Article
Biochemistry & Molecular Biology
Rinku Malhi, Jerry P. Jasinski, Manpreet Kaur, Kamaldeep Paul, Rekha Sharma
Summary: A variety of selenosemicarbazones were synthesized through reactions with different aldehydes and ketones. Reactions with aldehydes containing a single aromatic ring resulted in the formation of other compounds instead of selenosemicarbazones. The synthesized compounds were characterized using IR and NMR spectroscopy, and some were found to exhibit excellent anti-TB activity.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Rima D. Alharthy, Nadeem Ahmed, Saman Mubarak, Muhammad Yaqub, Muhammad Khalid, Iqra Shafiq, Muhammad Adnan Asghar, Ataualpa Albert Carmo Braga, Zahid Shafiq
Summary: A series of sensors, SM-1 to SM-3, were designed and synthesized using indole carboxaldehydes and 2,4-dinitrophenyl hydrazine. The synthesis was accompanied by a density functional theory investigation, which revealed a reduction in band gap, a bathochromic shift, and charge transference. SM-3 displayed high selectivity toward F- ions, with a low detection limit and a binding constant of 7.7 x 105.
Article
Chemistry, Multidisciplinary
Rima D. Alharthy, Nadeem Ahmed, Saman Mubarak, Muhammad Yaqub, Muhammad Khalid, Iqra Shafiq, Muhammad Adnan Asghar, Ataualpa Albert Carmo Braga, Zahid Shafiq
Summary: A new series of sensors (SM-1 to SM-3) were synthesized using indole carboxaldehydes and 2,4-dinitrophenyl hydrazine. The deprotonated chromophores exhibited a smaller band gap and a red shift compared to the neutral sensors. Charge transfer from indole to dinitrophenyl hydrazine was observed. Sensor SM-3 showed high selectivity for F- ions, while SM-1 and SM-2 responded to both F- and CN- ions.
Article
Chemistry, Medicinal
Gabriel Jasinski, Emir Salas-Sarduy, Daniel Vega, Lucas Fabian, M. Florencia Martini, Albertina G. Moglioni
Summary: Based on literature data, a QSAR model was developed to predict the activity of TSCs. New TSCs were designed and tested against CZP, resulting in highly potent inhibitors. Molecular docking and QM/QM ONIOM refinement studies confirmed the expected binding mode for the active TSCs. Kinetic experiments showed that the new TSCs act through the formation of a reversible covalent adduct. These findings highlight the effectiveness of QSAR and molecular modeling techniques in the design of potent CZ/CZP inhibitors.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Rima D. Alharthy, Ifra Urooj, Mussarat Tasleem, Muhammad Khalid, Muhammad Adnan Asghar, Shaista Ijaz Khan, Muhammad Ajmal, Nadeem Ahmed, Zahid Shafiq
Summary: The development of an effective and selective chemosensor for CN- ions is urgently needed due to their hazardous impact. Two novel chemosensors, IF-1 and IF-2, based on 3-hydroxy-2-naphthohydrazide and aldehyde derivatives, have been synthesized and shown selective sensing of CN- ions. IF-2 exhibited exclusive binding with CN- ions, confirmed by a binding constant value of 4.77 x 10(4) M-1 and a low detection limit (8.2 μM). The color change from colorless to yellow, visible by the naked eye, is attributed to the deprotonation of the labile Schiff base center by CN- ions.
Article
Chemistry, Inorganic & Nuclear
Jillian J. Davidson, S. Olivia Gunther, Derek W. Leong, Oleg V. Ozerov
Summary: This paper reports the synthesis of a series of hydrocarbon-soluble triarylamines bearing F, CF3, and Br substituents, which exhibit quasi-reversible redox events in the range of 0.59-1.32 V. A few aminium salts have been isolated successfully.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Multidisciplinary
John Douglas Johnson, Charles Reece Teeples, Nicholas Rajai Akkawi, Sidney M. Wilkerson-Hill
Summary: In this study, a new platform for transferring 1,1-dialkylcarbene units to olefins using carbometalation reactions was introduced. By reacting dialkyl sulfones with styrenes and arylbutadienes, 1,1-dialkylcyclopropanes were synthesized successfully. The potential of this method was showcased through various examples.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Behavioral Sciences
Iris I. A. Groen, Tessa M. Dekker, Tomas Knapen, Edward H. Silson
Summary: Recent studies have shown that visuospatial coding is present not only in the visual cortex, but also in other brain areas. This widespread access to visuospatial coding raises important questions about its role in cognitive functioning.
