Article
Chemistry, Organic
Jian Ji, Cong Guan, Qinghua Wei, Xuwen Chen, Yun Zhao, Shunying Liu
Summary: This study developed a highly regioselective synthesis of N-2-substituted 1,2,3-triazoles using N-sulfonyl-1,2,3-triazoles and alkyl bromides/alkyl iodides at room temperature. The mechanistic pathway proposed explains the high N-2 regioselectivity, and the protocol showed good to excellent product yields (72-90%).
Article
Biochemistry & Molecular Biology
Yunyun Zheng, Jiuling Li, Kai Wei
Summary: An efficient, high-yielding, and scalable method for the regioselective 3-acylation of indoles with anhydrides promoted by boron trifluoride etherate under mild conditions was reported. This novel protocol provides a simple way to prepare 3-(benzofuran-2-yl) indole in three steps.
Article
Chemistry, Multidisciplinary
Hua Zhang, Rong-Chuan Su, Yu-Li Qin, Xiao-Juan Wang, Dan Chen, Xiao-Rong Liu, Yu-Xin Jiang, Peng Zhao
Summary: An electrophilic substitution reaction using indole and ammonium tetramethylnitrate was developed for the synthesis of 3-nitroindole. Trifluoroacetyl nitrate was produced by metathesis of ammonium tetramethyl nitrate and trifluoroacetic anhydride, and it served as an electrophilic nitrating agent for various indoles. This method has the potential to construct the skeleton structure of bioactive molecules and further derivatize 3-nitroindole into pyrrolo[2,3-b]indole.
Article
Chemistry, Organic
Rachel Szpara, Alexander Goyder, Michael J. Porter, Helen C. Hailes, Tom D. Sheppard
Summary: Sugars in waste biomass are sustainable chiral building blocks for organic synthesis, especially for pharmaceutical applications of chiral saturated heterocyclic rings. A range of sugar thioacetals can be selectively dehydrated at C-2 under mild basic conditions, and the resulting ketene thioacetals can be used for the production of useful chiral building blocks through further selective dehydration reactions.
Article
Chemistry, Organic
Wei Wu, Shunli Wen, Xinyu Zhang, Qi Lin, Zhiqiang Weng
Summary: A highly efficient and regioselective synthesis of highly substituted 2-trifluoromethyl pyrrole derivatives is reported via a silver-catalyzed cyclization of vinyl azides with ethyl 4,4,4-trifluoro-3-oxobutanoate. Various types of alpha-(heteo)aryl, alkyl, alpha-aryl, and alpha,beta-disubstituted vinyl azides can participate in this transformation. The proposed reaction mechanism involves the addition of in situ generated 2H-azirine to the diketone species, followed by intramolecular addition, N-C-1 cleavage, and elimination.
Article
Materials Science, Multidisciplinary
Chiranjit Nandi, Rohan Phatak, Muhammed Shafeeq, Swayam Kesari, Rekha Rao, Amrit Prakash
Summary: The Am-substituted UO2 solid solutions are considered as advanced fuels for heterogeneous transmutation of americium, while the U-substituted Am2O3 with cubic structure is considered as a promising candidate for radioisotope heat unit and radioisotope thermoelectric generator.
JOURNAL OF NUCLEAR MATERIALS
(2023)
Article
Chemistry, Physical
Mengting Jin, Mingxiu Liu, Petr Nachtigall, Lukas Grajciar, Christopher James Heard
Summary: Controlled desilication of zeolites is an effective method to increase their application potential by modifying the Si/Al ratio and improving diffusion restrictions in industrial processes. However, the mechanism of alkaline hydrolysis in zeolites is still not well understood, with collective effects playing a decisive role in the reaction mechanism.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Organic
Yurii Ostapiuk, Maksym Shehedyn, Oksana Barabash, Bohdan Demydchuk, Sviatoslav Batsyts, Colin Herzberger, Andreas Schmidt
Summary: Methyl 3-aryl-2-bromo-2-chloropropanoates were prepared via Meerwein reaction catalyzed by copper(II) bromide, and were utilized as starting materials for the synthesis of substituted 3-hydroxythiophenes. The structural variety of the obtained 2-substituted 5-aryl-3-hydroxythiophenes was achieved due to the wide range of available starting materials, including both anilines and thiols.
