Review
Immunology
Zhaoyang Yin, Ge Gong, Xinhui Liu, Jian Yin
Summary: Joint replacement surgery is the most effective treatment for end-stage arthritis, but aseptic loosening caused by periprosthetic osteolysis is a common complication. Inflammation induced by wear particles and its effect on macrophages/osteoclasts play a key role in this process. Researchers have developed intervention approaches to regulate macrophage/osteoclast activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jian Yin, Zhaoyang Yin, Peng Lai, Xinhui Liu, Jinzhong Ma
Summary: This review examines the pathological process of periprosthetic osteolysis (PPO) and the molecular mechanism of pyroptosis, discussing interventions to inhibit inflammation and pyroptosis. The study provides theoretical support for finding new strategies and targets for the treatment of PPO.
Article
Engineering, Biomedical
Sipeng Lin, Zhenkang Wen, Shixun Li, Zhong Chen, Changchuan Li, Zhuji Ouyang, Chuangxin Lin, Manyuan Kuang, Chunyu Xue, Yue Ding
Summary: Aseptic loosening (AL) is a major cause of artificial joint failure, and long noncoding RNA (lncRNA) Neat1 plays a key role in regulating particle-induced osteolysis. This study reveals that Neat1 affects osteolysis by activating the NF KB pathway, NLRP3 inflammation, and M1 polarization, and it also regulates BTK expression through anti-miRNA activity in the post-transcriptional stage, offering a novel strategy for the treatment of osteolysis.
ACTA BIOMATERIALIA
(2022)
Article
Pharmacology & Pharmacy
Minghui Gu, Baiqi Pan, Weishen Chen, Hai Xu, Xiaoyu Wu, Xuantao Hu, Linli Zheng, Yongyu Ye, Qing Meng, Guoyan Xian, Ziji Zhang, Puyi Sheng
Summary: In this study, we found that SPHK inhibitors (ABC294640 and FTY720) combined with ZA decreased the degree of inflammatory osteolysis in vivo. However, ABC294640 and ZA suppressed osteoclast differentiation and osteoclast-specific genes in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Orthopedics
Peng Wang, Guang-qian Shang, Shuai Xiang, Hai-ning Zhang, Ying-zhen Wang, Hao Xu
Summary: This study confirmed that the combination of zoledronic acid and teriparatide could effectively prevent and treat aseptic loosening of the prosthesis, showing different mechanisms of action for each drug. However, further experiments and clinical research are needed to ensure the safety and feasibility of long-term application in clinical settings.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Yi Deng, Paul N. Smith, Rachel W. Li
Summary: Diabetes mellitus is associated with aseptic loosening around hip and knee arthroplasty, as patients with diabetes mellitus are more prone to develop chronic inflammation around the prosthesis, increasing the risk of aseptic loosening.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Engineering, Biomedical
Christina Polan, Christina Brenner, Monika Herten, Gero Hilken, Florian Grabellus, Heinz-Lothar Meyer, Manuel Burggraf, Marcel Dudda, Willi Jahnen-Dechent, Christian Wedemeyer, Max Daniel Kauther
Summary: Particle-induced osteolysis is a major cause of prosthetic loosening. In this study, the influence of fetuin-A on particle-induced osteolysis was investigated using fetuin-A-deficient mice. The results showed that fetuin-A deficiency led to increased bone resorption, eroded surface areas, and osteoclast numbers. Fetuin-A deficiency also caused changes in bone metabolism parameters. These findings suggest that fetuin-A deficiency may be a risk factor for particle-induced osteolysis.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Pharmacology & Pharmacy
Michal Eger, Tamar Liron, Sahar Hiram-Bab, Zamzam Awida, Eliezer Giladi, David Dangoor, Mati Fridkin, David Kohavi, Illana Gozes, Yankel Gabet
Summary: The study found that a lipophilic super-active derivative of vasoactive intestinal peptide (VIP), namely stearyl-norleucine-VIP (SNV), exhibited superior anti-inflammatory and anti-osteoclastogenic effects compared to VIP.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Daishui Yang, Yejun Tan, Xi Xie, Wenbiao Xiao, Jin Kang
Summary: This study aimed to explore the pharmacological properties of zingerone (ZO) in attenuating osteoclast-mediated periprosthetic osteolysis and how ZO modulates osteoclas-togenesis. The results showed that ZO has an obvious inhibitory effect on osteoclastogenesis and bone resorption in a dose-dependent manner by mainly suppressing the activation of NF-KB signaling pathways. Furthermore, ZO administration successfully attenuated titanium (Ti) particle-stimulated periprosthetic osteolysis and osteoporosis by regulating osteoclast formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Nicholas A. Hodges, Eric M. Sussman, Jan P. Stegemann
Summary: The success of total joint replacements has led to increased use of arthroplasty in younger patients, but over 10% require revisions due to implant failure, with loosening caused by wear debris being a significant factor. Loosening can be aseptic or septic, with subclinical biofilms potentially being overlooked in diagnosis. Wear debris inhibits the immune response, contributing to implant failure and osteolysis.