TRENDS IN COGNITIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Minhal Yildiz, Murat Bingul, Yunus Zorlu, Mehmet F. Saglam, Mehmet Boga, Mutesir Temel, Mehmet Serdar Koca, Hakan Kandemir, Ibrahim F. Sengul
Summary: A range of novel indole based thiosemicarbazone derivatives were synthesized and studied for their potential as cholinesterase inhibitors and antioxidants. Compounds 18 and 19 showed the best inhibitory activity against butyrylcholinesterase and exhibited moderate antioxidant potential. Molecular docking studies suggested that compound 19 could compete with galantamine as a cholinesterase inhibitor.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Chongyang Li, Yongli Huang, Chang Q. Sun, Lei Zhang
Summary: Recent research has found that nitrogen lone-pair electron delocalization in nitrogen heterocycles can lead to a second sigma-aromaticity, resulting in dual-aromatic compounds with distinct chemistry compared to traditional pi-aromatics. Despite being basic in nature, these compounds are surprisingly unstable and susceptible to electrophilic attack. Quantum mechanical calculations revealed a competition between their basicity and dual aromaticity. Furthermore, when the number of acidic ions is three times higher than the basic heterocyclic anions, the anions violate acid-base neutralization and remain unprotonated, with the surrounding acidic ions showing a stabilizing effect.
Article
Chemistry, Multidisciplinary
Han Xie, Tyler J. Finnegan, Vageesha W. Liyana Gunawardana, Radoslav Z. Pavlovic, Curtis E. Moore, Jovica D. Badjic
Summary: This study describes the preparation, structure, and recognition capabilities of a novel hexapodal capsule 1. The capsule shows high adaptability in complexation reactions with various anionic guests, with its structure adjusting to complement each guest. Additionally, the stability of sulfate ions within the capsule in competitive DMSO is notable, suggesting potential applications in controlling chemical reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Rabia Basri, Saeed Ullah, Ajmal Khan, Suraj N. Mali, Oussama Abchir, Samir Chtita, Ahmed El-Gokha, Parham Taslimi, Ammena Y. Binsaleh, Attalla F. El-kott, Ahmed Al-Harrasi, Zahid Shafiq
Summary: In this study, the synthesis, alpha-glucosidase inhibition, structure activity relationship, pharmacokinetics, and docking analysis of novel chromone-based thiosemicarbazones were reported. The derivatives exhibited potent activity against alpha-glucosidase, with certain compounds showing higher inhibitory activity than the standard acarbose. Moreover, a statistically significant 2D-QSAR model was developed for further design of potent thiosemicarbazones as alpha-glucosidase inhibitors.
BIOORGANIC CHEMISTRY
(2023)
Review
Chemistry, Applied
Christiane Schotten, Richard A. Bourne, Nikil Kapur, Bao N. Nguyen, Charlotte E. Willans
Summary: The electrochemical generation of N-heterocyclic carbenes (NHCs) provides a mild and selective alternative to traditional synthetic methods, which usually rely on strong bases and air-sensitive materials. The use of electrons as reagents results in an efficient and clean synthesis, enabling the direct application of NHCs in various fields such as organocatalysis, synthesis, and organometallic chemistry.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Inorganic & Nuclear
Matthew L. Gettings, Sarah E. Davis Finch, Ashank Sethia, Edward F. C. Byrd, Matthias Zeller, Davin G. Piercey
Summary: The study showcases the diverse nitrogen-rich heterocyclic products prepared from a nitrilimine, with the first cyclization of a nitrilimine with a diazonium species resulting in the formation of a tetrazole, a previously unknown transformation. Characterization of the new materials was done both chemically and energetically, with sensitivities and performances reported.
INORGANIC CHEMISTRY
(2021)
Review
Chemistry, Organic
Poonam, Ram Singh
Summary: The review summarizes the successful use of plant parts in the synthesis of bimetallic nanoparticles and their utility in the synthesis of heterocyclic molecules.
