Article
Chemistry, Organic
Jie Jia, Fushan Yuan, Zihao Zhang, Xuejiao Song, Fangdong Hu, Ying Xia
Summary: In this study, a copper-catalyzed reaction of gem-fluorinated cyclobutenes with bis(pinacolato)diboron was reported, leading to the formation of B,F-bifunctional 1,3-dienes. The transformation was achieved through a sequence of reactions, allowing for the stereoselective synthesis of highly functionalized 1,3-dienes.
Article
Chemistry, Organic
Laura Cunningham, Sourabh Mishra, Leon Matthews, Stephen P. Fletcher
Summary: We report a general, catalyst-controlled route to prostaglandin F2 alpha and its analogues. The approach utilizes a Rh catalyzed dynamic kinetic asymmetric Suzuki-Miyaura coupling reaction to synthesize intermediates, and the final two stereocenters are installed via Pd-catalyzed reactions. Prostaglandin F2 alpha was synthesized in 19% yield in 16 longest linear steps.
Article
Chemistry, Multidisciplinary
Alessandro Bismuto, Patrick Mueller, Patrick Finkelstein, Nils Trapp, Gunnar Jeschke, Bill Morandi
Summary: This study presents a simple and general route to access a variety of Ni(I)-phenolate complexes, offering exciting opportunities for the discovery of new stoichiometric and catalytic reactivity, as well as the mechanistic elucidation of Ni-based catalytic cycles.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Applied
Elena Chikunova, Dmitry Dar'in, Vadim Yu Kukushkin, Alexey Yu Dubovtsev
Summary: The gold-catalyzed annulation of alkynylsulfones provides a diazo-free route to valuable organic compounds. This reaction operates under relatively mild conditions and is compatible with various functional groups.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Simon Greiner, Jan Hettig, Alec Laws, Katharina Baumgaertner, Jenna Bustos, Ann-Christin Poeppler, Adam H. Clark, May Nyman, Carsten Streb, Montaha Anjass
Summary: In this paper, we report a universal precursor that can be used to synthesize metal-functionalized polyoxovanadate clusters. The precursor is synthesized through a novel solid-state thermal treatment method. By reacting the precursor with various metal nitrate salts, a range of metal-functionalized POVs can be obtained, providing new components for molecular magnetism, energy technologies, or catalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Shuo Liu, Chaochao Dun, Junjie Chen, Satyarit Rao, Mihir Shah, Jilun Wei, Kaiwen Chen, Zhengxi Xuan, Eleni A. Kyriakidou, Jeffrey J. Urban, Mark T. Swihart
Summary: Mesoporous silica is a versatile material that can be synthesized with hollow structure and high specific surface area using a flame aerosol method. It can be used to produce mesoporous nanoshell-supported nanocatalysts with active nanoclusters for improved catalytic performance in various reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Kaitlin R. Albanese, Parker T. Morris, Javier Read de Alaniz, Christopher M. Bates, Craig J. Hawker
Summary: This study presents the synthesis and characterization of statistical and block copolymers containing alpha-lipoic acid (LA) using reversible addition-fragmentation chain-transfer (RAFT) polymerization. The controlled copolymerization of LA and vinyl monomers allows for the synthesis of copolymers with predictable molecular weights and low molar-mass dispersities. The presence of lipoic acid diads in the resulting copolymers, which include disulfide bonds, enables efficient degradation when exposed to mild reducing agents.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Jian-Qiang Chen, Nana Liu, Qian Hu, Jin Liu, Junwei Wu, Qinling Cai, Jie Wu
Summary: A photoredox-catalyzed three-component radical cascade reaction has been developed to afford diverse isoxazoline/dihydropyrazole-substituted aliphatic sulfones in good to excellent yields under mild conditions. This reaction shows good functional group compatibility and excellent regioselectivity, with a proposed mechanism involving a radical cascade process and the insertion of sulfur dioxide.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Stanislav V. Shcherbakov, Alexander V. Aksenov, Maksim V. Vendin, Viktoria Yu. Shcherbakova, Anna Yu. Ivanova, Maksim O. Shcheglov, Sergei N. Ovcharov, Michael Rubin
