Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 6, Pages 2579-2588Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo302794z
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Funding
- Queens College Research Enhancement Award
- CUNY Collaborative Incentive Research Grant
- South China Normal University
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1228921] Funding Source: National Science Foundation
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A facile synthetic route toward pharmaceutically interesting 1-aminoisoquinoline derivatives by gold(III)-mediated domino reactions is described. This synthetic protocol starts from readily available 2-alkynylbenzamides and ammonium acetate and takes place under mild reaction conditions compatible with a variety of functional groups. A plausible mechanism for the domino process is proposed, supported by the reaction of a possible intermediate, N-(3-phenyl-1H-isochromen-1-ylidene)propan-1-amine.
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