Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 18, Pages 7957-7967Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo3011717
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Funding
- National Natural Science Foundation of China [21172245]
- National Basic Research Program of China [2012CB821600]
- Key Program of the National Natural Science Foundation of China [21032006]
- Shanghai Pujiang program [11PJ1412200]
- SIOC startup fund
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A new class of stable, strongly pi-accepting and modular bis(perfluoroalkyl)-phosphine-oxazoline ligands (FOX) as CO mimics was prepared. It was demonstrated that these ligands, when coordinated to palladium catalysts, promote the asymmetric alkylation of monosubstituted allyl substrates with excellent regio- and enantioselectivity. Solid and solution structure analysis of the FOX-ligated Pd-allyl intermediate reveals that the combination of relative steric and strong trans influences presented by the P(CF3)(2) moiety gave rise to the excellent selectivity.
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