Article
Pharmacology & Pharmacy
Huidong Wang, Xiankun Cao, Jiadong Guo, Xiao Yang, Xiaojiang Sun, Zhiyi Fu, An Qin, Yujie Wu, Jie Zhao
Summary: The artificially synthesized compound BNTA has antioxidant and anti-inflammatory properties, and can effectively inhibit the activation and overproliferation of osteoclasts, reducing bone resorption. It may be a potential drug for preventing inflammatory osteolytic bone diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physics, Applied
Shuo Du, Yang Guo, Xin Huang, Chi Sun, Zhaoqian Zhang, Leyong Hu, Ruixuan Zheng, Qinghu Bai, Aizi Jin, Haifang Yang, Yanfeng Zhang, Junjie Li, Changzhi Gu
Summary: Strain engineering is a promising method to adjust the physical properties of semiconductors, and two-dimensional materials are ideal candidates for strain engineered devices. However, traditional strain modulation methods for two-dimensional materials lack consistency, reproducibility, and design flexibility. In this study, a non-contact approach based on photoresist degeneration induced by electron irradiation is presented, which allows for accurate and direct writing of strains in two-dimensional materials.
APPLIED PHYSICS LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Lisa-Marie Wackernagel, Mohsen Abdi Sarabi, Sonke Weinert, Werner Zuschratter, Karin Richter, Klaus Dieter Fischer, Ruediger C. Braun-Dullaeus, Senad Medunjanin
Summary: The NF-κB pathway plays a central role in inflammatory and immune responses, and the activation of NF-κB is dependent on IKK gamma/NEMO. This study reveals that GSK-3 beta phosphorylates NEMO, leading to its localization into multivesicular bodies (MVBs) and endosomes. The AAA-ATPase Vps4A is identified as a key player in NEMO stability and NF-κB activation, interacting directly with phosphorylated NEMO. Manipulation of Vps4A expression results in changes in NEMO expression and NF-κB activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cell Biology
Peter ten Dijke, David Baker
Summary: Editing linear polyubiquitination of protein substrates by LUBAC and OTULIN plays a critical role in immune responses. A recent study reveals how reversible linear polyubiquitination of ALK1 controls developmental angiogenesis and leads to vascular malformations in humans.
TRENDS IN CELL BIOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Zhengrui Zhang, Chittaranjan Das
Summary: The bacterial pathogen Legionella pneumophila has developed various mechanisms to manipulate host ubiquitin signaling. In a recent study, Warren et al. elucidated the structure of the Legionella deubiquitinase LotA and its recognition of K6-polyubiquitination, suggesting its potential as a tool for studying specific types of ubiquitination. Additionally, LotA was found to counteract the recruitment of valosin-containing protein (VCP) to the Legionella-containing vacuole during infection.
TRENDS IN MICROBIOLOGY
(2023)
Article
Immunology
Ruixuan Yu, Yongjian Yuan, Zhicheng Liu, Long Liu, Zhaoning Xu, Yunpeng Zhao, Chunwang Jia, Pengfei Zhang, Hang Li, Yuhao Liu, Yi Wang, Weiwei Li, Lin Nie, Xuecheng Sun, Yuhua Li, Ben Liu, Haichun Liu
Summary: The study found that selenium methionine (Se-Met) has inhibitory effects on titanium particle-induced osteolysis, possibly by regulating ROS-dependent NLRP3 inflammasome activation and the beta-catenin signaling pathway to alleviate inflammation. These findings suggest that Se-Met may serve as a potential therapeutic agent for treating titanium particle-induced osteolysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
T. Holm-Glad, M. Rokkum, S. M. Rohrl, S. Roness, K. Godang, O. Reigstad
Summary: This study analyzed the short-term outcomes of two types of total wrist arthroplasty and found that both implants provided matched function and stability, but with a high complication rate.
BONE & JOINT JOURNAL
(2022)
Editorial Material
Hematology
Qian-Fei Wang, Hong -Hu Zhu
Summary: In this study, Poplineau et al identified a retinoic acid resistance network involving the E2F-EZH2 axis in a PLZF-RARA transgenic acute promyelocytic leukemia mouse model. They demonstrated that the nonenzymatic activity of EZH2 is crucial for retinoic acid resistance. Targeting the pan-EZH2 activity significantly improved survival in mice reconstituted with retinoic acid-resistant PLZF-RARA leukemia cells.
