Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 77, Issue 6, Pages 2743-2755Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo2025543
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Funding
- National Science Foundation
- National Institutes of Health Kansas University Center of Excellence in Chemical Methodology and Library Development [P50 GM069663]
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Pyrido[1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lack of efficient methods for their synthesis. We report a convenient and efficient route to these privileged structures starting from easily accessible 2-substituted pyridines and aryne precursors. A small library of compounds has been synthesized utilizing the developed method, affording variously substituted pyrido[1,2-a]-indoles in moderate to good yields.
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