4.7 Article

A Microwave-Assisted Diastereoselective Multicomponent Reaction To Access Dibenzo[c,e]azepinones: Synthesis and Biological Evaluation

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 8, Pages 2828-2839

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo200251q

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Funding

  1. FWO (Fund for Scientific Research Flanders (Belgium))
  2. Research Fund
  3. Katholieke Universiteit Leuven [GOA 10/15]
  4. IRO (Interfacultaire Raad voor Ontwikkelingssamenwerking)

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An unprecedented microwave-assisted multicomponent strategy has been elaborated for the fast, efficient, and diastereoselective generation of the dibenzo[c,e]azepinone scaffold. The generated compounds were evaluated for their bioactivity.

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