Article
Cell Biology
Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang, Jinsong Wang, Songlin Wang, Junji Xu
Summary: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication in patients with osteoporosis or metastatic bone cancer. The study found that dietary nitrate, abundant in green vegetables, can protect against BRONJ-like lesions in mice. Nitrate intake increased plasma nitric oxide levels, reducing monocyte necrosis and inflammatory cytokine production. The findings suggest that dietary nitrate can inhibit monocyte necroptosis in BRONJ and promote bone remodeling after injury.
CELL PROLIFERATION
(2023)
Article
Medicine, General & Internal
Cheng-Ta Wu, Rio L. C. Lin, Pei-Hsun Sung, Feng-Chih Kuo, Hon-Kan Yip, Mel S. Lee
Summary: This study identified the association between NOS polymorphism and ONFH, as well as its relationship with coagulopathy, which may contribute to a higher risk of bilateral ONFH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Hongyuan Zhang, Zhiqiang Zhao, Shengnan Sun, Sen Zhang, Yuequan Wang, Xuanbo Zhang, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: In this study, the authors developed a self-propelling nano-penetrator assembled with a photothermal photosensitizer and a photothermal-activable NO donor. The nano-penetrator showed advantages in terms of NO productivity and autonomous motion under laser irradiation. In animal models, it successfully navigated to thrombus, penetrated deep into the clot, and achieved effective thrombolysis and prevention of thrombosis recurrence and ischemic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Jung Hun Kim, Quanzhe Liu, Uk-Jae Lee, Arun Kumar Rajendran, Minjoon Cho, Sivashanmugam Amirthalingam, Tae Hoon Kang, Beom Seok Kim, Gyeong-Guk Park, Byung-Gee Kim, Jae Hyup Lee, Nathaniel S. Hwang
Summary: Core decompression is a common surgery for early-stage osteonecrosis of the femoral head. However, there is a lack of bone scaffolds that can reduce oxidative stress and inflammation. We introduce an antioxidant-coated bone scaffold that has shown successful bone regeneration and anti-inflammatory effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Endocrinology & Metabolism
Yidan Hu, Chenyang Lu, Hui Lin
Summary: Glucocorticoids (GCs) are commonly used in autoimmune diseases, but long-term or high-dose usage can lead to severe side effects, such as steroid myopathy and osteonecrosis. This case report describes a pemphigus vulgaris patient who developed muscle weakness and osteonecrosis after a cumulative dose of methylprednisolone. Genotyping showed the patient was sensitive to GCs. Tapering the GC dosage improved the patient's condition.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Physiology
Laura A. Bienvenu, James R. Bell, Kate L. Weeks, Lea M. D. Delbridge, Morag J. Young
Summary: The global burden of ischemic heart disease is increasing for both men and women. The activation of mineralocorticoid receptors exacerbates ischemic damage, while their inhibition can alleviate injury and enhance recovery. The interaction between mineralocorticoid and sex steroid receptors may determine sex-specific outcomes. Developing sex-specific therapies targeting mineralocorticoid receptors could improve ischemic heart disease outcomes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dimitri N. Graf, Anne Thallinger, Veronika Zubler, Reto Sutter
Summary: This study found that intraarticular steroid injections have a lower rate of severe complications compared to previous smaller studies, but the rate of complications in women is disproportionately higher than in men.
Article
Engineering, Biomedical
Maheshika Somarathna, Patrick TJ. Hwang, Reid C. Millican, Grant C. Alexander, Tatyana Isayeva-Waldrop, Jennifer A. Sherwood, Brigitta C. Brott, Isabelle Falzon, Hannah Northrup, Yan-Ting Shiu, Chris J. Stubben, John Totenhagen, Ho-Wook Jun, Timmy Lee
Summary: The study found that nitric oxide plays an important regulatory role in AVF development, but there are currently no effective treatments to prevent AVF maturation failure. By using a self-assembled NO releasing nanomatrix gel, intimal hyperplasia formation can be inhibited, and vascular outward remodeling and hemodynamic adaptation can be improved, thereby enhancing AVF development. This research is crucial for providing long-term and durable vascular access for hemodialysis patients.
Article
Chemistry, Multidisciplinary
Wen Zhou, Wanxiang Yang, Keyu Fan, Wuyang Hua, Shaohua Gou
Summary: In this study, a novel hypoxia-activated NO donor (Hano) was designed and prepared, which can increase NO release, dilate blood vessels, and attenuate myocardial hypoxia injury. This drug shows great potential for the treatment of hypoxic heart diseases.
Article
Chemistry, Multidisciplinary
Jenna L. Gordon, Kristin J. Hinsen, Melissa M. Reynolds, Tyler A. Smith, Haley O. Tucker, Mark A. Brown
Summary: The study found that nitric oxide delivered via S-nitrosoglutathione can exert anti-tumor effects in neuroblastoma, resulting in decreased metabolic activity, reduced clonogenic activity, and lower cell counts and increased dead cell numbers.
