Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 726, Issue -, Pages 62-70Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2012.12.022
Keywords
Ultrasonic; Ferrocene; Quinoline; Chalcone; Claisen-Schmidt condensation
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Funding
- Department of Science and Technology, India [SR/FTP/CS-57/2007]
- Council of Scientific and Industrial Research (CSIR), India
- Ministry of Higher Education (Malaysia) [UM.C/HIR-MOHE/SC/12]
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The facile and efficient synthesis of quinoline-appended ferrocenyl chalcones via the condensation of acetylferrocene (or substituted 2-methyl-3-acetylquinoline) with 2-chloro-3-formylquinoline (or ferrocenecarboxaldehyde) in ethanol under basic conditions by the ultrasonic method is reported and compared to the results of synthesis achieved through conventional methods. Two derivatives were investigated crystallographically which confirmed the E-conformation about the C=C ethylene bond in each case. Redox chemistry of the new chalcones was investigated by cyclic voltammetry which showed quasi-reversible one-electron redox processed with potentials correlated with electron-withdrawing substituents. The compounds showed promising antimicrobial properties, with derivatives 3a and 6a showing the maximum activity against bacterial and fungal strains, respectively. (C) 2012 Elsevier B. V. All rights reserved.
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