4.7 Article

Hybrid Gold/Chiral Bronsted Acid Relay Catalysis Allows an Enantioselective Synthesis of (-)-5-epi-Eupomatilone-6

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 79, Issue 1, Pages 419-425

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo4024232

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Funding

  1. NSFC [21302177]
  2. FRFCU [WK2340000043]

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An enantioselective synthesis of (-)-5-epi-eupomatilone-6 has been accomplished by using relay catalytic cascade intramolecular hydrosiloxylation and Mukaiyama aldol reaction of 2,3,4-trimethoxy-6-(phenylethynyl)phenyl dimethylsilanol with fluorenylglyoxylate.

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