Article
Chemistry, Multidisciplinary
Xiao Fang, Shuxian Cai, Min Wang, Zhaowei Chen, Chunhua Lu, Huanghao Yang
Summary: The study introduces a NO-based phototherapeutic strategy for hypoxic tumors using photogenerated holes to oxidize water into H2O2, subsequently producing NO. In vitro and in vivo experiments demonstrated that this strategy induced cancer cell apoptosis, paving the way for the development of NO therapeutic strategies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Anubhuti Sood, Vivek Nayyar, Ajoy Roychoudhury, Ashu Seith Bhalla, Deepika Mishra
Summary: The COVID-19 pandemic has led to the emergence of new variants of SARS-CoV-2 and the development of several post-COVID conditions. This report describes a new post-COVID condition observed in patients who have recently recovered from COVID-19 and have received high dose steroid treatment - spontaneous de novo development of steroid induced avascular necrosis in the jaws. This condition is distinct from previously reported medication-related osteonecrosis of the jaws and further research is needed to understand its features.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Article
Pharmacology & Pharmacy
I Koca, M. Ucar, H. O. Arik, M. Yilmaz, R. Dokuyucu
Summary: This study reveals the protective effect of alpha-lipoic acid on glucocorticoid-induced osteonecrosis in rats by reducing oxidative stress and DNA damage.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Orthopedics
Rio L. C. Lin, Pei-Hsun Sung, Chen-Ta Wu, Yuan-Kun Tu, Yu-Der Lu, Hon-Kan Yip, Mel S. Lee
Summary: This study found that the decreased expression of Ankyrin in bone marrow stem cells (BMSCs) from patients with osteonecrosis of the femoral head (ONFH) is associated with aberrant eNOS signaling, reduced cell proliferation, and osteogenic differentiation potential.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Multidisciplinary Sciences
Jianwen Song, Xiaoying Kang, Lu Wang, Dan Ding, Deling Kong, Wen Li, Ji Qi
Summary: Researchers have developed a polymer nanoplatform for thrombus imaging and treatment in the near-infrared-II region, offering a versatile approach for the diagnosis and treatment of life-threatening diseases caused by thrombotic disorders.
NATURE COMMUNICATIONS
(2023)
Article
Emergency Medicine
Jesse Peek, Valerie Kremo, Reinier Beks, Nicole van Veelen, Alfred Leiser, Bjoern-Christian Link, Roderick M. Houwert, Fabrizio Minervini, Matthias Knobe, Reto H. Babst, Frank J. P. Beeres
Summary: The study aimed to evaluate the long-term quality of life and functional outcome after rib fracture fixation in patients with multiple rib fractures or flail chest, and to identify risk factors associated with quality of life. The findings showed that patients who underwent rib fracture fixation experienced good quality of life at least 1 year after surgery. A longer stay in the intensive care unit was independently associated with impaired quality of life. There were no significant differences in long-term quality of life and functional outcome between patients with multiple rib fractures and flail chest. Implant-related irritation was the most common long-term complication, occurring in one-third of patients.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Review
Emergency Medicine
Bryan J. M. van de Wall, Ralf Baumgartner, R. Marijn Houwert, Bjoern C. Link, Marilyn Heng, Matthias Knobe, Rolf H. H. Groenwold, Reto Babst, Frank J. P. Beeres
Summary: This meta-analysis comparing MIPO with nail fixation for humeral shaft fractures found that MIPO has a lower risk for non-union and re-intervention, and leads to better shoulder and elbow function. The evidence suggests that MIPO should be the preferred treatment of choice, considering the learning curve of minimal-invasive plating.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Emergency Medicine
Bastian Pass, Lukas Nowak, Daphne Eschbach, Ruth Volland, Tom Knauf, Matthias Knobe, Ludwig Oberkircher, Sven Lendemans, Carsten Schoeneberg
Summary: A retrospective registry analysis was conducted on elderly patients undergoing hemiarthroplasty (HA) vs. total hip arthroplasty (THA), finding no significant differences in mortality rate, in-house revision rate and quality of life 7 days postoperatively, but after 120 days, the HA group had lower surgical complications while the THA group had higher rates of independent walking and quality of life.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Emergency Medicine
Robbert Josephus Hendrik van Leeuwen, Bryan Joost Marinus van de Wall, Nicole M. van Veleen, Sandro Hodel, Bjorn-Christian Link, Matthias Knobe, Reto Babst, Frank Joseph Paulus Beeres
Summary: This prospective observational study compared the outcomes of one-stage direct osteosynthesis and two-stage external fixation followed by definitive fixation in complex distal radius fractures. The results showed no significant differences in complications, patient-rated wrist evaluation scores, range of motion, and radiologic parameters between the two groups. It may be concluded that both one- and two-staged surgical techniques are equally effective for treating complex distal radius fractures.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Emergency Medicine
Remy Liechti, Reto Babst, Urs Hug, Bjorn-Christian Link, Bryan J. M. van de Wall, Matthias Knobe, Frank J. P. Beeres
Summary: The study analyzed the outcomes of minimally invasive temporary spanning plate (SP) fixation in complex distal radius fractures (DRFs) and found that the method demonstrated good results in selected patients with complex fractures.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Orthopedics
Matthias Aurich, Mark Lenz, Gunther O. Hofmann, Wiebke Schubert, Matthias Knobe, Klaus Edgar Roth, Paul Simons, Kajetan Klos
Summary: Lateral lengthening calcaneal osteotomy through the sinus tarsi may cause damage to the sustentaculum tali and medial articular facets.
