4.7 Article

Copper(I)-Catalyzed Synthesis of 5-Arylindazolo[3,2-b]quinazolin-7(5H)-one via Ullmann-Type Reaction

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 78, Issue 11, Pages 5700-5704

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo400420b

Keywords

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Funding

  1. National Natural Science foundation of China [20802061, 21104064]
  2. Priority Academic Program Development of Jiangsu Higher Education Institutions
  3. Cling Lan Project [10QLD008, GSFM2011003]
  4. College Industrialization Project Jiangsu Province [JHB2012-31]

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The treatment of 2-amino-N'-arylbenzohydrazide and o-halogenated benzaldehyde in the presence of CuBr and Cs2CO3 gave 5-arylindazolo[3,2-b]quinazolin-7(5H)-one in high yields. This procedure contains an Ullmann-type reaction and provides an efficient method to construct fused tetracyclic heterocycles.

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