SYNTHESIS-STUTTGART
(2022)
Article
Chemistry, Multidisciplinary
Gaurav Badhani, Valvi Mangesh Biramya, Subbarayappa Adimurthy
Summary: This research describes the oxygenation of quinoxalin-2(1H)-one using ionic liquid as a catalyst and aerobic oxygen as a green oxidant under visible light conditions at room temperature. The reaction yielded high product yields and can be used to convert the target product into pharmaceuticals.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Organic
Hiroki Yoneyama, Kumi Takatsuji, Aiko Ito, Yoshihide Usami, Shinya Harusawa
Summary: The reaction of cyanophosphates with TMSN3/Bu2SnO in refluxing toluene directly synthesized 3-substituted-2-cyclopentenones in modest to good yield under mild conditions. This method was also applied to the synthesis of dechlorotrichodenone C isolated from Trichoderma asperellum.
Article
Chemistry, Organic
Rulin Zhao, Zhenqiu Hong, Bei Wang, James Kempson, Lyndon Cornelius, Jianqing Li, Yi-Xin Li, Arvind Mathur
Summary: A simple and efficient method for the synthesis of N1-substituted-4-nitropyrazole-5-carboxylates has been developed, with excellent regioselectivity and good yields.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Energy & Fuels
David Alam, Matthew Y. Lui, Alexander K. L. Yuen, Zuo Li, Xiao Liang, Thomas Maschmeyer, Brian S. Haynes, Alejandro Montoya
Summary: The reaction kinetics and product formation of hydroxy and methoxy-substituted aromatic aldehydes under hydrothermal conditions were investigated. The presence of methoxy groups resulted in hydrolytic demethylation reactions, while hydroxy groups enhanced the cleavage of the formyl group. The ortho position substitution with hydroxy groups showed the most prominent effect. The study proposed a hypothetical reaction pathway involving water in the aldehyde cleavage from the aromatic ring. Importantly, the aldehydes did not decompose following a Cannizzaro pathway.
Article
Chemistry, Organic
Sivanna Chithanna, Animesh Roy, Ding-Yah Yang
Summary: An efficient strategy for synthesizing structurally diverse 3,4-dihydropyridones and 2-piperidinones is described in this study. The former is prepared through acid-catalyzed Michael addition of enaminones to electron-deficient alpha-substituted cinnamic acids followed by lactamization, while the latter is synthesized through the same methodology using coumarin 3-carboxylic acids instead of cinnamic acids. The unique regioselective reactivity of enaminones towards different cinnamic acid derivatives is highlighted.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Sun Yamin, Li Xiyong, Yuan Jinwen, Yu Jialin, Liu Shuainan
Summary: A mild and convenient method has been developed for the construction of 3-arylcoumarins through a CuI-catalyzed reaction of coumarins with arylamines under mild conditions.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Changjun Zhang, Tingting Wei, Zhichen Yu, Yuxin Ding, Weike Su, Yuanyuan Xie
Summary: We report an unprecedented metal-free regioselective halogenation of 2H-indazoles, which achieved highly selective synthesis of mono-halogenated products and completed poly-halogenations by fine tuning the reaction conditions. Various mono-/poly-/hetero-halogenated indazoles were obtained in moderate to excellent yields. Importantly, this approach offers environmentally friendly solvents, mild reaction conditions, simple execution, and short reaction time.
