4.7 Article

Synthesis of Biindolizines through Highly Regioselective Palladium-Catalyzed C-H Functionalization

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 1, Pages 456-458

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo802227u

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Funding

  1. National Natural Science Foundation of China
  2. National Basic Research Program of China [2009CB825300]
  3. Chinese Academy of Sciences
  4. Science and Technology Commission of Shanghai Municipality [07pj14106, 07JC14063]

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Biindolizines were synthesized under mild conditions with excellent regioselectivity in high yields through palladium-catalyzed C-H functionalization of indolizines. Synthesis of a macrocyclic compound was also achieved via intramolecular double C-H functionalization.

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