Article
Chemistry, Multidisciplinary
Tayyala Kiranmye, Murugan Vadivelu, Sugirdha Sampath, Kesavan Muthu, Kesavan Karthikeyan
Summary: This strategy for the synthesis of 1-substituted-4-acyl-1,2,3-triazoles and 1,5-disubstituted-1,2,3-triazoles via eliminative [3 + 2] cycloaddition of azides with beta-enaminones/nitroolefins is catalyst free and utilizes ultrasound irradiation, offering features such as broad substrate scope, short reaction time, simple work-up, high regioselectivity and suitability for large-scale synthesis.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Biochemistry & Molecular Biology
Samy Cecioni, Roger A. Ashmus, Pierre-Andre Gilormini, Sha Zhu, Xi Chen, Xiaoyang Shan, Christina Gros, Matthew C. Deen, Yang Wang, Robert Britton, David J. Vocadlo
Summary: Understanding the function and regulation of enzymes within cells requires quality tools to report their activities. This article introduces a strategy for quantitatively monitoring enzyme activities within live cells and describes the design and synthesis of fluorescence-quenched substrates for sensitive quantitation. The substrates can be used to measure the engagement of target enzymes by inhibitors and the efficiency of pharmacological chaperones, highlighting the importance of quantifying activity within cells.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Hung-Yi Lin, Shih-Ying Chang, Huang-Yi Li, Chia-Chun Cheng, Chih-Kuang Chuang, Hsiang-Yu Lin, Shuan-Pei Lin, Wei-Chieh Cheng
Summary: This study describes the synthesis of L-iduronic acid (IdoA)-and imino-IdoA-typed C-glycosides for modulating alpha-L-iduronidase (IDUA) activity. The IdoA-typed C-glycosides showed greater potency than the imino-IdoA analogs in enzyme inhibition studies, with the most potent C-glycoside 27c exhibiting an IC50 value of 1 μM. Co-treatment of 12 with rh-alpha-IDUA in mucopolysaccharidosis type I (MPS I) fibroblasts resulted in a significant increase in IDUA activity and reduction of accumulated heparan sulfate (HS), indicating the feasibility and promise of small molecules as rh-alpha-IDUA stabilizers for improving enzyme replacement therapy (ERT) efficacy in MPS I.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Immunology
Xuefang Pan, Mahsa Taherzadeh, Poulomee Bose, Rachel Heon-Roberts, Annie L. A. Nguyen, TianMeng Xu, Camila Para, Yojiro Yamanaka, David A. Priestman, Frances M. Platt, Shaukat Khan, Nidhi Fnu, Shunji Tomatsu, Carlos R. Morales, Alexey Pshezhetsky
Summary: The majority of MPS IIIC patients have missense variants causing misfolding of HGSNAT, which can be potentially treated with pharmacological chaperones. A novel mouse model expressing a misfolded HGSNAT variant shows deficits in memory and neuroimmune response, which can be rescued by treatment with a chaperone, glucosamine.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Stefan J. Marciniak, Joseph E. Chambers, David Ron
Summary: Research on drug-like molecules targeting ER stress and UPR has made progress, but limitations still exist. Understanding these limitations is crucial for the development of these molecules into therapeutic drugs.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Review
Chemistry, Multidisciplinary
Brij Pal Singh, Sougata Ghosh, Ashwini Chauhan
Summary: Antimicrobial resistance poses a major health issue due to the inefficiency of antimicrobial drugs. Biofilm formation on medical devices and food industrial equipment is a significant cause of infections and food spoilage. Strategies to control and destroy biofilms, such as quorum sensing inhibitors and antimicrobial peptides, have shown promising results in combating bacterial resistance.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Review
Materials Science, Multidisciplinary
Sougata Ghosh, Thomas J. Webster
Summary: Porous nano-scaffolds offer great potential for tissue regeneration, with remarkable progress in controlled synthesis of multifunctional MSNs. Research also covers surface modification, functionalization, and attempts to conjugate various drugs on MSNs.
FRONTIERS IN MATERIALS
(2021)
Article
Infectious Diseases
Mallika Sengupta, Soma Sarkar, Manideepa SenGupta, Sougata Ghosh, Riya Sarkar, Parthajit Banerjee
Summary: This prospective study conducted over a period of 2 years at a Medical College found Enterococcus to be a significant pathogen causing vaginitis infections, with biofilm production being an important virulence factor in these isolates.