FOOT & ANKLE INTERNATIONAL
(2022)
Article
Orthopedics
Torsten Pastor, Ivan Zderic, Dominic Gehweiler, Michael J. Gardner, Karl Stoffel, Geoff Richards, Matthias Knobe, Boyko Gueorguiev
Summary: In a study using a cadaveric model with low bone quality, nailing trochanteric femoral fractures with helical blades showed similar fixation strength to interlocking dual screws, with significantly greater strength when augmented with bone cement.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Emergency Medicine
Nils Jan Bleeker, Nicole M. van Veelen, Bryan J. M. van de Wall, Inger N. Sierevelt, Bjoern-Christian Link, Reto Babst, Matthias Knobe, Frank J. P. Beeres
Summary: This study compared MIPO and IMN in the treatment of distal extra-articular fractures of the tibia. The results showed that IMN treatment had a higher incidence of non-union, while MIPO treatment increased the risk of infection. Intra-operative alignment control effectively reduced the occurrence of malalignment.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Emergency Medicine
Isabelle R. Buenter, Valerie Kremo, Philipp Schelbert, Nicole M. van Veelen, Nadine Diwersi, Matthias Knobe, Bjoern-Christian Link, Reto Babst, Frank J. P. Beeres, Bryan J. M. van de Wall
Summary: The value of postoperative X-rays after operative treatment for clavicular fractures is questionable. This study shows that in most cases, there is no change in treatment plan based on postoperative X-rays.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Emergency Medicine
Markus Laubach, Felix M. Blaesius, Ruth Volland, Matthias Knobe, Christian D. Weber, Frank Hildebrand, Miguel Pishnamaz
Summary: In geriatric nondisplaced femoral neck fracture patients, hip arthroplasty (HA) was associated with poorer mobility at short-term follow-up compared to internal fixation (IF), but no significant differences were observed in residential status, reoperation rate, EQ-5D index score, or mortality. Further prospective, randomized, long-term studies are needed to confirm these findings before definitive treatment recommendations can be made.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Environmental Sciences
Thomas Rauer, Hans-Christoph Pape, Zoe Stehlin, Sandro Heining, Matthias Knobe, Tim Pohlemann, Bergita Ganse
Summary: Performance in pair skating and ice dance has increased at international competitions, potentially due to changes in athlete age. Total points and complexity of jumps have increased in recent years, particularly at the European Championships. However, age has not significantly changed. Attention should be given to the possibility of acute and overuse injuries following this development.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Karen Mys, Luke Visscher, Kenneth Petrus van Knegsel, Dominic Gehweiler, Torsten Pastor, Amirsiavosh Bashardoust, Anna Sophie Knill, Carolin Danker, Jan Dauwe, Rayna Mechkarska, Georgi Raykov, Grzegorz Marek Karwacki, Matthias Knobe, Boyko Gueorguiev, Markus Windolf, Simon Lambert, Stefaan Nijs, Peter Varga
Summary: This study aimed to develop a 3D segmentation fracture mapping technique to describe the spatial pattern and cortical bone loss in complex proximal humerus fractures (PHFs). The results showed that the fracture lines mainly passed through the surgical neck and between the tuberosities and tendon insertions. This information is important for future studies on surgical training and implant design.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Torsten Pastor, Ivan Zderic, Clemens Schopper, Pascal C. Haefeli, Philipp Kastner, Firas Souleiman, Boyko Gueorguiev, Matthias Knobe
Summary: This study compares the biomechanical competence of two recently launched cephalic implants in ideal and less-ideal positions, as well as investigates the effect of bone cement augmentation. The results highlight the importance of proper implant positioning and suggest that a helical blade is preferable in less ideal positions, while cement augmentation can increase the resistance against failure.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Christopher Bliemel, Katherine Rascher, Ludwig Oberkircher, Torsten Schlosshauer, Carsten Schoeneberg, Matthias Knobe, Bastian Pass, Steffen Ruchholtz, Antonio Klasan
Summary: This study analyzed data from a large international geriatric trauma registry to examine the outcomes of patients with pathologic hip fractures compared with patients with typical osteoporotic hip fractures. The study found that patients with pathologic hip fractures had a higher mortality rate, but did not experience higher complication rates.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Torsten Pastor, Tatjana Pastor, Philipp Kastner, Firas Souleiman, Matthias Knobe, Boyko Gueorguiev, Markus Windolf, Jan Buschbaum
Summary: The study evaluated the digitally enhanced hands-on surgical training concept and device for distal interlocking of intramedullary nails, showing high scores in training capability and realism. Construct validity was proven by reliably discriminating between experts and novices, with participants indicating high further training potential for the device.
MEDICINA-LITHUANIA
(2022)