Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 17, Pages 7749-7754Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo301227w
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Funding
- Max Planck Society
- Icelandic Research Fund [090026023]
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The nitroxide-containing nucleoside Cm is reported as the first rigid spin label for paramagnetic modification of RNA by solid-phase synthesis. The spin label is well accommodated in several RNA secondary structures as judged by its minor effect on the thermodynamic stability of hairpin and duplex RNA. Electron paramagnetic resonance (EPR) spectroscopic characterization of mono-, bi-, and trimolecular RNA structures shows that Cm will be applicable for advanced EPR studies to elucidate structural and dynamic aspects of folded RNA.
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