Lu, Yinuo Fan, Qian Yan, Zhiwen Chen, Zhiming Wei, Yuhao Liu, Jiahao Zhang, Zeqing Huang, Hanjun Fang, Chi Zhou, Zhenqiu Chen
Summary: This study identified and validated hub genes related to ferroptosis and investigated the correlation between these genes and immune cell infiltration in steroid-induced osteonecrosis of the femoral head (SIONFH).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ping Zhao, Shuai Zhao, Jiaqi Zhang, Manlin Lai, Litao Sun, Fei Yan
Summary: This study developed an ultrasound molecular imaging (UMI) approach for early diagnosis of osteonecrosis of the femoral head (ONFH) by detecting the expression of integrin alpha(v)beta(3). In rat models, targeted microbubbles were used for in vivo molecular imaging and showed significantly higher UMI signals in 3-week and 5-week SIONFH rats compared to non-targeted microbubbles.
Article
Biochemistry & Molecular Biology
Boyu Tang, Yu Chen, Pei Zhao, Wenlong Yan, Xiao Huang, Weiqian Jiang, Mingjie Sun, Hongrui Zhang, Dulei Xiang, Tingmei Chen, Chengjie Lian, Jian Zhang
Summary: This study revealed that cellular senescence is a major cause of imbalanced differentiation of bone marrow mesenchymal stem cells (BMSCs) and the progression of steroid-induced osteonecrosis of the femoral head (SONFH). MiR-601 and SIRT1 were identified to play important roles in BMSCs senescence, and metformin was shown to alleviate BMSCs senescence and SONFH progression. These findings provide a new perspective for the prevention and treatment of SONFH.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Orthopedics
Tingwen Cai, Siyuan Chen, Chenghu Wu, Chao Lou, Weidan Wang, Chihao Lin, Hongyi Jiang, Xinxian Xu
Summary: EPO can alleviate SANFH by inhibiting the STAT1-caspase 3 signaling pathway, suggesting its potential as a treatment option.
BMC MUSCULOSKELETAL DISORDERS
(2023)