Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 20, Pages 7974-7977Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo9017183
Keywords
-
Categories
Funding
- Chinese Academy of Sciences
- National Natural Science Foundation of China [20621062, 20872156]
Ask authors/readers for more resources
CuI/L-proline catalyzed coupling of aqueous ammonia with 2-iodoacetanilides and 2-iodophenylcarbamates affords the aryl amination products at room temperature, which undergo in situ additive cyclization under acidic conditions or heating to give substituted 1H-benzimidazoles and 1,3-dihydrobenzimidazol-2-ones, respectively. A wide range of functional groups including ketone, nitro, iodo, bromo, and ester are tolerated under these reaction conditions, providing these heterocycles with great diversity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available