Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 76, Issue 15, Pages 6146-6158Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo200864x
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- MEXT
- JSPS
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1-Alkynyl- and 1-alkenyl-3-arylimidazo[1,5-a]pyridines were synthesized. The Sonogashira coupling of 3-aryl-1-iodoimidazo[1,5-a]pyridines and various terminal alkynes with Pd(PPh3)(2)Cl-2 (10 mol %) and CuI (10 mol %) in triethylamine at 80 degrees C for 12 h afforded the corresponding 1-alkenyl-3-arylimidazo[1,5-a]pyridines in good to excellent yields. The Mizoroki-Heck reaction of 3-aryl-1-iodoimidazo[1,5-a]pyridines and various styrene derivatives proceeded smoothly with Pd(OAc)(2) (5 mol %), IMes center dot HCl (10 mol %), and Cs2CO3 (2 equiv) in DMA at 130 degrees C for 20 h to give the alkenylated imidazo[1,5-a]pyridines in moderate to high yields. The fluorescence maxima and fluorescence quantum yields of the alkynylated products were 458-560 nm and Phi(F) = 0.08-0.26 in chloroform solution, and those of the alkenylated imidazopyridines were 479-537 nm and Phi(F) = 0.03-0.13. The absorption behaviors of the obtained alkynylated and alkenylated imidazo[1,5-a]pyridines showed a good fit to the values predicted by TDDFT calculations at the B3LYP/6-311++G(d,p) level. In addition, the alkynylated imidazo[1,5-a]pyridines obtained showed linear correlations between the Hammett substituent constants Of the substituents on the arylalkynyl group and their fluorescence wavelengths.
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