Summary: Unusual rearrangements were observed during Bronsted acid-assisted peri-annulations of 1H-perimidines with 5-alkynylpyrimidines. The reactions take different pathways depending on the nature of the acetylene precursor, ultimately leading to the formation of 7-formyl-1,3-diazopyrenes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jiawang Liu, Carolin Schneider, Ji Yang, Zhihong Wei, Haijun Jiao, Robert Franke, Ralf Jackstell, Matthias Beller
Summary: This study describes a new method for chemo-, regio-, and stereoselective mono-hydroamidation of (un)symmetrical 1,3-diynes, utilizing an advanced palladium catalyst system with the ligand Neolephos. The success of this novel transformation is demonstrated by the diversification of several structurally complex molecules and marketed drugs, highlighting the synthetic value of the approach for synthesizing useful α-alkynyl-α, β-unsaturated amides. Control experiments and density-functional theory computations indicate the crucial role of the substrate in controlling the regioselectivity of unsymmetrical 1,3-diynes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Huseyin Erguven, Cuihan Zhou, Bruce A. Arndtsen
Summary: A new class of phosphorus-containing 1,3-dipoles can be generated through the multicomponent reaction of aldehydes, acid chlorides, and the phosphonite PhP(catechyl), allowing for a unique, modular route to furans with independent control of all four substituents.
Article
Chemistry, Analytical
Li Fu, Bin Zhang, Xuwen Gao, Shuangtian Dong, Dongyang Wang, Guizheng Zou
Summary: This study proposes a general approach to trigger chemiluminescence using charge transfer between oxidants and n-type nanocrystals. The chemiluminescent system developed through this method can be used for ultrasensitive immunoassays.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Christian A. M. R. van Slagmaat, Gerard K. M. Verzijl, Peter J. L. M. Quaedflieg, Paul L. Alsters, Stefaan M. A. De Wildeman
Summary: The hydrogenation of cyclopentane-1,3-dione into cyclopentane-1,3-diol was systematically investigated, with temperature, pressure, and solvent choice found to significantly affect the reaction rate and product structure. The transformation of product structure at elevated temperatures was studied from a thermodynamic perspective using DFT. Optimization of reaction conditions led to high yield and successful scaled-up reactions, demonstrating the general applicability of this catalytic approach.
Article
Chemistry, Multidisciplinary
Wafa Amdouni, Mojca Otonicar, Pascale Gemeiner, Vincent Butin, Nicolas Guiblin, Hager Maghraoui-Meherzi, Brahim Dkhil
Summary: The current methods for synthesizing perovskite oxide (ABO(3)) nanoparticles (NPs) have limitations such as high reagent costs and sophisticated equipment, long time and high-temperature processing, or multiple post-processing and thermal treatment steps. In this study, a facile low temperature chemical bath synthesis and one annealing step are used to produce high quality rare-earth-based REMO3 NPs. The versatility of this approach is demonstrated by synthesizing La0.7Sr0.3MnO3 solid solution and non-RE-based BiFeO3 perovskite. The as-prepared REFeO3 and REMnO3 NPs show high efficiency in the photocatalytic degradation of norfloxacin antibiotic, indicating their potential for practical applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jonathan L. Rowell, Yafu Jia, Zixiao Shi, Andres Molina Villarino, Minsoo Kang, Dasol Yoon, Kevin Zhijian Jiang, Hector D. Abruna, David A. Muller, Richard D. Robinson
Summary: In this study, a synthetic method for small, colloidally stable cobalt-manganese oxide (CMO) spinel nanocrystals with tunable composition and low dispersity is described. By reacting metal-acetylacetonate precursors in an amine solvent under an oxidizing environment, the highly reducing conditions of typical colloidal synthesis reactions are avoided. Through surface chemistry studies, organic byproducts and their formation mechanism are identified, enabling the engineering of the surface to obtain colloidally stable nanocrystals with low organic loading. The CMO/carbon composite produced using this method exhibits high activity in the oxygen reduction reaction.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)