CURRENT ORGANIC CHEMISTRY
(2021)
Correction
Chemistry, Analytical
Beatriz Lozano-Torres, Alba Garcia-Fernandez, Marcia Dominguez, Felix Sancenon, Juan F. Blandez, Ramon Martinez-Manez
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Beatriz Lozano-Torres, Alba Garcia-Fernandez, Marcia Dominguez, Felix Sancenon, Juan F. Blandez, Ramon Martinez-Manez
Summary: In this study, a beta-galactosidase-activatable near-infrared (NIR) senoprobe called NBGal was developed for the detection of senescent cells using the FDA-approved Nile blue (NB) fluorophore. NBGal exhibited selective tracking of senescent cells in vitro and in vivo, making it a qualitative and minimally invasive probe for direct detection of senescent cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Antoni Llopis-Lorente, Bastiaan C. Buddingh', R. Martinez-Manez, Jan C. M. van Hest, Loai K. E. Abdelmohsen
Summary: This article demonstrates population behavior in microorganisms based on quorum sensing communication. Researchers utilized giant lipid vesicles loaded with sender-receiver machinery (enzymes and responsive biomolecules) to achieve quorum sensing behavior in an artificial cell population. The system allows for the examination of collective output based on cell density, fuel concentration, and proximity, which are important factors controlling natural quorum sensing behavior.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Marcia Dominguez, Kathleen Meyer, Felix Sancenon, Juan F. Blandez, Manuel Serrano, Ramon Martinez-Manez
Summary: Kidney damage can be monitored using different biomarkers in blood, urine or serum, and kidney failure leads to the overexpression of the alanine aminopeptidase (APN) enzyme in urine. In this study, a molecular probe (NB-ALA) based on the Nile Blue fluorophore (NB) was designed to detect APN enzyme in urine through simple fluorometric measurements.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Eva Garrido, Guillermo Hernandez-Siguenza, Estela Climent, M. Dolores Marcos, Knut Rurack, Pablo Gavina, Margarita Parra, Felix Sancenon, Vicente Marti-Centelles, Ramon Martinez-Manez
Summary: The use of gamma-hydroxybutyric acid (GHB) in drug-facilitated sexual assault has increased, leading to the need for rapid GHB detection methods. A portable strip-based lateral flow assay (LFA) using a smartphone for fluorescence readout was developed for GHB analysis. This method is based on a Cu2+ complex with a tetradentate ligand and the fluorescent dye coumarin 343, and can detect GHB at concentrations as low as 0.03 μM in MES buffer solution and 0.1 μM in soft drinks and alcoholic beverages in just 1 min.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Migle Ziemyte, Andrea Escudero, Paula Diez, Maria D. Ferrer, Jose R. Murguia, Vicente Marti-Centelles, Alex Mira, Ramon Martinez-Manez
Summary: Development of bioinspired nanomotors with effective propulsion and cargo delivery capabilities has gained significant attention for potential biomedical applications. This study presents the design and application of a multifunctional gated Janus platinum-mesoporous silica nanomotor for disrupting bacterial biofilms. The nanomotor achieves high efficacy in EPS biomass disruption and reduction in cell viability, showcasing its potential as a promising strategy for biofilm elimination.
CHEMISTRY OF MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Goncalo A. Marcelo, David Montpeyo, Joana Galhano, Ramon Martinez-Manez, Jose Luis Capelo-Martinez, Julia Lorenzo, Carlos Lodeiro, Elisabete Oliveira
Summary: In this study, a combinatory antitumoral nanotherapy was developed using magneto-fluorescent nanoparticles as carriers for a combination of two drugs (doxorubicin and ofloxacin) and surface modification with two targeting agents (AZM-SH and Cetuximab). The results showed that the nanoparticles modified with AZM-SH had higher cellular uptake than those modified with Cetuximab, making them more effective for colorectal cancer cells. Furthermore, the oral administration of the nanoparticles with an enteric coating was successfully achieved under extreme conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Patricia M. R. Batista, Catia D. F. Martins, M. Manuela M. Raposo, Susana P. G. Costa
Summary: A series of highly emissive heterocyclic alanines bearing a benzo[d]oxazolyl unit functionalized with different heterocyclic pi-spacers and (aza)crown ether moieties were synthesized. These compounds were characterized and evaluated as fluorimetric chemosensors. The sensory properties of these unnatural amino acids towards Pd2+ and Fe3+ were fine-tuned by the different crown ether binding moieties and the electronic nature of the pi-bridge, as observed by spectrofluorimetric titrations.
Article
Biotechnology & Applied Microbiology
Jose Manuel Terres-Haro, Javier Monreal-Trigo, Andy Hernandez-Montoto, Francisco Javier Ibanez-Civera, Rafael Masot-Peris, Ramon Martinez-Manez
Summary: In this study, a Finite Element Model is used to calculate the absorption and electric field enhancement of metal nanoparticles in an optical, electromagnetic field. The temperature rise caused by irradiating a suspension of nanoparticles was also measured and compared with experimental results.