Article
Medicine, Legal
Roberta Tittarelli, Simona Pichini, Daniel S. Pedersen, Roberta Pacifici, Monica Moresco, Fabio Pizza, Francesco Paolo Busardo, Giuseppe Plazzi
FORENSIC SCIENCE INTERNATIONAL
(2017)
Article
Chemistry, Medicinal
Philipp Fronik, Birgit I. Gaiser, Daniel Sejer Pedersen
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Review
Biochemistry & Molecular Biology
Olivier Van der Poorten, Baptiste Legrand, Lubomir L. Vezenkov, Julia Garcia-Pindado, Nadir Bettache, Astrid Knuhtsen, Daniel Sejer Pedersen, Macarena Sanchez-Navarro, Jean Martinez, Meritxell Teixido, Marcel Garcia, Dirk Tourwe, Muriel Amblard, Steven Ballet
Article
Chemistry, Multidisciplinary
Lotte-Emilie Boyhus, Mia Danielsen, Nina Smidt Bengtson, Micha Ben Achim Kunze, Xavier Kubiak, Tjerk J. Sminia, Jacob Hartvig Loper, Phuong Thu Tran, Kresten Lindorff-Larsen, Soren G. F. Rasmussen, Jesper Mosolff Mathiesen, Daniel Sejer Pedersen
Article
Pharmacology & Pharmacy
Wenqi Wu, Korbinian Lobmann, Jan Schnitzkewitz, Astrid Knuhtsen, Daniel Sejer Pedersen, Holger Grohganz, Thomas Rades
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2018)
Article
Pharmacology & Pharmacy
Wenqi Wu, Korbinian Lobmann, Jan Schnitzkewitz, Astrid Knuhtsen, Daniel Sejer Pedersen, Thomas Rades, Holger Grohganz
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2019)
Article
Biochemical Research Methods
Daniel Sejer Pedersen, Patrick Belanger, Mikael Frykman, Kirsten Andreasen, Danielle Goudreault, Henrik Pedersen, Peter Hindersson, Torben Breindahl
DRUG TESTING AND ANALYSIS
(2019)
Article
Chemistry, Medicinal
Birgit I. Gaiser, Mia Danielsen, Emil Marcher-Rorsted, Kira Ropke Jorgensen, Tomasz M. Wrobel, Mikael Frykman, Henrik Johansson, Hans Brauner-Osborne, David E. Gloriam, Jesper Mosolff Mathiesen, Daniel Sejer Pedersen
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Henrik Johansson, Omar Hussain, Simon J. Allison, Tony V. Robinson, Roger M. Phillips, Daniel Sejer Pedersen
Article
Chemistry, Multidisciplinary
Peter H. G. Egelund, Sandip Jadhav, Vincent Martin, Henrik Johansson Castro, Franziska Richner, Sebastian Thordal Le Quement, Frank Dettner, Carolin Lechner, Ralph Schoenleber, Daniel Sejer Pedersen
Summary: This study explores the use of pyrrolidine as a base to expand the available solvent polarity space for green solid-phase peptide synthesis, investigating the effects of different solvent mixtures on Fmoc removal and coupling reactions, and comparing the synthesis results of different peptide targets.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Review
Chemistry, Multidisciplinary
Vincent Martin, Peter H. G. Egelund, Henrik Johansson, Sebastian Thordal Le Quement, Felix Wojcik, Daniel Sejer Pedersen
Meeting Abstract
Cell Biology
C. Ma, J. Calahatian, W. Fraser, H. Osborne, D. Pedersen, K. Nash, D. Morgan, P. Bickford, D. Lee
MOLECULAR BIOLOGY OF THE CELL
(2017)
Article
Chemistry, Multidisciplinary
Charlotte Martin, Samuel L. C. Moors, Mia Danielsen, Cecilia Betti, Cecilia Fabris, Daniel Sejer Pedersen, Els Pardon, Marion Peyressatre, Krisztina Feher, Jose C. Martins, Jesper Mosolff Mathiesen, May C. Morris, Nick Devoogdt, Vicky Caveliers, Frank De Proft, Jan Steyaert, Steven Ballet
CHEMISTRY-A EUROPEAN JOURNAL
(2017)
Article
Chemistry, Organic
Svenja Domeyer, Mark Bjerregaard, Henrik Johansson, Daniel Sejer Pedersen
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Phuong Thu Tran, Christian Ornbol Larsen, Tobias Rondbjerg, Martina De Foresta, Micha B. A. Kunze, Ales Marek, Jacob Hartvig Loper, Lotte-Emilie Boyhus, Astrid Knuhtsen, Kresten Lindorff-Larsen, Daniel Sejer Pedersen
CHEMISTRY-A EUROPEAN JOURNAL
(2017)