Article
Pharmacology & Pharmacy
Yue Xing, Jing Ying Wang, Ming Yue Li, Zhi Hong Zhang, Hong Lan Jin, Hong Xiang Zuo, Juan Ma, Xuejun Jin
Summary: The study reveals that convallatoxin inhibits IL-1 beta production by down-regulating ZFP91, thus preventing inappropriate inflammatory responses and maintaining immune homeostasis. This finding provides new insights for the development of convallatoxin as a novel anti-inflammatory drug targeting ZFP91.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xueer Wang, Honghai Zhang, Zhugui Shao, Wanxin Zhuang, Chao Sui, Feng Liu, Xiaorong Chen, Jinxiu Hou, Lingli Kong, Hansen Liu, Yi Zheng, Bingyu Liu, Tian Chen, Lei Zhang, Xinming Jia, Chengjiang Gao
Summary: The study revealed that TRIM31 regulates SYK activation through K27-linked polyubiquitination, promoting its translocation to the plasma membrane and binding with CLRs, while preventing interaction with SHP-1. Deficiency of Trim31 dampens SYK-mediated signaling, leading to impaired immune responses against Candida albicans infection.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Cell Biology
Guixin Zhu, Meenhard Herlyn, Xiaolu Yang
Summary: ERK1 and ERK2, the key mitogenic pathway in mammalian cells, are not only activated by MAPK/ERK kinase, but also modified by K63-linked polyubiquitin chains. TRIM15 and CYLD regulate ERK ubiquitination through different interactions and activities. K63-linked polyubiquitination enhances ERK interaction with and activation by MEK, providing a potential target for cancer therapy.
NATURE CELL BIOLOGY
(2021)
Article
Polymer Science
Rimadani Pratiwi, Vandie Charlie, Nyi Mekar Saptarini, Driyanti Rahayu
Summary: A polymer-based indicator was developed to detect dexamethasone in herbal medicine samples. The indicator strips, made of PMMA polymer and H2SO4 as a reagent, changed color when reacting with dexamethasone. These strips selectively detected dexamethasone with a small detection limit and had good stability.
Article
Cell Biology
Wei Jiang, Xinyu Li, Henan Xu, Xiuling Gu, Shan Li, Li Zhu, Jiao Lu, Xuefeng Duan, Wei Li, Min Fang
Summary: UBL7 is a ubiquitin-like protein that is upregulated during RNA virus infection and induced by type I interferon as an ISG. It enhances innate immune response to viral infection by promoting the K27-linked polyubiquitination of MAVS and interacts with TRIM21 to facilitate the recruitment of TBK1 and enhance the IFN signaling pathway. UBL7 also has a broad-spectrum antiviral function as an immunomodulatory adaptor protein.
Article
Geosciences, Multidisciplinary
Julien Jouanno, Rachid Benshila, Leo Berline, Antonin Soulie, Marie-Helene Radenac, Guillaume Morvan, Frederic Diaz, Julio Sheinbaum, Cristele Chevalier, Thierry Thibaut, Thomas Changeux, Frederic Menard, Sarah Berthet, Olivier Aumont, Christian Ethe, Pierre Nabat, Marc Mallet
Summary: Researchers have developed a modeling framework based on the NEMO ocean model to study the transport and physiology of Sargassum, successfully reproducing and forecasting the seasonal cycle and large-scale distribution of Sargassum biomass.
GEOSCIENTIFIC MODEL DEVELOPMENT
(2021)
Article
Pharmacology & Pharmacy
Linhua Wei, Weiwei Chen, Linke Huang, Hui Wang, Yuangang Su, Jiamin Liang, Haoyu Lian, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: This study explored the effects and mechanism of Alpinetin (Alp) on inflammatory osteolysis. The results showed that Alp suppressed the differentiation and function of osteoclasts, reduced reactive oxygen species production, and inhibited the expression of inflammatory genes. Moreover, Alp inhibited the phosphorylation of specific pathways and minimized LPS-induced osteolysis in mice.
PHARMACOLOGICAL RESEARCH
(2022)