An Alternative Synthesis of 1,1′-Bis-valienamine from D-Glucose

An alternative synthesis of 1,1 '-bis-valienamine 5, which was demonstrated to be a potent trehalase inhibitor, has been achieved from D-glucose in 12 steps with 15% overall yield via enone 12 as the key intermediate, involving a direct aldol reaction of a glucose-derived diketone and a palladium-catalyzed allylic coupling reaction as the key steps.