Journal
JOURNAL OF ORTHOPAEDIC RESEARCH
Volume 30, Issue 7, Pages 1083-1088Publisher
WILEY
DOI: 10.1002/jor.22027
Keywords
erythropoietin; bone formation; posterolateral spinal fusion; rabbit; in vivo
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Funding
- VELUX Foundation
- Helga and Peter Kornings Foundation
- Mogens Svarre Mogensens Foundation
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We tested the hypothesis that erythropoietin (EPO) enhances bone formation after posterolateral spinal fusion (PLF) in a rabbit model. Thirty-four adult rabbits underwent posterolateral intertransverse arthrodesis at the L5L6 level using 2.0?g autograft per side. The animals were randomly divided into two groups receiving subcutaneous daily injections of either EPO or saline for 20 days. Treatment commenced 2 days preoperatively. Hemoglobin was monitored at baseline and 2, 4, and 6 weeks after fusion surgery. After euthanasia 6 weeks postoperatively, manual palpation, radiographic, and histomorphometric examinations were performed. Bone volume of the fusion mass was estimated by CT after 6 weeks. EPO increased bone fusion volume to 3.85?ccm (3.664.05) compared with 3.26?ccm (2.973.55) in the control group (p?
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