BIOENGINEERING-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Iris Garrido-Cano, Anna Adam-Artigues, Ana Lameirinhas, Juan F. F. Blandez, Vicente Candela-Noguera, Ana Lluch, Begona Bermejo, Felix Sancenon, Juan Miguel Cejalvo, Ramoin Martinez-Manez, Pilar Eroles
Summary: Despite advances in breast cancer treatment, it remains the leading cause of cancer-related death in women worldwide. In this study, a nanodevice using mesoporous silica nanoparticles for miR-200c-3p delivery was designed and validated. The nanodevice demonstrated biocompatibility, escape ability from endosomes/lysosomes, and inhibition of tumor progression, invasion, migration, and proliferation in vitro. In vivo experiments confirmed tumor targeting, effective miR-200c-3p delivery, therapeutic efficacy with reduced tumor size and lung metastasis, and no signs of toxicity. Overall, miR-200c-3p-loaded nanoparticles present a potential strategy for breast cancer therapy and safe tumor-targeted delivery of microRNAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Catia D. F. Martins, M. Manuela M. Raposo, Susana P. G. Costa
Summary: Industrial activity has caused widespread metal ion pollution, leading to concerns for ecosystems and human health. Therefore, it is crucial to develop sensors that can selectively and sensitively detect these analytes. In this study, an azo dye, Dabcyl 2, was synthesized and tested for its ability to detect metal ions with environmental and industrial relevance. The results showed that chemosensor 2 had a selective response for Pd2+, Sn2+ and Fe3+, with a visible color change and significant shifts in the UV-Vis spectrum.
Article
Chemistry, Analytical
Oscar Nieves, David Ortiz de Zarate, Elena Aznar, Isabel Caballos, Eva Garrido, Ramon Martinez-Manez, Fabian Dortu, Damien Bernier, Beatriz Mengual-Chulia, F. Xavier Lopez-Labrador, Jens J. Sloth, Katrin Loeschner, Lene Duedahl-Olesen, Natalia Prado, Martin Hervello, Armando Menendez, Rainer Gransee, Thomas Klotzbuecher, M. Clara Goncalves, Fahimeh Zare, Ana Fuentes Lopez, Isabel Fernandez Segovia, Jose M. Barat Baviera, Jaime Salcedo, Sara Recuero, Santiago Simon, Ana Fernandez Blanco, Sergio Peransi, Maribel Gomez-Gomez, Amadeu Griol
Summary: This paper presents a concept for a novel adaptable sensing solution developed under the PHOTONGATE project. The solution allows for quantification of multiple analytes, with high sensitivity and selectivity. It relies on biochemical and photonic technologies and has potential applications in health diagnosis and food safety sectors.
Article
Chemistry, Analytical
Sonia C. S. Pinto, Raquel C. R. Goncalves, Susana P. G. Costa, M. Manuela M. Raposo
Summary: This study reports a meso-triphenylamine-BODIPY derivative for the highly selective detection of Cu2+ and Fe3+. The compound showed a significant color change from yellow to blue-green in the presence of Cu2+ and Fe3+. It exhibited excellent sensitivity towards Cu2+ and Fe3+ detection with low LODs.
Article
Chemistry, Multidisciplinary
Rui P. C. L. Sousa, Rita B. Figueira, Emanuela Callone, Sandra Dire, Susana P. G. Costa, Maria Manuela M. Raposo
Summary: In this study, four novel organic-inorganic hybrid materials were synthesized using the sol-gel method. The materials were based on different molecular weights of Jeffamines and ECHETMS, and characterized using various techniques. The influence of Jeffamine molecular weight on the suitability of these materials as a supporting matrix for heteroaromatic probes was assessed and discussed, and the materials were found to exhibit interesting properties for a wide range of sensing applications.
Article
Chemistry, Applied
Vicente Candela-Noguera, Maria Alfonso, Pedro Amoros, Elena Aznar, Maria Dolores Marcos, Ramon Martinez-Manez
Summary: This study comprehensively investigates the factors affecting the formation of MCM-41 type mesoporous silica nanoparticles (MSN). The hydrolysis and condensation rates are found to play a central role in nanoparticle formation, and disregarded parameters such as stirring strength and surfactant addition rate are shown to modulate nucleation and growth. Furthermore, the aging and evolution of MSN are studied through the analysis of silica framework consolidation over time, providing insights into obtaining reproducible, homogeneous, and tailored-made MCM-41 type MSN.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)