Article
Materials Science, Biomaterials
Harshal B. Desai, Sougata Ghosh, Rabia Pandit, Ashish R. Tanna
Summary: Nanomagnetic functional oxides were synthesized using an auto combustion method, with confirmed purity and magnetism. Coating with streptomycin sulfate enhanced the antibacterial activity of the nanomagnetic oxides against various bacteria.
Article
Environmental Sciences
Sougata Ghosh, Bishwarup Sarkar, Ajeet Kaushik, Ebrahim Mostafavi
Summary: Nanotechnology has been applied in various aspects of life, and environmentally friendly green routes are preferred for the synthesis of nanoparticles. However, there is limited literature on the use of probiotic bacteria for nanoparticle synthesis. This review comprehensively explores the potential of probiotic bacteria for synthesizing various nanoparticles.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Rahul Nitnavare, Joorie Bhattacharya, Sirikanjana Thongmee, Sougata Ghosh
Summary: Photosynthetic microbes like algae have been utilized in nanotechnology for the synthesis of metal nanoparticles, which provide a non-toxic and environmentally friendly alternative to traditional chemical and physical routes. Various techniques are used to characterize the nanoparticles and their functional groups, allowing the fabrication of different types of metal nanoparticles. These phycogenic nanoparticles have unique properties and find applications in infection control, diagnosis, drug delivery, and other fields.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Sougata Ghosh, Tanay Bhagwat, Rohini Kitture, Sirikanjana Thongmee, Thomas J. Webster
Summary: Developing novel materials for bone tissue engineering utilizing graphene nanoribbons (GNRs) and nanoparticles of hydroxyapatite (nHAPs) has shown potential for improving bone tissue regeneration. Two different approaches were used to prepare nanohybrids, resulting in slightly different morphologies and structures, but both successfully integrating nHAP and GNRs in the nanocomposites.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Chemistry, Multidisciplinary
Khalida Bloch, Shahansha M. M. Mohammed, Srikanta Karmakar, Satyajit Shukla, Adersh Asok, Kaushik Banerjee, Reshma Patil-Sawant, Noor Haida Mohd Kaus, Sirikanjana Thongmee, Sougata Ghosh
Summary: This study synthesized zinc oxide particles and silver mixed zinc oxide particles using a medicinal plant, Plumbago auriculata leaf extract, and investigated their physicochemical properties and photocatalytic performance. The results showed that the silver mixed zinc oxide particles synthesized using the plant extract have great potential for removing hazardous dyes from wastewater.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Bansuri Gami, Khalida Bloch, Shahansha M. Mohammed, Srikanta Karmakar, Satyajit Shukla, Adersh Asok, Sirikanjana Thongmee, Sougata Ghosh
Summary: This study successfully fabricated silver and gold nanoparticles using a plant-based approach, with good characterization properties and catalytic dye degradation performance.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Madhumita S. Tawre, Aishwarya Shiledar, Surekha K. Satpute, Kedar Ahire, Sougata Ghosh, Karishma Pardesi
Summary: This study synthesized silver nanoparticles (CAAgNPs) with antibacterial and antibiofilm activity using the rhizome extract of Curcuma aromatica and demonstrated their synergistic effects with antibiotics. The findings suggest that CAAgNPs have the potential to be used as wound dressings and ointments.
FRONTIERS IN CHEMISTRY
(2022)
Review
Infectious Diseases
Brij Pal Singh, K. M. Manju, Rohit Sharma, Bharat Bhushan, Sougata Ghosh, Gunjan Goel
Summary: In recent years, the expansion of the food industry and processed food products has led to increased attention towards microbial food safety and the development of novel preservation methods. Food-derived antimicrobial peptides (F-AMPs) are emerging as a pragmatic alternative for extending the shelf-life of food products, with their wide spectrum antimicrobial efficacy and low propensity for antibiotic resistance. However, their direct application in food is limited and the development of nanocarriers for their conjugation and distribution could greatly enhance their bioactivity.
Article
Chemistry, Physical
Asfeeaz Chaudhari, Taslim Kaida, Harshal B. Desai, Sougata Ghosh, Rajesh P. Bhatt, Ashish R. Tanna
Summary: Manganese Ferrite nanoparticles were synthesized using biological agents as a fuel by the self-combustion method. The green synthesis of these nanoparticles using plant extract has advantages in terms of being eco-friendly, inexpensive, and suitable for large-scale production. The nanoparticles were characterized for their size, structure, crystallinity, and photocatalytic properties. The results showed potential applications of these nanoparticles in dye degradation and antibacterial activities.
CHEMICAL PHYSICS IMPACT
(2022)