Article
Engineering, Biomedical
Baiqi Pan, Ziji Zhang, Xiaoyu Wu, Guoyan Xian, Xuantao Hu, Minghui Gu, Linli Zheng, Xiang Li, Lingli Long, Weishen Chen, Puyi Sheng
Summary: Aseptic prosthesis loosening (APL) is a common complication in arthroplasty caused by wear particle-induced periprosthetic osteolysis. However, the mechanisms of immune cell and osteoclast/osteoblast crosstalk during osteolysis are unclear. This study reveals that macrophage-derived exosomes play a role in wear particle-induced osteolysis and highlights the importance of miR-3470b in this process. The findings suggest that engineering exosomes enriched with miR-3470b might be a promising strategy for treating bone resorption-related diseases.
BIOACTIVE MATERIALS
(2023)
Article
Cell Biology
Hao Chai, Zai Hang Zhang, Jing Yi Fang, Chang She, De Chun Geng, Wei Xu
Summary: This study investigated the effects of titanium particles on MLO-Y4 osteocytic cells and their impact on osteoblastic cells. The results showed that titanium particles increased osteocytic marker expression, apoptosis, and the expression of inflammatory factors. The particles also inhibited the differentiation of osteoblastic cells through direct cell-to-cell contact. Silencing of SOST/sclerostin attenuated these effects. These findings highlight the extensive impact of titanium particles on osteocytic cells and the importance of SOST/sclerostin in cell interaction.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Fanxiao Liu, Jun Dong, Dongsheng Zhou, Qingyu Zhang
Summary: This study aimed to identify potential therapeutic targets for inflammatory osteolysis by analyzing DEGs in macrophages exposed to UHMWPE or VE-UHMWPE particles. The results revealed key genes such as IL13, CXCL1, ICAM1, CCL5, and CCL4, and highlighted the significant role of immune and inflammatory responses in inflammatory osteolysis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Tianliang Ma, Sijie Chen, Jiahao Wang, Shuailong Liang, Mingyu Chen, Qimeng Liu, Zheyu Zhang, Guanzhi Liu, Yute Yang, Yihe Hu, Jie Xie
Summary: Aseptic loosening of prostheses is a significant issue, and exosomes derived from bone marrow mesenchymal stem cells (BMSCs-Exos) and M2 macrophages (M2-Exos) show potential for targeted therapy in preventing and treating peri-prosthetic osteolysis.
Article
Biochemistry & Molecular Biology
Xin Yu, Hao Ding, Dongsheng Wang, Zhengrong Ren, Bin Chen, Qi Wu, Tao Yuan, Yang Liu, Lei Zhang, Jianning Zhao, Zhongyang Sun
Summary: This study demonstrates that endoplasmic reticulum stress (ER stress) plays a crucial role in wear particle-induced osteoblast apoptosis and impaired osteogenic function. Furthermore, treatment with the ER stress inhibitor, 4PBA, effectively alleviates wear particle-induced detrimental effects on osteoblasts. These findings highlight the importance of ER stress in wear particle-induced osteolysis and suggest ER stress as a potential therapeutic target for ameliorating wear particle-induced osteogenic reduction and bone destruction.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell & Tissue Engineering
Sharada Paudel, Wen-han Lee, Moses Lee, Talal Zahoor, Reed Mitchell, Shang-you Yang, Haiqing Zhao, Lew Schon, Zijun Zhang
REGENERATIVE MEDICINE
(2019)
Article
Chemistry, Physical
Nathan Drummond, Bradley W. Bruner, Michael H. Heggeness, Bradley Dart, Shang-You Yang
Article
Cell Biology
HongFei Xiang, WeiLiang Su, XiaoLin Wu, WuJun Chen, WenBin Cong, Shuai Yang, Chang Liu, ChenSheng Qiu, Shang-You Yang, Yan Wang, GuoQing Zhang, Zhu Guo, DongMing Xing, BoHua Chen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Orthopedics
Wenzhao Wang, Liang Ma, Jun Li, Shang-You Yang, Zheng Yi, Mingjie Sun, Jianan Chen, Wei Xie
Summary: This study identified differentially expressed lncRNAs in the lesion epicenter of spinal tissues following traumatic SCI, and predicted potential regulatory networks using high-throughput sequencing and bioinformatics analysis. The findings contribute to a better understanding of the mechanisms underlying subacute SCI, highlighting the involvement of lncRNAs in regulating multiple pathways in pathophysiological processes. Further research is needed to reveal the exact mechanisms of competing endogenous RNA pathways in vivo and in vitro.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Cell Biology
Xiaolin Wu, Chang Liu, Shuai Yang, Nana Shen, Yan Wang, Youfu Zhu, Zhaoyang Guo, Shang-you Yang, Dongming Xing, Houxi Li, Zhu Guo, Bohua Chen, Hongfei Xiang
Summary: The study utilized omics analysis and mass spectrometry techniques to identify a series of metabolic pathways associated with the Gly-Ser-Thr metabolic axis that affect carbohydrate patterns and energy utilization efficiency, ultimately delaying intervertebral disc degeneration through antioxidant effects.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Zhu Guo, WeiLiang Su, RongYao Zhou, GuoQing Zhang, Shuai Yang, XiaoLin Wu, ChenSheng Qiu, WenBin Cong, Nana Shen, JianWei Guo, Chang Liu, Shang-You Yang, DongMing Xing, Yan Wang, BoHua Chen, HongFei Xiang
Summary: The study found that human urine-derived stem cell exosomes (USC-exos) could promote nucleus pulposus cell (NPC) proliferation and extracellular matrix (ECM) synthesis by transferring the MATN3 protein, potentially playing a role in alleviating intervertebral disc degeneration.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Clinical Neurology
Nana Shen, Xiaolin Wu, Zhu Guo, Shuai Yang, Chang Liu, Zhaoyang Guo, Shang-You Yang, Dongming Xing, Bohua Chen, Hongfei Xiang
Summary: This study introduces a treatment-oriented fracture classification method for cervical spine fractures in patients with ankylosing spondylitis and evaluates its clinical efficacy. The classification and selection of surgical treatment methods were based on the evaluation of three main types and four subtypes of cervical spine fractures.
