Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 75, Issue 17, Pages 6016-6018Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo1010334
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Funding
- National Nature Science Foundation of China [20772024, 20802016]
- Henan National Nature Science Foundation [092300410225]
- Program for Innovative Research Team in University of Henan Province [2008IRTSTHN002]
- Ministry of Education [NCET-09-0122]
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Highly functionalized C6-aryl-substituted purine analogues were synthesized through direct arylation of 6-chloropurine with aromatics promoted by anhydrous AlCl(3) in a single step. The reactions, which were conducted using a 3-fold excess of AlCl(3) in refluxing 1,2-dichloroethane, gave moderate to excellent product yields in 0.5 h. This work is complementary to the classical coupling reactions for the synthesis of C6-aryl-substituted purine analogues.
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