Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 8, Pages 2756-2759Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo100344k
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Funding
- NIH-NIGMS [GM071650]
- Camille and Henry Dreyfus Foundation
- GlaxoSmithKline
- Eli Lilly
- Amgen
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The development of conditions that allow use of inexpensive aryl chlorides as electrophiles in Pd-catalyzed alkene carboamination and carboetherification reactions is described. A catalyst composed of Pd(OAc)(2) and S-Phos minimizes N-arylation of the substrate and prevents formation of mixtures of regioisomeric products. A number of heterocycles, including pyrrolidines, isoxazolidines, tetrahydrofurans, and pyrazolidines, are efficiently generated with this method.
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