4.7 Article

Development of Catalysts for the Stereoselective Hydrogenation of α,β-Unsaturated Ketones

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 11, Pages 5139-5143

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo300246c

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Funding

  1. Deutsche Forschungsgemeinschaft

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Iridium phosphinitoxazoline complexes were found to be new efficient catalysts for the asymmetric hydrogenation of arylated alpha,beta-unsaturated ketones. Linear as well as cyclic substrates are hydrogenated with similar success, giving selectivities of up to 99.7% ee.

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