PAIN RESEARCH & MANAGEMENT
(2022)
Article
Oncology
Lin Shen, Han Li, Ronghan Liu, Chendan Zhou, Morgan Bretches, Xuan Gong, Laitong Lu, Ying Zhang, Kai Zhao, Bin Ning, Shang-You Yang, Aijun Zhang
Summary: This study aims to elucidate the critical role of DEPDC1, a tumor-related gene, in the progression of osteosarcoma. It was found that DEPDC1 is highly expressed in human osteosarcoma cells and tumor tissue, and its silencing can inhibit cell proliferation, promote apoptosis, and prevent tumor metastasis. Clinical analysis also showed a correlation between overexpression of DEPDC1 and reduced patient survival rate. This study suggests that targeting or inhibiting DEPDC1 may be a promising strategy for treating human osteosarcoma.
Article
Endocrinology & Metabolism
Hui Dong, Ronghan Liu, Ke Zou, Zhengxin Jin, Jianning Kang, Ying Zhang, Xiaodi Zhang, Zhengfang Sun, Guilian Yu, Nana Huang, Morgan Bretches, Shang-You Yang, Bin Ning
Summary: Osteoporosis, a common bone disease, can be treated by higenamine (HG), a small-molecule compound that promotes bone formation through the SMAD2/3 pathway. In vitro experiments showed that HG induced expressions of osteogenic markers in mouse bone marrow stromal cell (BMSCs) and preosteoblastic cell cultures, while in vivo experiments on animal models confirmed enhanced bone formation and prevented bone loss. IQGAP1 was identified as a novel target of HG, and HG exerted its osteogenic effects by binding to the Glu-1019 site of IQGAP1 and promoting SMAD2/3 phosphorylation while inhibiting SMAD4 ubiquitination.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Clinical Neurology
Zhaoyang Guo, Yuanye Ma, Yaqing Wang, Hongfei Xiang, Shang -You Yang, Zhu Guo, Ronghuan Wang, Wujun Chen, Dongming Xing, Bohua Chen, Hao Tao, Xiaolin Wu
Summary: This study investigates the relationship between IL-6 and TMEM100 in discogenic low back pain. Metabolomic analysis reveals that TMEM100 expression change is associated with the metabolic axis of Gly-Ser-Thr and plays a significant role in relieving discogenic pain.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Jianhua Ge, Ramazan Asmatulu, Bo Zhu, Qiu Zhang, Shang-You Yang
Summary: This study characterized novel magnetic scaffolds that can be used as a central station to regulate the drug delivery of a magnetic nanoparticle system. The scaffolds exhibited magnetic, mechanical, and biological properties, with higher mechanical performances observed in scaffolds with a micron-sized Fe3O4 to PCL weight ratio of 0.1:0.9.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Renyi Sun, Tanghong Jia, Bradley Dart, Sunaina Shrestha, Morgan Bretches, Michael H. Heggeness, Shang-You Yang
Summary: A population of cells within human peripheral nerves has been identified that display pluripotency potential and can differentiate into various cell types when exposed to specific stimuli. These cells, similar to rodent NEDAPS cells, respond to BMP-2 and express multiple transcription factors, suggesting a previously unknown natural mechanism for healing injuries in peripheral nerves.
BIOENGINEERING-BASEL
(2021)
Proceedings Paper
Engineering, Biomedical
Shang-You Yang, Yuan-Pin Lin
42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20
(2020)
Article
Polymer Science
Anil Mahapatro, Kayla Jensen, Shang-You Yang
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
(2020)
Article
Surgery
Michelle J. Nentwig, Camden M. Whitaker, Shang-You Yang
JOURNAL OF SURGICAL CASE REPORTS
(2019)