☆ 4.7 Article

Synthesis of Isocoumarin Derivatives via the Copper-Catalyzed Tandem Sequential Cyclization of 2-Halo-N-phenyl Benzamides and Acyclic 1,3-Diketones

JOURNAL OF ORGANIC CHEMISTRY (2012)

Journal

JOURNAL OF ORGANIC CHEMISTRY

Volume 77, Issue 11, Pages 5022-5029

Publisher

AMER CHEMICAL SOC

DOI: 10.1021/jo300501j

Keywords

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Categories

Chemistry, Organic

Funding

National Science Council of the Republic of China [NSC 100-2113-M-003-008-MY3]
National Taiwan Normal University [99T3030-2, 99-D, 100-D-06]

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Abstract

A facile and rapid synthesis of isocoumarin derivatives using a copper-catalyzed tandem C-C/C-O coupling strategy from readily available substrates is described. The reactions of a wide range of 2-iodo-N-phenyl benzamides and acyclic diketones as starting materials were investigated.

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